P00848 (ATP6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit a

Alternative name(s):
F-ATPase protein 6

Gene names

Name:	Mtatp6
Synonyms:	Atp6, Atpase6, mt-Atp6

Encoded on

Mitochondrion

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial proton-transporting ATP synthase complex Inferred from sequence or structural similarity. Source: UniProtKB proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATPase activity Inferred from electronic annotation. Source: Compara hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	ATP synthase subunit a		PRO_0000082139
Regions
	Transmembrane	6 – 26	21	Helical; Potential
	Transmembrane	68 – 88	21	Helical; Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	164 – 184	21	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P00848 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 9941E80F027C4DA7	FASTA	226	25,096
	10 20 30 40 50 60 MNENLFASFI TPTMMGFPIV VAIIMFPSIL FPSSKRLINN RLHSFQHWLV KLIIKQMMLI 70 80 90 100 110 120 HTPKGRTWTL MIVSLIMFIG STNLLGLLPH TFTPTTQLSM NLSMAIPLWA GAVITGFRHK 130 140 150 160 170 180 LKSSLAHFLP QGTPISLIPM LIIIETISLF IQPMALAVRL TANITAGHLL MHLIGGATLV 190 200 210 220 LMNISPPTAT ITFIILLLLT ILEFAVALIQ AYVFTLLVSL YLHDNT

References

[1]	"Sequence and gene organization of mouse mitochondrial DNA." Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A. Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Sato M., Matsuki Y., Oguma T., Tadakuma T. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J01420 Genomic DNA. Translation: AAB48649.1. V00711 Genomic DNA. Translation: CAA24085.1. AF093677 mRNA. Translation: AAC63375.1.
IPI	IPI00135698.
PIR	PWMS6. A01051.
RefSeq	NP_904333.1. NC_005089.1.
3D structure databases
ProteinModelPortal	P00848.
ModBase	Search...
Proteomic databases
PaxDb	P00848.
PRIDE	P00848.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000082408; ENSMUSP00000080996; ENSMUSG00000064357.
GeneID	17705.
KEGG	mmu:17705.
Organism-specific databases
CTD	4508.
MGI	MGI:99927. mt-Atp6.
Phylogenomic databases
eggNOG	COG0356.
HOGENOM	HOG000034185.
HOVERGEN	HBG016693.
InParanoid	P00848.
KO	K02126.
OrthoDB	EOG4F7NM6.
ProtClustDB	MTH00101.
Gene expression databases
ArrayExpress	P00848.
Bgee	P00848.
Genevestigator	P00848.
Family and domain databases
Gene3D	1.20.120.220. 1 hit.
InterPro	IPR000568. ATPase_F0-cplx_asu. IPR023011. ATPase_F0-cplx_asu_AS. [Graphical view]
PANTHER	PTHR11410. PTHR11410. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
SUPFAM	SSF81336. ATPase_F0_A. 1 hit.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Atpase6. mouse.
NextBio	292306.
SOURCE	Search...

Entry information

Entry name

ATP6_MOUSE

Accession

Primary (citable) accession number: P00848

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program