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P00848 (ATP6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit a
Alternative name(s):
F-ATPase protein 6
Gene names
Name:Mtatp6
Synonyms:Atp6, Atpase6, mt-Atp6
Encoded onMitochondrion
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ATPase A chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226ATP synthase subunit a
PRO_0000082139

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane68 – 8821Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane189 – 20921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P00848 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 9941E80F027C4DA7

FASTA22625,096
        10         20         30         40         50         60 
MNENLFASFI TPTMMGFPIV VAIIMFPSIL FPSSKRLINN RLHSFQHWLV KLIIKQMMLI 

        70         80         90        100        110        120 
HTPKGRTWTL MIVSLIMFIG STNLLGLLPH TFTPTTQLSM NLSMAIPLWA GAVITGFRHK 

       130        140        150        160        170        180 
LKSSLAHFLP QGTPISLIPM LIIIETISLF IQPMALAVRL TANITAGHLL MHLIGGATLV 

       190        200        210        220 
LMNISPPTAT ITFIILLLLT ILEFAVALIQ AYVFTLLVSL YLHDNT 

« Hide

References

[1]"Sequence and gene organization of mouse mitochondrial DNA."
Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Sato M., Matsuki Y., Oguma T., Tadakuma T.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J01420 Genomic DNA. Translation: AAB48649.1.
V00711 Genomic DNA. Translation: CAA24085.1.
AF093677 mRNA. Translation: AAC63375.1.
PIRPWMS6. A01051.
RefSeqNP_904333.1. NC_005089.1.

3D structure databases

ProteinModelPortalP00848.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP00848.
PRIDEP00848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082408; ENSMUSP00000080996; ENSMUSG00000064357.
GeneID17705.
KEGGmmu:17705.

Organism-specific databases

CTD4508.
MGIMGI:99927. mt-Atp6.

Phylogenomic databases

eggNOGCOG0356.
HOGENOMHOG000034185.
HOVERGENHBG016693.
InParanoidP00848.
KOK02126.
OMAIPLWAGT.
OrthoDBEOG769ZND.
PhylomeDBP00848.
ProtClustDBMTH00101.
TreeFamTF343395.

Gene expression databases

BgeeP00848.
GenevestigatorP00848.

Family and domain databases

Gene3D1.20.120.220. 1 hit.
InterProIPR000568. ATPase_F0-cplx_asu.
IPR023011. ATPase_F0-cplx_asu_AS.
[Graphical view]
PANTHERPTHR11410. PTHR11410. 1 hit.
PfamPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSPR00123. ATPASEA.
SUPFAMSSF81336. SSF81336. 1 hit.
TIGRFAMsTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEPS00449. ATPASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAtpase6. mouse.
NextBio292306.
SOURCESearch...

Entry information

Entry nameATP6_MOUSE
AccessionPrimary (citable) accession number: P00848
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot