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P00848

- ATP6_MOUSE

UniProt

P00848 - ATP6_MOUSE

Protein

ATP synthase subunit a

Gene

Mtatp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

    GO - Molecular functioni

    1. ATPase activity Source: Ensembl
    2. hydrogen ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. ATP synthesis coupled proton transport Source: InterPro

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit a
    Alternative name(s):
    F-ATPase protein 6
    Gene namesi
    Name:Mtatp6
    Synonyms:Atp6, Atpase6, mt-Atp6
    Encoded oniMitochondrion
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:99927. mt-Atp6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
    3. mitochondrion Source: MGI
    4. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW

    Keywords - Cellular componenti

    CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226ATP synthase subunit aPRO_0000082139Add
    BLAST

    Proteomic databases

    PaxDbiP00848.
    PRIDEiP00848.

    Expressioni

    Gene expression databases

    BgeeiP00848.
    GenevestigatoriP00848.

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP00848.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase A chain family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0356.
    HOGENOMiHOG000034185.
    HOVERGENiHBG016693.
    InParanoidiP00848.
    KOiK02126.
    OMAiAMIQAYV.
    OrthoDBiEOG769ZND.
    PhylomeDBiP00848.
    TreeFamiTF343395.

    Family and domain databases

    Gene3Di1.20.120.220. 1 hit.
    InterProiIPR000568. ATPase_F0-cplx_asu.
    IPR023011. ATPase_F0-cplx_asu_AS.
    [Graphical view]
    PANTHERiPTHR11410. PTHR11410. 1 hit.
    PfamiPF00119. ATP-synt_A. 1 hit.
    [Graphical view]
    PRINTSiPR00123. ATPASEA.
    SUPFAMiSSF81336. SSF81336. 1 hit.
    TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
    PROSITEiPS00449. ATPASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00848-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNENLFASFI TPTMMGFPIV VAIIMFPSIL FPSSKRLINN RLHSFQHWLV    50
    KLIIKQMMLI HTPKGRTWTL MIVSLIMFIG STNLLGLLPH TFTPTTQLSM 100
    NLSMAIPLWA GAVITGFRHK LKSSLAHFLP QGTPISLIPM LIIIETISLF 150
    IQPMALAVRL TANITAGHLL MHLIGGATLV LMNISPPTAT ITFIILLLLT 200
    ILEFAVALIQ AYVFTLLVSL YLHDNT 226
    Length:226
    Mass (Da):25,096
    Last modified:July 21, 1986 - v1
    Checksum:i9941E80F027C4DA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48649.1.
    V00711 Genomic DNA. Translation: CAA24085.1.
    AF093677 mRNA. Translation: AAC63375.1.
    PIRiA01051. PWMS6.
    RefSeqiNP_904333.1. NC_005089.1.

    Genome annotation databases

    EnsembliENSMUST00000082408; ENSMUSP00000080996; ENSMUSG00000064357.
    GeneIDi17705.
    KEGGimmu:17705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01420 Genomic DNA. Translation: AAB48649.1 .
    V00711 Genomic DNA. Translation: CAA24085.1 .
    AF093677 mRNA. Translation: AAC63375.1 .
    PIRi A01051. PWMS6.
    RefSeqi NP_904333.1. NC_005089.1.

    3D structure databases

    ProteinModelPortali P00848.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P00848.
    PRIDEi P00848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082408 ; ENSMUSP00000080996 ; ENSMUSG00000064357 .
    GeneIDi 17705.
    KEGGi mmu:17705.

    Organism-specific databases

    CTDi 4508.
    MGIi MGI:99927. mt-Atp6.

    Phylogenomic databases

    eggNOGi COG0356.
    HOGENOMi HOG000034185.
    HOVERGENi HBG016693.
    InParanoidi P00848.
    KOi K02126.
    OMAi AMIQAYV.
    OrthoDBi EOG769ZND.
    PhylomeDBi P00848.
    TreeFami TF343395.

    Miscellaneous databases

    ChiTaRSi Atpase6. mouse.
    NextBioi 292306.
    SOURCEi Search...

    Gene expression databases

    Bgeei P00848.
    Genevestigatori P00848.

    Family and domain databases

    Gene3Di 1.20.120.220. 1 hit.
    InterProi IPR000568. ATPase_F0-cplx_asu.
    IPR023011. ATPase_F0-cplx_asu_AS.
    [Graphical view ]
    PANTHERi PTHR11410. PTHR11410. 1 hit.
    Pfami PF00119. ATP-synt_A. 1 hit.
    [Graphical view ]
    PRINTSi PR00123. ATPASEA.
    SUPFAMi SSF81336. SSF81336. 1 hit.
    TIGRFAMsi TIGR01131. ATP_synt_6_or_A. 1 hit.
    PROSITEi PS00449. ATPASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene organization of mouse mitochondrial DNA."
      Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.
      Cell 26:167-180(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Sato M., Matsuki Y., Oguma T., Tadakuma T.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.

    Entry informationi

    Entry nameiATP6_MOUSE
    AccessioniPrimary (citable) accession number: P00848
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3