Reviewed, UniProtKB/Swiss-Prot P00821 (ACYP2_MELGA)

Names and origin

Protein names

Recommended name:
    Acylphosphatase-2
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 2
    Acylphosphatase, muscle type isozyme
    Acylphosphatase isozyme TU1

Gene names

Name:

ACYP2

Organism

Meleagris gallopavo (Common turkey)

Taxonomic identifier

9103 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Meleagridinae › Meleagris

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Subunit structure	Monomer (TU1) or homodimer (TU3) in absence of reducing factors; disulfide linked.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation Disulfide bond Glutathionylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 103	102	Acylphosphatase-2		PRO_0000158549
Regions
	Domain	13 – 103	91	Acylphosphatase-like
Sites
	Active site	28	1	Potential
	Active site	46	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.1
	Modified residue	26	1	S-glutathionyl cysteine; alternate
	Disulfide bond	26		Interchain; alternate

Sequences

	Sequence		Length	Mass (Da)
	P00821-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 23D12EB987EC37C8	FASTA	103	11,448
	10 20 30 40 50 60 MSALTKASGA LKSVDYEVFG RVQGVCFRMY TEEEARKLGV VGWVKNTRQG TVTGQVQGPE 70 80 90 100 DKVNAMKSWL SKVGSPSSRI DRTNFSNEKE ISKLDFSGFS TRY

References

[1]	"The primary structure of turkey muscle acylphosphatase." Camici G., Manao G., Cappugi G., Berti A., Stefani M., Liguri G., Ramponi G. Eur. J. Biochem. 137:269-277(1983) [PubMed: 6317387] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-103. Tissue: Skeletal muscle.

Cross-references

Sequence databases
PIR	QPTK. A01018.
3D structure databases
HSSP	HSSP built from PDB template 1APS based on UniProtKB P00818.
SMR	P00821. Positions 11-103.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P00821.
Enzyme and pathway databases
BRENDA	3.6.1.7. 7.
Family and domain databases
InterPro	IPR020456. Acylphosphatase. IPR001792. Acylphosphatase-like. IPR017968. Acylphosphatase_CS. [Graphical view]
PANTHER	PTHR10029. Acylphosphatase. 1 hit.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
PRINTS	PR00112. ACYLPHPHTASE.
ProDom	PD001884. Acylphosphatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACYP2_MELGA

Accession

Primary (citable) accession number: P00821

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	July 28, 2009
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)