Reviewed, UniProtKB/Swiss-Prot P00820 (ACYP2_RABIT)

Names and origin

Protein names

Recommended name:
    Acylphosphatase-2
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 2
    Acylphosphatase, muscle type isozyme

Gene names

Name:	ACYP2
Synonyms:	ACYP

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Subunit structure	Monomer (RA1) and homodimer (RA3); disulfide linked.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation Disulfide bond Glutathionylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 99	98	Acylphosphatase-2		PRO_0000158545
Regions
	Domain	9 – 99	91	Acylphosphatase-like
Sites
	Active site	24	1	Potential
	Active site	42	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.1
	Modified residue	22	1	S-glutathionyl cysteine; alternate
	Disulfide bond	22		Interchain; alternate

Sequences

	Sequence		Length	Mass (Da)
	P00820-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 1EB9AA7CF8F13620	FASTA	99	10,992
	10 20 30 40 50 60 MSTAGPLKSV DYEVFGRVQG VCFRMYTEGE AKKIGVVGWV KNTSKGTVTG QVQGPEDKVN 70 80 90 SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY

References

[1]	"Amino acid sequence of acylphosphatase from rabbit skeletal muscle." Kizaki T., Takasawa T., Mizuno Y., Shiokawa H. J. Biochem. 97:1155-1161(1985) [PubMed: 2993260] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99. Tissue: Skeletal muscle.
[2]	"Rabbit skeletal muscle acylphosphatase: the amino acid sequence of form Ra1." Manao G., Camici G., Cappugi G., Stefani M., Liguri G., Berti A., Ramponi G. Arch. Biochem. Biophys. 241:418-423(1985) [PubMed: 2994566] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99. Tissue: Skeletal muscle.

Cross-references

Sequence databases
PIR	QPRB. A91988.
3D structure databases
HSSP	HSSP built from PDB template 1APS based on UniProtKB P00818.
SMR	P00820. Positions 2-99.
ModBase	Search...
Genome annotation databases
Ensembl	ENSOCUG00000015408. Oryctolagus cuniculus. [Contig view]
Phylogenomic databases
HOVERGEN	P00820.
OMA	P00820. NFSNEKT.
Enzyme and pathway databases
BRENDA	3.6.1.7. 255.
Family and domain databases
InterPro	IPR001792. Acylphosphatase. IPR017968. Acylphosphatase_CS. [Graphical view]
PANTHER	PTHR10029. Acylphosphatase. 1 hit.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
ProDom	PD001884. Acylphosphatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACYP2_RABIT

Accession

Primary (citable) accession number: P00820

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)