Reviewed, UniProtKB/Swiss-Prot P00819 (ACYP2_PIG)

Names and origin

Protein names

Recommended name:
    Acylphosphatase-2
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 2
    Acylphosphatase, muscle type isozyme

Gene names

Name:	ACYP2
Synonyms:	ACYP

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 99	98	Acylphosphatase-2		PRO_0000158544
Regions
	Domain	9 – 99	91	Acylphosphatase-like
Sites
	Active site	24	1	Potential
	Active site	42	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P00819-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 0A9CBC9831A42961	FASTA	99	11,206
	10 20 30 40 50 60 MSTARPLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEEKVN 70 80 90 SMKSWLSKIG SPSSRIDRTN FSNEKTISKL EYSNFSIRY

References

[1]	"Amino acid sequence of acylphosphatase from porcine skeletal muscle." Mizuno Y., Yamazaki M., Takasawa T., Kizaki T., Shiokawa H. J. Biochem. 97:1135-1142(1985) [PubMed: 2993259] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99. Tissue: Skeletal muscle.

Cross-references

Sequence databases
PIR	QPPG. A01016.
3D structure databases
SMR	P00819. Positions 2-99.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P00819.
Enzyme and pathway databases
BRENDA	3.6.1.7. 249.
Family and domain databases
InterPro	IPR020456. Acylphosphatase. IPR001792. Acylphosphatase-like. IPR017968. Acylphosphatase_CS. [Graphical view]
PANTHER	PTHR10029. Acylphosphatase. 1 hit.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
PRINTS	PR00112. ACYLPHPHTASE.
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACYP2_PIG

Accession

Primary (citable) accession number: P00819

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	November 24, 2009
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)