##gff-version 3 P00813 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8 P00813 UniProtKB Chain 2 363 . . . ID=PRO_0000194352;Note=Adenosine deaminase P00813 UniProtKB Region 126 143 . . . Note=Required for binding to DDP4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15016824;Dbxref=PMID:15016824 P00813 UniProtKB Active site 217 217 . . . Note=Proton donor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03958 P00813 UniProtKB Binding site 15 15 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.24 P00813 UniProtKB Binding site 17 17 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.24,ECO:0007744|PDB:3IAR P00813 UniProtKB Binding site 17 17 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.24 P00813 UniProtKB Binding site 19 19 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.24,ECO:0007744|PDB:3IAR P00813 UniProtKB Binding site 184 184 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.24,ECO:0007744|PDB:3IAR P00813 UniProtKB Binding site 214 214 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.24 P00813 UniProtKB Binding site 295 295 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305|Ref.24 P00813 UniProtKB Binding site 296 296 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|Ref.24,ECO:0007744|PDB:3IAR P00813 UniProtKB Site 58 58 . . . Note=Important for interaction with adenosine receptors and increasing their affinity for agonists;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Site 62 62 . . . Note=Important for interaction with adenosine receptors and increasing their affinity for agonists;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Site 238 238 . . . Note=Important for catalytic activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03958 P00813 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8 P00813 UniProtKB Modified residue 54 54 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P00813 UniProtKB Modified residue 232 232 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P00813 UniProtKB Natural variant 8 8 . . . ID=VAR_002209;Note=Allele ADA*2%3B found in about 10%25 of the population%3B affects duration and intensity of deep sleep%3B enhances negative effects of sleep loss during sleep deprivation%3B may have a protective role against male infertility%3B 20%25 to 30%25 decrease in activity. D->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16221767,ECO:0000269|PubMed:21734253,ECO:0000269|PubMed:26166670,ECO:0000269|PubMed:8031011;Dbxref=dbSNP:rs73598374,PMID:16221767,PMID:21734253,PMID:26166670,PMID:8031011 P00813 UniProtKB Natural variant 15 15 . . . ID=VAR_002210;Note=In ADASCID%3B loss of activity. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7599635;Dbxref=dbSNP:rs121908725,PMID:7599635 P00813 UniProtKB Natural variant 20 20 . . . ID=VAR_002211;Note=In ADASCID%3B loss of activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8299233;Dbxref=dbSNP:rs121908724,PMID:8299233 P00813 UniProtKB Natural variant 74 74 . . . ID=VAR_002212;Note=In ADASCID%3B delayed-onset. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10200056;Dbxref=dbSNP:rs121908730,PMID:10200056 P00813 UniProtKB Natural variant 76 76 . . . ID=VAR_002213;Note=In ADASCID. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2166947;Dbxref=dbSNP:rs121908736,PMID:2166947 P00813 UniProtKB Natural variant 80 80 . . . ID=VAR_002214;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8589684;Dbxref=dbSNP:rs11555566,PMID:8589684 P00813 UniProtKB Natural variant 83 83 . . . ID=VAR_002215;Note=In ADASCID%3B loss of activity. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7599635;Dbxref=dbSNP:rs121908726,PMID:7599635 P00813 UniProtKB Natural variant 97 97 . . . ID=VAR_076954;Note=In ADASCID%3B uncertain significance%3B loss of activity on its own%3B total loss of activity%3B when associated with V-106. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9361033;Dbxref=dbSNP:rs267606634,PMID:9361033 P00813 UniProtKB Natural variant 101 101 . . . ID=VAR_002216;Note=In ADASCID. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8227344;Dbxref=dbSNP:rs121908714,PMID:8227344 P00813 UniProtKB Natural variant 101 101 . . . ID=VAR_002218;Note=In ADASCID%3B loss of activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3839802;Dbxref=dbSNP:rs121908714,PMID:3839802 P00813 UniProtKB Natural variant 101 101 . . . ID=VAR_002217;Note=In ADASCID. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3182793;Dbxref=dbSNP:rs121908717,PMID:3182793 P00813 UniProtKB Natural variant 106 106 . . . ID=VAR_076955;Note=In ADASCID%3B uncertain significance%3B 30%25 of activity%3B total loss of activity%3B when associated with C-97. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9361033;Dbxref=dbSNP:rs267606635,PMID:9361033 P00813 UniProtKB Natural variant 107 107 . . . ID=VAR_002219;Note=In ADASCID. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2166947;Dbxref=dbSNP:rs121908739,PMID:2166947 P00813 UniProtKB Natural variant 129 129 . . . ID=VAR_002220;Note=In ADASCID%3B delayed-onset. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10200056;Dbxref=dbSNP:rs121908731,PMID:10200056 P00813 UniProtKB Natural variant 140 140 . . . ID=VAR_002221;Note=In ADASCID. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10200056;Dbxref=dbSNP:rs121908732,PMID:10200056 P00813 UniProtKB Natural variant 142 142 . . . ID=VAR_002222;Note=In a pancreatic ductal adenocarcinoma sample%3B somatic mutation. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18772397,ECO:0000269|PubMed:8589684;Dbxref=dbSNP:rs61732239,PMID:18772397,PMID:8589684 P00813 UniProtKB Natural variant 149 149 . . . ID=VAR_002223;Note=In ADASCID. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2166947;Dbxref=dbSNP:rs121908737,PMID:2166947 P00813 UniProtKB Natural variant 149 149 . . . ID=VAR_002224;Note=In ADASCID. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10200056;Dbxref=dbSNP:rs121908733,PMID:10200056 P00813 UniProtKB Natural variant 152 152 . . . ID=VAR_002225;Note=In an individual with partial ADA deficiency but no immunodeficiency%3B 1%2C5%25 of activity. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9225964;Dbxref=dbSNP:rs121908728,PMID:9225964 P00813 UniProtKB Natural variant 156 156 . . . ID=VAR_002226;Note=In ADASCID. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1284479;Dbxref=dbSNP:rs121908735,PMID:1284479 P00813 UniProtKB Natural variant 156 156 . . . ID=VAR_002227;Note=In ADASCID%3B loss of activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8227344;Dbxref=dbSNP:rs121908722,PMID:8227344 P00813 UniProtKB Natural variant 177 177 . . . ID=VAR_002228;Note=In ADASCID%3B loss of activity. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8227344;Dbxref=dbSNP:rs121908719,PMID:8227344 P00813 UniProtKB Natural variant 179 179 . . . ID=VAR_002229;Note=In ADASCID%3B loss of activity. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7599635;Dbxref=dbSNP:rs121908727,PMID:7599635 P00813 UniProtKB Natural variant 199 199 . . . ID=VAR_002230;Note=In ADASCID%3B delayed-onset. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10200056;Dbxref=dbSNP:rs121908734,PMID:10200056 P00813 UniProtKB Natural variant 211 211 . . . ID=VAR_002231;Note=In ADASCID%3B late onset%3B 4%25 of activity. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2166947,ECO:0000269|PubMed:9361033;Dbxref=dbSNP:rs121908740,PMID:2166947,PMID:9361033 P00813 UniProtKB Natural variant 211 211 . . . ID=VAR_002232;Note=In ADASCID. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3182793;Dbxref=dbSNP:rs121908716,PMID:3182793 P00813 UniProtKB Natural variant 215 215 . . . ID=VAR_002233;Note=In ADASCID%3B 8%25 of activity. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2166947,ECO:0000269|PubMed:9361033;Dbxref=dbSNP:rs114025668,PMID:2166947,PMID:9361033 P00813 UniProtKB Natural variant 216 216 . . . ID=VAR_002234;Note=In ADASCID%3B severe. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8227344;Dbxref=dbSNP:rs121908723,PMID:8227344 P00813 UniProtKB Natural variant 233 233 . . . ID=VAR_002235;Note=In an individual with partial ADA deficiency but no immunodeficiency%3B 20%25 of activity. T->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9225964,ECO:0000269|PubMed:9361033;Dbxref=dbSNP:rs121908729,PMID:9225964,PMID:9361033 P00813 UniProtKB Natural variant 274 274 . . . ID=VAR_002236;Note=In ADASCID. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2166947;Dbxref=dbSNP:rs121908738,PMID:2166947 P00813 UniProtKB Natural variant 291 291 . . . ID=VAR_002237;Note=In ADASCID. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1284479,ECO:0000269|PubMed:8227344;Dbxref=dbSNP:rs121908721,PMID:1284479,PMID:8227344 P00813 UniProtKB Natural variant 297 297 . . . ID=VAR_002238;Note=In ADASCID. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2783588;Dbxref=dbSNP:rs121908718,PMID:2783588 P00813 UniProtKB Natural variant 304 304 . . . ID=VAR_002239;Note=In ADASCID%3B loss of activity. L->R;Dbxref=dbSNP:rs199422327 P00813 UniProtKB Natural variant 329 329 . . . ID=VAR_002240;Note=In ADASCID. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3182793;Dbxref=dbSNP:rs121908715,PMID:3182793 P00813 UniProtKB Natural variant 337 337 . . . ID=VAR_002241;Note=In ADASCID. Missing P00813 UniProtKB Mutagenesis 58 58 . . . Note=Decreases enzyme activity by reducing substrate affinity and maximum velocity%3B abolishes ADORA1 and ADORA2A modulator function. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 60 60 . . . Note=Moderately reduces enzyme activity%3B reduces ADORA1 and ADORA2A modulation. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 61 61 . . . Note=Decreases enzyme activity by reducing maximum velocity%3B reduces ADORA1 modulation. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 62 62 . . . Note=Decreases enzyme activity by reducing substrate affinity and maximum velocity%3B abolishes ADORA1 and ADORA2A modulator function. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 64 64 . . . Note=Moderately reduces enzyme activity%3B no change in ADORA1 and ADORA2A modulation. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 65 65 . . . Note=Decreases enzyme activity by reducing substrate affinity and maximum velocity%3B reduces ADORA1 and ADORA2A modulation. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 66 66 . . . Note=No change in enzyme activity%3B no change in ADORA1 and ADORA2A modulation. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 69 69 . . . Note=Decreases enzyme activity by reducing maximum velocity%3B reduces ADORA2A modulation. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 115 115 . . . Note=No change in enzyme activity%3B no change in ADORA1 and ADORA2A modulation. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 118 118 . . . Note=Moderately reduces enzyme activity%3B no change in ADORA1 and ADORA2A modulation. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 155 155 . . . Note=Decreases enzyme activity by reducing substrate affinity and maximum velocity. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 157 157 . . . Note=Moderately reduces enzyme activity%3B no change in ADORA1 and ADORA2A modulation. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 184 184 . . . Note=Moderately reduces enzyme activity. G->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 185 185 . . . Note=Moderately reduces enzyme activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Mutagenesis 194 194 . . . Note=No change in enzyme activity. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23193172;Dbxref=PMID:23193172 P00813 UniProtKB Sequence conflict 340 340 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P00813 UniProtKB Beta strand 11 13 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 18 20 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 24 34 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 43 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 58 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 63 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 69 72 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 76 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Turn 92 94 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 95 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 104 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 109 111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 116 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 126 144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 147 155 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 159 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 162 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Turn 172 176 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 177 184 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 191 193 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 195 207 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 210 219 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 221 229 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 234 238 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 240 244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 246 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 258 261 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 263 268 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 270 272 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 279 285 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 290 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 297 300 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 304 315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 319 331 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Beta strand 333 335 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 337 351 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR P00813 UniProtKB Helix 355 362 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IAR