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P00797

- RENI_HUMAN

UniProt

P00797 - RENI_HUMAN

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Protein

Renin

Gene

REN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Catalytic activityi

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Enzyme regulationi

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.

Kineticsi

  1. KM=1 µM for angiotensinogen (in absence of ATP6AP2)
  2. KM=0.15 µM for angiotensinogen (in presence of membrane-bound ATP6AP2)

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041
Active sitei292 – 2921

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: HGNC
  2. peptidase activity Source: HGNC
  3. receptor binding Source: HGNC

GO - Biological processi

  1. angiotensin maturation Source: HGNC
  2. beta-amyloid metabolic process Source: Ensembl
  3. cell maturation Source: Ensembl
  4. cellular protein metabolic process Source: Reactome
  5. cellular response to drug Source: Ensembl
  6. drinking behavior Source: Ensembl
  7. hormone-mediated signaling pathway Source: Ensembl
  8. kidney development Source: BHF-UCL
  9. male gonad development Source: Ensembl
  10. mesonephros development Source: Ensembl
  11. proteolysis Source: HGNC
  12. regulation of blood pressure Source: ProtInc
  13. regulation of MAPK cascade Source: HGNC
  14. renin-angiotensin regulation of aldosterone production Source: Ensembl
  15. response to cAMP Source: Ensembl
  16. response to cGMP Source: Ensembl
  17. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiREACT_147707. Metabolism of Angiotensinogen to Angiotensins.

Protein family/group databases

MEROPSiA01.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin (EC:3.4.23.15)
Alternative name(s):
Angiotensinogenase
Gene namesi
Name:REN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:9958. REN.

Subcellular locationi

Secreted. Membrane
Note: Associated to membranes via binding to ATP6AP2.

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: HGNC
  3. intracellular Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041D → N in RTD. 1 Publication
VAR_035088
Natural varianti230 – 2301R → K in RTD. 1 Publication
VAR_035087
Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) [MIM:613092]: A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161L → R in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion. 1 Publication
VAR_063770

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi267430. phenotype.
613092. phenotype.
Orphaneti217330. Hyperuricemia - anemia - renal failure.
97369. Renal tubular dysgenesis of genetic origin.
PharmGKBiPA297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Propeptidei24 – 6643Activation peptide1 PublicationPRO_0000026081Add
BLAST
Chaini67 – 406340ReninPRO_0000026082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)
Disulfide bondi117 ↔ 1241 Publication
Glycosylationi141 – 1411N-linked (GlcNAc...)
Disulfide bondi283 ↔ 2871 Publication
Disulfide bondi325 ↔ 3621 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP00797.
PRIDEiP00797.

PTM databases

PhosphoSiteiP00797.
UniCarbKBiP00797.

Miscellaneous databases

PMAP-CutDBP00797.

Expressioni

Gene expression databases

BgeeiP00797.
CleanExiHS_REN.
ExpressionAtlasiP00797. baseline.
GenevestigatoriP00797.

Organism-specific databases

HPAiCAB025903.
HPA005131.

Interactioni

Subunit structurei

Interacts with ATP6AP2.2 Publications

Protein-protein interaction databases

BioGridi111904. 3 interactions.
DIPiDIP-59219N.
IntActiP00797. 1 interaction.
MINTiMINT-1381167.
STRINGi9606.ENSP00000272190.

Structurei

Secondary structure

1
406
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353Combined sources
Helixi42 – 498Combined sources
Helixi53 – 564Combined sources
Beta strandi59 – 613Combined sources
Beta strandi74 – 818Combined sources
Turni82 – 843Combined sources
Beta strandi85 – 928Combined sources
Turni93 – 964Combined sources
Beta strandi97 – 1048Combined sources
Beta strandi110 – 1145Combined sources
Helixi119 – 1213Combined sources
Helixi122 – 1254Combined sources
Helixi132 – 1343Combined sources
Beta strandi139 – 14911Combined sources
Beta strandi152 – 16514Combined sources
Beta strandi168 – 17912Combined sources
Helixi182 – 1854Combined sources
Beta strandi189 – 1957Combined sources
Helixi199 – 2013Combined sources
Helixi203 – 2053Combined sources
Helixi209 – 2157Combined sources
Beta strandi219 – 22810Combined sources
Beta strandi233 – 2364Combined sources
Beta strandi240 – 2467Combined sources
Helixi249 – 2513Combined sources
Beta strandi252 – 2609Combined sources
Beta strandi262 – 2665Combined sources
Beta strandi268 – 2714Combined sources
Beta strandi274 – 2763Combined sources
Beta strandi279 – 2824Combined sources
Turni284 – 2863Combined sources
Beta strandi287 – 2915Combined sources
Beta strandi296 – 3005Combined sources
Helixi302 – 31211Combined sources
Beta strandi315 – 3173Combined sources
Beta strandi318 – 3203Combined sources
Beta strandi321 – 3244Combined sources
Helixi325 – 3306Combined sources
Beta strandi334 – 3385Combined sources
Beta strandi341 – 3455Combined sources
Helixi347 – 3504Combined sources
Beta strandi360 – 3689Combined sources
Turni373 – 3753Combined sources
Beta strandi379 – 3813Combined sources
Helixi383 – 3864Combined sources
Beta strandi389 – 3946Combined sources
Turni395 – 3984Combined sources
Beta strandi399 – 4057Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BBSX-ray2.80A/B67-406[»]
1BILX-ray2.40A/B70-406[»]
1BIMX-ray2.80A/B70-406[»]
1HRNX-ray1.80A/B70-406[»]
1RNEX-ray2.40A67-406[»]
2BKSX-ray2.20A/B67-406[»]
2BKTX-ray2.30A/B67-406[»]
2FS4X-ray2.20A/B74-406[»]
2G1NX-ray2.90A/B74-406[»]
2G1OX-ray2.70A/B74-406[»]
2G1RX-ray2.42A/B74-406[»]
2G1SX-ray2.50A/B74-406[»]
2G1YX-ray2.50A/B74-406[»]
2G20X-ray2.40A/B74-406[»]
2G21X-ray2.20A/B74-406[»]
2G22X-ray2.50A/B74-406[»]
2G24X-ray1.90A/B74-406[»]
2G26X-ray2.10A/B74-406[»]
2G27X-ray2.90A/B74-406[»]
2I4QX-ray2.30A/B73-406[»]
2IKOX-ray1.90A/B67-406[»]
2IKUX-ray2.60A/B67-406[»]
2IL2X-ray2.24A/B67-406[»]
2RENX-ray2.50A67-406[»]
2V0ZX-ray2.20C/O67-406[»]
2V10X-ray3.10C/O67-406[»]
2V11X-ray3.10C/O67-406[»]
2V12X-ray3.20C/O67-406[»]
2V13X-ray2.80A67-406[»]
2V16X-ray2.80C/O67-406[»]
2X0BX-ray4.33A/C/E/G24-406[»]
3D91X-ray2.20A/B67-406[»]
3G6ZX-ray2.00A/B67-406[»]
3G70X-ray2.00A/B67-406[»]
3G72X-ray1.90A/B67-406[»]
3GW5X-ray2.00A/B70-406[»]
3K1WX-ray1.50A/B67-406[»]
3KM4X-ray1.90A/B70-406[»]
3O9LX-ray2.40A/C67-232[»]
B/D237-406[»]
3OADX-ray2.17A/C67-232[»]
B/D237-406[»]
3OAGX-ray2.30A/C67-232[»]
B/D237-406[»]
3OOTX-ray2.55A/B67-406[»]
3OQFX-ray2.78A/B67-406[»]
3OQKX-ray2.90A/B67-406[»]
3OWNX-ray2.00A/B67-406[»]
3Q3TX-ray2.60A/B67-406[»]
3Q4BX-ray2.19A/B67-406[»]
3Q5HX-ray2.16A/B67-406[»]
3SFCX-ray2.10A/B67-406[»]
3VCMX-ray2.93A/B67-406[»]
P/Q24-66[»]
3VSWX-ray3.00A/B67-406[»]
3VSXX-ray2.80A/B67-406[»]
3VUCX-ray2.60A/B67-406[»]
3VYDX-ray2.81A/B67-406[»]
3VYEX-ray2.70A/B67-406[»]
3VYFX-ray2.80A/B67-406[»]
4AMTX-ray2.60A24-406[»]
4GJ5X-ray2.40A/B67-406[»]
4GJ6X-ray2.58A/B67-406[»]
4GJ7X-ray2.80A/B67-406[»]
4GJ8X-ray2.50A/B67-406[»]
4GJ9X-ray2.60A/B67-406[»]
4GJAX-ray2.60A/B67-406[»]
4GJBX-ray2.75A/B67-406[»]
4GJCX-ray2.40A/B67-406[»]
4GJDX-ray2.65A/B67-406[»]
4PYVX-ray2.65A/B67-406[»]
4Q1NX-ray2.09A/B67-406[»]
ProteinModelPortaliP00797.
SMRiP00797. Positions 29-406.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00797.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248684.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiP00797.
KOiK01380.
OMAiIARYYTE.
OrthoDBiEOG7HQN88.
PhylomeDBiP00797.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P00797-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG
60 70 80 90 100
VDMARLGPEW SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK
110 120 130 140 150
VVFDTGSSNV WVPSSKCSRL YTACVYHKLF DASDSSSYKH NGTELTLRYS
160 170 180 190 200
TGTVSGFLSQ DIITVGGITV TQMFGEVTEM PALPFMLAEF DGVVGMGFIE
210 220 230 240 250
QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG QIVLGGSDPQ
260 270 280 290 300
HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG
310 320 330 340 350
STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY
360 370 380 390 400
VFQESYSSKK LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI

GFALAR
Length:406
Mass (Da):45,057
Last modified:January 1, 1988 - v1
Checksum:i5AFDF8E973B21EDA
GO
Isoform 2 (identifier: P00797-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-233: Missing.

Show »
Length:403
Mass (Da):44,726
Checksum:i4DEF0016D9EF5854
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551R → S in AAA60364. (PubMed:3530608)Curated
Sequence conflicti189 – 1891E → Q in AAA60364. (PubMed:3530608)Curated
Sequence conflicti304 – 3041S → C in AAA60364. (PubMed:3530608)Curated
Sequence conflicti351 – 3511V → I(PubMed:6138751)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161L → R in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion. 1 Publication
VAR_063770
Natural varianti33 – 331R → W.
Corresponds to variant rs11571098 [ dbSNP | Ensembl ].
VAR_020375
Natural varianti104 – 1041D → N in RTD. 1 Publication
VAR_035088
Natural varianti160 – 1601Q → K.
Corresponds to variant rs11571083 [ dbSNP | Ensembl ].
VAR_029171
Natural varianti217 – 2171G → R.
Corresponds to variant rs11571117 [ dbSNP | Ensembl ].
VAR_020376
Natural varianti230 – 2301R → K in RTD. 1 Publication
VAR_035087

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 2333Missing in isoform 2. CuratedVSP_012899

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00073
, L00064, L00065, L00066, L00067, L00068, L00069, L00070, L00071, L00072 Genomic DNA. Translation: AAA60363.1.
M26901, M26899, M26900 Genomic DNA. Translation: AAA60364.1.
M10152
, M10030, M10128, M10150, M10151 Genomic DNA. Translation: AAD03461.1.
AY436324 Genomic DNA. Translation: AAR03502.1.
CR536498 mRNA. Translation: CAG38737.1.
EU332871 Genomic DNA. Translation: ABY87560.1.
AL592114, AL592146 Genomic DNA. Translation: CAH71224.1.
AL592146, AL592114 Genomic DNA. Translation: CAI16594.1.
BC033474 mRNA. Translation: AAH33474.1.
BC047752 mRNA. Translation: AAH47752.1.
M15410 Genomic DNA. Translation: AAA60263.1.
M26440 Genomic DNA. Translation: AAA60365.1.
M13253 Genomic DNA. Translation: AAA60262.1.
CCDSiCCDS30981.1. [P00797-1]
PIRiA21454. REHUK.
RefSeqiNP_000528.1. NM_000537.3. [P00797-1]
UniGeneiHs.3210.

Genome annotation databases

EnsembliENST00000272190; ENSP00000272190; ENSG00000143839. [P00797-1]
GeneIDi5972.
KEGGihsa:5972.
UCSCiuc001haq.2. human. [P00797-1]

Polymorphism databases

DMDMi132326.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Renin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00073
, L00064 , L00065 , L00066 , L00067 , L00068 , L00069 , L00070 , L00071 , L00072 Genomic DNA. Translation: AAA60363.1 .
M26901 , M26899 , M26900 Genomic DNA. Translation: AAA60364.1 .
M10152
, M10030 , M10128 , M10150 , M10151 Genomic DNA. Translation: AAD03461.1 .
AY436324 Genomic DNA. Translation: AAR03502.1 .
CR536498 mRNA. Translation: CAG38737.1 .
EU332871 Genomic DNA. Translation: ABY87560.1 .
AL592114 , AL592146 Genomic DNA. Translation: CAH71224.1 .
AL592146 , AL592114 Genomic DNA. Translation: CAI16594.1 .
BC033474 mRNA. Translation: AAH33474.1 .
BC047752 mRNA. Translation: AAH47752.1 .
M15410 Genomic DNA. Translation: AAA60263.1 .
M26440 Genomic DNA. Translation: AAA60365.1 .
M13253 Genomic DNA. Translation: AAA60262.1 .
CCDSi CCDS30981.1. [P00797-1 ]
PIRi A21454. REHUK.
RefSeqi NP_000528.1. NM_000537.3. [P00797-1 ]
UniGenei Hs.3210.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BBS X-ray 2.80 A/B 67-406 [» ]
1BIL X-ray 2.40 A/B 70-406 [» ]
1BIM X-ray 2.80 A/B 70-406 [» ]
1HRN X-ray 1.80 A/B 70-406 [» ]
1RNE X-ray 2.40 A 67-406 [» ]
2BKS X-ray 2.20 A/B 67-406 [» ]
2BKT X-ray 2.30 A/B 67-406 [» ]
2FS4 X-ray 2.20 A/B 74-406 [» ]
2G1N X-ray 2.90 A/B 74-406 [» ]
2G1O X-ray 2.70 A/B 74-406 [» ]
2G1R X-ray 2.42 A/B 74-406 [» ]
2G1S X-ray 2.50 A/B 74-406 [» ]
2G1Y X-ray 2.50 A/B 74-406 [» ]
2G20 X-ray 2.40 A/B 74-406 [» ]
2G21 X-ray 2.20 A/B 74-406 [» ]
2G22 X-ray 2.50 A/B 74-406 [» ]
2G24 X-ray 1.90 A/B 74-406 [» ]
2G26 X-ray 2.10 A/B 74-406 [» ]
2G27 X-ray 2.90 A/B 74-406 [» ]
2I4Q X-ray 2.30 A/B 73-406 [» ]
2IKO X-ray 1.90 A/B 67-406 [» ]
2IKU X-ray 2.60 A/B 67-406 [» ]
2IL2 X-ray 2.24 A/B 67-406 [» ]
2REN X-ray 2.50 A 67-406 [» ]
2V0Z X-ray 2.20 C/O 67-406 [» ]
2V10 X-ray 3.10 C/O 67-406 [» ]
2V11 X-ray 3.10 C/O 67-406 [» ]
2V12 X-ray 3.20 C/O 67-406 [» ]
2V13 X-ray 2.80 A 67-406 [» ]
2V16 X-ray 2.80 C/O 67-406 [» ]
2X0B X-ray 4.33 A/C/E/G 24-406 [» ]
3D91 X-ray 2.20 A/B 67-406 [» ]
3G6Z X-ray 2.00 A/B 67-406 [» ]
3G70 X-ray 2.00 A/B 67-406 [» ]
3G72 X-ray 1.90 A/B 67-406 [» ]
3GW5 X-ray 2.00 A/B 70-406 [» ]
3K1W X-ray 1.50 A/B 67-406 [» ]
3KM4 X-ray 1.90 A/B 70-406 [» ]
3O9L X-ray 2.40 A/C 67-232 [» ]
B/D 237-406 [» ]
3OAD X-ray 2.17 A/C 67-232 [» ]
B/D 237-406 [» ]
3OAG X-ray 2.30 A/C 67-232 [» ]
B/D 237-406 [» ]
3OOT X-ray 2.55 A/B 67-406 [» ]
3OQF X-ray 2.78 A/B 67-406 [» ]
3OQK X-ray 2.90 A/B 67-406 [» ]
3OWN X-ray 2.00 A/B 67-406 [» ]
3Q3T X-ray 2.60 A/B 67-406 [» ]
3Q4B X-ray 2.19 A/B 67-406 [» ]
3Q5H X-ray 2.16 A/B 67-406 [» ]
3SFC X-ray 2.10 A/B 67-406 [» ]
3VCM X-ray 2.93 A/B 67-406 [» ]
P/Q 24-66 [» ]
3VSW X-ray 3.00 A/B 67-406 [» ]
3VSX X-ray 2.80 A/B 67-406 [» ]
3VUC X-ray 2.60 A/B 67-406 [» ]
3VYD X-ray 2.81 A/B 67-406 [» ]
3VYE X-ray 2.70 A/B 67-406 [» ]
3VYF X-ray 2.80 A/B 67-406 [» ]
4AMT X-ray 2.60 A 24-406 [» ]
4GJ5 X-ray 2.40 A/B 67-406 [» ]
4GJ6 X-ray 2.58 A/B 67-406 [» ]
4GJ7 X-ray 2.80 A/B 67-406 [» ]
4GJ8 X-ray 2.50 A/B 67-406 [» ]
4GJ9 X-ray 2.60 A/B 67-406 [» ]
4GJA X-ray 2.60 A/B 67-406 [» ]
4GJB X-ray 2.75 A/B 67-406 [» ]
4GJC X-ray 2.40 A/B 67-406 [» ]
4GJD X-ray 2.65 A/B 67-406 [» ]
4PYV X-ray 2.65 A/B 67-406 [» ]
4Q1N X-ray 2.09 A/B 67-406 [» ]
ProteinModelPortali P00797.
SMRi P00797. Positions 29-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111904. 3 interactions.
DIPi DIP-59219N.
IntActi P00797. 1 interaction.
MINTi MINT-1381167.
STRINGi 9606.ENSP00000272190.

Chemistry

BindingDBi P00797.
ChEMBLi CHEMBL286.
DrugBanki DB01258. Aliskiren.
DB00212. Remikiren.
GuidetoPHARMACOLOGYi 2413.

Protein family/group databases

MEROPSi A01.007.

PTM databases

PhosphoSitei P00797.
UniCarbKBi P00797.

Polymorphism databases

DMDMi 132326.

Proteomic databases

PaxDbi P00797.
PRIDEi P00797.

Protocols and materials databases

DNASUi 5972.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272190 ; ENSP00000272190 ; ENSG00000143839 . [P00797-1 ]
GeneIDi 5972.
KEGGi hsa:5972.
UCSCi uc001haq.2. human. [P00797-1 ]

Organism-specific databases

CTDi 5972.
GeneCardsi GC01M204123.
GeneReviewsi REN.
HGNCi HGNC:9958. REN.
HPAi CAB025903.
HPA005131.
MIMi 179820. gene.
267430. phenotype.
613092. phenotype.
neXtProti NX_P00797.
Orphaneti 217330. Hyperuricemia - anemia - renal failure.
97369. Renal tubular dysgenesis of genetic origin.
PharmGKBi PA297.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248684.
GeneTreei ENSGT00760000118929.
HOGENOMi HOG000197681.
HOVERGENi HBG000482.
InParanoidi P00797.
KOi K01380.
OMAi IARYYTE.
OrthoDBi EOG7HQN88.
PhylomeDBi P00797.
TreeFami TF314990.

Enzyme and pathway databases

Reactomei REACT_147707. Metabolism of Angiotensinogen to Angiotensins.

Miscellaneous databases

EvolutionaryTracei P00797.
GeneWikii Renin.
GenomeRNAii 5972.
NextBioi 23249.
PMAP-CutDB P00797.
PROi P00797.
SOURCEi Search...

Gene expression databases

Bgeei P00797.
CleanExi HS_REN.
ExpressionAtlasi P00797. baseline.
Genevestigatori P00797.

Family and domain databases

Gene3Di 2.40.70.10. 2 hits.
InterProi IPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
PANTHERi PTHR13683. PTHR13683. 1 hit.
Pfami PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view ]
PRINTSi PR00792. PEPSIN.
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS00141. ASP_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  2. "New possibilities for intracellular renin and inactive renin now that the structure of the human renin gene has been elucidated."
    Morris B.J.
    Clin. Sci. 71:345-355(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fetal liver.
  4. Rieder M.J., da Ponte S.H., Kuldanek S.A., Rajkumar N., Smith J.D., Toth E.J., Krauss R.M., Nickerson D.A.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. NIEHS SNPs program
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon and Ovary.
  9. "Molecular cloning and nucleotide sequence of a human renin cDNA fragment."
    Soubrier F., Panthier J.-J., Corvol P., Rougeon F.
    Nucleic Acids Res. 11:7181-7190(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-406 (ISOFORM 1).
  10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33.
  11. "Identification of negative and positive regulatory elements in the human renin gene."
    Burt D.W., Nakamura N., Kelley P., Dzau V.J.
    J. Biol. Chem. 264:7357-7362(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33.
  12. "Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions."
    Soubrier F., Panthier J.J., Houot A.-M., Rougeon F., Corvol P.
    Gene 41:85-92(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33.
  13. "Isolation and characterization of recombinant human prorenin in Chinese hamster ovary cells."
    Ishizuka Y., Shoda A., Yoshida S., Kawamura Y., Haraguchi K., Murakami K.
    J. Biochem. 109:30-35(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-42 AND 67-86.
  14. "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin."
    Nguyen G., Delarue F., Burckle C., Bouzhir L., Giller T., Sraer J.-D.
    J. Clin. Invest. 109:1417-1427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATP6AP2, CHARACTERIZATION.
  15. "Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5-A resolution."
    Sielecki A.R., Hayakawa K., Fujinaga M., Murphy M.E.P., Fraser M., Muir A.K., Carilli C.T., Lewicki J.A., Baxter J.D., James M.N.G.
    Science 243:1346-1351(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
  16. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  17. Cited for: X-RAY CRYSTALLOGRAPHY (4.33 ANGSTROMS) OF 24-406 OF MUTANT ALA-292 IN COMPLEX WITH ANGIOTENSINOGEN, DISULFIDE BONDS.
  18. Cited for: VARIANTS RTD ASN-104 AND LYS-230.
  19. Cited for: VARIANT HNFJ2 ARG-16, CHARACTERIZATION OF VARIANT HNFJ2 ARG-16.

Entry informationi

Entry nameiRENI_HUMAN
AccessioniPrimary (citable) accession number: P00797
Secondary accession number(s): Q6FI38, Q6T5C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: November 26, 2014
This is version 183 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3