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P00779

- STRP_STREQ

UniProt

P00779 - STRP_STREQ

Protein

Streptokinase C

Gene

skc

Organism
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Plasminogen activation, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Streptokinase C
    Gene namesi
    Name:skc
    OrganismiStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
    Taxonomic identifieri119602 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 440414Streptokinase CPRO_0000022428Add
    BLAST

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PLGP007472EBI-1035089,EBI-999394From a different organism.

    Protein-protein interaction databases

    IntActiP00779. 1 interaction.

    Structurei

    Secondary structure

    1
    440
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 353
    Beta strandi43 – 5210
    Turni53 – 553
    Beta strandi58 – 603
    Beta strandi64 – 707
    Beta strandi96 – 1016
    Helixi102 – 11514
    Beta strandi119 – 1213
    Beta strandi124 – 1296
    Beta strandi134 – 1374
    Beta strandi149 – 1524
    Beta strandi155 – 1573
    Beta strandi160 – 17112
    Beta strandi178 – 1803
    Beta strandi184 – 19613
    Beta strandi209 – 2146
    Beta strandi219 – 2213
    Helixi222 – 23615
    Beta strandi240 – 25213
    Beta strandi263 – 2653
    Beta strandi268 – 2703
    Beta strandi278 – 2803
    Turni282 – 2843
    Beta strandi287 – 2893
    Beta strandi292 – 30413
    Beta strandi310 – 3123
    Beta strandi316 – 32712
    Turni328 – 3303
    Beta strandi333 – 34210
    Helixi344 – 3463
    Turni355 – 3584
    Helixi367 – 3693
    Beta strandi373 – 38210
    Beta strandi386 – 39712

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BMLX-ray2.90C/D38-398[»]
    1L4DX-ray2.30B40-173[»]
    1L4ZX-ray2.80B27-173[»]
    1QQRX-ray2.30A/B/C/D177-314[»]
    ProteinModelPortaliP00779.
    SMRiP00779. Positions 38-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00779.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR004093. SAK/SK.
    IPR008124. SK.
    [Graphical view]
    PfamiPF02821. Staphylokinase. 3 hits.
    [Graphical view]
    PRINTSiPR01753. STREPKINASE.
    SUPFAMiSSF54328. SSF54328. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG    50
    TVEGTNQDIS LKFFEIDLTS RPAHGGKTEQ GLSPKSKPFA TDSGAMSHKL 100
    EKADLLKAIQ EQLIANVHSN DDYFEVIDFA SDATITDRNG KVYFADKDGS 150
    VTLPTQPVQE FLLSGHVRVR PYKEKPIQNQ AKSVDVEYTV QFTPLNPDDD 200
    FRPGLKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY TIYERDSSIV 250
    THDNDIFRTI LPMDQEFTYR VKNREQAYRI NKKSGLNEEI NNTDLISEKY 300
    YVLKKGEKPY DPFDRSHLKL FTIKYVDVDT NELLKSEQLL TASERNLDFR 350
    DLYDPRDKAK LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE 400
    GENASYHLAY DKDRYTEEER EVYSYLRYTG TPIPDNPNDK 440
    Length:440
    Mass (Da):50,140
    Last modified:April 1, 1988 - v1
    Checksum:i8FC1F22648ACC77A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti298 – 3003EKY → LEYK AA sequence (PubMed:6760891)Curated
    Sequence conflicti438 – 4381N → D AA sequence (PubMed:6760891)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti195 – 1951L → D.
    Natural varianti207 – 2071D → L.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02986 Genomic DNA. Translation: AAA26974.1.
    X72832 Genomic DNA. Translation: CAA51351.1.
    PIRiA00967. BZSO.
    A22801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02986 Genomic DNA. Translation: AAA26974.1 .
    X72832 Genomic DNA. Translation: CAA51351.1 .
    PIRi A00967. BZSO.
    A22801.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BML X-ray 2.90 C/D 38-398 [» ]
    1L4D X-ray 2.30 B 40-173 [» ]
    1L4Z X-ray 2.80 B 27-173 [» ]
    1QQR X-ray 2.30 A/B/C/D 177-314 [» ]
    ProteinModelPortali P00779.
    SMRi P00779. Positions 38-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00779. 1 interaction.

    Chemistry

    DrugBanki DB00086. Streptokinase.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P00779.

    Family and domain databases

    InterProi IPR004093. SAK/SK.
    IPR008124. SK.
    [Graphical view ]
    Pfami PF02821. Staphylokinase. 3 hits.
    [Graphical view ]
    PRINTSi PR01753. STREPKINASE.
    SUPFAMi SSF54328. SSF54328. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the streptokinase gene from Streptococcus equisimilis H46A."
      Malke H., Roe B.A., Ferretti J.J.
      Gene 34:357-362(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: H46A.
    2. "Complete amino acid sequence of streptokinase and its homology with serine proteases."
      Jackson K.W., Tang J.
      Biochemistry 21:6620-6625(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-440.

    Entry informationi

    Entry nameiSTRP_STREQ
    AccessioniPrimary (citable) accession number: P00779
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3