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P00779 (STRP_STREQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Streptokinase C
Gene names
Name:skc
OrganismStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Taxonomic identifier119602 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.

Ontologies

Keywords
   Biological processPlasminogen activation
Virulence
   DomainSignal
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PLGP007472EBI-1035089,EBI-999394From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Ref.2
Chain27 – 440414Streptokinase C
PRO_0000022428

Natural variations

Natural variant1951L → D.
Natural variant2071D → L.

Experimental info

Sequence conflict298 – 3003EKY → LEYK AA sequence Ref.2
Sequence conflict4381N → D AA sequence Ref.2

Secondary structure

1 ................................................................. 440
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00779 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 8FC1F22648ACC77A

FASTA44050,140
        10         20         30         40         50         60 
MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG TVEGTNQDIS 

        70         80         90        100        110        120 
LKFFEIDLTS RPAHGGKTEQ GLSPKSKPFA TDSGAMSHKL EKADLLKAIQ EQLIANVHSN 

       130        140        150        160        170        180 
DDYFEVIDFA SDATITDRNG KVYFADKDGS VTLPTQPVQE FLLSGHVRVR PYKEKPIQNQ 

       190        200        210        220        230        240 
AKSVDVEYTV QFTPLNPDDD FRPGLKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY 

       250        260        270        280        290        300 
TIYERDSSIV THDNDIFRTI LPMDQEFTYR VKNREQAYRI NKKSGLNEEI NNTDLISEKY 

       310        320        330        340        350        360 
YVLKKGEKPY DPFDRSHLKL FTIKYVDVDT NELLKSEQLL TASERNLDFR DLYDPRDKAK 

       370        380        390        400        410        420 
LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE GENASYHLAY DKDRYTEEER 

       430        440 
EVYSYLRYTG TPIPDNPNDK

« Hide

References

[1]"Nucleotide sequence of the streptokinase gene from Streptococcus equisimilis H46A."
Malke H., Roe B.A., Ferretti J.J.
Gene 34:357-362(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: H46A.
[2]"Complete amino acid sequence of streptokinase and its homology with serine proteases."
Jackson K.W., Tang J.
Biochemistry 21:6620-6625(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-440.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		K02986 Genomic DNA. Translation: AAA26974.1.
X72832 Genomic DNA. Translation: CAA51351.1.
PIRBZSO. A00967.
A22801.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMLX-ray2.90C/D38-398[»]
1L4DX-ray2.30B40-173[»]
1L4ZX-ray2.80B27-173[»]
1QQRX-ray2.30A/B/C/D177-314[»]
ProteinModelPortalP00779.
SMRP00779. Positions 38-398.
ModBaseSearch...

Protein-protein interaction databases

IntActP00779. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004093. Staphylokinase.
IPR008124. Streptokinase_streptococcus.
[Graphical view]
PfamPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSPR01753. STREPKINASE.
SUPFAMSSF54328. Staphylokinase. 3 hits.
ProtoNetSearch...

Other

DrugBankDB00086. Streptokinase.
EvolutionaryTraceP00779.

Entry information

Entry nameSTRP_STREQ
AccessionPrimary (citable) accession number: P00779
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

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