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Protein

Streptokinase C

Gene

skc

Organism
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Plasminogen activation, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Streptokinase C
Gene namesi
Name:skc
OrganismiStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Taxonomic identifieri119602 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000002242827 – 440Streptokinase CAdd BLAST414

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLGP007472EBI-1035089,EBI-999394From a different organism.

Protein-protein interaction databases

IntActiP00779. 1 interactor.

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 35Combined sources3
Beta strandi43 – 52Combined sources10
Turni53 – 55Combined sources3
Beta strandi58 – 60Combined sources3
Beta strandi64 – 70Combined sources7
Beta strandi96 – 101Combined sources6
Helixi102 – 115Combined sources14
Beta strandi119 – 121Combined sources3
Beta strandi124 – 129Combined sources6
Beta strandi134 – 137Combined sources4
Beta strandi149 – 152Combined sources4
Beta strandi155 – 157Combined sources3
Beta strandi160 – 171Combined sources12
Beta strandi178 – 180Combined sources3
Beta strandi184 – 196Combined sources13
Beta strandi209 – 214Combined sources6
Beta strandi219 – 221Combined sources3
Helixi222 – 236Combined sources15
Beta strandi240 – 252Combined sources13
Beta strandi263 – 265Combined sources3
Beta strandi268 – 270Combined sources3
Beta strandi278 – 280Combined sources3
Turni282 – 284Combined sources3
Beta strandi287 – 289Combined sources3
Beta strandi292 – 304Combined sources13
Beta strandi310 – 312Combined sources3
Beta strandi316 – 327Combined sources12
Turni328 – 330Combined sources3
Beta strandi333 – 342Combined sources10
Helixi344 – 346Combined sources3
Turni355 – 358Combined sources4
Helixi367 – 369Combined sources3
Beta strandi373 – 382Combined sources10
Beta strandi386 – 397Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMLX-ray2.90C/D38-398[»]
1L4DX-ray2.30B40-173[»]
1L4ZX-ray2.80B27-173[»]
1QQRX-ray2.30A/B/C/D177-314[»]
ProteinModelPortaliP00779.
SMRiP00779.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00779.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR004093. SAK/SK.
IPR008124. SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG
60 70 80 90 100
TVEGTNQDIS LKFFEIDLTS RPAHGGKTEQ GLSPKSKPFA TDSGAMSHKL
110 120 130 140 150
EKADLLKAIQ EQLIANVHSN DDYFEVIDFA SDATITDRNG KVYFADKDGS
160 170 180 190 200
VTLPTQPVQE FLLSGHVRVR PYKEKPIQNQ AKSVDVEYTV QFTPLNPDDD
210 220 230 240 250
FRPGLKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY TIYERDSSIV
260 270 280 290 300
THDNDIFRTI LPMDQEFTYR VKNREQAYRI NKKSGLNEEI NNTDLISEKY
310 320 330 340 350
YVLKKGEKPY DPFDRSHLKL FTIKYVDVDT NELLKSEQLL TASERNLDFR
360 370 380 390 400
DLYDPRDKAK LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE
410 420 430 440
GENASYHLAY DKDRYTEEER EVYSYLRYTG TPIPDNPNDK
Length:440
Mass (Da):50,140
Last modified:April 1, 1988 - v1
Checksum:i8FC1F22648ACC77A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298 – 300EKY → LEYK AA sequence (PubMed:6760891).Curated3
Sequence conflicti438N → D AA sequence (PubMed:6760891).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti195L → D.1
Natural varianti207D → L.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02986 Genomic DNA. Translation: AAA26974.1.
X72832 Genomic DNA. Translation: CAA51351.1.
PIRiA00967. BZSO.
A22801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02986 Genomic DNA. Translation: AAA26974.1.
X72832 Genomic DNA. Translation: CAA51351.1.
PIRiA00967. BZSO.
A22801.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMLX-ray2.90C/D38-398[»]
1L4DX-ray2.30B40-173[»]
1L4ZX-ray2.80B27-173[»]
1QQRX-ray2.30A/B/C/D177-314[»]
ProteinModelPortaliP00779.
SMRiP00779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00779. 1 interactor.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP00779.

Family and domain databases

InterProiIPR004093. SAK/SK.
IPR008124. SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSTRP_STREQ
AccessioniPrimary (citable) accession number: P00779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.