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P00779

- STRP_STREQ

UniProt

P00779 - STRP_STREQ

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Protein

Streptokinase C

Gene

skc

Organism
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. plasminogen activation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Plasminogen activation, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Streptokinase C
Gene namesi
Name:skc
OrganismiStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Taxonomic identifieri119602 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 440414Streptokinase CPRO_0000022428Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLGP007472EBI-1035089,EBI-999394From a different organism.

Protein-protein interaction databases

IntActiP00779. 1 interaction.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 353
Beta strandi43 – 5210
Turni53 – 553
Beta strandi58 – 603
Beta strandi64 – 707
Beta strandi96 – 1016
Helixi102 – 11514
Beta strandi119 – 1213
Beta strandi124 – 1296
Beta strandi134 – 1374
Beta strandi149 – 1524
Beta strandi155 – 1573
Beta strandi160 – 17112
Beta strandi178 – 1803
Beta strandi184 – 19613
Beta strandi209 – 2146
Beta strandi219 – 2213
Helixi222 – 23615
Beta strandi240 – 25213
Beta strandi263 – 2653
Beta strandi268 – 2703
Beta strandi278 – 2803
Turni282 – 2843
Beta strandi287 – 2893
Beta strandi292 – 30413
Beta strandi310 – 3123
Beta strandi316 – 32712
Turni328 – 3303
Beta strandi333 – 34210
Helixi344 – 3463
Turni355 – 3584
Helixi367 – 3693
Beta strandi373 – 38210
Beta strandi386 – 39712

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMLX-ray2.90C/D38-398[»]
1L4DX-ray2.30B40-173[»]
1L4ZX-ray2.80B27-173[»]
1QQRX-ray2.30A/B/C/D177-314[»]
ProteinModelPortaliP00779.
SMRiP00779. Positions 38-398.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00779.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR004093. SAK/SK.
IPR008124. SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00779-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG
60 70 80 90 100
TVEGTNQDIS LKFFEIDLTS RPAHGGKTEQ GLSPKSKPFA TDSGAMSHKL
110 120 130 140 150
EKADLLKAIQ EQLIANVHSN DDYFEVIDFA SDATITDRNG KVYFADKDGS
160 170 180 190 200
VTLPTQPVQE FLLSGHVRVR PYKEKPIQNQ AKSVDVEYTV QFTPLNPDDD
210 220 230 240 250
FRPGLKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY TIYERDSSIV
260 270 280 290 300
THDNDIFRTI LPMDQEFTYR VKNREQAYRI NKKSGLNEEI NNTDLISEKY
310 320 330 340 350
YVLKKGEKPY DPFDRSHLKL FTIKYVDVDT NELLKSEQLL TASERNLDFR
360 370 380 390 400
DLYDPRDKAK LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE
410 420 430 440
GENASYHLAY DKDRYTEEER EVYSYLRYTG TPIPDNPNDK
Length:440
Mass (Da):50,140
Last modified:April 1, 1988 - v1
Checksum:i8FC1F22648ACC77A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 3003EKY → LEYK AA sequence (PubMed:6760891)Curated
Sequence conflicti438 – 4381N → D AA sequence (PubMed:6760891)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti195 – 1951L → D.
Natural varianti207 – 2071D → L.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02986 Genomic DNA. Translation: AAA26974.1.
X72832 Genomic DNA. Translation: CAA51351.1.
PIRiA00967. BZSO.
A22801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02986 Genomic DNA. Translation: AAA26974.1 .
X72832 Genomic DNA. Translation: CAA51351.1 .
PIRi A00967. BZSO.
A22801.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BML X-ray 2.90 C/D 38-398 [» ]
1L4D X-ray 2.30 B 40-173 [» ]
1L4Z X-ray 2.80 B 27-173 [» ]
1QQR X-ray 2.30 A/B/C/D 177-314 [» ]
ProteinModelPortali P00779.
SMRi P00779. Positions 38-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00779. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P00779.

Family and domain databases

InterProi IPR004093. SAK/SK.
IPR008124. SK.
[Graphical view ]
Pfami PF02821. Staphylokinase. 3 hits.
[Graphical view ]
PRINTSi PR01753. STREPKINASE.
SUPFAMi SSF54328. SSF54328. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the streptokinase gene from Streptococcus equisimilis H46A."
    Malke H., Roe B.A., Ferretti J.J.
    Gene 34:357-362(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: H46A.
  2. "Complete amino acid sequence of streptokinase and its homology with serine proteases."
    Jackson K.W., Tang J.
    Biochemistry 21:6620-6625(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-440.

Entry informationi

Entry nameiSTRP_STREQ
AccessioniPrimary (citable) accession number: P00779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3