Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Streptokinase C

Gene

skc

Organism
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. plasminogen activation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Plasminogen activation, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Streptokinase C
Gene namesi
Name:skc
OrganismiStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Taxonomic identifieri119602 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 440414Streptokinase CPRO_0000022428Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PLGP007472EBI-1035089,EBI-999394From a different organism.

Protein-protein interaction databases

IntActiP00779. 1 interaction.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 353Combined sources
Beta strandi43 – 5210Combined sources
Turni53 – 553Combined sources
Beta strandi58 – 603Combined sources
Beta strandi64 – 707Combined sources
Beta strandi96 – 1016Combined sources
Helixi102 – 11514Combined sources
Beta strandi119 – 1213Combined sources
Beta strandi124 – 1296Combined sources
Beta strandi134 – 1374Combined sources
Beta strandi149 – 1524Combined sources
Beta strandi155 – 1573Combined sources
Beta strandi160 – 17112Combined sources
Beta strandi178 – 1803Combined sources
Beta strandi184 – 19613Combined sources
Beta strandi209 – 2146Combined sources
Beta strandi219 – 2213Combined sources
Helixi222 – 23615Combined sources
Beta strandi240 – 25213Combined sources
Beta strandi263 – 2653Combined sources
Beta strandi268 – 2703Combined sources
Beta strandi278 – 2803Combined sources
Turni282 – 2843Combined sources
Beta strandi287 – 2893Combined sources
Beta strandi292 – 30413Combined sources
Beta strandi310 – 3123Combined sources
Beta strandi316 – 32712Combined sources
Turni328 – 3303Combined sources
Beta strandi333 – 34210Combined sources
Helixi344 – 3463Combined sources
Turni355 – 3584Combined sources
Helixi367 – 3693Combined sources
Beta strandi373 – 38210Combined sources
Beta strandi386 – 39712Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMLX-ray2.90C/D38-398[»]
1L4DX-ray2.30B40-173[»]
1L4ZX-ray2.80B27-173[»]
1QQRX-ray2.30A/B/C/D177-314[»]
ProteinModelPortaliP00779.
SMRiP00779. Positions 38-398.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00779.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR004093. SAK/SK.
IPR008124. SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG
60 70 80 90 100
TVEGTNQDIS LKFFEIDLTS RPAHGGKTEQ GLSPKSKPFA TDSGAMSHKL
110 120 130 140 150
EKADLLKAIQ EQLIANVHSN DDYFEVIDFA SDATITDRNG KVYFADKDGS
160 170 180 190 200
VTLPTQPVQE FLLSGHVRVR PYKEKPIQNQ AKSVDVEYTV QFTPLNPDDD
210 220 230 240 250
FRPGLKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY TIYERDSSIV
260 270 280 290 300
THDNDIFRTI LPMDQEFTYR VKNREQAYRI NKKSGLNEEI NNTDLISEKY
310 320 330 340 350
YVLKKGEKPY DPFDRSHLKL FTIKYVDVDT NELLKSEQLL TASERNLDFR
360 370 380 390 400
DLYDPRDKAK LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE
410 420 430 440
GENASYHLAY DKDRYTEEER EVYSYLRYTG TPIPDNPNDK
Length:440
Mass (Da):50,140
Last modified:March 31, 1988 - v1
Checksum:i8FC1F22648ACC77A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 3003EKY → LEYK AA sequence (PubMed:6760891).Curated
Sequence conflicti438 – 4381N → D AA sequence (PubMed:6760891).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti195 – 1951L → D.
Natural varianti207 – 2071D → L.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02986 Genomic DNA. Translation: AAA26974.1.
X72832 Genomic DNA. Translation: CAA51351.1.
PIRiA00967. BZSO.
A22801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02986 Genomic DNA. Translation: AAA26974.1.
X72832 Genomic DNA. Translation: CAA51351.1.
PIRiA00967. BZSO.
A22801.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMLX-ray2.90C/D38-398[»]
1L4DX-ray2.30B40-173[»]
1L4ZX-ray2.80B27-173[»]
1QQRX-ray2.30A/B/C/D177-314[»]
ProteinModelPortaliP00779.
SMRiP00779. Positions 38-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00779. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP00779.

Family and domain databases

InterProiIPR004093. SAK/SK.
IPR008124. SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the streptokinase gene from Streptococcus equisimilis H46A."
    Malke H., Roe B.A., Ferretti J.J.
    Gene 34:357-362(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: H46A.
  2. "Complete amino acid sequence of streptokinase and its homology with serine proteases."
    Jackson K.W., Tang J.
    Biochemistry 21:6620-6625(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-440.

Entry informationi

Entry nameiSTRP_STREQ
AccessioniPrimary (citable) accession number: P00779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 20, 1986
Last sequence update: March 31, 1988
Last modified: November 25, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.