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P00769

- CTR2_VESCR

UniProt

P00769 - CTR2_VESCR

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Protein
Chymotrypsin-2
Gene
N/A
Organism
Vespa crabro (European hornet)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Charge relay system
Active sitei84 – 841Charge relay system
Active sitei175 – 1751Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.438.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-2 (EC:3.4.21.1)
Alternative name(s):
Chymotrypsin II
OrganismiVespa crabro (European hornet)
Taxonomic identifieri7445 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Chymotrypsin-2
PRO_0000088676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 40
Disulfide bondi148 ↔ 161
Disulfide bondi171 ↔ 195

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP00769.
SMRiP00769. Positions 1-216.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 218218Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00769-1 [UniParc]FASTAAdd to Basket

« Hide

IVGGTDAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSKHQVT    50
VHAGSVLLNK EEAVYNAEEL IVNKNYNSIR LINDIGLIRV SKDISYTQLV 100
QPVKLPVSNT IKAGDPVVLT GWGRIYVNGP IPNNLQQITL SIVNQQTCKF 150
KHWGLTDSQI CTFTKLGEGA CDGDSGGPLV ANGVQIGIVS YGHPCAVGSP 200
NVFTRVYSFL DWIQKNQL 218
Length:218
Mass (Da):23,677
Last modified:July 21, 1986 - v1
Checksum:i509AB50DE190EB39
GO

Sequence databases

PIRiA00955. KYVH2C.

Cross-referencesi

Sequence databases

PIRi A00955. KYVH2C.

3D structure databases

ProteinModelPortali P00769.
SMRi P00769. Positions 1-216.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of the chymotryptic protease II from the larvae of the nornet, Vespa crabro."
    Jany K.-D., Haug H.
    FEBS Lett. 158:98-102(1983)
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiCTR2_VESCR
AccessioniPrimary (citable) accession number: P00769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

An additional Arg at the carboxyl end was found in some of the molecules.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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