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P00769 (CTR2_VESCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsin-2

EC=3.4.21.1
Alternative name(s):
Chymotrypsin II
OrganismVespa crabro (European hornet)
Taxonomic identifier7445 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secretedextracellular space.

Miscellaneous

An additional Arg at the carboxyl end was found in some of the molecules.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Chymotrypsin-2
PRO_0000088676

Regions

Domain1 – 218218Peptidase S1

Sites

Active site391Charge relay system
Active site841Charge relay system
Active site1751Charge relay system

Amino acid modifications

Disulfide bond25 ↔ 40
Disulfide bond148 ↔ 161
Disulfide bond171 ↔ 195

Sequences

Sequence LengthMass (Da)Tools
P00769 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 509AB50DE190EB39

FASTA21823,677
        10         20         30         40         50         60 
IVGGTDAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSKHQVT VHAGSVLLNK 

        70         80         90        100        110        120 
EEAVYNAEEL IVNKNYNSIR LINDIGLIRV SKDISYTQLV QPVKLPVSNT IKAGDPVVLT 

       130        140        150        160        170        180 
GWGRIYVNGP IPNNLQQITL SIVNQQTCKF KHWGLTDSQI CTFTKLGEGA CDGDSGGPLV 

       190        200        210 
ANGVQIGIVS YGHPCAVGSP NVFTRVYSFL DWIQKNQL 

« Hide

References

[1]"Amino acid sequence of the chymotryptic protease II from the larvae of the nornet, Vespa crabro."
Jany K.-D., Haug H.
FEBS Lett. 158:98-102(1983)
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRKYVH2C. A00955.

3D structure databases

ProteinModelPortalP00769.
SMRP00769. Positions 1-216.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTR2_VESCR
AccessionPrimary (citable) accession number: P00769
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries