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P00769

- CTR2_VESCR

UniProt

P00769 - CTR2_VESCR

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Protein

Chymotrypsin-2

Gene
N/A
Organism
Vespa crabro (European hornet)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Charge relay system
Active sitei84 – 841Charge relay system
Active sitei175 – 1751Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.438.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-2 (EC:3.4.21.1)
Alternative name(s):
Chymotrypsin II
OrganismiVespa crabro (European hornet)
Taxonomic identifieri7445 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Chymotrypsin-2PRO_0000088676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 40
Disulfide bondi148 ↔ 161
Disulfide bondi171 ↔ 195

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP00769.
SMRiP00769. Positions 1-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 218218Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00769-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IVGGTDAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSKHQVT
60 70 80 90 100
VHAGSVLLNK EEAVYNAEEL IVNKNYNSIR LINDIGLIRV SKDISYTQLV
110 120 130 140 150
QPVKLPVSNT IKAGDPVVLT GWGRIYVNGP IPNNLQQITL SIVNQQTCKF
160 170 180 190 200
KHWGLTDSQI CTFTKLGEGA CDGDSGGPLV ANGVQIGIVS YGHPCAVGSP
210
NVFTRVYSFL DWIQKNQL
Length:218
Mass (Da):23,677
Last modified:July 21, 1986 - v1
Checksum:i509AB50DE190EB39
GO

Sequence databases

PIRiA00955. KYVH2C.

Cross-referencesi

Sequence databases

PIRi A00955. KYVH2C.

3D structure databases

ProteinModelPortali P00769.
SMRi P00769. Positions 1-216.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of the chymotryptic protease II from the larvae of the nornet, Vespa crabro."
    Jany K.-D., Haug H.
    FEBS Lett. 158:98-102(1983)
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiCTR2_VESCR
AccessioniPrimary (citable) accession number: P00769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

An additional Arg at the carboxyl end was found in some of the molecules.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3