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P00768

- CTR2_VESOR

UniProt

P00768 - CTR2_VESOR

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Protein
Chymotrypsin-2
Gene
N/A
Organism
Vespa orientalis (Oriental hornet)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Charge relay system1 Publication
Active sitei82 – 821Charge relay system1 Publication
Active sitei173 – 1731Charge relay system1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.438.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-2 (EC:3.4.21.1)
Alternative name(s):
Chymotrypsin II
OrganismiVespa orientalis (Oriental hornet)
Taxonomic identifieri7447 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Chymotrypsin-2
PRO_0000088677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 401 Publication
Disulfide bondi146 ↔ 1591 Publication
Disulfide bondi169 ↔ 1931 Publication

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP00768.
SMRiP00768. Positions 1-214.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 216216Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00768-1 [UniParc]FASTAAdd to Basket

« Hide

IVGGTNAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSEHQVT    50
VGSVLLNKEE AVYNAKELIV NKNYNSIRLI NDIGLIRVSK DISFTQLVQP 100
VKLPVSNTIK AGDPVVLTGW GRIYVNGPIP NNLQQITLSI VNQQTCKSKH 150
WGLTDSQICT FTKRGEGACH GDSGGPLVAN GVQIGIVSYG HPCAIGSPNV 200
FTRVYSFLDW IQKNQL 216
Length:216
Mass (Da):23,471
Last modified:July 21, 1986 - v1
Checksum:iF235BF992AEFEDE1
GO

Sequence databases

PIRiA00954. KYVH2O.

Cross-referencesi

Sequence databases

PIRi A00954. KYVH2O.

3D structure databases

ProteinModelPortali P00768.
SMRi P00768. Positions 1-214.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of an insect chymotrypsin from the larvae of the hornet, Vespa orientalis."
    Jany K.-D., Bekelar K., Pfleiderer G., Ishay J.
    Biochem. Biophys. Res. Commun. 110:1-7(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
  2. "The amino acid sequences around the reactive serine and histidine residues of the chymotrypsin-like protease from the hornet, Vespa orientalis."
    Jany K.-D., Bekelar K., Ishay J.
    Biochim. Biophys. Acta 668:197-200(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVE SITE.

Entry informationi

Entry nameiCTR2_VESOR
AccessioniPrimary (citable) accession number: P00768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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