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P00768 (CTR2_VESOR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsin-2

EC=3.4.21.1
Alternative name(s):
Chymotrypsin II
OrganismVespa orientalis (Oriental hornet)
Taxonomic identifier7447 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Chymotrypsin-2
PRO_0000088677

Regions

Domain1 – 216216Peptidase S1

Sites

Active site391Charge relay system Ref.2
Active site821Charge relay system Ref.2
Active site1731Charge relay system Ref.2

Amino acid modifications

Disulfide bond25 ↔ 40 Ref.1
Disulfide bond146 ↔ 159 Ref.1
Disulfide bond169 ↔ 193 Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00768 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: F235BF992AEFEDE1

FASTA21623,471
        10         20         30         40         50         60 
IVGGTNAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSEHQVT VGSVLLNKEE 

        70         80         90        100        110        120 
AVYNAKELIV NKNYNSIRLI NDIGLIRVSK DISFTQLVQP VKLPVSNTIK AGDPVVLTGW 

       130        140        150        160        170        180 
GRIYVNGPIP NNLQQITLSI VNQQTCKSKH WGLTDSQICT FTKRGEGACH GDSGGPLVAN 

       190        200        210 
GVQIGIVSYG HPCAIGSPNV FTRVYSFLDW IQKNQL 

« Hide

References

[1]"Amino acid sequence of an insect chymotrypsin from the larvae of the hornet, Vespa orientalis."
Jany K.-D., Bekelar K., Pfleiderer G., Ishay J.
Biochem. Biophys. Res. Commun. 110:1-7(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
[2]"The amino acid sequences around the reactive serine and histidine residues of the chymotrypsin-like protease from the hornet, Vespa orientalis."
Jany K.-D., Bekelar K., Ishay J.
Biochim. Biophys. Acta 668:197-200(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: ACTIVE SITE.

Cross-references

Sequence databases

PIRKYVH2O. A00954.

3D structure databases

ProteinModelPortalP00768.
SMRP00768. Positions 1-214.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTR2_VESOR
AccessionPrimary (citable) accession number: P00768
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries