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P00768

- CTR2_VESOR

UniProt

P00768 - CTR2_VESOR

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Protein

Chymotrypsin-2

Gene
N/A
Organism
Vespa orientalis (Oriental hornet)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Charge relay system1 Publication
Active sitei82 – 821Charge relay system1 Publication
Active sitei173 – 1731Charge relay system1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.438.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-2 (EC:3.4.21.1)
Alternative name(s):
Chymotrypsin II
OrganismiVespa orientalis (Oriental hornet)
Taxonomic identifieri7447 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Chymotrypsin-2PRO_0000088677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 401 PublicationPROSITE-ProRule annotation
Disulfide bondi146 ↔ 1591 PublicationPROSITE-ProRule annotation
Disulfide bondi169 ↔ 1931 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP00768.
SMRiP00768. Positions 1-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 216216Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00768-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IVGGTNAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSEHQVT
60 70 80 90 100
VGSVLLNKEE AVYNAKELIV NKNYNSIRLI NDIGLIRVSK DISFTQLVQP
110 120 130 140 150
VKLPVSNTIK AGDPVVLTGW GRIYVNGPIP NNLQQITLSI VNQQTCKSKH
160 170 180 190 200
WGLTDSQICT FTKRGEGACH GDSGGPLVAN GVQIGIVSYG HPCAIGSPNV
210
FTRVYSFLDW IQKNQL
Length:216
Mass (Da):23,471
Last modified:July 21, 1986 - v1
Checksum:iF235BF992AEFEDE1
GO

Sequence databases

PIRiA00954. KYVH2O.

Cross-referencesi

Sequence databases

PIRi A00954. KYVH2O.

3D structure databases

ProteinModelPortali P00768.
SMRi P00768. Positions 1-214.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of an insect chymotrypsin from the larvae of the hornet, Vespa orientalis."
    Jany K.-D., Bekelar K., Pfleiderer G., Ishay J.
    Biochem. Biophys. Res. Commun. 110:1-7(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
  2. "The amino acid sequences around the reactive serine and histidine residues of the chymotrypsin-like protease from the hornet, Vespa orientalis."
    Jany K.-D., Bekelar K., Ishay J.
    Biochim. Biophys. Acta 668:197-200(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVE SITE.

Entry informationi

Entry nameiCTR2_VESOR
AccessioniPrimary (citable) accession number: P00768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3