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P00768

- CTR2_VESOR

UniProt

P00768 - CTR2_VESOR

Protein

Chymotrypsin-2

Gene
N/A
Organism
Vespa orientalis (Oriental hornet)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391Charge relay system1 Publication
    Active sitei82 – 821Charge relay system1 Publication
    Active sitei173 – 1731Charge relay system1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.438.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsin-2 (EC:3.4.21.1)
    Alternative name(s):
    Chymotrypsin II
    OrganismiVespa orientalis (Oriental hornet)
    Taxonomic identifieri7447 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Chymotrypsin-2PRO_0000088677Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 401 PublicationPROSITE-ProRule annotation
    Disulfide bondi146 ↔ 1591 PublicationPROSITE-ProRule annotation
    Disulfide bondi169 ↔ 1931 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP00768.
    SMRiP00768. Positions 1-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 216216Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00768-1 [UniParc]FASTAAdd to Basket

    « Hide

    IVGGTNAPRG KYPYQVSLRA PKHFCGGSIS KRYVLTAAHC LVGKSEHQVT    50
    VGSVLLNKEE AVYNAKELIV NKNYNSIRLI NDIGLIRVSK DISFTQLVQP 100
    VKLPVSNTIK AGDPVVLTGW GRIYVNGPIP NNLQQITLSI VNQQTCKSKH 150
    WGLTDSQICT FTKRGEGACH GDSGGPLVAN GVQIGIVSYG HPCAIGSPNV 200
    FTRVYSFLDW IQKNQL 216
    Length:216
    Mass (Da):23,471
    Last modified:July 21, 1986 - v1
    Checksum:iF235BF992AEFEDE1
    GO

    Sequence databases

    PIRiA00954. KYVH2O.

    Cross-referencesi

    Sequence databases

    PIRi A00954. KYVH2O.

    3D structure databases

    ProteinModelPortali P00768.
    SMRi P00768. Positions 1-214.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of an insect chymotrypsin from the larvae of the hornet, Vespa orientalis."
      Jany K.-D., Bekelar K., Pfleiderer G., Ishay J.
      Biochem. Biophys. Res. Commun. 110:1-7(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
    2. "The amino acid sequences around the reactive serine and histidine residues of the chymotrypsin-like protease from the hornet, Vespa orientalis."
      Jany K.-D., Bekelar K., Ishay J.
      Biochim. Biophys. Acta 668:197-200(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACTIVE SITE.

    Entry informationi

    Entry nameiCTR2_VESOR
    AccessioniPrimary (citable) accession number: P00768
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3