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Protein

Cationic trypsin

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Charge relay system1
Metal bindingi75Calcium1
Metal bindingi77Calcium; via carbonyl oxygen1
Metal bindingi80Calcium; via carbonyl oxygen1
Metal bindingi85Calcium1
Active sitei107Charge relay system1
Active sitei200Charge relay system1
Binding sitei200Substrate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.21.4. 908.
SABIO-RKP00760.

Protein family/group databases

MEROPSiS01.151.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic trypsin (EC:3.4.21.4)
Alternative name(s):
Beta-trypsin
Cleaved into the following 2 chains:
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000002818518 – 23Activation peptide6
ChainiPRO_000002818624 – 246Cationic trypsinAdd BLAST223
ChainiPRO_000002818724 – 148Alpha-trypsin chain 1Add BLAST125
ChainiPRO_0000028188149 – 246Alpha-trypsin chain 2Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 160
Disulfide bondi48 ↔ 64
Disulfide bondi132 ↔ 233
Disulfide bondi139 ↔ 206
Disulfide bondi171 ↔ 185
Disulfide bondi196 ↔ 220

Post-translational modificationi

Autocatalytic cleavage after Lys-23 leads to beta-trypsin by releasing a terminal hexapeptide. Subsequent cleavage after Lys-148 leads to alpha-trypsin. Further cleavage after Lys-193 yields pseudotrypsin. A cleavage may also occur after Arg-122.
Not sulfated on tyrosine residue(s).

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP00760.
PeptideAtlasiP00760.
PRIDEiP00760.

Miscellaneous databases

PMAP-CutDBP00760.

Expressioni

Tissue specificityi

Synthesized in the acinar cells of the pancreas.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P009744EBI-986385,EBI-1032263
SERPINA1P010095EBI-986385,EBI-986224From a different organism.

Protein-protein interaction databases

IntActiP00760. 5 interactors.
MINTiMINT-87966.
STRINGi9913.ENSBTAP00000033392.

Chemistry databases

BindingDBiP00760.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni23 – 26Combined sources4
Turni32 – 34Combined sources3
Beta strandi38 – 52Combined sources15
Beta strandi54 – 60Combined sources7
Helixi62 – 64Combined sources3
Beta strandi70 – 74Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi81 – 84Combined sources4
Beta strandi86 – 95Combined sources10
Turni101 – 103Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi121 – 123Combined sources3
Beta strandi138 – 145Combined sources8
Beta strandi149 – 151Combined sources3
Beta strandi159 – 165Combined sources7
Helixi168 – 174Combined sources7
Turni176 – 178Combined sources3
Turni180 – 182Combined sources3
Beta strandi183 – 187Combined sources5
Beta strandi189 – 192Combined sources4
Turni197 – 201Combined sources5
Beta strandi203 – 206Combined sources4
Beta strandi209 – 216Combined sources8
Beta strandi218 – 221Combined sources4
Beta strandi227 – 231Combined sources5
Helixi232 – 235Combined sources4
Helixi236 – 239Combined sources4
Turni243 – 245Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQ7X-ray2.20A24-246[»]
1AUJX-ray2.10A24-246[»]
1AZ8X-ray1.80A24-246[»]
1BJUX-ray1.80A24-246[»]
1BJVX-ray1.80A24-246[»]
1BTPX-ray2.20A18-246[»]
1BTWX-ray1.70A18-246[»]
1BTXX-ray1.70A18-246[»]
1BTYX-ray1.50A18-246[»]
1BTZX-ray2.00A18-246[»]
1C1NX-ray1.40A24-246[»]
1C1OX-ray1.40A24-246[»]
1C1PX-ray1.37A24-246[»]
1C1QX-ray1.37A24-246[»]
1C1RX-ray1.37A24-246[»]
1C1SX-ray1.63A24-246[»]
1C1TX-ray1.37A24-246[»]
1C2DX-ray1.65A24-246[»]
1C2EX-ray1.65A24-246[»]
1C2FX-ray1.70A24-246[»]
1C2GX-ray1.65A24-246[»]
1C2HX-ray1.40A24-246[»]
1C2IX-ray1.47A24-246[»]
1C2JX-ray1.40A24-246[»]
1C2KX-ray1.65A24-246[»]
1C2LX-ray1.50A24-246[»]
1C2MX-ray1.40A24-246[»]
1C5PX-ray1.43A24-246[»]
1C5QX-ray1.43A24-246[»]
1C5RX-ray1.47A24-246[»]
1C5SX-ray1.36A24-246[»]
1C5TX-ray1.37A24-246[»]
1C5UX-ray1.37A24-246[»]
1C5VX-ray1.48A24-246[»]
1C9TX-ray3.30A/B/C/D/E/F24-246[»]
1CE5X-ray1.90A24-246[»]
1CU7model-A24-246[»]
1CU8model-A24-246[»]
1CU9model-A24-246[»]
1D6RX-ray2.30A24-246[»]
1EB2X-ray2.00A24-246[»]
1EJMX-ray1.85A/C/E24-246[»]
1EZXX-ray2.60C4-246[»]
1F0TX-ray1.80A4-246[»]
1F0UX-ray1.90A4-246[»]
1F2SX-ray1.79E24-246[»]
1G36X-ray1.90A24-246[»]
1G3BX-ray1.80A19-239[»]
1G3CX-ray1.80A19-239[»]
1G3DX-ray1.80A19-239[»]
1G3EX-ray1.80A19-239[»]
1G9IX-ray2.20E24-246[»]
1GBTX-ray2.00A24-246[»]
1GHZX-ray1.39A24-246[»]
1GI0X-ray1.42A24-239[»]
1GI1X-ray1.42A24-246[»]
1GI2X-ray1.38A24-246[»]
1GI3X-ray1.44A24-246[»]
1GI4X-ray1.37A24-246[»]
1GI5X-ray1.60A24-246[»]
1GI6X-ray1.49A24-246[»]
1GJ6X-ray1.50A24-246[»]
1HJ9X-ray0.95A24-246[»]
1J8AX-ray1.21A24-246[»]
1JIRX-ray2.00A24-246[»]
1JRSX-ray1.80A24-246[»]
1JRTX-ray1.70A24-246[»]
1K1IX-ray2.20A24-246[»]
1K1JX-ray2.20A24-246[»]
1K1LX-ray2.50A24-246[»]
1K1MX-ray2.20A24-246[»]
1K1NX-ray2.00A24-246[»]
1K1OX-ray2.00A24-246[»]
1K1PX-ray1.90A24-246[»]
1LQEX-ray2.20A4-246[»]
1MAXX-ray1.80A24-246[»]
1MAYX-ray1.80A24-246[»]
1MTSX-ray1.90A24-246[»]
1MTUX-ray1.90A24-246[»]
1MTVX-ray1.90A24-246[»]
1MTWX-ray1.90A24-246[»]
1N6XX-ray1.40A24-246[»]
1N6YX-ray1.40A24-246[»]
1NC6X-ray1.90A24-246[»]
1NTPneutron diffraction1.80A24-246[»]
1O2HX-ray1.77A24-246[»]
1O2IX-ray1.50A24-246[»]
1O2JX-ray1.65A24-246[»]
1O2KX-ray1.63A24-246[»]
1O2LX-ray1.68A24-246[»]
1O2MX-ray1.69A24-246[»]
1O2NX-ray1.50A24-246[»]
1O2OX-ray1.63A24-246[»]
1O2PX-ray1.47A24-246[»]
1O2QX-ray1.50A24-246[»]
1O2RX-ray1.45A24-246[»]
1O2SX-ray1.65A24-246[»]
1O2TX-ray1.62A24-246[»]
1O2UX-ray1.41A24-246[»]
1O2VX-ray1.50A24-246[»]
1O2WX-ray1.38A24-246[»]
1O2XX-ray1.46A24-246[»]
1O2YX-ray1.45A24-246[»]
1O2ZX-ray1.65A24-246[»]
1O30X-ray1.55A24-246[»]
1O31X-ray1.66A24-246[»]
1O32X-ray1.78A24-246[»]
1O33X-ray1.46A24-246[»]
1O34X-ray1.50A24-246[»]
1O35X-ray1.41A24-246[»]
1O36X-ray1.70A24-246[»]
1O37X-ray1.45A24-246[»]
1O38X-ray1.38A24-246[»]
1O39X-ray1.59A24-246[»]
1O3AX-ray2.00A24-246[»]
1O3BX-ray1.75A24-246[»]
1O3CX-ray1.64A24-246[»]
1O3DX-ray1.33A24-246[»]
1O3EX-ray1.64A24-246[»]
1O3FX-ray1.55A24-246[»]
1O3GX-ray1.55A24-246[»]
1O3HX-ray1.53A24-246[»]
1O3IX-ray1.51A24-246[»]
1O3JX-ray1.40A24-246[»]
1O3KX-ray1.43A24-246[»]
1O3LX-ray1.40A24-246[»]
1O3MX-ray1.55A24-246[»]
1O3NX-ray1.55A24-246[»]
1O3OX-ray1.55A24-246[»]
1OPHX-ray2.30B4-246[»]
1OX1X-ray2.00A24-246[»]
1OYQX-ray1.90A24-239[»]
1P2IX-ray1.65A24-246[»]
1P2JX-ray1.35A24-246[»]
1P2KX-ray1.60A24-246[»]
1PPCX-ray1.80E24-246[»]
1PPEX-ray2.00E24-246[»]
1PPHX-ray1.90E24-246[»]
1QA0X-ray1.80A24-246[»]
1QB1X-ray1.80A24-246[»]
1QB6X-ray1.80A24-246[»]
1QB9X-ray1.80A24-246[»]
1QBNX-ray1.80A24-246[»]
1QBOX-ray1.80A24-246[»]
1QCPX-ray1.80A24-246[»]
1QL7X-ray2.10A24-246[»]
1QL8X-ray3.00A24-246[»]
1RXPX-ray1.70A24-239[»]
1S0QX-ray1.02A24-246[»]
1S0RX-ray1.02A24-246[»]
1SBWX-ray1.80A24-246[»]
1SFIX-ray1.65A24-246[»]
1SMFX-ray2.10E24-246[»]
1TABX-ray2.30E24-246[»]
1TAWX-ray1.80A24-246[»]
1TGBX-ray1.80A18-246[»]
1TGCX-ray1.80A18-246[»]
1TGNX-ray1.65A18-246[»]
1TGSX-ray1.80Z18-246[»]
1TGTX-ray1.70A18-246[»]
1TIOX-ray1.93A24-246[»]
1TLDX-ray1.50A24-246[»]
1TNGX-ray1.80A18-246[»]
1TNHX-ray1.80A18-246[»]
1TNIX-ray1.90A18-246[»]
1TNJX-ray1.80A18-246[»]
1TNKX-ray1.80A18-246[»]
1TNLX-ray1.90A18-246[»]
1TPAX-ray1.90E24-246[»]
1TPOX-ray1.70A24-246[»]
1TPPX-ray1.40A24-246[»]
1TPSX-ray1.90A24-246[»]
1TX7X-ray1.75A24-239[»]
1TX8X-ray1.70A24-239[»]
1TYNX-ray2.00A24-246[»]
1UTNX-ray1.15A4-246[»]
1UTOX-ray1.15A4-246[»]
1UTPX-ray1.30A4-246[»]
1UTQX-ray1.15A4-246[»]
1V2JX-ray1.90T24-246[»]
1V2KX-ray2.00T24-246[»]
1V2LX-ray1.60T24-246[»]
1V2MX-ray1.65T24-246[»]
1V2NX-ray1.80T24-246[»]
1V2OX-ray1.62T24-246[»]
1V2PX-ray1.92T24-246[»]
1V2QX-ray2.30T24-246[»]
1V2RX-ray1.70T24-246[»]
1V2SX-ray1.72T24-246[»]
1V2TX-ray1.90T24-246[»]
1V2UX-ray1.80T24-246[»]
1V2VX-ray1.80T24-246[»]
1V2WX-ray1.75T24-246[»]
1XUFX-ray1.90A24-246[»]
1XUGX-ray1.50A24-246[»]
1XUHX-ray2.20A24-246[»]
1XUIX-ray1.50A24-246[»]
1XUJX-ray1.92A24-246[»]
1XUKX-ray1.80A24-246[»]
1Y3UX-ray1.80A24-246[»]
1Y3VX-ray1.60A24-246[»]
1Y3WX-ray1.80A24-246[»]
1Y3XX-ray1.70A24-239[»]
1Y3YX-ray1.75A24-239[»]
1Y59X-ray1.20T24-246[»]
1Y5AX-ray1.40T24-246[»]
1Y5BX-ray1.65T24-246[»]
1Y5UX-ray1.60T24-246[»]
1YP9X-ray2.10A24-246[»]
1YYYX-ray2.10124-246[»]
1ZR0X-ray1.80A/C24-246[»]
1ZZZX-ray1.90A10-246[»]
2A7HX-ray2.10A24-246[»]
2AGEX-ray1.15X24-239[»]
2AGGX-ray1.28X24-239[»]
2AGIX-ray1.14X24-239[»]
2AH4X-ray1.13X24-239[»]
2AYWX-ray0.97A24-246[»]
2BLVX-ray1.20A24-246[»]
2BLWX-ray1.20A24-246[»]
2BTCX-ray1.50E24-246[»]
2BY5X-ray1.30X4-246[»]
2BY6X-ray1.30X4-246[»]
2BY7X-ray1.30X4-246[»]
2BY8X-ray1.30X4-246[»]
2BY9X-ray1.30X4-246[»]
2BYAX-ray1.30X4-246[»]
2BZAX-ray1.90A24-246[»]
2CMYX-ray2.25A24-246[»]
2D8WX-ray2.00A24-246[»]
2F3CX-ray2.50E24-246[»]
2FI3X-ray1.58E24-239[»]
2FI4X-ray1.58E24-246[»]
2FI5X-ray1.58E24-239[»]
2FTLX-ray1.62E24-239[»]
2FTMX-ray1.65A24-239[»]
2FX4X-ray1.65A24-246[»]
2FX6X-ray1.57A24-246[»]
2G55X-ray1.82A24-246[»]
2G5NX-ray1.51A24-246[»]
2G5VX-ray1.45A24-246[»]
2G81X-ray1.55E24-246[»]
2G8TX-ray1.41A24-246[»]
2ILNX-ray2.00A/B24-246[»]
2J9NX-ray1.50A24-246[»]
2O9QX-ray1.70A24-246[»]
2OTVX-ray1.56A24-246[»]
2OXSX-ray1.32A24-246[»]
2PLXX-ray1.56A24-246[»]
2PTCX-ray1.90E24-246[»]
2PTNX-ray1.55A24-246[»]
2QN5X-ray3.00T24-246[»]
2QYIX-ray2.60A/C24-246[»]
2TGAX-ray1.80A18-246[»]
2TGDX-ray2.10A18-246[»]
2TGPX-ray1.90Z18-246[»]
2TGTX-ray1.70A18-246[»]
2TIOX-ray1.93A24-246[»]
2TLDX-ray2.60E24-246[»]
2TPIX-ray2.10Z18-246[»]
2UUYX-ray1.15A24-246[»]
2XTTX-ray0.93B24-246[»]
2ZDKX-ray1.67A24-246[»]
2ZDLX-ray1.80A24-246[»]
2ZDMX-ray1.93A24-246[»]
2ZDNX-ray1.98A24-246[»]
2ZFSX-ray1.51A24-246[»]
2ZFTX-ray1.76A24-246[»]
2ZHDX-ray1.94A24-246[»]
2ZQ1X-ray1.68A24-246[»]
2ZQ2X-ray1.40A24-246[»]
3A7TX-ray1.75A24-246[»]
3A7VX-ray1.75A24-246[»]
3A7WX-ray1.75A24-246[»]
3A7XX-ray1.75A24-246[»]
3A7YX-ray1.81A24-246[»]
3A7ZX-ray1.80A24-246[»]
3A80X-ray1.75A24-246[»]
3A81X-ray1.78A24-246[»]
3A82X-ray1.75A24-246[»]
3A83X-ray1.78A24-246[»]
3A84X-ray1.75A24-246[»]
3A85X-ray1.75A24-246[»]
3A86X-ray1.75A24-246[»]
3A87X-ray1.75A24-246[»]
3A88X-ray1.75A24-246[»]
3A89X-ray1.80A24-246[»]
3A8AX-ray1.40A24-246[»]
3A8BX-ray1.75A24-246[»]
3A8CX-ray1.85A24-246[»]
3A8DX-ray1.75A24-246[»]
3AASX-ray1.75A24-246[»]
3AAUX-ray1.80A24-246[»]
3AAVX-ray1.70A/B24-246[»]
3ATIX-ray1.71A24-246[»]
3ATKX-ray1.74A24-246[»]
3ATLX-ray1.74A24-246[»]
3ATMX-ray1.72A24-246[»]
3BTDX-ray1.90E24-246[»]
3BTEX-ray1.85E24-246[»]
3BTFX-ray1.80E24-246[»]
3BTGX-ray1.90E24-246[»]
3BTHX-ray1.75E24-246[»]
3BTKX-ray1.85E24-246[»]
3BTMX-ray1.80E24-246[»]
3BTQX-ray1.90E24-246[»]
3BTTX-ray1.90E24-246[»]
3BTWX-ray2.05E24-246[»]
3D65X-ray1.64E24-246[»]
3E8LX-ray2.48A/B24-246[»]
3GY2X-ray1.57A24-246[»]
3GY3X-ray1.70A24-246[»]
3GY4X-ray1.55A24-246[»]
3GY5X-ray1.57A24-246[»]
3GY6X-ray1.70A24-246[»]
3GY7X-ray1.55A24-246[»]
3GY8X-ray1.75A24-246[»]
3I29X-ray2.40A24-246[»]
3ITIX-ray1.55A24-246[»]
3LJJX-ray1.55A24-246[»]
3LJOX-ray1.50A24-246[»]
3M35X-ray2.20A24-246[»]
3M7QX-ray1.70A24-246[»]
3MFJX-ray0.80A24-246[»]
3MI4X-ray0.80A24-246[»]
3NK8X-ray1.15A24-246[»]
3NKKX-ray1.12A24-246[»]
3OTJOther2.15E24-246[»]
3PLBX-ray1.18A24-246[»]
3PLKX-ray1.53A24-246[»]
3PLPX-ray1.63A24-246[»]
3PM3X-ray1.53A24-246[»]
3PMJX-ray1.45A24-246[»]
3PTBX-ray1.70A24-246[»]
3PTNX-ray1.70A24-246[»]
3PWBX-ray1.63A24-246[»]
3PWCX-ray1.60A24-246[»]
3PYHX-ray2.00A24-246[»]
3Q00X-ray1.70A24-246[»]
3QK1X-ray2.08A24-246[»]
3RDZX-ray2.26A/B24-246[»]
3RU4X-ray1.68T24-246[»]
3RXAX-ray1.70A24-246[»]
3RXBX-ray1.70A24-246[»]
3RXCX-ray1.70A24-246[»]
3RXDX-ray1.70A24-246[»]
3RXEX-ray1.70A24-246[»]
3RXFX-ray1.70A24-246[»]
3RXGX-ray1.70A24-246[»]
3RXHX-ray1.70A24-246[»]
3RXIX-ray1.60A24-246[»]
3RXJX-ray1.70A24-246[»]
3RXKX-ray1.60A24-246[»]
3RXLX-ray1.70A24-246[»]
3RXMX-ray1.70A24-246[»]
3RXOX-ray1.60A24-246[»]
3RXPX-ray1.60A24-246[»]
3RXQX-ray1.68A24-246[»]
3RXRX-ray1.72A24-246[»]
3RXSX-ray1.74A24-246[»]
3RXTX-ray1.70A24-246[»]
3RXUX-ray1.68A24-246[»]
3RXVX-ray1.70A24-246[»]
3T25X-ray1.70A24-246[»]
3T26X-ray1.70A24-246[»]
3T27X-ray1.95A24-246[»]
3T28X-ray2.80A24-246[»]
3T29X-ray1.75A24-246[»]
3TPIX-ray1.90Z18-246[»]
3UNQX-ray1.62A24-246[»]
3UNRX-ray1.20A24-246[»]
3UNSX-ray1.80A24-246[»]
3UOPX-ray1.69A24-246[»]
3UPEX-ray1.54A24-246[»]
3UQOX-ray1.80A24-246[»]
3UQVX-ray2.40A24-246[»]
3UUZX-ray2.10A/B24-246[»]
3UWIX-ray1.43A24-246[»]
3UY9X-ray3.22A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-246[»]
3V0XX-ray1.90A24-246[»]
3V12X-ray1.80A24-246[»]
3V13X-ray1.63A24-246[»]
3VEQX-ray2.25B24-246[»]
3VPKX-ray1.94A24-246[»]
4AB8X-ray1.60A24-246[»]
4AB9X-ray1.20A24-246[»]
4ABAX-ray1.25A24-246[»]
4ABBX-ray1.25A24-246[»]
4ABDX-ray1.25A24-246[»]
4ABEX-ray1.30A24-246[»]
4ABFX-ray1.30A24-246[»]
4ABGX-ray1.52A24-246[»]
4ABHX-ray1.25A24-246[»]
4ABIX-ray1.55A24-246[»]
4ABJX-ray1.45A24-246[»]
4AOQX-ray2.00A/B/C24-246[»]
4AORX-ray1.70A/B/C24-246[»]
4B1TX-ray1.78A/C24-246[»]
4B2AX-ray1.89A/C24-246[»]
4B2BX-ray1.36A/C24-246[»]
4B2CX-ray1.43A/C24-246[»]
4GUXX-ray1.80A/B/C1-246[»]
4HGCX-ray1.29A24-246[»]
4I8GX-ray0.80A24-239[»]
4I8HX-ray0.75A24-239[»]
4I8JX-ray0.87A24-239[»]
4I8KX-ray0.85A24-239[»]
4I8LX-ray0.87A24-239[»]
4J2YX-ray2.00B24-246[»]
4KTSX-ray1.30A24-246[»]
4KTUX-ray1.35A24-246[»]
4MTBX-ray1.22A24-246[»]
4NCYX-ray1.42A24-246[»]
4NIVX-ray1.00A24-246[»]
4NIWX-ray1.31A24-246[»]
4NIXX-ray1.30A24-246[»]
4NIYX-ray2.84A/B/C/D24-246[»]
4TPIX-ray2.20Z18-246[»]
4TPYX-ray1.30A24-246[»]
4U2WX-ray1.00A24-246[»]
4XOJX-ray0.91A1-246[»]
4Y0YX-ray1.25E24-246[»]
4Y0ZX-ray1.37E24-246[»]
4Y10X-ray1.37E24-246[»]
4Y11X-ray1.30E24-246[»]
4YTAX-ray1.20A24-246[»]
5EG4X-ray1.32A24-246[»]
5F6MX-ray1.10A24-246[»]
5FXLX-ray1.78A1-246[»]
5GIBX-ray2.70A/B24-246[»]
5JYIX-ray1.91A1-246[»]
5LGOX-ray1.12A24-246[»]
5LH8X-ray1.54A24-246[»]
5PTPX-ray1.34A24-246[»]
DisProtiDP00728.
ProteinModelPortaliP00760.
SMRiP00760.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00760.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 244Peptidase S1PROSITE-ProRule annotationAdd BLAST221

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 195Substrate binding2
Regioni197 – 198Substrate binding2

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP00760.
KOiK01312.
OMAiNTIALPT.
OrthoDBiEOG091G0DF7.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG
60 70 80 90 100
SLINSQWVVS AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN
110 120 130 140 150
SNTLNNDIML IKLKSAASLN SRVASISLPT SCASAGTQCL ISGWGNTKSS
160 170 180 190 200
GTSYPDVLKC LKAPILSDSS CKSAYPGQIT SNMFCAGYLE GGKDSCQGDS
210 220 230 240
GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK QTIASN
Length:246
Mass (Da):25,785
Last modified:September 2, 2008 - v3
Checksum:i092E3D8ACCCCC4D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134797 mRNA. Translation: AAI34798.1.
BC146041 mRNA. Translation: AAI46042.1.
D38507 mRNA. Translation: BAA07516.1.
PIRiA90164. TRBOTR.
RefSeqiNP_001107199.1. NM_001113727.1.
XP_002687054.3. XM_002687008.5.
XP_871686.4. XM_866593.7.
UniGeneiBt.91423.

Genome annotation databases

EnsembliENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633.
ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245.
GeneIDi615026.
780933.
KEGGibta:615026.
bta:780933.

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134797 mRNA. Translation: AAI34798.1.
BC146041 mRNA. Translation: AAI46042.1.
D38507 mRNA. Translation: BAA07516.1.
PIRiA90164. TRBOTR.
RefSeqiNP_001107199.1. NM_001113727.1.
XP_002687054.3. XM_002687008.5.
XP_871686.4. XM_866593.7.
UniGeneiBt.91423.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQ7X-ray2.20A24-246[»]
1AUJX-ray2.10A24-246[»]
1AZ8X-ray1.80A24-246[»]
1BJUX-ray1.80A24-246[»]
1BJVX-ray1.80A24-246[»]
1BTPX-ray2.20A18-246[»]
1BTWX-ray1.70A18-246[»]
1BTXX-ray1.70A18-246[»]
1BTYX-ray1.50A18-246[»]
1BTZX-ray2.00A18-246[»]
1C1NX-ray1.40A24-246[»]
1C1OX-ray1.40A24-246[»]
1C1PX-ray1.37A24-246[»]
1C1QX-ray1.37A24-246[»]
1C1RX-ray1.37A24-246[»]
1C1SX-ray1.63A24-246[»]
1C1TX-ray1.37A24-246[»]
1C2DX-ray1.65A24-246[»]
1C2EX-ray1.65A24-246[»]
1C2FX-ray1.70A24-246[»]
1C2GX-ray1.65A24-246[»]
1C2HX-ray1.40A24-246[»]
1C2IX-ray1.47A24-246[»]
1C2JX-ray1.40A24-246[»]
1C2KX-ray1.65A24-246[»]
1C2LX-ray1.50A24-246[»]
1C2MX-ray1.40A24-246[»]
1C5PX-ray1.43A24-246[»]
1C5QX-ray1.43A24-246[»]
1C5RX-ray1.47A24-246[»]
1C5SX-ray1.36A24-246[»]
1C5TX-ray1.37A24-246[»]
1C5UX-ray1.37A24-246[»]
1C5VX-ray1.48A24-246[»]
1C9TX-ray3.30A/B/C/D/E/F24-246[»]
1CE5X-ray1.90A24-246[»]
1CU7model-A24-246[»]
1CU8model-A24-246[»]
1CU9model-A24-246[»]
1D6RX-ray2.30A24-246[»]
1EB2X-ray2.00A24-246[»]
1EJMX-ray1.85A/C/E24-246[»]
1EZXX-ray2.60C4-246[»]
1F0TX-ray1.80A4-246[»]
1F0UX-ray1.90A4-246[»]
1F2SX-ray1.79E24-246[»]
1G36X-ray1.90A24-246[»]
1G3BX-ray1.80A19-239[»]
1G3CX-ray1.80A19-239[»]
1G3DX-ray1.80A19-239[»]
1G3EX-ray1.80A19-239[»]
1G9IX-ray2.20E24-246[»]
1GBTX-ray2.00A24-246[»]
1GHZX-ray1.39A24-246[»]
1GI0X-ray1.42A24-239[»]
1GI1X-ray1.42A24-246[»]
1GI2X-ray1.38A24-246[»]
1GI3X-ray1.44A24-246[»]
1GI4X-ray1.37A24-246[»]
1GI5X-ray1.60A24-246[»]
1GI6X-ray1.49A24-246[»]
1GJ6X-ray1.50A24-246[»]
1HJ9X-ray0.95A24-246[»]
1J8AX-ray1.21A24-246[»]
1JIRX-ray2.00A24-246[»]
1JRSX-ray1.80A24-246[»]
1JRTX-ray1.70A24-246[»]
1K1IX-ray2.20A24-246[»]
1K1JX-ray2.20A24-246[»]
1K1LX-ray2.50A24-246[»]
1K1MX-ray2.20A24-246[»]
1K1NX-ray2.00A24-246[»]
1K1OX-ray2.00A24-246[»]
1K1PX-ray1.90A24-246[»]
1LQEX-ray2.20A4-246[»]
1MAXX-ray1.80A24-246[»]
1MAYX-ray1.80A24-246[»]
1MTSX-ray1.90A24-246[»]
1MTUX-ray1.90A24-246[»]
1MTVX-ray1.90A24-246[»]
1MTWX-ray1.90A24-246[»]
1N6XX-ray1.40A24-246[»]
1N6YX-ray1.40A24-246[»]
1NC6X-ray1.90A24-246[»]
1NTPneutron diffraction1.80A24-246[»]
1O2HX-ray1.77A24-246[»]
1O2IX-ray1.50A24-246[»]
1O2JX-ray1.65A24-246[»]
1O2KX-ray1.63A24-246[»]
1O2LX-ray1.68A24-246[»]
1O2MX-ray1.69A24-246[»]
1O2NX-ray1.50A24-246[»]
1O2OX-ray1.63A24-246[»]
1O2PX-ray1.47A24-246[»]
1O2QX-ray1.50A24-246[»]
1O2RX-ray1.45A24-246[»]
1O2SX-ray1.65A24-246[»]
1O2TX-ray1.62A24-246[»]
1O2UX-ray1.41A24-246[»]
1O2VX-ray1.50A24-246[»]
1O2WX-ray1.38A24-246[»]
1O2XX-ray1.46A24-246[»]
1O2YX-ray1.45A24-246[»]
1O2ZX-ray1.65A24-246[»]
1O30X-ray1.55A24-246[»]
1O31X-ray1.66A24-246[»]
1O32X-ray1.78A24-246[»]
1O33X-ray1.46A24-246[»]
1O34X-ray1.50A24-246[»]
1O35X-ray1.41A24-246[»]
1O36X-ray1.70A24-246[»]
1O37X-ray1.45A24-246[»]
1O38X-ray1.38A24-246[»]
1O39X-ray1.59A24-246[»]
1O3AX-ray2.00A24-246[»]
1O3BX-ray1.75A24-246[»]
1O3CX-ray1.64A24-246[»]
1O3DX-ray1.33A24-246[»]
1O3EX-ray1.64A24-246[»]
1O3FX-ray1.55A24-246[»]
1O3GX-ray1.55A24-246[»]
1O3HX-ray1.53A24-246[»]
1O3IX-ray1.51A24-246[»]
1O3JX-ray1.40A24-246[»]
1O3KX-ray1.43A24-246[»]
1O3LX-ray1.40A24-246[»]
1O3MX-ray1.55A24-246[»]
1O3NX-ray1.55A24-246[»]
1O3OX-ray1.55A24-246[»]
1OPHX-ray2.30B4-246[»]
1OX1X-ray2.00A24-246[»]
1OYQX-ray1.90A24-239[»]
1P2IX-ray1.65A24-246[»]
1P2JX-ray1.35A24-246[»]
1P2KX-ray1.60A24-246[»]
1PPCX-ray1.80E24-246[»]
1PPEX-ray2.00E24-246[»]
1PPHX-ray1.90E24-246[»]
1QA0X-ray1.80A24-246[»]
1QB1X-ray1.80A24-246[»]
1QB6X-ray1.80A24-246[»]
1QB9X-ray1.80A24-246[»]
1QBNX-ray1.80A24-246[»]
1QBOX-ray1.80A24-246[»]
1QCPX-ray1.80A24-246[»]
1QL7X-ray2.10A24-246[»]
1QL8X-ray3.00A24-246[»]
1RXPX-ray1.70A24-239[»]
1S0QX-ray1.02A24-246[»]
1S0RX-ray1.02A24-246[»]
1SBWX-ray1.80A24-246[»]
1SFIX-ray1.65A24-246[»]
1SMFX-ray2.10E24-246[»]
1TABX-ray2.30E24-246[»]
1TAWX-ray1.80A24-246[»]
1TGBX-ray1.80A18-246[»]
1TGCX-ray1.80A18-246[»]
1TGNX-ray1.65A18-246[»]
1TGSX-ray1.80Z18-246[»]
1TGTX-ray1.70A18-246[»]
1TIOX-ray1.93A24-246[»]
1TLDX-ray1.50A24-246[»]
1TNGX-ray1.80A18-246[»]
1TNHX-ray1.80A18-246[»]
1TNIX-ray1.90A18-246[»]
1TNJX-ray1.80A18-246[»]
1TNKX-ray1.80A18-246[»]
1TNLX-ray1.90A18-246[»]
1TPAX-ray1.90E24-246[»]
1TPOX-ray1.70A24-246[»]
1TPPX-ray1.40A24-246[»]
1TPSX-ray1.90A24-246[»]
1TX7X-ray1.75A24-239[»]
1TX8X-ray1.70A24-239[»]
1TYNX-ray2.00A24-246[»]
1UTNX-ray1.15A4-246[»]
1UTOX-ray1.15A4-246[»]
1UTPX-ray1.30A4-246[»]
1UTQX-ray1.15A4-246[»]
1V2JX-ray1.90T24-246[»]
1V2KX-ray2.00T24-246[»]
1V2LX-ray1.60T24-246[»]
1V2MX-ray1.65T24-246[»]
1V2NX-ray1.80T24-246[»]
1V2OX-ray1.62T24-246[»]
1V2PX-ray1.92T24-246[»]
1V2QX-ray2.30T24-246[»]
1V2RX-ray1.70T24-246[»]
1V2SX-ray1.72T24-246[»]
1V2TX-ray1.90T24-246[»]
1V2UX-ray1.80T24-246[»]
1V2VX-ray1.80T24-246[»]
1V2WX-ray1.75T24-246[»]
1XUFX-ray1.90A24-246[»]
1XUGX-ray1.50A24-246[»]
1XUHX-ray2.20A24-246[»]
1XUIX-ray1.50A24-246[»]
1XUJX-ray1.92A24-246[»]
1XUKX-ray1.80A24-246[»]
1Y3UX-ray1.80A24-246[»]
1Y3VX-ray1.60A24-246[»]
1Y3WX-ray1.80A24-246[»]
1Y3XX-ray1.70A24-239[»]
1Y3YX-ray1.75A24-239[»]
1Y59X-ray1.20T24-246[»]
1Y5AX-ray1.40T24-246[»]
1Y5BX-ray1.65T24-246[»]
1Y5UX-ray1.60T24-246[»]
1YP9X-ray2.10A24-246[»]
1YYYX-ray2.10124-246[»]
1ZR0X-ray1.80A/C24-246[»]
1ZZZX-ray1.90A10-246[»]
2A7HX-ray2.10A24-246[»]
2AGEX-ray1.15X24-239[»]
2AGGX-ray1.28X24-239[»]
2AGIX-ray1.14X24-239[»]
2AH4X-ray1.13X24-239[»]
2AYWX-ray0.97A24-246[»]
2BLVX-ray1.20A24-246[»]
2BLWX-ray1.20A24-246[»]
2BTCX-ray1.50E24-246[»]
2BY5X-ray1.30X4-246[»]
2BY6X-ray1.30X4-246[»]
2BY7X-ray1.30X4-246[»]
2BY8X-ray1.30X4-246[»]
2BY9X-ray1.30X4-246[»]
2BYAX-ray1.30X4-246[»]
2BZAX-ray1.90A24-246[»]
2CMYX-ray2.25A24-246[»]
2D8WX-ray2.00A24-246[»]
2F3CX-ray2.50E24-246[»]
2FI3X-ray1.58E24-239[»]
2FI4X-ray1.58E24-246[»]
2FI5X-ray1.58E24-239[»]
2FTLX-ray1.62E24-239[»]
2FTMX-ray1.65A24-239[»]
2FX4X-ray1.65A24-246[»]
2FX6X-ray1.57A24-246[»]
2G55X-ray1.82A24-246[»]
2G5NX-ray1.51A24-246[»]
2G5VX-ray1.45A24-246[»]
2G81X-ray1.55E24-246[»]
2G8TX-ray1.41A24-246[»]
2ILNX-ray2.00A/B24-246[»]
2J9NX-ray1.50A24-246[»]
2O9QX-ray1.70A24-246[»]
2OTVX-ray1.56A24-246[»]
2OXSX-ray1.32A24-246[»]
2PLXX-ray1.56A24-246[»]
2PTCX-ray1.90E24-246[»]
2PTNX-ray1.55A24-246[»]
2QN5X-ray3.00T24-246[»]
2QYIX-ray2.60A/C24-246[»]
2TGAX-ray1.80A18-246[»]
2TGDX-ray2.10A18-246[»]
2TGPX-ray1.90Z18-246[»]
2TGTX-ray1.70A18-246[»]
2TIOX-ray1.93A24-246[»]
2TLDX-ray2.60E24-246[»]
2TPIX-ray2.10Z18-246[»]
2UUYX-ray1.15A24-246[»]
2XTTX-ray0.93B24-246[»]
2ZDKX-ray1.67A24-246[»]
2ZDLX-ray1.80A24-246[»]
2ZDMX-ray1.93A24-246[»]
2ZDNX-ray1.98A24-246[»]
2ZFSX-ray1.51A24-246[»]
2ZFTX-ray1.76A24-246[»]
2ZHDX-ray1.94A24-246[»]
2ZQ1X-ray1.68A24-246[»]
2ZQ2X-ray1.40A24-246[»]
3A7TX-ray1.75A24-246[»]
3A7VX-ray1.75A24-246[»]
3A7WX-ray1.75A24-246[»]
3A7XX-ray1.75A24-246[»]
3A7YX-ray1.81A24-246[»]
3A7ZX-ray1.80A24-246[»]
3A80X-ray1.75A24-246[»]
3A81X-ray1.78A24-246[»]
3A82X-ray1.75A24-246[»]
3A83X-ray1.78A24-246[»]
3A84X-ray1.75A24-246[»]
3A85X-ray1.75A24-246[»]
3A86X-ray1.75A24-246[»]
3A87X-ray1.75A24-246[»]
3A88X-ray1.75A24-246[»]
3A89X-ray1.80A24-246[»]
3A8AX-ray1.40A24-246[»]
3A8BX-ray1.75A24-246[»]
3A8CX-ray1.85A24-246[»]
3A8DX-ray1.75A24-246[»]
3AASX-ray1.75A24-246[»]
3AAUX-ray1.80A24-246[»]
3AAVX-ray1.70A/B24-246[»]
3ATIX-ray1.71A24-246[»]
3ATKX-ray1.74A24-246[»]
3ATLX-ray1.74A24-246[»]
3ATMX-ray1.72A24-246[»]
3BTDX-ray1.90E24-246[»]
3BTEX-ray1.85E24-246[»]
3BTFX-ray1.80E24-246[»]
3BTGX-ray1.90E24-246[»]
3BTHX-ray1.75E24-246[»]
3BTKX-ray1.85E24-246[»]
3BTMX-ray1.80E24-246[»]
3BTQX-ray1.90E24-246[»]
3BTTX-ray1.90E24-246[»]
3BTWX-ray2.05E24-246[»]
3D65X-ray1.64E24-246[»]
3E8LX-ray2.48A/B24-246[»]
3GY2X-ray1.57A24-246[»]
3GY3X-ray1.70A24-246[»]
3GY4X-ray1.55A24-246[»]
3GY5X-ray1.57A24-246[»]
3GY6X-ray1.70A24-246[»]
3GY7X-ray1.55A24-246[»]
3GY8X-ray1.75A24-246[»]
3I29X-ray2.40A24-246[»]
3ITIX-ray1.55A24-246[»]
3LJJX-ray1.55A24-246[»]
3LJOX-ray1.50A24-246[»]
3M35X-ray2.20A24-246[»]
3M7QX-ray1.70A24-246[»]
3MFJX-ray0.80A24-246[»]
3MI4X-ray0.80A24-246[»]
3NK8X-ray1.15A24-246[»]
3NKKX-ray1.12A24-246[»]
3OTJOther2.15E24-246[»]
3PLBX-ray1.18A24-246[»]
3PLKX-ray1.53A24-246[»]
3PLPX-ray1.63A24-246[»]
3PM3X-ray1.53A24-246[»]
3PMJX-ray1.45A24-246[»]
3PTBX-ray1.70A24-246[»]
3PTNX-ray1.70A24-246[»]
3PWBX-ray1.63A24-246[»]
3PWCX-ray1.60A24-246[»]
3PYHX-ray2.00A24-246[»]
3Q00X-ray1.70A24-246[»]
3QK1X-ray2.08A24-246[»]
3RDZX-ray2.26A/B24-246[»]
3RU4X-ray1.68T24-246[»]
3RXAX-ray1.70A24-246[»]
3RXBX-ray1.70A24-246[»]
3RXCX-ray1.70A24-246[»]
3RXDX-ray1.70A24-246[»]
3RXEX-ray1.70A24-246[»]
3RXFX-ray1.70A24-246[»]
3RXGX-ray1.70A24-246[»]
3RXHX-ray1.70A24-246[»]
3RXIX-ray1.60A24-246[»]
3RXJX-ray1.70A24-246[»]
3RXKX-ray1.60A24-246[»]
3RXLX-ray1.70A24-246[»]
3RXMX-ray1.70A24-246[»]
3RXOX-ray1.60A24-246[»]
3RXPX-ray1.60A24-246[»]
3RXQX-ray1.68A24-246[»]
3RXRX-ray1.72A24-246[»]
3RXSX-ray1.74A24-246[»]
3RXTX-ray1.70A24-246[»]
3RXUX-ray1.68A24-246[»]
3RXVX-ray1.70A24-246[»]
3T25X-ray1.70A24-246[»]
3T26X-ray1.70A24-246[»]
3T27X-ray1.95A24-246[»]
3T28X-ray2.80A24-246[»]
3T29X-ray1.75A24-246[»]
3TPIX-ray1.90Z18-246[»]
3UNQX-ray1.62A24-246[»]
3UNRX-ray1.20A24-246[»]
3UNSX-ray1.80A24-246[»]
3UOPX-ray1.69A24-246[»]
3UPEX-ray1.54A24-246[»]
3UQOX-ray1.80A24-246[»]
3UQVX-ray2.40A24-246[»]
3UUZX-ray2.10A/B24-246[»]
3UWIX-ray1.43A24-246[»]
3UY9X-ray3.22A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-246[»]
3V0XX-ray1.90A24-246[»]
3V12X-ray1.80A24-246[»]
3V13X-ray1.63A24-246[»]
3VEQX-ray2.25B24-246[»]
3VPKX-ray1.94A24-246[»]
4AB8X-ray1.60A24-246[»]
4AB9X-ray1.20A24-246[»]
4ABAX-ray1.25A24-246[»]
4ABBX-ray1.25A24-246[»]
4ABDX-ray1.25A24-246[»]
4ABEX-ray1.30A24-246[»]
4ABFX-ray1.30A24-246[»]
4ABGX-ray1.52A24-246[»]
4ABHX-ray1.25A24-246[»]
4ABIX-ray1.55A24-246[»]
4ABJX-ray1.45A24-246[»]
4AOQX-ray2.00A/B/C24-246[»]
4AORX-ray1.70A/B/C24-246[»]
4B1TX-ray1.78A/C24-246[»]
4B2AX-ray1.89A/C24-246[»]
4B2BX-ray1.36A/C24-246[»]
4B2CX-ray1.43A/C24-246[»]
4GUXX-ray1.80A/B/C1-246[»]
4HGCX-ray1.29A24-246[»]
4I8GX-ray0.80A24-239[»]
4I8HX-ray0.75A24-239[»]
4I8JX-ray0.87A24-239[»]
4I8KX-ray0.85A24-239[»]
4I8LX-ray0.87A24-239[»]
4J2YX-ray2.00B24-246[»]
4KTSX-ray1.30A24-246[»]
4KTUX-ray1.35A24-246[»]
4MTBX-ray1.22A24-246[»]
4NCYX-ray1.42A24-246[»]
4NIVX-ray1.00A24-246[»]
4NIWX-ray1.31A24-246[»]
4NIXX-ray1.30A24-246[»]
4NIYX-ray2.84A/B/C/D24-246[»]
4TPIX-ray2.20Z18-246[»]
4TPYX-ray1.30A24-246[»]
4U2WX-ray1.00A24-246[»]
4XOJX-ray0.91A1-246[»]
4Y0YX-ray1.25E24-246[»]
4Y0ZX-ray1.37E24-246[»]
4Y10X-ray1.37E24-246[»]
4Y11X-ray1.30E24-246[»]
4YTAX-ray1.20A24-246[»]
5EG4X-ray1.32A24-246[»]
5F6MX-ray1.10A24-246[»]
5FXLX-ray1.78A1-246[»]
5GIBX-ray2.70A/B24-246[»]
5JYIX-ray1.91A1-246[»]
5LGOX-ray1.12A24-246[»]
5LH8X-ray1.54A24-246[»]
5PTPX-ray1.34A24-246[»]
DisProtiDP00728.
ProteinModelPortaliP00760.
SMRiP00760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00760. 5 interactors.
MINTiMINT-87966.
STRINGi9913.ENSBTAP00000033392.

Chemistry databases

BindingDBiP00760.
ChEMBLiCHEMBL3769.

Protein family/group databases

MEROPSiS01.151.

Proteomic databases

PaxDbiP00760.
PeptideAtlasiP00760.
PRIDEiP00760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633.
ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245.
GeneIDi615026.
780933.
KEGGibta:615026.
bta:780933.

Organism-specific databases

CTDi5644.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP00760.
KOiK01312.
OMAiNTIALPT.
OrthoDBiEOG091G0DF7.
TreeFamiTF331065.

Enzyme and pathway databases

BRENDAi3.4.21.4. 908.
SABIO-RKP00760.

Miscellaneous databases

EvolutionaryTraceiP00760.
PMAP-CutDBP00760.
PROiP00760.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRY1_BOVIN
AccessioniPrimary (citable) accession number: P00760
Secondary accession number(s): A6H6Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 181 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.