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P00760 (TRY1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 157. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cationic trypsin

EC=3.4.21.4
Alternative name(s):
Beta-trypsin

Cleaved into the following 2 chains:

  1. Alpha-trypsin chain 1
  2. Alpha-trypsin chain 2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactor

Binds 1 calcium ion per subunit.

Subcellular location

Secretedextracellular space.

Tissue specificity

Synthesized in the acinar cells of the pancreas.

Post-translational modification

Autocatalytic cleavage after Lys-23 leads to beta-trypsin by releasing a terminal hexapeptide. Subsequent cleavage after Lys-148 leads to alpha-trypsin. Further cleavage after Lys-193 yields pseudotrypsin. A cleavage may also occur after Arg-122.

Not sulfated on tyrosine residue(s).

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

P009744EBI-986385,EBI-1032263
SERPINA1P010095EBI-986385,EBI-986224From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.3
Propeptide18 – 236Activation peptide
PRO_0000028185
Chain24 – 246223Cationic trypsin
PRO_0000028186
Chain24 – 148125Alpha-trypsin chain 1
PRO_0000028187
Chain149 – 24698Alpha-trypsin chain 2
PRO_0000028188

Regions

Domain24 – 244221Peptidase S1
Region194 – 1952Substrate binding
Region197 – 1982Substrate binding

Sites

Active site631Charge relay system
Active site1071Charge relay system
Active site2001Charge relay system
Metal binding751Calcium
Metal binding771Calcium; via carbonyl oxygen
Metal binding801Calcium; via carbonyl oxygen
Metal binding851Calcium
Binding site2001Substrate

Amino acid modifications

Disulfide bond30 ↔ 160 Ref.3 Ref.7 Ref.10 Ref.11
Disulfide bond48 ↔ 64 Ref.3 Ref.7 Ref.10 Ref.11
Disulfide bond132 ↔ 233 Ref.3 Ref.7 Ref.10 Ref.11
Disulfide bond139 ↔ 206 Ref.3 Ref.7 Ref.10 Ref.11
Disulfide bond171 ↔ 185 Ref.3 Ref.7 Ref.10 Ref.11
Disulfide bond196 ↔ 220 Ref.3 Ref.7 Ref.10 Ref.11

Secondary structure

...................................................... 246
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00760 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 092E3D8ACCCCC4D3

FASTA24625,785
        10         20         30         40         50         60 
MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG SLINSQWVVS 

        70         80         90        100        110        120 
AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN SNTLNNDIML IKLKSAASLN 

       130        140        150        160        170        180 
SRVASISLPT SCASAGTQCL ISGWGNTKSS GTSYPDVLKC LKAPILSDSS CKSAYPGQIT 

       190        200        210        220        230        240 
SNMFCAGYLE GGKDSCQGDS GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK 


QTIASN 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pancreas.
[2]Okajima T., Maniwa M., Nagao S., Fujikawa H., Goto S.
Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-246.
Tissue: Pancreas.
[3]"Covalent structure of bovine trypsinogen. The position of the remaining amides."
Mikes O., Holeysovsky V., Tomasek V., Sorm F.
Biochem. Biophys. Res. Commun. 24:346-352(1966) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 18-246, DISULFIDE BONDS.
[4]"Homologies in serine proteinases."
Hartley B.S.
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 257:77-87(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Amino acid sequence of dogfish trypsin."
Titani K., Ericsson L.H., Neurath H., Walsh K.A.
Biochemistry 14:1358-1366(1975) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[6]"Human cationic trypsinogen is sulfated on Tyr154."
Sahin-Toth M., Kukor Z., Nemoda Z.
FEBS J. 273:5044-5050(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: ABSENCE OF SULFATED TYROSINE.
[7]"The disulphide bridges of trypsin."
Kauffman D.L.
J. Mol. Biol. 12:929-932(1965) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
[8]"The refined crystal structure of bovine beta-trypsin at 1.8-A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0."
Bode W., Schwager P.
J. Mol. Biol. 98:693-717(1975) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF CALCIUM-BINDING SITE.
[9]"Structure of bovine trypsinogen at 1.9-A resolution."
Kossiakoff A.A., Chambers J.L., Kay L.M., Stroud R.M.
Biochemistry 16:654-664(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
[10]"An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.)."
Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J., Joseph-Horne T., Shewry P., Brady R.L.
J. Biol. Chem. 282:27760-27768(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 24-246 IN COMPLEX WITH V.HEDERIFOLIA TRYPSIN INHIBITOR, DISULFIDE BONDS.
[11]"The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake."
Millers E.K., Johnson L.A., Birrell G.W., Masci P.P., Lavin M.F., de Jersey J., Guddat L.W.
PLoS ONE 8:E54104-E54104(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 24-246 IN COMPLEX WITH THE SNAKE VENOM PROTEASE INHIBITOR TEXTILININ-1, DISULFIDE BONDS, METAL-BINDING SITES GLU-75; ASN-77; VAL-80 AND GLU-85.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC134797 mRNA. Translation: AAI34798.1.
BC146041 mRNA. Translation: AAI46042.1.
D38507 mRNA. Translation: BAA07516.1.
PIRTRBOTR. A90164.
RefSeqNP_001107199.1. NM_001113727.1.
XP_002687054.3. XM_002687008.3.
XP_871686.4. XM_866593.5.
UniGeneBt.91423.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AQ7X-ray2.20A24-246[»]
1AUJX-ray2.10A24-246[»]
1AZ8X-ray1.80A24-246[»]
1BJUX-ray1.80A24-246[»]
1BJVX-ray1.80A24-246[»]
1BTPX-ray2.20A18-246[»]
1BTWX-ray1.70A18-246[»]
1BTXX-ray1.70A18-246[»]
1BTYX-ray1.50A18-246[»]
1BTZX-ray2.00A18-246[»]
1C1NX-ray1.40A24-246[»]
1C1OX-ray1.40A24-246[»]
1C1PX-ray1.37A24-246[»]
1C1QX-ray1.37A24-246[»]
1C1RX-ray1.37A24-246[»]
1C1SX-ray1.63A24-246[»]
1C1TX-ray1.37A24-246[»]
1C2DX-ray1.65A24-246[»]
1C2EX-ray1.65A24-246[»]
1C2FX-ray1.70A24-246[»]
1C2GX-ray1.65A24-246[»]
1C2HX-ray1.40A24-246[»]
1C2IX-ray1.47A24-246[»]
1C2JX-ray1.40A24-246[»]
1C2KX-ray1.65A24-246[»]
1C2LX-ray1.50A24-246[»]
1C2MX-ray1.40A24-246[»]
1C5PX-ray1.43A24-246[»]
1C5QX-ray1.43A24-246[»]
1C5RX-ray1.47A24-246[»]
1C5SX-ray1.36A24-246[»]
1C5TX-ray1.37A24-246[»]
1C5UX-ray1.37A24-246[»]
1C5VX-ray1.48A24-246[»]
1C9TX-ray3.30A/B/C/D/E/F24-246[»]
1CE5X-ray1.90A24-246[»]
1CU7model-A24-246[»]
1CU8model-A24-246[»]
1CU9model-A24-246[»]
1D6RX-ray2.30A24-246[»]
1EB2X-ray2.00A24-246[»]
1EJMX-ray1.85A/C/E24-246[»]
1EZXX-ray2.60C4-246[»]
1F0TX-ray1.80A4-246[»]
1F0UX-ray1.90A4-246[»]
1F2SX-ray1.79E24-246[»]
1G36X-ray1.90A24-246[»]
1G3BX-ray1.80A19-239[»]
1G3CX-ray1.80A19-239[»]
1G3DX-ray1.80A19-239[»]
1G3EX-ray1.80A19-239[»]
1G9IX-ray2.20E24-246[»]
1GBTX-ray2.00A24-246[»]
1GHZX-ray1.39A24-246[»]
1GI0X-ray1.42A24-239[»]
1GI1X-ray1.42A24-246[»]
1GI2X-ray1.38A24-246[»]
1GI3X-ray1.44A24-246[»]
1GI4X-ray1.37A24-246[»]
1GI5X-ray1.60A24-246[»]
1GI6X-ray1.49A24-246[»]
1GJ6X-ray1.50A24-246[»]
1HJ9X-ray0.95A24-246[»]
1J8AX-ray1.21A24-246[»]
1JIRX-ray2.00A24-246[»]
1JRSX-ray1.80A24-246[»]
1JRTX-ray1.70A24-246[»]
1K1IX-ray2.20A24-246[»]
1K1JX-ray2.20A24-246[»]
1K1LX-ray2.50A24-246[»]
1K1MX-ray2.20A24-246[»]
1K1NX-ray2.00A24-246[»]
1K1OX-ray2.00A24-246[»]
1K1PX-ray1.90A24-246[»]
1LQEX-ray2.20A4-246[»]
1MAXX-ray1.80A24-246[»]
1MAYX-ray1.80A24-246[»]
1MTSX-ray1.90A24-246[»]
1MTUX-ray1.90A24-246[»]
1MTVX-ray1.90A24-246[»]
1MTWX-ray1.90A24-246[»]
1N6XX-ray1.40A24-246[»]
1N6YX-ray1.40A24-246[»]
1NC6X-ray1.90A24-246[»]
1NTPneutron diffraction1.80A24-246[»]
1O2HX-ray1.77A24-246[»]
1O2IX-ray1.50A24-246[»]
1O2JX-ray1.65A24-246[»]
1O2KX-ray1.63A24-246[»]
1O2LX-ray1.68A24-246[»]
1O2MX-ray1.69A24-246[»]
1O2NX-ray1.50A24-246[»]
1O2OX-ray1.63A24-246[»]
1O2PX-ray1.47A24-246[»]
1O2QX-ray1.50A24-246[»]
1O2RX-ray1.45A24-246[»]
1O2SX-ray1.65A24-246[»]
1O2TX-ray1.62A24-246[»]
1O2UX-ray1.41A24-246[»]
1O2VX-ray1.50A24-246[»]
1O2WX-ray1.38A24-246[»]
1O2XX-ray1.46A24-246[»]
1O2YX-ray1.45A24-246[»]
1O2ZX-ray1.65A24-246[»]
1O30X-ray1.55A24-246[»]
1O31X-ray1.66A24-246[»]
1O32X-ray1.78A24-246[»]
1O33X-ray1.46A24-246[»]
1O34X-ray1.50A24-246[»]
1O35X-ray1.41A24-246[»]
1O36X-ray1.70A24-246[»]
1O37X-ray1.45A24-246[»]
1O38X-ray1.38A24-246[»]
1O39X-ray1.59A24-246[»]
1O3AX-ray2.00A24-246[»]
1O3BX-ray1.75A24-246[»]
1O3CX-ray1.64A24-246[»]
1O3DX-ray1.33A24-246[»]
1O3EX-ray1.64A24-246[»]
1O3FX-ray1.55A24-246[»]
1O3GX-ray1.55A24-246[»]
1O3HX-ray1.53A24-246[»]
1O3IX-ray1.51A24-246[»]
1O3JX-ray1.40A24-246[»]
1O3KX-ray1.43A24-246[»]
1O3LX-ray1.40A24-246[»]
1O3MX-ray1.55A24-246[»]
1O3NX-ray1.55A24-246[»]
1O3OX-ray1.55A24-246[»]
1OPHX-ray2.30B4-246[»]
1OX1X-ray2.00A24-246[»]
1OYQX-ray1.90A24-239[»]
1P2IX-ray1.65A24-246[»]
1P2JX-ray1.35A24-246[»]
1P2KX-ray1.60A24-246[»]
1PPCX-ray1.80E24-246[»]
1PPEX-ray2.00E24-246[»]
1PPHX-ray1.90E24-246[»]
1QA0X-ray1.80A24-246[»]
1QB1X-ray1.80A24-246[»]
1QB6X-ray1.80A24-246[»]
1QB9X-ray1.80A24-246[»]
1QBNX-ray1.80A24-246[»]
1QBOX-ray1.80A24-246[»]
1QCPX-ray1.80A24-246[»]
1QL7X-ray2.10A24-246[»]
1QL8X-ray3.00A24-246[»]
1RXPX-ray1.70A24-239[»]
1S0QX-ray1.02A24-246[»]
1S0RX-ray1.02A24-246[»]
1SBWX-ray1.80A24-246[»]
1SFIX-ray1.65A24-246[»]
1SMFX-ray2.10E24-246[»]
1TABX-ray2.30E24-246[»]
1TAWX-ray1.80A24-246[»]
1TGBX-ray1.80A18-246[»]
1TGCX-ray1.80A18-246[»]
1TGNX-ray1.65A18-246[»]
1TGSX-ray1.80Z18-246[»]
1TGTX-ray1.70A18-246[»]
1TIOX-ray1.93A24-246[»]
1TLDX-ray1.50A24-246[»]
1TNGX-ray1.80A18-246[»]
1TNHX-ray1.80A18-246[»]
1TNIX-ray1.90A18-246[»]
1TNJX-ray1.80A18-246[»]
1TNKX-ray1.80A18-246[»]
1TNLX-ray1.90A18-246[»]
1TPAX-ray1.90E24-246[»]
1TPOX-ray1.70A24-246[»]
1TPPX-ray1.40A24-246[»]
1TPSX-ray1.90A24-246[»]
1TX7X-ray1.75A24-239[»]
1TX8X-ray1.70A24-239[»]
1TYNX-ray2.00A24-246[»]
1UTNX-ray1.15A4-246[»]
1UTOX-ray1.15A4-246[»]
1UTPX-ray1.30A4-246[»]
1UTQX-ray1.15A4-246[»]
1V2JX-ray1.90T24-246[»]
1V2KX-ray2.00T24-246[»]
1V2LX-ray1.60T24-246[»]
1V2MX-ray1.65T24-246[»]
1V2NX-ray1.80T24-246[»]
1V2OX-ray1.62T24-246[»]
1V2PX-ray1.92T24-246[»]
1V2QX-ray2.30T24-246[»]
1V2RX-ray1.70T24-246[»]
1V2SX-ray1.72T24-246[»]
1V2TX-ray1.90T24-246[»]
1V2UX-ray1.80T24-246[»]
1V2VX-ray1.80T24-246[»]
1V2WX-ray1.75T24-246[»]
1XUFX-ray1.90A24-246[»]
1XUGX-ray1.50A24-246[»]
1XUHX-ray2.20A24-246[»]
1XUIX-ray1.50A24-246[»]
1XUJX-ray1.92A24-246[»]
1XUKX-ray1.80A24-246[»]
1Y3UX-ray1.80A24-246[»]
1Y3VX-ray1.60A24-246[»]
1Y3WX-ray1.80A24-246[»]
1Y3XX-ray1.70A24-239[»]
1Y3YX-ray1.75A24-239[»]
1Y59X-ray1.20T24-246[»]
1Y5AX-ray1.40T24-246[»]
1Y5BX-ray1.65T24-246[»]
1Y5UX-ray1.60T24-246[»]
1YP9X-ray2.10A24-246[»]
1YYYX-ray2.10124-246[»]
1ZR0X-ray1.80A/C24-246[»]
1ZZZX-ray1.90A10-246[»]
2A7HX-ray2.10A24-246[»]
2AGEX-ray1.15X24-239[»]
2AGGX-ray1.28X24-239[»]
2AGIX-ray1.14X24-239[»]
2AH4X-ray1.13X24-239[»]
2AYWX-ray0.97A24-246[»]
2BLVX-ray1.20A24-246[»]
2BLWX-ray1.20A24-246[»]
2BTCX-ray1.50E24-246[»]
2BY5X-ray1.30X4-246[»]
2BY6X-ray1.30X4-246[»]
2BY7X-ray1.30X4-246[»]
2BY8X-ray1.30X4-246[»]
2BY9X-ray1.30X4-246[»]
2BYAX-ray1.30X4-246[»]
2BZAX-ray1.90A24-246[»]
2CMYX-ray2.25A24-246[»]
2D8WX-ray2.00A24-246[»]
2F3CX-ray2.50E24-246[»]
2FI3X-ray1.58E24-239[»]
2FI4X-ray1.58E24-246[»]
2FI5X-ray1.58E24-239[»]
2FTLX-ray1.62E24-239[»]
2FTMX-ray1.65A24-239[»]
2FX4X-ray1.65A24-246[»]
2FX6X-ray1.57A24-246[»]
2G55X-ray1.82A24-246[»]
2G5NX-ray1.51A24-246[»]
2G5VX-ray1.45A24-246[»]
2G81X-ray1.55E24-246[»]
2G8TX-ray1.41A24-246[»]
2ILNX-ray2.00A/B24-246[»]
2J9NX-ray1.50A24-246[»]
2O9QX-ray1.70A24-246[»]
2OTVX-ray1.56A24-246[»]
2OXSX-ray1.32A24-246[»]
2PLXX-ray1.56A24-246[»]
2PTCX-ray1.90E24-246[»]
2PTNX-ray1.55A24-246[»]
2QN5X-ray3.00T24-246[»]
2QYIX-ray2.60A/C24-246[»]
2TGAX-ray1.80A18-246[»]
2TGDX-ray2.10A18-246[»]
2TGPX-ray1.90Z18-246[»]
2TGTX-ray1.70A18-246[»]
2TIOX-ray1.93A24-246[»]
2TLDX-ray2.60E24-246[»]
2TPIX-ray2.10Z18-246[»]
2UUYX-ray1.15A24-246[»]
2XTTX-ray0.93B24-246[»]
2ZDKX-ray1.67A24-246[»]
2ZDLX-ray1.80A24-246[»]
2ZDMX-ray1.93A24-246[»]
2ZDNX-ray1.98A24-246[»]
2ZFSX-ray1.51A24-246[»]
2ZFTX-ray1.76A24-246[»]
2ZHDX-ray1.94A24-246[»]
2ZQ1X-ray1.68A24-246[»]
2ZQ2X-ray1.40A24-246[»]
3A7TX-ray1.75A24-246[»]
3A7VX-ray1.75A24-246[»]
3A7WX-ray1.75A24-246[»]
3A7XX-ray1.75A24-246[»]
3A7YX-ray1.81A24-246[»]
3A7ZX-ray1.80A24-246[»]
3A80X-ray1.75A24-246[»]
3A81X-ray1.78A24-246[»]
3A82X-ray1.75A24-246[»]
3A83X-ray1.78A24-246[»]
3A84X-ray1.75A24-246[»]
3A85X-ray1.75A24-246[»]
3A86X-ray1.75A24-246[»]
3A87X-ray1.75A24-246[»]
3A88X-ray1.75A24-246[»]
3A89X-ray1.80A24-246[»]
3A8AX-ray1.40A24-246[»]
3A8BX-ray1.75A24-246[»]
3A8CX-ray1.85A24-246[»]
3A8DX-ray1.75A24-246[»]
3AASX-ray1.75A24-246[»]
3AAUX-ray1.80A24-246[»]
3AAVX-ray1.70A/B24-246[»]
3ATIX-ray1.71A24-246[»]
3ATKX-ray1.74A24-246[»]
3ATLX-ray1.74A24-246[»]
3ATMX-ray1.72A24-246[»]
3BTDX-ray1.90E24-246[»]
3BTEX-ray1.85E24-246[»]
3BTFX-ray1.80E24-246[»]
3BTGX-ray1.90E24-246[»]
3BTHX-ray1.75E24-246[»]
3BTKX-ray1.85E24-246[»]
3BTMX-ray1.80E24-246[»]
3BTQX-ray1.90E24-246[»]
3BTTX-ray1.90E24-246[»]
3BTWX-ray2.05E24-246[»]
3D65X-ray1.64E24-246[»]
3E8LX-ray2.48A/B24-246[»]
3GY2X-ray1.57A24-246[»]
3GY3X-ray1.70A24-246[»]
3GY4X-ray1.55A24-246[»]
3GY5X-ray1.57A24-246[»]
3GY6X-ray1.70A24-246[»]
3GY7X-ray1.55A24-246[»]
3GY8X-ray1.75A24-246[»]
3I29X-ray2.40A24-246[»]
3ITIX-ray1.55A24-246[»]
3LJJX-ray1.55A24-246[»]
3LJOX-ray1.50A24-246[»]
3M35X-ray2.20A24-246[»]
3M7QX-ray1.70A24-246[»]
3MFJX-ray0.80A24-246[»]
3MI4X-ray0.80A24-246[»]
3NK8X-ray1.15A24-246[»]
3NKKX-ray1.12A24-246[»]
3OTJOther2.15E24-246[»]
3PLBX-ray1.18A24-246[»]
3PLKX-ray1.53A24-246[»]
3PLPX-ray1.63A24-246[»]
3PM3X-ray1.53A24-246[»]
3PMJX-ray1.45A24-246[»]
3PTBX-ray1.70A24-246[»]
3PTNX-ray1.70A24-246[»]
3PWBX-ray1.63A24-246[»]
3PWCX-ray1.60A24-246[»]
3PYHX-ray2.00A24-246[»]
3Q00X-ray1.70A24-246[»]
3QK1X-ray2.08A24-246[»]
3RDZX-ray2.26A/B24-246[»]
3RU4X-ray1.68T24-246[»]
3RXAX-ray1.70A24-246[»]
3RXBX-ray1.70A24-246[»]
3RXCX-ray1.70A24-246[»]
3RXDX-ray1.70A24-246[»]
3RXEX-ray1.70A24-246[»]
3RXFX-ray1.70A24-246[»]
3RXGX-ray1.70A24-246[»]
3RXHX-ray1.70A24-246[»]
3RXIX-ray1.60A24-246[»]
3RXJX-ray1.70A24-246[»]
3RXKX-ray1.60A24-246[»]
3RXLX-ray1.70A24-246[»]
3RXMX-ray1.70A24-246[»]
3RXOX-ray1.60A24-246[»]
3RXPX-ray1.60A24-246[»]
3RXQX-ray1.68A24-246[»]
3RXRX-ray1.72A24-246[»]
3RXSX-ray1.74A24-246[»]
3RXTX-ray1.70A24-246[»]
3RXUX-ray1.68A24-246[»]
3RXVX-ray1.70A24-246[»]
3T25X-ray1.70A24-246[»]
3T26X-ray1.70A24-246[»]
3T27X-ray1.95A24-246[»]
3T28X-ray2.80A24-246[»]
3T29X-ray1.75A24-246[»]
3TPIX-ray1.90Z18-246[»]
3UNQX-ray1.62A24-246[»]
3UNRX-ray1.20A24-246[»]
3UNSX-ray1.80A24-246[»]
3UOPX-ray1.69A24-246[»]
3UPEX-ray1.54A24-246[»]
3UQOX-ray1.80A24-246[»]
3UQVX-ray2.40A24-246[»]
3UUZX-ray2.10A/B24-246[»]
3UWIX-ray1.43A24-246[»]
3UY9X-ray3.22A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-246[»]
3V0XX-ray1.90A24-246[»]
3V12X-ray1.80A24-246[»]
3V13X-ray1.63A24-246[»]
3VEQX-ray2.25B24-246[»]
3VPKX-ray1.94A24-246[»]
4AB8X-ray1.60A24-246[»]
4AB9X-ray1.20A24-246[»]
4ABAX-ray1.25A24-246[»]
4ABBX-ray1.25A24-246[»]
4ABDX-ray1.25A24-246[»]
4ABEX-ray1.30A24-246[»]
4ABFX-ray1.30A24-246[»]
4ABGX-ray1.52A24-246[»]
4ABHX-ray1.25A24-246[»]
4ABIX-ray1.55A24-246[»]
4ABJX-ray1.45A24-246[»]
4AOQX-ray2.00A/B/C24-246[»]
4AORX-ray1.70A/B/C24-246[»]
4B1TX-ray1.78A/C24-246[»]
4B2AX-ray1.89A/C24-246[»]
4B2BX-ray1.36A/C24-246[»]
4B2CX-ray1.43A/C24-246[»]
4GUXX-ray1.80A/B/C1-246[»]
4HGCX-ray1.29A24-246[»]
4I8GX-ray0.80A24-239[»]
4I8HX-ray0.75A24-239[»]
4I8JX-ray0.87A24-239[»]
4I8KX-ray0.85A24-239[»]
4I8LX-ray0.87A24-239[»]
4J2YX-ray2.00B24-246[»]
4KTSX-ray1.30A24-246[»]
4KTUX-ray1.35A24-246[»]
4NCYX-ray1.42A24-246[»]
4NIVX-ray1.00A24-246[»]
4NIWX-ray1.31A24-246[»]
4NIXX-ray1.30A24-246[»]
4NIYX-ray2.84A/B/C/D24-246[»]
4TPIX-ray2.20Z18-246[»]
5PTPX-ray1.34A24-246[»]
DisProtDP00728.
ProteinModelPortalP00760.
SMRP00760. Positions 22-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00760. 4 interactions.
MINTMINT-87966.

Chemistry

BindingDBP00760.
ChEMBLCHEMBL3769.
DrugBankDB01093. Dimethyl sulfoxide.

Protein family/group databases

MEROPSS01.151.

Proteomic databases

PaxDbP00760.
PRIDEP00760.
ProMEXP00760.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633.
ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245.
GeneID615026.
780933.
KEGGbta:615026.
bta:780933.

Organism-specific databases

CTD5644.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00740000115192.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP00760.
KOK01312.
OMAWIRQTIS.
OrthoDBEOG75B84T.
TreeFamTF331065.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP00760.
NextBio20899409.
PMAP-CutDBP00760.

Entry information

Entry nameTRY1_BOVIN
AccessionPrimary (citable) accession number: P00760
Secondary accession number(s): A6H6Y3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references