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P00760

- TRY1_BOVIN

UniProt

P00760 - TRY1_BOVIN

Protein

Cationic trypsin

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 3 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Charge relay system
    Metal bindingi75 – 751Calcium
    Metal bindingi77 – 771Calcium; via carbonyl oxygen
    Metal bindingi80 – 801Calcium; via carbonyl oxygen
    Metal bindingi85 – 851Calcium
    Active sitei107 – 1071Charge relay system
    Active sitei200 – 2001Charge relay system
    Binding sitei200 – 2001Substrate

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    MEROPSiS01.151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cationic trypsin (EC:3.4.21.4)
    Alternative name(s):
    Beta-trypsin
    Cleaved into the following 2 chains:
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Propeptidei18 – 236Activation peptidePRO_0000028185
    Chaini24 – 246223Cationic trypsinPRO_0000028186Add
    BLAST
    Chaini24 – 148125Alpha-trypsin chain 1PRO_0000028187Add
    BLAST
    Chaini149 – 24698Alpha-trypsin chain 2PRO_0000028188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 160
    Disulfide bondi48 ↔ 64
    Disulfide bondi132 ↔ 233
    Disulfide bondi139 ↔ 206
    Disulfide bondi171 ↔ 185
    Disulfide bondi196 ↔ 220

    Post-translational modificationi

    Autocatalytic cleavage after Lys-23 leads to beta-trypsin by releasing a terminal hexapeptide. Subsequent cleavage after Lys-148 leads to alpha-trypsin. Further cleavage after Lys-193 yields pseudotrypsin. A cleavage may also occur after Arg-122.
    Not sulfated on tyrosine residue(s).

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP00760.
    PRIDEiP00760.
    ProMEXiP00760.

    Miscellaneous databases

    PMAP-CutDBP00760.

    Expressioni

    Tissue specificityi

    Synthesized in the acinar cells of the pancreas.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P009744EBI-986385,EBI-1032263
    SERPINA1P010095EBI-986385,EBI-986224From a different organism.

    Protein-protein interaction databases

    IntActiP00760. 5 interactions.
    MINTiMINT-87966.

    Structurei

    Secondary structure

    1
    246
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni23 – 264
    Turni32 – 343
    Beta strandi38 – 5215
    Beta strandi54 – 607
    Helixi62 – 643
    Beta strandi70 – 745
    Beta strandi76 – 805
    Beta strandi81 – 844
    Beta strandi86 – 9510
    Turni101 – 1033
    Beta strandi109 – 1157
    Beta strandi121 – 1233
    Beta strandi138 – 1458
    Beta strandi149 – 1513
    Beta strandi159 – 1657
    Helixi168 – 1747
    Turni176 – 1783
    Turni180 – 1823
    Beta strandi183 – 1875
    Turni189 – 1913
    Beta strandi192 – 1943
    Turni197 – 2015
    Beta strandi203 – 2064
    Beta strandi209 – 2168
    Beta strandi218 – 2214
    Beta strandi227 – 2315
    Helixi232 – 2354
    Helixi236 – 2394
    Turni243 – 2453

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AQ7X-ray2.20A24-246[»]
    1AUJX-ray2.10A24-246[»]
    1AZ8X-ray1.80A24-246[»]
    1BJUX-ray1.80A24-246[»]
    1BJVX-ray1.80A24-246[»]
    1BTPX-ray2.20A18-246[»]
    1BTWX-ray1.70A18-246[»]
    1BTXX-ray1.70A18-246[»]
    1BTYX-ray1.50A18-246[»]
    1BTZX-ray2.00A18-246[»]
    1C1NX-ray1.40A24-246[»]
    1C1OX-ray1.40A24-246[»]
    1C1PX-ray1.37A24-246[»]
    1C1QX-ray1.37A24-246[»]
    1C1RX-ray1.37A24-246[»]
    1C1SX-ray1.63A24-246[»]
    1C1TX-ray1.37A24-246[»]
    1C2DX-ray1.65A24-246[»]
    1C2EX-ray1.65A24-246[»]
    1C2FX-ray1.70A24-246[»]
    1C2GX-ray1.65A24-246[»]
    1C2HX-ray1.40A24-246[»]
    1C2IX-ray1.47A24-246[»]
    1C2JX-ray1.40A24-246[»]
    1C2KX-ray1.65A24-246[»]
    1C2LX-ray1.50A24-246[»]
    1C2MX-ray1.40A24-246[»]
    1C5PX-ray1.43A24-246[»]
    1C5QX-ray1.43A24-246[»]
    1C5RX-ray1.47A24-246[»]
    1C5SX-ray1.36A24-246[»]
    1C5TX-ray1.37A24-246[»]
    1C5UX-ray1.37A24-246[»]
    1C5VX-ray1.48A24-246[»]
    1C9TX-ray3.30A/B/C/D/E/F24-246[»]
    1CE5X-ray1.90A24-246[»]
    1CU7model-A24-246[»]
    1CU8model-A24-246[»]
    1CU9model-A24-246[»]
    1D6RX-ray2.30A24-246[»]
    1EB2X-ray2.00A24-246[»]
    1EJMX-ray1.85A/C/E24-246[»]
    1EZXX-ray2.60C4-246[»]
    1F0TX-ray1.80A4-246[»]
    1F0UX-ray1.90A4-246[»]
    1F2SX-ray1.79E24-246[»]
    1G36X-ray1.90A24-246[»]
    1G3BX-ray1.80A19-239[»]
    1G3CX-ray1.80A19-239[»]
    1G3DX-ray1.80A19-239[»]
    1G3EX-ray1.80A19-239[»]
    1G9IX-ray2.20E24-246[»]
    1GBTX-ray2.00A24-246[»]
    1GHZX-ray1.39A24-246[»]
    1GI0X-ray1.42A24-239[»]
    1GI1X-ray1.42A24-246[»]
    1GI2X-ray1.38A24-246[»]
    1GI3X-ray1.44A24-246[»]
    1GI4X-ray1.37A24-246[»]
    1GI5X-ray1.60A24-246[»]
    1GI6X-ray1.49A24-246[»]
    1GJ6X-ray1.50A24-246[»]
    1HJ9X-ray0.95A24-246[»]
    1J8AX-ray1.21A24-246[»]
    1JIRX-ray2.00A24-246[»]
    1JRSX-ray1.80A24-246[»]
    1JRTX-ray1.70A24-246[»]
    1K1IX-ray2.20A24-246[»]
    1K1JX-ray2.20A24-246[»]
    1K1LX-ray2.50A24-246[»]
    1K1MX-ray2.20A24-246[»]
    1K1NX-ray2.00A24-246[»]
    1K1OX-ray2.00A24-246[»]
    1K1PX-ray1.90A24-246[»]
    1LQEX-ray2.20A4-246[»]
    1MAXX-ray1.80A24-246[»]
    1MAYX-ray1.80A24-246[»]
    1MTSX-ray1.90A24-246[»]
    1MTUX-ray1.90A24-246[»]
    1MTVX-ray1.90A24-246[»]
    1MTWX-ray1.90A24-246[»]
    1N6XX-ray1.40A24-246[»]
    1N6YX-ray1.40A24-246[»]
    1NC6X-ray1.90A24-246[»]
    1NTPneutron diffraction1.80A24-246[»]
    1O2HX-ray1.77A24-246[»]
    1O2IX-ray1.50A24-246[»]
    1O2JX-ray1.65A24-246[»]
    1O2KX-ray1.63A24-246[»]
    1O2LX-ray1.68A24-246[»]
    1O2MX-ray1.69A24-246[»]
    1O2NX-ray1.50A24-246[»]
    1O2OX-ray1.63A24-246[»]
    1O2PX-ray1.47A24-246[»]
    1O2QX-ray1.50A24-246[»]
    1O2RX-ray1.45A24-246[»]
    1O2SX-ray1.65A24-246[»]
    1O2TX-ray1.62A24-246[»]
    1O2UX-ray1.41A24-246[»]
    1O2VX-ray1.50A24-246[»]
    1O2WX-ray1.38A24-246[»]
    1O2XX-ray1.46A24-246[»]
    1O2YX-ray1.45A24-246[»]
    1O2ZX-ray1.65A24-246[»]
    1O30X-ray1.55A24-246[»]
    1O31X-ray1.66A24-246[»]
    1O32X-ray1.78A24-246[»]
    1O33X-ray1.46A24-246[»]
    1O34X-ray1.50A24-246[»]
    1O35X-ray1.41A24-246[»]
    1O36X-ray1.70A24-246[»]
    1O37X-ray1.45A24-246[»]
    1O38X-ray1.38A24-246[»]
    1O39X-ray1.59A24-246[»]
    1O3AX-ray2.00A24-246[»]
    1O3BX-ray1.75A24-246[»]
    1O3CX-ray1.64A24-246[»]
    1O3DX-ray1.33A24-246[»]
    1O3EX-ray1.64A24-246[»]
    1O3FX-ray1.55A24-246[»]
    1O3GX-ray1.55A24-246[»]
    1O3HX-ray1.53A24-246[»]
    1O3IX-ray1.51A24-246[»]
    1O3JX-ray1.40A24-246[»]
    1O3KX-ray1.43A24-246[»]
    1O3LX-ray1.40A24-246[»]
    1O3MX-ray1.55A24-246[»]
    1O3NX-ray1.55A24-246[»]
    1O3OX-ray1.55A24-246[»]
    1OPHX-ray2.30B4-246[»]
    1OX1X-ray2.00A24-246[»]
    1OYQX-ray1.90A24-239[»]
    1P2IX-ray1.65A24-246[»]
    1P2JX-ray1.35A24-246[»]
    1P2KX-ray1.60A24-246[»]
    1PPCX-ray1.80E24-246[»]
    1PPEX-ray2.00E24-246[»]
    1PPHX-ray1.90E24-246[»]
    1QA0X-ray1.80A24-246[»]
    1QB1X-ray1.80A24-246[»]
    1QB6X-ray1.80A24-246[»]
    1QB9X-ray1.80A24-246[»]
    1QBNX-ray1.80A24-246[»]
    1QBOX-ray1.80A24-246[»]
    1QCPX-ray1.80A24-246[»]
    1QL7X-ray2.10A24-246[»]
    1QL8X-ray3.00A24-246[»]
    1RXPX-ray1.70A24-239[»]
    1S0QX-ray1.02A24-246[»]
    1S0RX-ray1.02A24-246[»]
    1SBWX-ray1.80A24-246[»]
    1SFIX-ray1.65A24-246[»]
    1SMFX-ray2.10E24-246[»]
    1TABX-ray2.30E24-246[»]
    1TAWX-ray1.80A24-246[»]
    1TGBX-ray1.80A18-246[»]
    1TGCX-ray1.80A18-246[»]
    1TGNX-ray1.65A18-246[»]
    1TGSX-ray1.80Z18-246[»]
    1TGTX-ray1.70A18-246[»]
    1TIOX-ray1.93A24-246[»]
    1TLDX-ray1.50A24-246[»]
    1TNGX-ray1.80A18-246[»]
    1TNHX-ray1.80A18-246[»]
    1TNIX-ray1.90A18-246[»]
    1TNJX-ray1.80A18-246[»]
    1TNKX-ray1.80A18-246[»]
    1TNLX-ray1.90A18-246[»]
    1TPAX-ray1.90E24-246[»]
    1TPOX-ray1.70A24-246[»]
    1TPPX-ray1.40A24-246[»]
    1TPSX-ray1.90A24-246[»]
    1TX7X-ray1.75A24-239[»]
    1TX8X-ray1.70A24-239[»]
    1TYNX-ray2.00A24-246[»]
    1UTNX-ray1.15A4-246[»]
    1UTOX-ray1.15A4-246[»]
    1UTPX-ray1.30A4-246[»]
    1UTQX-ray1.15A4-246[»]
    1V2JX-ray1.90T24-246[»]
    1V2KX-ray2.00T24-246[»]
    1V2LX-ray1.60T24-246[»]
    1V2MX-ray1.65T24-246[»]
    1V2NX-ray1.80T24-246[»]
    1V2OX-ray1.62T24-246[»]
    1V2PX-ray1.92T24-246[»]
    1V2QX-ray2.30T24-246[»]
    1V2RX-ray1.70T24-246[»]
    1V2SX-ray1.72T24-246[»]
    1V2TX-ray1.90T24-246[»]
    1V2UX-ray1.80T24-246[»]
    1V2VX-ray1.80T24-246[»]
    1V2WX-ray1.75T24-246[»]
    1XUFX-ray1.90A24-246[»]
    1XUGX-ray1.50A24-246[»]
    1XUHX-ray2.20A24-246[»]
    1XUIX-ray1.50A24-246[»]
    1XUJX-ray1.92A24-246[»]
    1XUKX-ray1.80A24-246[»]
    1Y3UX-ray1.80A24-246[»]
    1Y3VX-ray1.60A24-246[»]
    1Y3WX-ray1.80A24-246[»]
    1Y3XX-ray1.70A24-239[»]
    1Y3YX-ray1.75A24-239[»]
    1Y59X-ray1.20T24-246[»]
    1Y5AX-ray1.40T24-246[»]
    1Y5BX-ray1.65T24-246[»]
    1Y5UX-ray1.60T24-246[»]
    1YP9X-ray2.10A24-246[»]
    1YYYX-ray2.10124-246[»]
    1ZR0X-ray1.80A/C24-246[»]
    1ZZZX-ray1.90A10-246[»]
    2A7HX-ray2.10A24-246[»]
    2AGEX-ray1.15X24-239[»]
    2AGGX-ray1.28X24-239[»]
    2AGIX-ray1.14X24-239[»]
    2AH4X-ray1.13X24-239[»]
    2AYWX-ray0.97A24-246[»]
    2BLVX-ray1.20A24-246[»]
    2BLWX-ray1.20A24-246[»]
    2BTCX-ray1.50E24-246[»]
    2BY5X-ray1.30X4-246[»]
    2BY6X-ray1.30X4-246[»]
    2BY7X-ray1.30X4-246[»]
    2BY8X-ray1.30X4-246[»]
    2BY9X-ray1.30X4-246[»]
    2BYAX-ray1.30X4-246[»]
    2BZAX-ray1.90A24-246[»]
    2CMYX-ray2.25A24-246[»]
    2D8WX-ray2.00A24-246[»]
    2F3CX-ray2.50E24-246[»]
    2FI3X-ray1.58E24-239[»]
    2FI4X-ray1.58E24-246[»]
    2FI5X-ray1.58E24-239[»]
    2FTLX-ray1.62E24-239[»]
    2FTMX-ray1.65A24-239[»]
    2FX4X-ray1.65A24-246[»]
    2FX6X-ray1.57A24-246[»]
    2G55X-ray1.82A24-246[»]
    2G5NX-ray1.51A24-246[»]
    2G5VX-ray1.45A24-246[»]
    2G81X-ray1.55E24-246[»]
    2G8TX-ray1.41A24-246[»]
    2ILNX-ray2.00A/B24-246[»]
    2J9NX-ray1.50A24-246[»]
    2O9QX-ray1.70A24-246[»]
    2OTVX-ray1.56A24-246[»]
    2OXSX-ray1.32A24-246[»]
    2PLXX-ray1.56A24-246[»]
    2PTCX-ray1.90E24-246[»]
    2PTNX-ray1.55A24-246[»]
    2QN5X-ray3.00T24-246[»]
    2QYIX-ray2.60A/C24-246[»]
    2TGAX-ray1.80A18-246[»]
    2TGDX-ray2.10A18-246[»]
    2TGPX-ray1.90Z18-246[»]
    2TGTX-ray1.70A18-246[»]
    2TIOX-ray1.93A24-246[»]
    2TLDX-ray2.60E24-246[»]
    2TPIX-ray2.10Z18-246[»]
    2UUYX-ray1.15A24-246[»]
    2XTTX-ray0.93B24-246[»]
    2ZDKX-ray1.67A24-246[»]
    2ZDLX-ray1.80A24-246[»]
    2ZDMX-ray1.93A24-246[»]
    2ZDNX-ray1.98A24-246[»]
    2ZFSX-ray1.51A24-246[»]
    2ZFTX-ray1.76A24-246[»]
    2ZHDX-ray1.94A24-246[»]
    2ZQ1X-ray1.68A24-246[»]
    2ZQ2X-ray1.40A24-246[»]
    3A7TX-ray1.75A24-246[»]
    3A7VX-ray1.75A24-246[»]
    3A7WX-ray1.75A24-246[»]
    3A7XX-ray1.75A24-246[»]
    3A7YX-ray1.81A24-246[»]
    3A7ZX-ray1.80A24-246[»]
    3A80X-ray1.75A24-246[»]
    3A81X-ray1.78A24-246[»]
    3A82X-ray1.75A24-246[»]
    3A83X-ray1.78A24-246[»]
    3A84X-ray1.75A24-246[»]
    3A85X-ray1.75A24-246[»]
    3A86X-ray1.75A24-246[»]
    3A87X-ray1.75A24-246[»]
    3A88X-ray1.75A24-246[»]
    3A89X-ray1.80A24-246[»]
    3A8AX-ray1.40A24-246[»]
    3A8BX-ray1.75A24-246[»]
    3A8CX-ray1.85A24-246[»]
    3A8DX-ray1.75A24-246[»]
    3AASX-ray1.75A24-246[»]
    3AAUX-ray1.80A24-246[»]
    3AAVX-ray1.70A/B24-246[»]
    3ATIX-ray1.71A24-246[»]
    3ATKX-ray1.74A24-246[»]
    3ATLX-ray1.74A24-246[»]
    3ATMX-ray1.72A24-246[»]
    3BTDX-ray1.90E24-246[»]
    3BTEX-ray1.85E24-246[»]
    3BTFX-ray1.80E24-246[»]
    3BTGX-ray1.90E24-246[»]
    3BTHX-ray1.75E24-246[»]
    3BTKX-ray1.85E24-246[»]
    3BTMX-ray1.80E24-246[»]
    3BTQX-ray1.90E24-246[»]
    3BTTX-ray1.90E24-246[»]
    3BTWX-ray2.05E24-246[»]
    3D65X-ray1.64E24-246[»]
    3E8LX-ray2.48A/B24-246[»]
    3GY2X-ray1.57A24-246[»]
    3GY3X-ray1.70A24-246[»]
    3GY4X-ray1.55A24-246[»]
    3GY5X-ray1.57A24-246[»]
    3GY6X-ray1.70A24-246[»]
    3GY7X-ray1.55A24-246[»]
    3GY8X-ray1.75A24-246[»]
    3I29X-ray2.40A24-246[»]
    3ITIX-ray1.55A24-246[»]
    3LJJX-ray1.55A24-246[»]
    3LJOX-ray1.50A24-246[»]
    3M35X-ray2.20A24-246[»]
    3M7QX-ray1.70A24-246[»]
    3MFJX-ray0.80A24-246[»]
    3MI4X-ray0.80A24-246[»]
    3NK8X-ray1.15A24-246[»]
    3NKKX-ray1.12A24-246[»]
    3OTJOther2.15E24-246[»]
    3PLBX-ray1.18A24-246[»]
    3PLKX-ray1.53A24-246[»]
    3PLPX-ray1.63A24-246[»]
    3PM3X-ray1.53A24-246[»]
    3PMJX-ray1.45A24-246[»]
    3PTBX-ray1.70A24-246[»]
    3PTNX-ray1.70A24-246[»]
    3PWBX-ray1.63A24-246[»]
    3PWCX-ray1.60A24-246[»]
    3PYHX-ray2.00A24-246[»]
    3Q00X-ray1.70A24-246[»]
    3QK1X-ray2.08A24-246[»]
    3RDZX-ray2.26A/B24-246[»]
    3RU4X-ray1.68T24-246[»]
    3RXAX-ray1.70A24-246[»]
    3RXBX-ray1.70A24-246[»]
    3RXCX-ray1.70A24-246[»]
    3RXDX-ray1.70A24-246[»]
    3RXEX-ray1.70A24-246[»]
    3RXFX-ray1.70A24-246[»]
    3RXGX-ray1.70A24-246[»]
    3RXHX-ray1.70A24-246[»]
    3RXIX-ray1.60A24-246[»]
    3RXJX-ray1.70A24-246[»]
    3RXKX-ray1.60A24-246[»]
    3RXLX-ray1.70A24-246[»]
    3RXMX-ray1.70A24-246[»]
    3RXOX-ray1.60A24-246[»]
    3RXPX-ray1.60A24-246[»]
    3RXQX-ray1.68A24-246[»]
    3RXRX-ray1.72A24-246[»]
    3RXSX-ray1.74A24-246[»]
    3RXTX-ray1.70A24-246[»]
    3RXUX-ray1.68A24-246[»]
    3RXVX-ray1.70A24-246[»]
    3T25X-ray1.70A24-246[»]
    3T26X-ray1.70A24-246[»]
    3T27X-ray1.95A24-246[»]
    3T28X-ray2.80A24-246[»]
    3T29X-ray1.75A24-246[»]
    3TPIX-ray1.90Z18-246[»]
    3UNQX-ray1.62A24-246[»]
    3UNRX-ray1.20A24-246[»]
    3UNSX-ray1.80A24-246[»]
    3UOPX-ray1.69A24-246[»]
    3UPEX-ray1.54A24-246[»]
    3UQOX-ray1.80A24-246[»]
    3UQVX-ray2.40A24-246[»]
    3UUZX-ray2.10A/B24-246[»]
    3UWIX-ray1.43A24-246[»]
    3UY9X-ray3.22A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-246[»]
    3V0XX-ray1.90A24-246[»]
    3V12X-ray1.80A24-246[»]
    3V13X-ray1.63A24-246[»]
    3VEQX-ray2.25B24-246[»]
    3VPKX-ray1.94A24-246[»]
    4AB8X-ray1.60A24-246[»]
    4AB9X-ray1.20A24-246[»]
    4ABAX-ray1.25A24-246[»]
    4ABBX-ray1.25A24-246[»]
    4ABDX-ray1.25A24-246[»]
    4ABEX-ray1.30A24-246[»]
    4ABFX-ray1.30A24-246[»]
    4ABGX-ray1.52A24-246[»]
    4ABHX-ray1.25A24-246[»]
    4ABIX-ray1.55A24-246[»]
    4ABJX-ray1.45A24-246[»]
    4AOQX-ray2.00A/B/C24-246[»]
    4AORX-ray1.70A/B/C24-246[»]
    4B1TX-ray1.78A/C24-246[»]
    4B2AX-ray1.89A/C24-246[»]
    4B2BX-ray1.36A/C24-246[»]
    4B2CX-ray1.43A/C24-246[»]
    4GUXX-ray1.80A/B/C1-246[»]
    4HGCX-ray1.29A24-246[»]
    4I8GX-ray0.80A24-239[»]
    4I8HX-ray0.75A24-239[»]
    4I8JX-ray0.87A24-239[»]
    4I8KX-ray0.85A24-239[»]
    4I8LX-ray0.87A24-239[»]
    4J2YX-ray2.00B24-246[»]
    4KTSX-ray1.30A24-246[»]
    4KTUX-ray1.35A24-246[»]
    4NCYX-ray1.42A24-246[»]
    4NIVX-ray1.00A24-246[»]
    4NIWX-ray1.31A24-246[»]
    4NIXX-ray1.30A24-246[»]
    4NIYX-ray2.84A/B/C/D24-246[»]
    4TPIX-ray2.20Z18-246[»]
    5PTPX-ray1.34A24-246[»]
    DisProtiDP00728.
    ProteinModelPortaliP00760.
    SMRiP00760. Positions 22-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00760.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 244221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni194 – 1952Substrate binding
    Regioni197 – 1982Substrate binding

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115192.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP00760.
    KOiK01312.
    OMAiWIRQTIS.
    OrthoDBiEOG75B84T.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00760-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG    50
    SLINSQWVVS AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN 100
    SNTLNNDIML IKLKSAASLN SRVASISLPT SCASAGTQCL ISGWGNTKSS 150
    GTSYPDVLKC LKAPILSDSS CKSAYPGQIT SNMFCAGYLE GGKDSCQGDS 200
    GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK QTIASN 246
    Length:246
    Mass (Da):25,785
    Last modified:September 2, 2008 - v3
    Checksum:i092E3D8ACCCCC4D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134797 mRNA. Translation: AAI34798.1.
    BC146041 mRNA. Translation: AAI46042.1.
    D38507 mRNA. Translation: BAA07516.1.
    PIRiA90164. TRBOTR.
    RefSeqiNP_001107199.1. NM_001113727.1.
    XP_002687054.3. XM_002687008.3.
    XP_871686.4. XM_866593.5.
    UniGeneiBt.91423.

    Genome annotation databases

    EnsembliENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633.
    ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245.
    GeneIDi615026.
    780933.
    KEGGibta:615026.
    bta:780933.

    Cross-referencesi

    Web resourcesi

    Worthington enzyme manual

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC134797 mRNA. Translation: AAI34798.1 .
    BC146041 mRNA. Translation: AAI46042.1 .
    D38507 mRNA. Translation: BAA07516.1 .
    PIRi A90164. TRBOTR.
    RefSeqi NP_001107199.1. NM_001113727.1.
    XP_002687054.3. XM_002687008.3.
    XP_871686.4. XM_866593.5.
    UniGenei Bt.91423.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AQ7 X-ray 2.20 A 24-246 [» ]
    1AUJ X-ray 2.10 A 24-246 [» ]
    1AZ8 X-ray 1.80 A 24-246 [» ]
    1BJU X-ray 1.80 A 24-246 [» ]
    1BJV X-ray 1.80 A 24-246 [» ]
    1BTP X-ray 2.20 A 18-246 [» ]
    1BTW X-ray 1.70 A 18-246 [» ]
    1BTX X-ray 1.70 A 18-246 [» ]
    1BTY X-ray 1.50 A 18-246 [» ]
    1BTZ X-ray 2.00 A 18-246 [» ]
    1C1N X-ray 1.40 A 24-246 [» ]
    1C1O X-ray 1.40 A 24-246 [» ]
    1C1P X-ray 1.37 A 24-246 [» ]
    1C1Q X-ray 1.37 A 24-246 [» ]
    1C1R X-ray 1.37 A 24-246 [» ]
    1C1S X-ray 1.63 A 24-246 [» ]
    1C1T X-ray 1.37 A 24-246 [» ]
    1C2D X-ray 1.65 A 24-246 [» ]
    1C2E X-ray 1.65 A 24-246 [» ]
    1C2F X-ray 1.70 A 24-246 [» ]
    1C2G X-ray 1.65 A 24-246 [» ]
    1C2H X-ray 1.40 A 24-246 [» ]
    1C2I X-ray 1.47 A 24-246 [» ]
    1C2J X-ray 1.40 A 24-246 [» ]
    1C2K X-ray 1.65 A 24-246 [» ]
    1C2L X-ray 1.50 A 24-246 [» ]
    1C2M X-ray 1.40 A 24-246 [» ]
    1C5P X-ray 1.43 A 24-246 [» ]
    1C5Q X-ray 1.43 A 24-246 [» ]
    1C5R X-ray 1.47 A 24-246 [» ]
    1C5S X-ray 1.36 A 24-246 [» ]
    1C5T X-ray 1.37 A 24-246 [» ]
    1C5U X-ray 1.37 A 24-246 [» ]
    1C5V X-ray 1.48 A 24-246 [» ]
    1C9T X-ray 3.30 A/B/C/D/E/F 24-246 [» ]
    1CE5 X-ray 1.90 A 24-246 [» ]
    1CU7 model - A 24-246 [» ]
    1CU8 model - A 24-246 [» ]
    1CU9 model - A 24-246 [» ]
    1D6R X-ray 2.30 A 24-246 [» ]
    1EB2 X-ray 2.00 A 24-246 [» ]
    1EJM X-ray 1.85 A/C/E 24-246 [» ]
    1EZX X-ray 2.60 C 4-246 [» ]
    1F0T X-ray 1.80 A 4-246 [» ]
    1F0U X-ray 1.90 A 4-246 [» ]
    1F2S X-ray 1.79 E 24-246 [» ]
    1G36 X-ray 1.90 A 24-246 [» ]
    1G3B X-ray 1.80 A 19-239 [» ]
    1G3C X-ray 1.80 A 19-239 [» ]
    1G3D X-ray 1.80 A 19-239 [» ]
    1G3E X-ray 1.80 A 19-239 [» ]
    1G9I X-ray 2.20 E 24-246 [» ]
    1GBT X-ray 2.00 A 24-246 [» ]
    1GHZ X-ray 1.39 A 24-246 [» ]
    1GI0 X-ray 1.42 A 24-239 [» ]
    1GI1 X-ray 1.42 A 24-246 [» ]
    1GI2 X-ray 1.38 A 24-246 [» ]
    1GI3 X-ray 1.44 A 24-246 [» ]
    1GI4 X-ray 1.37 A 24-246 [» ]
    1GI5 X-ray 1.60 A 24-246 [» ]
    1GI6 X-ray 1.49 A 24-246 [» ]
    1GJ6 X-ray 1.50 A 24-246 [» ]
    1HJ9 X-ray 0.95 A 24-246 [» ]
    1J8A X-ray 1.21 A 24-246 [» ]
    1JIR X-ray 2.00 A 24-246 [» ]
    1JRS X-ray 1.80 A 24-246 [» ]
    1JRT X-ray 1.70 A 24-246 [» ]
    1K1I X-ray 2.20 A 24-246 [» ]
    1K1J X-ray 2.20 A 24-246 [» ]
    1K1L X-ray 2.50 A 24-246 [» ]
    1K1M X-ray 2.20 A 24-246 [» ]
    1K1N X-ray 2.00 A 24-246 [» ]
    1K1O X-ray 2.00 A 24-246 [» ]
    1K1P X-ray 1.90 A 24-246 [» ]
    1LQE X-ray 2.20 A 4-246 [» ]
    1MAX X-ray 1.80 A 24-246 [» ]
    1MAY X-ray 1.80 A 24-246 [» ]
    1MTS X-ray 1.90 A 24-246 [» ]
    1MTU X-ray 1.90 A 24-246 [» ]
    1MTV X-ray 1.90 A 24-246 [» ]
    1MTW X-ray 1.90 A 24-246 [» ]
    1N6X X-ray 1.40 A 24-246 [» ]
    1N6Y X-ray 1.40 A 24-246 [» ]
    1NC6 X-ray 1.90 A 24-246 [» ]
    1NTP neutron diffraction 1.80 A 24-246 [» ]
    1O2H X-ray 1.77 A 24-246 [» ]
    1O2I X-ray 1.50 A 24-246 [» ]
    1O2J X-ray 1.65 A 24-246 [» ]
    1O2K X-ray 1.63 A 24-246 [» ]
    1O2L X-ray 1.68 A 24-246 [» ]
    1O2M X-ray 1.69 A 24-246 [» ]
    1O2N X-ray 1.50 A 24-246 [» ]
    1O2O X-ray 1.63 A 24-246 [» ]
    1O2P X-ray 1.47 A 24-246 [» ]
    1O2Q X-ray 1.50 A 24-246 [» ]
    1O2R X-ray 1.45 A 24-246 [» ]
    1O2S X-ray 1.65 A 24-246 [» ]
    1O2T X-ray 1.62 A 24-246 [» ]
    1O2U X-ray 1.41 A 24-246 [» ]
    1O2V X-ray 1.50 A 24-246 [» ]
    1O2W X-ray 1.38 A 24-246 [» ]
    1O2X X-ray 1.46 A 24-246 [» ]
    1O2Y X-ray 1.45 A 24-246 [» ]
    1O2Z X-ray 1.65 A 24-246 [» ]
    1O30 X-ray 1.55 A 24-246 [» ]
    1O31 X-ray 1.66 A 24-246 [» ]
    1O32 X-ray 1.78 A 24-246 [» ]
    1O33 X-ray 1.46 A 24-246 [» ]
    1O34 X-ray 1.50 A 24-246 [» ]
    1O35 X-ray 1.41 A 24-246 [» ]
    1O36 X-ray 1.70 A 24-246 [» ]
    1O37 X-ray 1.45 A 24-246 [» ]
    1O38 X-ray 1.38 A 24-246 [» ]
    1O39 X-ray 1.59 A 24-246 [» ]
    1O3A X-ray 2.00 A 24-246 [» ]
    1O3B X-ray 1.75 A 24-246 [» ]
    1O3C X-ray 1.64 A 24-246 [» ]
    1O3D X-ray 1.33 A 24-246 [» ]
    1O3E X-ray 1.64 A 24-246 [» ]
    1O3F X-ray 1.55 A 24-246 [» ]
    1O3G X-ray 1.55 A 24-246 [» ]
    1O3H X-ray 1.53 A 24-246 [» ]
    1O3I X-ray 1.51 A 24-246 [» ]
    1O3J X-ray 1.40 A 24-246 [» ]
    1O3K X-ray 1.43 A 24-246 [» ]
    1O3L X-ray 1.40 A 24-246 [» ]
    1O3M X-ray 1.55 A 24-246 [» ]
    1O3N X-ray 1.55 A 24-246 [» ]
    1O3O X-ray 1.55 A 24-246 [» ]
    1OPH X-ray 2.30 B 4-246 [» ]
    1OX1 X-ray 2.00 A 24-246 [» ]
    1OYQ X-ray 1.90 A 24-239 [» ]
    1P2I X-ray 1.65 A 24-246 [» ]
    1P2J X-ray 1.35 A 24-246 [» ]
    1P2K X-ray 1.60 A 24-246 [» ]
    1PPC X-ray 1.80 E 24-246 [» ]
    1PPE X-ray 2.00 E 24-246 [» ]
    1PPH X-ray 1.90 E 24-246 [» ]
    1QA0 X-ray 1.80 A 24-246 [» ]
    1QB1 X-ray 1.80 A 24-246 [» ]
    1QB6 X-ray 1.80 A 24-246 [» ]
    1QB9 X-ray 1.80 A 24-246 [» ]
    1QBN X-ray 1.80 A 24-246 [» ]
    1QBO X-ray 1.80 A 24-246 [» ]
    1QCP X-ray 1.80 A 24-246 [» ]
    1QL7 X-ray 2.10 A 24-246 [» ]
    1QL8 X-ray 3.00 A 24-246 [» ]
    1RXP X-ray 1.70 A 24-239 [» ]
    1S0Q X-ray 1.02 A 24-246 [» ]
    1S0R X-ray 1.02 A 24-246 [» ]
    1SBW X-ray 1.80 A 24-246 [» ]
    1SFI X-ray 1.65 A 24-246 [» ]
    1SMF X-ray 2.10 E 24-246 [» ]
    1TAB X-ray 2.30 E 24-246 [» ]
    1TAW X-ray 1.80 A 24-246 [» ]
    1TGB X-ray 1.80 A 18-246 [» ]
    1TGC X-ray 1.80 A 18-246 [» ]
    1TGN X-ray 1.65 A 18-246 [» ]
    1TGS X-ray 1.80 Z 18-246 [» ]
    1TGT X-ray 1.70 A 18-246 [» ]
    1TIO X-ray 1.93 A 24-246 [» ]
    1TLD X-ray 1.50 A 24-246 [» ]
    1TNG X-ray 1.80 A 18-246 [» ]
    1TNH X-ray 1.80 A 18-246 [» ]
    1TNI X-ray 1.90 A 18-246 [» ]
    1TNJ X-ray 1.80 A 18-246 [» ]
    1TNK X-ray 1.80 A 18-246 [» ]
    1TNL X-ray 1.90 A 18-246 [» ]
    1TPA X-ray 1.90 E 24-246 [» ]
    1TPO X-ray 1.70 A 24-246 [» ]
    1TPP X-ray 1.40 A 24-246 [» ]
    1TPS X-ray 1.90 A 24-246 [» ]
    1TX7 X-ray 1.75 A 24-239 [» ]
    1TX8 X-ray 1.70 A 24-239 [» ]
    1TYN X-ray 2.00 A 24-246 [» ]
    1UTN X-ray 1.15 A 4-246 [» ]
    1UTO X-ray 1.15 A 4-246 [» ]
    1UTP X-ray 1.30 A 4-246 [» ]
    1UTQ X-ray 1.15 A 4-246 [» ]
    1V2J X-ray 1.90 T 24-246 [» ]
    1V2K X-ray 2.00 T 24-246 [» ]
    1V2L X-ray 1.60 T 24-246 [» ]
    1V2M X-ray 1.65 T 24-246 [» ]
    1V2N X-ray 1.80 T 24-246 [» ]
    1V2O X-ray 1.62 T 24-246 [» ]
    1V2P X-ray 1.92 T 24-246 [» ]
    1V2Q X-ray 2.30 T 24-246 [» ]
    1V2R X-ray 1.70 T 24-246 [» ]
    1V2S X-ray 1.72 T 24-246 [» ]
    1V2T X-ray 1.90 T 24-246 [» ]
    1V2U X-ray 1.80 T 24-246 [» ]
    1V2V X-ray 1.80 T 24-246 [» ]
    1V2W X-ray 1.75 T 24-246 [» ]
    1XUF X-ray 1.90 A 24-246 [» ]
    1XUG X-ray 1.50 A 24-246 [» ]
    1XUH X-ray 2.20 A 24-246 [» ]
    1XUI X-ray 1.50 A 24-246 [» ]
    1XUJ X-ray 1.92 A 24-246 [» ]
    1XUK X-ray 1.80 A 24-246 [» ]
    1Y3U X-ray 1.80 A 24-246 [» ]
    1Y3V X-ray 1.60 A 24-246 [» ]
    1Y3W X-ray 1.80 A 24-246 [» ]
    1Y3X X-ray 1.70 A 24-239 [» ]
    1Y3Y X-ray 1.75 A 24-239 [» ]
    1Y59 X-ray 1.20 T 24-246 [» ]
    1Y5A X-ray 1.40 T 24-246 [» ]
    1Y5B X-ray 1.65 T 24-246 [» ]
    1Y5U X-ray 1.60 T 24-246 [» ]
    1YP9 X-ray 2.10 A 24-246 [» ]
    1YYY X-ray 2.10 1 24-246 [» ]
    1ZR0 X-ray 1.80 A/C 24-246 [» ]
    1ZZZ X-ray 1.90 A 10-246 [» ]
    2A7H X-ray 2.10 A 24-246 [» ]
    2AGE X-ray 1.15 X 24-239 [» ]
    2AGG X-ray 1.28 X 24-239 [» ]
    2AGI X-ray 1.14 X 24-239 [» ]
    2AH4 X-ray 1.13 X 24-239 [» ]
    2AYW X-ray 0.97 A 24-246 [» ]
    2BLV X-ray 1.20 A 24-246 [» ]
    2BLW X-ray 1.20 A 24-246 [» ]
    2BTC X-ray 1.50 E 24-246 [» ]
    2BY5 X-ray 1.30 X 4-246 [» ]
    2BY6 X-ray 1.30 X 4-246 [» ]
    2BY7 X-ray 1.30 X 4-246 [» ]
    2BY8 X-ray 1.30 X 4-246 [» ]
    2BY9 X-ray 1.30 X 4-246 [» ]
    2BYA X-ray 1.30 X 4-246 [» ]
    2BZA X-ray 1.90 A 24-246 [» ]
    2CMY X-ray 2.25 A 24-246 [» ]
    2D8W X-ray 2.00 A 24-246 [» ]
    2F3C X-ray 2.50 E 24-246 [» ]
    2FI3 X-ray 1.58 E 24-239 [» ]
    2FI4 X-ray 1.58 E 24-246 [» ]
    2FI5 X-ray 1.58 E 24-239 [» ]
    2FTL X-ray 1.62 E 24-239 [» ]
    2FTM X-ray 1.65 A 24-239 [» ]
    2FX4 X-ray 1.65 A 24-246 [» ]
    2FX6 X-ray 1.57 A 24-246 [» ]
    2G55 X-ray 1.82 A 24-246 [» ]
    2G5N X-ray 1.51 A 24-246 [» ]
    2G5V X-ray 1.45 A 24-246 [» ]
    2G81 X-ray 1.55 E 24-246 [» ]
    2G8T X-ray 1.41 A 24-246 [» ]
    2ILN X-ray 2.00 A/B 24-246 [» ]
    2J9N X-ray 1.50 A 24-246 [» ]
    2O9Q X-ray 1.70 A 24-246 [» ]
    2OTV X-ray 1.56 A 24-246 [» ]
    2OXS X-ray 1.32 A 24-246 [» ]
    2PLX X-ray 1.56 A 24-246 [» ]
    2PTC X-ray 1.90 E 24-246 [» ]
    2PTN X-ray 1.55 A 24-246 [» ]
    2QN5 X-ray 3.00 T 24-246 [» ]
    2QYI X-ray 2.60 A/C 24-246 [» ]
    2TGA X-ray 1.80 A 18-246 [» ]
    2TGD X-ray 2.10 A 18-246 [» ]
    2TGP X-ray 1.90 Z 18-246 [» ]
    2TGT X-ray 1.70 A 18-246 [» ]
    2TIO X-ray 1.93 A 24-246 [» ]
    2TLD X-ray 2.60 E 24-246 [» ]
    2TPI X-ray 2.10 Z 18-246 [» ]
    2UUY X-ray 1.15 A 24-246 [» ]
    2XTT X-ray 0.93 B 24-246 [» ]
    2ZDK X-ray 1.67 A 24-246 [» ]
    2ZDL X-ray 1.80 A 24-246 [» ]
    2ZDM X-ray 1.93 A 24-246 [» ]
    2ZDN X-ray 1.98 A 24-246 [» ]
    2ZFS X-ray 1.51 A 24-246 [» ]
    2ZFT X-ray 1.76 A 24-246 [» ]
    2ZHD X-ray 1.94 A 24-246 [» ]
    2ZQ1 X-ray 1.68 A 24-246 [» ]
    2ZQ2 X-ray 1.40 A 24-246 [» ]
    3A7T X-ray 1.75 A 24-246 [» ]
    3A7V X-ray 1.75 A 24-246 [» ]
    3A7W X-ray 1.75 A 24-246 [» ]
    3A7X X-ray 1.75 A 24-246 [» ]
    3A7Y X-ray 1.81 A 24-246 [» ]
    3A7Z X-ray 1.80 A 24-246 [» ]
    3A80 X-ray 1.75 A 24-246 [» ]
    3A81 X-ray 1.78 A 24-246 [» ]
    3A82 X-ray 1.75 A 24-246 [» ]
    3A83 X-ray 1.78 A 24-246 [» ]
    3A84 X-ray 1.75 A 24-246 [» ]
    3A85 X-ray 1.75 A 24-246 [» ]
    3A86 X-ray 1.75 A 24-246 [» ]
    3A87 X-ray 1.75 A 24-246 [» ]
    3A88 X-ray 1.75 A 24-246 [» ]
    3A89 X-ray 1.80 A 24-246 [» ]
    3A8A X-ray 1.40 A 24-246 [» ]
    3A8B X-ray 1.75 A 24-246 [» ]
    3A8C X-ray 1.85 A 24-246 [» ]
    3A8D X-ray 1.75 A 24-246 [» ]
    3AAS X-ray 1.75 A 24-246 [» ]
    3AAU X-ray 1.80 A 24-246 [» ]
    3AAV X-ray 1.70 A/B 24-246 [» ]
    3ATI X-ray 1.71 A 24-246 [» ]
    3ATK X-ray 1.74 A 24-246 [» ]
    3ATL X-ray 1.74 A 24-246 [» ]
    3ATM X-ray 1.72 A 24-246 [» ]
    3BTD X-ray 1.90 E 24-246 [» ]
    3BTE X-ray 1.85 E 24-246 [» ]
    3BTF X-ray 1.80 E 24-246 [» ]
    3BTG X-ray 1.90 E 24-246 [» ]
    3BTH X-ray 1.75 E 24-246 [» ]
    3BTK X-ray 1.85 E 24-246 [» ]
    3BTM X-ray 1.80 E 24-246 [» ]
    3BTQ X-ray 1.90 E 24-246 [» ]
    3BTT X-ray 1.90 E 24-246 [» ]
    3BTW X-ray 2.05 E 24-246 [» ]
    3D65 X-ray 1.64 E 24-246 [» ]
    3E8L X-ray 2.48 A/B 24-246 [» ]
    3GY2 X-ray 1.57 A 24-246 [» ]
    3GY3 X-ray 1.70 A 24-246 [» ]
    3GY4 X-ray 1.55 A 24-246 [» ]
    3GY5 X-ray 1.57 A 24-246 [» ]
    3GY6 X-ray 1.70 A 24-246 [» ]
    3GY7 X-ray 1.55 A 24-246 [» ]
    3GY8 X-ray 1.75 A 24-246 [» ]
    3I29 X-ray 2.40 A 24-246 [» ]
    3ITI X-ray 1.55 A 24-246 [» ]
    3LJJ X-ray 1.55 A 24-246 [» ]
    3LJO X-ray 1.50 A 24-246 [» ]
    3M35 X-ray 2.20 A 24-246 [» ]
    3M7Q X-ray 1.70 A 24-246 [» ]
    3MFJ X-ray 0.80 A 24-246 [» ]
    3MI4 X-ray 0.80 A 24-246 [» ]
    3NK8 X-ray 1.15 A 24-246 [» ]
    3NKK X-ray 1.12 A 24-246 [» ]
    3OTJ Other 2.15 E 24-246 [» ]
    3PLB X-ray 1.18 A 24-246 [» ]
    3PLK X-ray 1.53 A 24-246 [» ]
    3PLP X-ray 1.63 A 24-246 [» ]
    3PM3 X-ray 1.53 A 24-246 [» ]
    3PMJ X-ray 1.45 A 24-246 [» ]
    3PTB X-ray 1.70 A 24-246 [» ]
    3PTN X-ray 1.70 A 24-246 [» ]
    3PWB X-ray 1.63 A 24-246 [» ]
    3PWC X-ray 1.60 A 24-246 [» ]
    3PYH X-ray 2.00 A 24-246 [» ]
    3Q00 X-ray 1.70 A 24-246 [» ]
    3QK1 X-ray 2.08 A 24-246 [» ]
    3RDZ X-ray 2.26 A/B 24-246 [» ]
    3RU4 X-ray 1.68 T 24-246 [» ]
    3RXA X-ray 1.70 A 24-246 [» ]
    3RXB X-ray 1.70 A 24-246 [» ]
    3RXC X-ray 1.70 A 24-246 [» ]
    3RXD X-ray 1.70 A 24-246 [» ]
    3RXE X-ray 1.70 A 24-246 [» ]
    3RXF X-ray 1.70 A 24-246 [» ]
    3RXG X-ray 1.70 A 24-246 [» ]
    3RXH X-ray 1.70 A 24-246 [» ]
    3RXI X-ray 1.60 A 24-246 [» ]
    3RXJ X-ray 1.70 A 24-246 [» ]
    3RXK X-ray 1.60 A 24-246 [» ]
    3RXL X-ray 1.70 A 24-246 [» ]
    3RXM X-ray 1.70 A 24-246 [» ]
    3RXO X-ray 1.60 A 24-246 [» ]
    3RXP X-ray 1.60 A 24-246 [» ]
    3RXQ X-ray 1.68 A 24-246 [» ]
    3RXR X-ray 1.72 A 24-246 [» ]
    3RXS X-ray 1.74 A 24-246 [» ]
    3RXT X-ray 1.70 A 24-246 [» ]
    3RXU X-ray 1.68 A 24-246 [» ]
    3RXV X-ray 1.70 A 24-246 [» ]
    3T25 X-ray 1.70 A 24-246 [» ]
    3T26 X-ray 1.70 A 24-246 [» ]
    3T27 X-ray 1.95 A 24-246 [» ]
    3T28 X-ray 2.80 A 24-246 [» ]
    3T29 X-ray 1.75 A 24-246 [» ]
    3TPI X-ray 1.90 Z 18-246 [» ]
    3UNQ X-ray 1.62 A 24-246 [» ]
    3UNR X-ray 1.20 A 24-246 [» ]
    3UNS X-ray 1.80 A 24-246 [» ]
    3UOP X-ray 1.69 A 24-246 [» ]
    3UPE X-ray 1.54 A 24-246 [» ]
    3UQO X-ray 1.80 A 24-246 [» ]
    3UQV X-ray 2.40 A 24-246 [» ]
    3UUZ X-ray 2.10 A/B 24-246 [» ]
    3UWI X-ray 1.43 A 24-246 [» ]
    3UY9 X-ray 3.22 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 24-246 [» ]
    3V0X X-ray 1.90 A 24-246 [» ]
    3V12 X-ray 1.80 A 24-246 [» ]
    3V13 X-ray 1.63 A 24-246 [» ]
    3VEQ X-ray 2.25 B 24-246 [» ]
    3VPK X-ray 1.94 A 24-246 [» ]
    4AB8 X-ray 1.60 A 24-246 [» ]
    4AB9 X-ray 1.20 A 24-246 [» ]
    4ABA X-ray 1.25 A 24-246 [» ]
    4ABB X-ray 1.25 A 24-246 [» ]
    4ABD X-ray 1.25 A 24-246 [» ]
    4ABE X-ray 1.30 A 24-246 [» ]
    4ABF X-ray 1.30 A 24-246 [» ]
    4ABG X-ray 1.52 A 24-246 [» ]
    4ABH X-ray 1.25 A 24-246 [» ]
    4ABI X-ray 1.55 A 24-246 [» ]
    4ABJ X-ray 1.45 A 24-246 [» ]
    4AOQ X-ray 2.00 A/B/C 24-246 [» ]
    4AOR X-ray 1.70 A/B/C 24-246 [» ]
    4B1T X-ray 1.78 A/C 24-246 [» ]
    4B2A X-ray 1.89 A/C 24-246 [» ]
    4B2B X-ray 1.36 A/C 24-246 [» ]
    4B2C X-ray 1.43 A/C 24-246 [» ]
    4GUX X-ray 1.80 A/B/C 1-246 [» ]
    4HGC X-ray 1.29 A 24-246 [» ]
    4I8G X-ray 0.80 A 24-239 [» ]
    4I8H X-ray 0.75 A 24-239 [» ]
    4I8J X-ray 0.87 A 24-239 [» ]
    4I8K X-ray 0.85 A 24-239 [» ]
    4I8L X-ray 0.87 A 24-239 [» ]
    4J2Y X-ray 2.00 B 24-246 [» ]
    4KTS X-ray 1.30 A 24-246 [» ]
    4KTU X-ray 1.35 A 24-246 [» ]
    4NCY X-ray 1.42 A 24-246 [» ]
    4NIV X-ray 1.00 A 24-246 [» ]
    4NIW X-ray 1.31 A 24-246 [» ]
    4NIX X-ray 1.30 A 24-246 [» ]
    4NIY X-ray 2.84 A/B/C/D 24-246 [» ]
    4TPI X-ray 2.20 Z 18-246 [» ]
    5PTP X-ray 1.34 A 24-246 [» ]
    DisProti DP00728.
    ProteinModelPortali P00760.
    SMRi P00760. Positions 22-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00760. 5 interactions.
    MINTi MINT-87966.

    Chemistry

    BindingDBi P00760.
    ChEMBLi CHEMBL3769.
    DrugBanki DB01093. Dimethyl sulfoxide.

    Protein family/group databases

    MEROPSi S01.151.

    Proteomic databases

    PaxDbi P00760.
    PRIDEi P00760.
    ProMEXi P00760.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000004737 ; ENSBTAP00000004737 ; ENSBTAG00000003633 .
    ENSBTAT00000033479 ; ENSBTAP00000033392 ; ENSBTAG00000024245 .
    GeneIDi 615026.
    780933.
    KEGGi bta:615026.
    bta:780933.

    Organism-specific databases

    CTDi 5644.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115192.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P00760.
    KOi K01312.
    OMAi WIRQTIS.
    OrthoDBi EOG75B84T.
    TreeFami TF331065.

    Miscellaneous databases

    EvolutionaryTracei P00760.
    NextBioi 20899409.
    PMAP-CutDB P00760.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pancreas.
    2. Okajima T., Maniwa M., Nagao S., Fujikawa H., Goto S.
      Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-246.
      Tissue: Pancreas.
    3. "Covalent structure of bovine trypsinogen. The position of the remaining amides."
      Mikes O., Holeysovsky V., Tomasek V., Sorm F.
      Biochem. Biophys. Res. Commun. 24:346-352(1966) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-246, DISULFIDE BONDS.
    4. Cited for: SEQUENCE REVISION.
    5. Cited for: SEQUENCE REVISION.
    6. "Human cationic trypsinogen is sulfated on Tyr154."
      Sahin-Toth M., Kukor Z., Nemoda Z.
      FEBS J. 273:5044-5050(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF SULFATED TYROSINE.
    7. "The disulphide bridges of trypsin."
      Kauffman D.L.
      J. Mol. Biol. 12:929-932(1965) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    8. "The refined crystal structure of bovine beta-trypsin at 1.8-A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0."
      Bode W., Schwager P.
      J. Mol. Biol. 98:693-717(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF CALCIUM-BINDING SITE.
    9. "Structure of bovine trypsinogen at 1.9-A resolution."
      Kossiakoff A.A., Chambers J.L., Kay L.M., Stroud R.M.
      Biochemistry 16:654-664(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
    10. "An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.)."
      Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J., Joseph-Horne T., Shewry P., Brady R.L.
      J. Biol. Chem. 282:27760-27768(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 24-246 IN COMPLEX WITH V.HEDERIFOLIA TRYPSIN INHIBITOR, DISULFIDE BONDS.
    11. "The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake."
      Millers E.K., Johnson L.A., Birrell G.W., Masci P.P., Lavin M.F., de Jersey J., Guddat L.W.
      PLoS ONE 8:E54104-E54104(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 24-246 IN COMPLEX WITH THE SNAKE VENOM PROTEASE INHIBITOR TEXTILININ-1, DISULFIDE BONDS, METAL-BINDING SITES GLU-75; ASN-77; VAL-80 AND GLU-85.

    Entry informationi

    Entry nameiTRY1_BOVIN
    AccessioniPrimary (citable) accession number: P00760
    Secondary accession number(s): A6H6Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 159 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3