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P00760

- TRY1_BOVIN

UniProt

P00760 - TRY1_BOVIN

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Protein

Cationic trypsin

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Ca2+Note: Binds 1 Ca(2+) ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Charge relay system
Metal bindingi75 – 751Calcium
Metal bindingi77 – 771Calcium; via carbonyl oxygen
Metal bindingi80 – 801Calcium; via carbonyl oxygen
Metal bindingi85 – 851Calcium
Active sitei107 – 1071Charge relay system
Active sitei200 – 2001Charge relay system
Binding sitei200 – 2001Substrate

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.151.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic trypsin (EC:3.4.21.4)
Alternative name(s):
Beta-trypsin
Cleaved into the following 2 chains:
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Propeptidei18 – 236Activation peptidePRO_0000028185
Chaini24 – 246223Cationic trypsinPRO_0000028186Add
BLAST
Chaini24 – 148125Alpha-trypsin chain 1PRO_0000028187Add
BLAST
Chaini149 – 24698Alpha-trypsin chain 2PRO_0000028188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 160
Disulfide bondi48 ↔ 64
Disulfide bondi132 ↔ 233
Disulfide bondi139 ↔ 206
Disulfide bondi171 ↔ 185
Disulfide bondi196 ↔ 220

Post-translational modificationi

Autocatalytic cleavage after Lys-23 leads to beta-trypsin by releasing a terminal hexapeptide. Subsequent cleavage after Lys-148 leads to alpha-trypsin. Further cleavage after Lys-193 yields pseudotrypsin. A cleavage may also occur after Arg-122.
Not sulfated on tyrosine residue(s).

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP00760.
PRIDEiP00760.

Miscellaneous databases

PMAP-CutDBP00760.

Expressioni

Tissue specificityi

Synthesized in the acinar cells of the pancreas.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P009744EBI-986385,EBI-1032263
SERPINA1P010095EBI-986385,EBI-986224From a different organism.

Protein-protein interaction databases

IntActiP00760. 5 interactions.
MINTiMINT-87966.

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni23 – 264Combined sources
Turni32 – 343Combined sources
Beta strandi38 – 5215Combined sources
Beta strandi54 – 607Combined sources
Helixi62 – 643Combined sources
Beta strandi70 – 745Combined sources
Beta strandi76 – 805Combined sources
Beta strandi81 – 844Combined sources
Beta strandi86 – 9510Combined sources
Turni101 – 1033Combined sources
Beta strandi109 – 1157Combined sources
Beta strandi121 – 1233Combined sources
Beta strandi138 – 1458Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi159 – 1657Combined sources
Helixi168 – 1747Combined sources
Turni176 – 1783Combined sources
Turni180 – 1823Combined sources
Beta strandi183 – 1875Combined sources
Turni189 – 1913Combined sources
Beta strandi192 – 1943Combined sources
Turni197 – 2015Combined sources
Beta strandi203 – 2064Combined sources
Beta strandi209 – 2168Combined sources
Beta strandi218 – 2214Combined sources
Beta strandi227 – 2315Combined sources
Helixi232 – 2354Combined sources
Helixi236 – 2394Combined sources
Turni243 – 2453Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AQ7X-ray2.20A24-246[»]
1AUJX-ray2.10A24-246[»]
1AZ8X-ray1.80A24-246[»]
1BJUX-ray1.80A24-246[»]
1BJVX-ray1.80A24-246[»]
1BTPX-ray2.20A18-246[»]
1BTWX-ray1.70A18-246[»]
1BTXX-ray1.70A18-246[»]
1BTYX-ray1.50A18-246[»]
1BTZX-ray2.00A18-246[»]
1C1NX-ray1.40A24-246[»]
1C1OX-ray1.40A24-246[»]
1C1PX-ray1.37A24-246[»]
1C1QX-ray1.37A24-246[»]
1C1RX-ray1.37A24-246[»]
1C1SX-ray1.63A24-246[»]
1C1TX-ray1.37A24-246[»]
1C2DX-ray1.65A24-246[»]
1C2EX-ray1.65A24-246[»]
1C2FX-ray1.70A24-246[»]
1C2GX-ray1.65A24-246[»]
1C2HX-ray1.40A24-246[»]
1C2IX-ray1.47A24-246[»]
1C2JX-ray1.40A24-246[»]
1C2KX-ray1.65A24-246[»]
1C2LX-ray1.50A24-246[»]
1C2MX-ray1.40A24-246[»]
1C5PX-ray1.43A24-246[»]
1C5QX-ray1.43A24-246[»]
1C5RX-ray1.47A24-246[»]
1C5SX-ray1.36A24-246[»]
1C5TX-ray1.37A24-246[»]
1C5UX-ray1.37A24-246[»]
1C5VX-ray1.48A24-246[»]
1C9TX-ray3.30A/B/C/D/E/F24-246[»]
1CE5X-ray1.90A24-246[»]
1CU7model-A24-246[»]
1CU8model-A24-246[»]
1CU9model-A24-246[»]
1D6RX-ray2.30A24-246[»]
1EB2X-ray2.00A24-246[»]
1EJMX-ray1.85A/C/E24-246[»]
1EZXX-ray2.60C4-246[»]
1F0TX-ray1.80A4-246[»]
1F0UX-ray1.90A4-246[»]
1F2SX-ray1.79E24-246[»]
1G36X-ray1.90A24-246[»]
1G3BX-ray1.80A19-239[»]
1G3CX-ray1.80A19-239[»]
1G3DX-ray1.80A19-239[»]
1G3EX-ray1.80A19-239[»]
1G9IX-ray2.20E24-246[»]
1GBTX-ray2.00A24-246[»]
1GHZX-ray1.39A24-246[»]
1GI0X-ray1.42A24-239[»]
1GI1X-ray1.42A24-246[»]
1GI2X-ray1.38A24-246[»]
1GI3X-ray1.44A24-246[»]
1GI4X-ray1.37A24-246[»]
1GI5X-ray1.60A24-246[»]
1GI6X-ray1.49A24-246[»]
1GJ6X-ray1.50A24-246[»]
1HJ9X-ray0.95A24-246[»]
1J8AX-ray1.21A24-246[»]
1JIRX-ray2.00A24-246[»]
1JRSX-ray1.80A24-246[»]
1JRTX-ray1.70A24-246[»]
1K1IX-ray2.20A24-246[»]
1K1JX-ray2.20A24-246[»]
1K1LX-ray2.50A24-246[»]
1K1MX-ray2.20A24-246[»]
1K1NX-ray2.00A24-246[»]
1K1OX-ray2.00A24-246[»]
1K1PX-ray1.90A24-246[»]
1LQEX-ray2.20A4-246[»]
1MAXX-ray1.80A24-246[»]
1MAYX-ray1.80A24-246[»]
1MTSX-ray1.90A24-246[»]
1MTUX-ray1.90A24-246[»]
1MTVX-ray1.90A24-246[»]
1MTWX-ray1.90A24-246[»]
1N6XX-ray1.40A24-246[»]
1N6YX-ray1.40A24-246[»]
1NC6X-ray1.90A24-246[»]
1NTPneutron diffraction1.80A24-246[»]
1O2HX-ray1.77A24-246[»]
1O2IX-ray1.50A24-246[»]
1O2JX-ray1.65A24-246[»]
1O2KX-ray1.63A24-246[»]
1O2LX-ray1.68A24-246[»]
1O2MX-ray1.69A24-246[»]
1O2NX-ray1.50A24-246[»]
1O2OX-ray1.63A24-246[»]
1O2PX-ray1.47A24-246[»]
1O2QX-ray1.50A24-246[»]
1O2RX-ray1.45A24-246[»]
1O2SX-ray1.65A24-246[»]
1O2TX-ray1.62A24-246[»]
1O2UX-ray1.41A24-246[»]
1O2VX-ray1.50A24-246[»]
1O2WX-ray1.38A24-246[»]
1O2XX-ray1.46A24-246[»]
1O2YX-ray1.45A24-246[»]
1O2ZX-ray1.65A24-246[»]
1O30X-ray1.55A24-246[»]
1O31X-ray1.66A24-246[»]
1O32X-ray1.78A24-246[»]
1O33X-ray1.46A24-246[»]
1O34X-ray1.50A24-246[»]
1O35X-ray1.41A24-246[»]
1O36X-ray1.70A24-246[»]
1O37X-ray1.45A24-246[»]
1O38X-ray1.38A24-246[»]
1O39X-ray1.59A24-246[»]
1O3AX-ray2.00A24-246[»]
1O3BX-ray1.75A24-246[»]
1O3CX-ray1.64A24-246[»]
1O3DX-ray1.33A24-246[»]
1O3EX-ray1.64A24-246[»]
1O3FX-ray1.55A24-246[»]
1O3GX-ray1.55A24-246[»]
1O3HX-ray1.53A24-246[»]
1O3IX-ray1.51A24-246[»]
1O3JX-ray1.40A24-246[»]
1O3KX-ray1.43A24-246[»]
1O3LX-ray1.40A24-246[»]
1O3MX-ray1.55A24-246[»]
1O3NX-ray1.55A24-246[»]
1O3OX-ray1.55A24-246[»]
1OPHX-ray2.30B4-246[»]
1OX1X-ray2.00A24-246[»]
1OYQX-ray1.90A24-239[»]
1P2IX-ray1.65A24-246[»]
1P2JX-ray1.35A24-246[»]
1P2KX-ray1.60A24-246[»]
1PPCX-ray1.80E24-246[»]
1PPEX-ray2.00E24-246[»]
1PPHX-ray1.90E24-246[»]
1QA0X-ray1.80A24-246[»]
1QB1X-ray1.80A24-246[»]
1QB6X-ray1.80A24-246[»]
1QB9X-ray1.80A24-246[»]
1QBNX-ray1.80A24-246[»]
1QBOX-ray1.80A24-246[»]
1QCPX-ray1.80A24-246[»]
1QL7X-ray2.10A24-246[»]
1QL8X-ray3.00A24-246[»]
1RXPX-ray1.70A24-239[»]
1S0QX-ray1.02A24-246[»]
1S0RX-ray1.02A24-246[»]
1SBWX-ray1.80A24-246[»]
1SFIX-ray1.65A24-246[»]
1SMFX-ray2.10E24-246[»]
1TABX-ray2.30E24-246[»]
1TAWX-ray1.80A24-246[»]
1TGBX-ray1.80A18-246[»]
1TGCX-ray1.80A18-246[»]
1TGNX-ray1.65A18-246[»]
1TGSX-ray1.80Z18-246[»]
1TGTX-ray1.70A18-246[»]
1TIOX-ray1.93A24-246[»]
1TLDX-ray1.50A24-246[»]
1TNGX-ray1.80A18-246[»]
1TNHX-ray1.80A18-246[»]
1TNIX-ray1.90A18-246[»]
1TNJX-ray1.80A18-246[»]
1TNKX-ray1.80A18-246[»]
1TNLX-ray1.90A18-246[»]
1TPAX-ray1.90E24-246[»]
1TPOX-ray1.70A24-246[»]
1TPPX-ray1.40A24-246[»]
1TPSX-ray1.90A24-246[»]
1TX7X-ray1.75A24-239[»]
1TX8X-ray1.70A24-239[»]
1TYNX-ray2.00A24-246[»]
1UTNX-ray1.15A4-246[»]
1UTOX-ray1.15A4-246[»]
1UTPX-ray1.30A4-246[»]
1UTQX-ray1.15A4-246[»]
1V2JX-ray1.90T24-246[»]
1V2KX-ray2.00T24-246[»]
1V2LX-ray1.60T24-246[»]
1V2MX-ray1.65T24-246[»]
1V2NX-ray1.80T24-246[»]
1V2OX-ray1.62T24-246[»]
1V2PX-ray1.92T24-246[»]
1V2QX-ray2.30T24-246[»]
1V2RX-ray1.70T24-246[»]
1V2SX-ray1.72T24-246[»]
1V2TX-ray1.90T24-246[»]
1V2UX-ray1.80T24-246[»]
1V2VX-ray1.80T24-246[»]
1V2WX-ray1.75T24-246[»]
1XUFX-ray1.90A24-246[»]
1XUGX-ray1.50A24-246[»]
1XUHX-ray2.20A24-246[»]
1XUIX-ray1.50A24-246[»]
1XUJX-ray1.92A24-246[»]
1XUKX-ray1.80A24-246[»]
1Y3UX-ray1.80A24-246[»]
1Y3VX-ray1.60A24-246[»]
1Y3WX-ray1.80A24-246[»]
1Y3XX-ray1.70A24-239[»]
1Y3YX-ray1.75A24-239[»]
1Y59X-ray1.20T24-246[»]
1Y5AX-ray1.40T24-246[»]
1Y5BX-ray1.65T24-246[»]
1Y5UX-ray1.60T24-246[»]
1YP9X-ray2.10A24-246[»]
1YYYX-ray2.10124-246[»]
1ZR0X-ray1.80A/C24-246[»]
1ZZZX-ray1.90A10-246[»]
2A7HX-ray2.10A24-246[»]
2AGEX-ray1.15X24-239[»]
2AGGX-ray1.28X24-239[»]
2AGIX-ray1.14X24-239[»]
2AH4X-ray1.13X24-239[»]
2AYWX-ray0.97A24-246[»]
2BLVX-ray1.20A24-246[»]
2BLWX-ray1.20A24-246[»]
2BTCX-ray1.50E24-246[»]
2BY5X-ray1.30X4-246[»]
2BY6X-ray1.30X4-246[»]
2BY7X-ray1.30X4-246[»]
2BY8X-ray1.30X4-246[»]
2BY9X-ray1.30X4-246[»]
2BYAX-ray1.30X4-246[»]
2BZAX-ray1.90A24-246[»]
2CMYX-ray2.25A24-246[»]
2D8WX-ray2.00A24-246[»]
2F3CX-ray2.50E24-246[»]
2FI3X-ray1.58E24-239[»]
2FI4X-ray1.58E24-246[»]
2FI5X-ray1.58E24-239[»]
2FTLX-ray1.62E24-239[»]
2FTMX-ray1.65A24-239[»]
2FX4X-ray1.65A24-246[»]
2FX6X-ray1.57A24-246[»]
2G55X-ray1.82A24-246[»]
2G5NX-ray1.51A24-246[»]
2G5VX-ray1.45A24-246[»]
2G81X-ray1.55E24-246[»]
2G8TX-ray1.41A24-246[»]
2ILNX-ray2.00A/B24-246[»]
2J9NX-ray1.50A24-246[»]
2O9QX-ray1.70A24-246[»]
2OTVX-ray1.56A24-246[»]
2OXSX-ray1.32A24-246[»]
2PLXX-ray1.56A24-246[»]
2PTCX-ray1.90E24-246[»]
2PTNX-ray1.55A24-246[»]
2QN5X-ray3.00T24-246[»]
2QYIX-ray2.60A/C24-246[»]
2TGAX-ray1.80A18-246[»]
2TGDX-ray2.10A18-246[»]
2TGPX-ray1.90Z18-246[»]
2TGTX-ray1.70A18-246[»]
2TIOX-ray1.93A24-246[»]
2TLDX-ray2.60E24-246[»]
2TPIX-ray2.10Z18-246[»]
2UUYX-ray1.15A24-246[»]
2XTTX-ray0.93B24-246[»]
2ZDKX-ray1.67A24-246[»]
2ZDLX-ray1.80A24-246[»]
2ZDMX-ray1.93A24-246[»]
2ZDNX-ray1.98A24-246[»]
2ZFSX-ray1.51A24-246[»]
2ZFTX-ray1.76A24-246[»]
2ZHDX-ray1.94A24-246[»]
2ZQ1X-ray1.68A24-246[»]
2ZQ2X-ray1.40A24-246[»]
3A7TX-ray1.75A24-246[»]
3A7VX-ray1.75A24-246[»]
3A7WX-ray1.75A24-246[»]
3A7XX-ray1.75A24-246[»]
3A7YX-ray1.81A24-246[»]
3A7ZX-ray1.80A24-246[»]
3A80X-ray1.75A24-246[»]
3A81X-ray1.78A24-246[»]
3A82X-ray1.75A24-246[»]
3A83X-ray1.78A24-246[»]
3A84X-ray1.75A24-246[»]
3A85X-ray1.75A24-246[»]
3A86X-ray1.75A24-246[»]
3A87X-ray1.75A24-246[»]
3A88X-ray1.75A24-246[»]
3A89X-ray1.80A24-246[»]
3A8AX-ray1.40A24-246[»]
3A8BX-ray1.75A24-246[»]
3A8CX-ray1.85A24-246[»]
3A8DX-ray1.75A24-246[»]
3AASX-ray1.75A24-246[»]
3AAUX-ray1.80A24-246[»]
3AAVX-ray1.70A/B24-246[»]
3ATIX-ray1.71A24-246[»]
3ATKX-ray1.74A24-246[»]
3ATLX-ray1.74A24-246[»]
3ATMX-ray1.72A24-246[»]
3BTDX-ray1.90E24-246[»]
3BTEX-ray1.85E24-246[»]
3BTFX-ray1.80E24-246[»]
3BTGX-ray1.90E24-246[»]
3BTHX-ray1.75E24-246[»]
3BTKX-ray1.85E24-246[»]
3BTMX-ray1.80E24-246[»]
3BTQX-ray1.90E24-246[»]
3BTTX-ray1.90E24-246[»]
3BTWX-ray2.05E24-246[»]
3D65X-ray1.64E24-246[»]
3E8LX-ray2.48A/B24-246[»]
3GY2X-ray1.57A24-246[»]
3GY3X-ray1.70A24-246[»]
3GY4X-ray1.55A24-246[»]
3GY5X-ray1.57A24-246[»]
3GY6X-ray1.70A24-246[»]
3GY7X-ray1.55A24-246[»]
3GY8X-ray1.75A24-246[»]
3I29X-ray2.40A24-246[»]
3ITIX-ray1.55A24-246[»]
3LJJX-ray1.55A24-246[»]
3LJOX-ray1.50A24-246[»]
3M35X-ray2.20A24-246[»]
3M7QX-ray1.70A24-246[»]
3MFJX-ray0.80A24-246[»]
3MI4X-ray0.80A24-246[»]
3NK8X-ray1.15A24-246[»]
3NKKX-ray1.12A24-246[»]
3OTJOther2.15E24-246[»]
3PLBX-ray1.18A24-246[»]
3PLKX-ray1.53A24-246[»]
3PLPX-ray1.63A24-246[»]
3PM3X-ray1.53A24-246[»]
3PMJX-ray1.45A24-246[»]
3PTBX-ray1.70A24-246[»]
3PTNX-ray1.70A24-246[»]
3PWBX-ray1.63A24-246[»]
3PWCX-ray1.60A24-246[»]
3PYHX-ray2.00A24-246[»]
3Q00X-ray1.70A24-246[»]
3QK1X-ray2.08A24-246[»]
3RDZX-ray2.26A/B24-246[»]
3RU4X-ray1.68T24-246[»]
3RXAX-ray1.70A24-246[»]
3RXBX-ray1.70A24-246[»]
3RXCX-ray1.70A24-246[»]
3RXDX-ray1.70A24-246[»]
3RXEX-ray1.70A24-246[»]
3RXFX-ray1.70A24-246[»]
3RXGX-ray1.70A24-246[»]
3RXHX-ray1.70A24-246[»]
3RXIX-ray1.60A24-246[»]
3RXJX-ray1.70A24-246[»]
3RXKX-ray1.60A24-246[»]
3RXLX-ray1.70A24-246[»]
3RXMX-ray1.70A24-246[»]
3RXOX-ray1.60A24-246[»]
3RXPX-ray1.60A24-246[»]
3RXQX-ray1.68A24-246[»]
3RXRX-ray1.72A24-246[»]
3RXSX-ray1.74A24-246[»]
3RXTX-ray1.70A24-246[»]
3RXUX-ray1.68A24-246[»]
3RXVX-ray1.70A24-246[»]
3T25X-ray1.70A24-246[»]
3T26X-ray1.70A24-246[»]
3T27X-ray1.95A24-246[»]
3T28X-ray2.80A24-246[»]
3T29X-ray1.75A24-246[»]
3TPIX-ray1.90Z18-246[»]
3UNQX-ray1.62A24-246[»]
3UNRX-ray1.20A24-246[»]
3UNSX-ray1.80A24-246[»]
3UOPX-ray1.69A24-246[»]
3UPEX-ray1.54A24-246[»]
3UQOX-ray1.80A24-246[»]
3UQVX-ray2.40A24-246[»]
3UUZX-ray2.10A/B24-246[»]
3UWIX-ray1.43A24-246[»]
3UY9X-ray3.22A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-246[»]
3V0XX-ray1.90A24-246[»]
3V12X-ray1.80A24-246[»]
3V13X-ray1.63A24-246[»]
3VEQX-ray2.25B24-246[»]
3VPKX-ray1.94A24-246[»]
4AB8X-ray1.60A24-246[»]
4AB9X-ray1.20A24-246[»]
4ABAX-ray1.25A24-246[»]
4ABBX-ray1.25A24-246[»]
4ABDX-ray1.25A24-246[»]
4ABEX-ray1.30A24-246[»]
4ABFX-ray1.30A24-246[»]
4ABGX-ray1.52A24-246[»]
4ABHX-ray1.25A24-246[»]
4ABIX-ray1.55A24-246[»]
4ABJX-ray1.45A24-246[»]
4AOQX-ray2.00A/B/C24-246[»]
4AORX-ray1.70A/B/C24-246[»]
4B1TX-ray1.78A/C24-246[»]
4B2AX-ray1.89A/C24-246[»]
4B2BX-ray1.36A/C24-246[»]
4B2CX-ray1.43A/C24-246[»]
4GUXX-ray1.80A/B/C1-246[»]
4HGCX-ray1.29A24-246[»]
4I8GX-ray0.80A24-239[»]
4I8HX-ray0.75A24-239[»]
4I8JX-ray0.87A24-239[»]
4I8KX-ray0.85A24-239[»]
4I8LX-ray0.87A24-239[»]
4J2YX-ray2.00B24-246[»]
4KTSX-ray1.30A24-246[»]
4KTUX-ray1.35A24-246[»]
4NCYX-ray1.42A24-246[»]
4NIVX-ray1.00A24-246[»]
4NIWX-ray1.31A24-246[»]
4NIXX-ray1.30A24-246[»]
4NIYX-ray2.84A/B/C/D24-246[»]
4TPIX-ray2.20Z18-246[»]
5PTPX-ray1.34A24-246[»]
DisProtiDP00728.
ProteinModelPortaliP00760.
SMRiP00760. Positions 22-246.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00760.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 244221Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni194 – 1952Substrate binding
Regioni197 – 1982Substrate binding

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP00760.
KOiK01312.
OMAiWIRQTIS.
OrthoDBiEOG75B84T.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00760-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG
60 70 80 90 100
SLINSQWVVS AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN
110 120 130 140 150
SNTLNNDIML IKLKSAASLN SRVASISLPT SCASAGTQCL ISGWGNTKSS
160 170 180 190 200
GTSYPDVLKC LKAPILSDSS CKSAYPGQIT SNMFCAGYLE GGKDSCQGDS
210 220 230 240
GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK QTIASN
Length:246
Mass (Da):25,785
Last modified:September 2, 2008 - v3
Checksum:i092E3D8ACCCCC4D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134797 mRNA. Translation: AAI34798.1.
BC146041 mRNA. Translation: AAI46042.1.
D38507 mRNA. Translation: BAA07516.1.
PIRiA90164. TRBOTR.
RefSeqiNP_001107199.1. NM_001113727.1.
XP_002687054.3. XM_002687008.3.
XP_871686.4. XM_866593.5.
UniGeneiBt.91423.

Genome annotation databases

EnsembliENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000003633.
ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000024245.
GeneIDi615026.
780933.
KEGGibta:615026.
bta:780933.

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134797 mRNA. Translation: AAI34798.1 .
BC146041 mRNA. Translation: AAI46042.1 .
D38507 mRNA. Translation: BAA07516.1 .
PIRi A90164. TRBOTR.
RefSeqi NP_001107199.1. NM_001113727.1.
XP_002687054.3. XM_002687008.3.
XP_871686.4. XM_866593.5.
UniGenei Bt.91423.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AQ7 X-ray 2.20 A 24-246 [» ]
1AUJ X-ray 2.10 A 24-246 [» ]
1AZ8 X-ray 1.80 A 24-246 [» ]
1BJU X-ray 1.80 A 24-246 [» ]
1BJV X-ray 1.80 A 24-246 [» ]
1BTP X-ray 2.20 A 18-246 [» ]
1BTW X-ray 1.70 A 18-246 [» ]
1BTX X-ray 1.70 A 18-246 [» ]
1BTY X-ray 1.50 A 18-246 [» ]
1BTZ X-ray 2.00 A 18-246 [» ]
1C1N X-ray 1.40 A 24-246 [» ]
1C1O X-ray 1.40 A 24-246 [» ]
1C1P X-ray 1.37 A 24-246 [» ]
1C1Q X-ray 1.37 A 24-246 [» ]
1C1R X-ray 1.37 A 24-246 [» ]
1C1S X-ray 1.63 A 24-246 [» ]
1C1T X-ray 1.37 A 24-246 [» ]
1C2D X-ray 1.65 A 24-246 [» ]
1C2E X-ray 1.65 A 24-246 [» ]
1C2F X-ray 1.70 A 24-246 [» ]
1C2G X-ray 1.65 A 24-246 [» ]
1C2H X-ray 1.40 A 24-246 [» ]
1C2I X-ray 1.47 A 24-246 [» ]
1C2J X-ray 1.40 A 24-246 [» ]
1C2K X-ray 1.65 A 24-246 [» ]
1C2L X-ray 1.50 A 24-246 [» ]
1C2M X-ray 1.40 A 24-246 [» ]
1C5P X-ray 1.43 A 24-246 [» ]
1C5Q X-ray 1.43 A 24-246 [» ]
1C5R X-ray 1.47 A 24-246 [» ]
1C5S X-ray 1.36 A 24-246 [» ]
1C5T X-ray 1.37 A 24-246 [» ]
1C5U X-ray 1.37 A 24-246 [» ]
1C5V X-ray 1.48 A 24-246 [» ]
1C9T X-ray 3.30 A/B/C/D/E/F 24-246 [» ]
1CE5 X-ray 1.90 A 24-246 [» ]
1CU7 model - A 24-246 [» ]
1CU8 model - A 24-246 [» ]
1CU9 model - A 24-246 [» ]
1D6R X-ray 2.30 A 24-246 [» ]
1EB2 X-ray 2.00 A 24-246 [» ]
1EJM X-ray 1.85 A/C/E 24-246 [» ]
1EZX X-ray 2.60 C 4-246 [» ]
1F0T X-ray 1.80 A 4-246 [» ]
1F0U X-ray 1.90 A 4-246 [» ]
1F2S X-ray 1.79 E 24-246 [» ]
1G36 X-ray 1.90 A 24-246 [» ]
1G3B X-ray 1.80 A 19-239 [» ]
1G3C X-ray 1.80 A 19-239 [» ]
1G3D X-ray 1.80 A 19-239 [» ]
1G3E X-ray 1.80 A 19-239 [» ]
1G9I X-ray 2.20 E 24-246 [» ]
1GBT X-ray 2.00 A 24-246 [» ]
1GHZ X-ray 1.39 A 24-246 [» ]
1GI0 X-ray 1.42 A 24-239 [» ]
1GI1 X-ray 1.42 A 24-246 [» ]
1GI2 X-ray 1.38 A 24-246 [» ]
1GI3 X-ray 1.44 A 24-246 [» ]
1GI4 X-ray 1.37 A 24-246 [» ]
1GI5 X-ray 1.60 A 24-246 [» ]
1GI6 X-ray 1.49 A 24-246 [» ]
1GJ6 X-ray 1.50 A 24-246 [» ]
1HJ9 X-ray 0.95 A 24-246 [» ]
1J8A X-ray 1.21 A 24-246 [» ]
1JIR X-ray 2.00 A 24-246 [» ]
1JRS X-ray 1.80 A 24-246 [» ]
1JRT X-ray 1.70 A 24-246 [» ]
1K1I X-ray 2.20 A 24-246 [» ]
1K1J X-ray 2.20 A 24-246 [» ]
1K1L X-ray 2.50 A 24-246 [» ]
1K1M X-ray 2.20 A 24-246 [» ]
1K1N X-ray 2.00 A 24-246 [» ]
1K1O X-ray 2.00 A 24-246 [» ]
1K1P X-ray 1.90 A 24-246 [» ]
1LQE X-ray 2.20 A 4-246 [» ]
1MAX X-ray 1.80 A 24-246 [» ]
1MAY X-ray 1.80 A 24-246 [» ]
1MTS X-ray 1.90 A 24-246 [» ]
1MTU X-ray 1.90 A 24-246 [» ]
1MTV X-ray 1.90 A 24-246 [» ]
1MTW X-ray 1.90 A 24-246 [» ]
1N6X X-ray 1.40 A 24-246 [» ]
1N6Y X-ray 1.40 A 24-246 [» ]
1NC6 X-ray 1.90 A 24-246 [» ]
1NTP neutron diffraction 1.80 A 24-246 [» ]
1O2H X-ray 1.77 A 24-246 [» ]
1O2I X-ray 1.50 A 24-246 [» ]
1O2J X-ray 1.65 A 24-246 [» ]
1O2K X-ray 1.63 A 24-246 [» ]
1O2L X-ray 1.68 A 24-246 [» ]
1O2M X-ray 1.69 A 24-246 [» ]
1O2N X-ray 1.50 A 24-246 [» ]
1O2O X-ray 1.63 A 24-246 [» ]
1O2P X-ray 1.47 A 24-246 [» ]
1O2Q X-ray 1.50 A 24-246 [» ]
1O2R X-ray 1.45 A 24-246 [» ]
1O2S X-ray 1.65 A 24-246 [» ]
1O2T X-ray 1.62 A 24-246 [» ]
1O2U X-ray 1.41 A 24-246 [» ]
1O2V X-ray 1.50 A 24-246 [» ]
1O2W X-ray 1.38 A 24-246 [» ]
1O2X X-ray 1.46 A 24-246 [» ]
1O2Y X-ray 1.45 A 24-246 [» ]
1O2Z X-ray 1.65 A 24-246 [» ]
1O30 X-ray 1.55 A 24-246 [» ]
1O31 X-ray 1.66 A 24-246 [» ]
1O32 X-ray 1.78 A 24-246 [» ]
1O33 X-ray 1.46 A 24-246 [» ]
1O34 X-ray 1.50 A 24-246 [» ]
1O35 X-ray 1.41 A 24-246 [» ]
1O36 X-ray 1.70 A 24-246 [» ]
1O37 X-ray 1.45 A 24-246 [» ]
1O38 X-ray 1.38 A 24-246 [» ]
1O39 X-ray 1.59 A 24-246 [» ]
1O3A X-ray 2.00 A 24-246 [» ]
1O3B X-ray 1.75 A 24-246 [» ]
1O3C X-ray 1.64 A 24-246 [» ]
1O3D X-ray 1.33 A 24-246 [» ]
1O3E X-ray 1.64 A 24-246 [» ]
1O3F X-ray 1.55 A 24-246 [» ]
1O3G X-ray 1.55 A 24-246 [» ]
1O3H X-ray 1.53 A 24-246 [» ]
1O3I X-ray 1.51 A 24-246 [» ]
1O3J X-ray 1.40 A 24-246 [» ]
1O3K X-ray 1.43 A 24-246 [» ]
1O3L X-ray 1.40 A 24-246 [» ]
1O3M X-ray 1.55 A 24-246 [» ]
1O3N X-ray 1.55 A 24-246 [» ]
1O3O X-ray 1.55 A 24-246 [» ]
1OPH X-ray 2.30 B 4-246 [» ]
1OX1 X-ray 2.00 A 24-246 [» ]
1OYQ X-ray 1.90 A 24-239 [» ]
1P2I X-ray 1.65 A 24-246 [» ]
1P2J X-ray 1.35 A 24-246 [» ]
1P2K X-ray 1.60 A 24-246 [» ]
1PPC X-ray 1.80 E 24-246 [» ]
1PPE X-ray 2.00 E 24-246 [» ]
1PPH X-ray 1.90 E 24-246 [» ]
1QA0 X-ray 1.80 A 24-246 [» ]
1QB1 X-ray 1.80 A 24-246 [» ]
1QB6 X-ray 1.80 A 24-246 [» ]
1QB9 X-ray 1.80 A 24-246 [» ]
1QBN X-ray 1.80 A 24-246 [» ]
1QBO X-ray 1.80 A 24-246 [» ]
1QCP X-ray 1.80 A 24-246 [» ]
1QL7 X-ray 2.10 A 24-246 [» ]
1QL8 X-ray 3.00 A 24-246 [» ]
1RXP X-ray 1.70 A 24-239 [» ]
1S0Q X-ray 1.02 A 24-246 [» ]
1S0R X-ray 1.02 A 24-246 [» ]
1SBW X-ray 1.80 A 24-246 [» ]
1SFI X-ray 1.65 A 24-246 [» ]
1SMF X-ray 2.10 E 24-246 [» ]
1TAB X-ray 2.30 E 24-246 [» ]
1TAW X-ray 1.80 A 24-246 [» ]
1TGB X-ray 1.80 A 18-246 [» ]
1TGC X-ray 1.80 A 18-246 [» ]
1TGN X-ray 1.65 A 18-246 [» ]
1TGS X-ray 1.80 Z 18-246 [» ]
1TGT X-ray 1.70 A 18-246 [» ]
1TIO X-ray 1.93 A 24-246 [» ]
1TLD X-ray 1.50 A 24-246 [» ]
1TNG X-ray 1.80 A 18-246 [» ]
1TNH X-ray 1.80 A 18-246 [» ]
1TNI X-ray 1.90 A 18-246 [» ]
1TNJ X-ray 1.80 A 18-246 [» ]
1TNK X-ray 1.80 A 18-246 [» ]
1TNL X-ray 1.90 A 18-246 [» ]
1TPA X-ray 1.90 E 24-246 [» ]
1TPO X-ray 1.70 A 24-246 [» ]
1TPP X-ray 1.40 A 24-246 [» ]
1TPS X-ray 1.90 A 24-246 [» ]
1TX7 X-ray 1.75 A 24-239 [» ]
1TX8 X-ray 1.70 A 24-239 [» ]
1TYN X-ray 2.00 A 24-246 [» ]
1UTN X-ray 1.15 A 4-246 [» ]
1UTO X-ray 1.15 A 4-246 [» ]
1UTP X-ray 1.30 A 4-246 [» ]
1UTQ X-ray 1.15 A 4-246 [» ]
1V2J X-ray 1.90 T 24-246 [» ]
1V2K X-ray 2.00 T 24-246 [» ]
1V2L X-ray 1.60 T 24-246 [» ]
1V2M X-ray 1.65 T 24-246 [» ]
1V2N X-ray 1.80 T 24-246 [» ]
1V2O X-ray 1.62 T 24-246 [» ]
1V2P X-ray 1.92 T 24-246 [» ]
1V2Q X-ray 2.30 T 24-246 [» ]
1V2R X-ray 1.70 T 24-246 [» ]
1V2S X-ray 1.72 T 24-246 [» ]
1V2T X-ray 1.90 T 24-246 [» ]
1V2U X-ray 1.80 T 24-246 [» ]
1V2V X-ray 1.80 T 24-246 [» ]
1V2W X-ray 1.75 T 24-246 [» ]
1XUF X-ray 1.90 A 24-246 [» ]
1XUG X-ray 1.50 A 24-246 [» ]
1XUH X-ray 2.20 A 24-246 [» ]
1XUI X-ray 1.50 A 24-246 [» ]
1XUJ X-ray 1.92 A 24-246 [» ]
1XUK X-ray 1.80 A 24-246 [» ]
1Y3U X-ray 1.80 A 24-246 [» ]
1Y3V X-ray 1.60 A 24-246 [» ]
1Y3W X-ray 1.80 A 24-246 [» ]
1Y3X X-ray 1.70 A 24-239 [» ]
1Y3Y X-ray 1.75 A 24-239 [» ]
1Y59 X-ray 1.20 T 24-246 [» ]
1Y5A X-ray 1.40 T 24-246 [» ]
1Y5B X-ray 1.65 T 24-246 [» ]
1Y5U X-ray 1.60 T 24-246 [» ]
1YP9 X-ray 2.10 A 24-246 [» ]
1YYY X-ray 2.10 1 24-246 [» ]
1ZR0 X-ray 1.80 A/C 24-246 [» ]
1ZZZ X-ray 1.90 A 10-246 [» ]
2A7H X-ray 2.10 A 24-246 [» ]
2AGE X-ray 1.15 X 24-239 [» ]
2AGG X-ray 1.28 X 24-239 [» ]
2AGI X-ray 1.14 X 24-239 [» ]
2AH4 X-ray 1.13 X 24-239 [» ]
2AYW X-ray 0.97 A 24-246 [» ]
2BLV X-ray 1.20 A 24-246 [» ]
2BLW X-ray 1.20 A 24-246 [» ]
2BTC X-ray 1.50 E 24-246 [» ]
2BY5 X-ray 1.30 X 4-246 [» ]
2BY6 X-ray 1.30 X 4-246 [» ]
2BY7 X-ray 1.30 X 4-246 [» ]
2BY8 X-ray 1.30 X 4-246 [» ]
2BY9 X-ray 1.30 X 4-246 [» ]
2BYA X-ray 1.30 X 4-246 [» ]
2BZA X-ray 1.90 A 24-246 [» ]
2CMY X-ray 2.25 A 24-246 [» ]
2D8W X-ray 2.00 A 24-246 [» ]
2F3C X-ray 2.50 E 24-246 [» ]
2FI3 X-ray 1.58 E 24-239 [» ]
2FI4 X-ray 1.58 E 24-246 [» ]
2FI5 X-ray 1.58 E 24-239 [» ]
2FTL X-ray 1.62 E 24-239 [» ]
2FTM X-ray 1.65 A 24-239 [» ]
2FX4 X-ray 1.65 A 24-246 [» ]
2FX6 X-ray 1.57 A 24-246 [» ]
2G55 X-ray 1.82 A 24-246 [» ]
2G5N X-ray 1.51 A 24-246 [» ]
2G5V X-ray 1.45 A 24-246 [» ]
2G81 X-ray 1.55 E 24-246 [» ]
2G8T X-ray 1.41 A 24-246 [» ]
2ILN X-ray 2.00 A/B 24-246 [» ]
2J9N X-ray 1.50 A 24-246 [» ]
2O9Q X-ray 1.70 A 24-246 [» ]
2OTV X-ray 1.56 A 24-246 [» ]
2OXS X-ray 1.32 A 24-246 [» ]
2PLX X-ray 1.56 A 24-246 [» ]
2PTC X-ray 1.90 E 24-246 [» ]
2PTN X-ray 1.55 A 24-246 [» ]
2QN5 X-ray 3.00 T 24-246 [» ]
2QYI X-ray 2.60 A/C 24-246 [» ]
2TGA X-ray 1.80 A 18-246 [» ]
2TGD X-ray 2.10 A 18-246 [» ]
2TGP X-ray 1.90 Z 18-246 [» ]
2TGT X-ray 1.70 A 18-246 [» ]
2TIO X-ray 1.93 A 24-246 [» ]
2TLD X-ray 2.60 E 24-246 [» ]
2TPI X-ray 2.10 Z 18-246 [» ]
2UUY X-ray 1.15 A 24-246 [» ]
2XTT X-ray 0.93 B 24-246 [» ]
2ZDK X-ray 1.67 A 24-246 [» ]
2ZDL X-ray 1.80 A 24-246 [» ]
2ZDM X-ray 1.93 A 24-246 [» ]
2ZDN X-ray 1.98 A 24-246 [» ]
2ZFS X-ray 1.51 A 24-246 [» ]
2ZFT X-ray 1.76 A 24-246 [» ]
2ZHD X-ray 1.94 A 24-246 [» ]
2ZQ1 X-ray 1.68 A 24-246 [» ]
2ZQ2 X-ray 1.40 A 24-246 [» ]
3A7T X-ray 1.75 A 24-246 [» ]
3A7V X-ray 1.75 A 24-246 [» ]
3A7W X-ray 1.75 A 24-246 [» ]
3A7X X-ray 1.75 A 24-246 [» ]
3A7Y X-ray 1.81 A 24-246 [» ]
3A7Z X-ray 1.80 A 24-246 [» ]
3A80 X-ray 1.75 A 24-246 [» ]
3A81 X-ray 1.78 A 24-246 [» ]
3A82 X-ray 1.75 A 24-246 [» ]
3A83 X-ray 1.78 A 24-246 [» ]
3A84 X-ray 1.75 A 24-246 [» ]
3A85 X-ray 1.75 A 24-246 [» ]
3A86 X-ray 1.75 A 24-246 [» ]
3A87 X-ray 1.75 A 24-246 [» ]
3A88 X-ray 1.75 A 24-246 [» ]
3A89 X-ray 1.80 A 24-246 [» ]
3A8A X-ray 1.40 A 24-246 [» ]
3A8B X-ray 1.75 A 24-246 [» ]
3A8C X-ray 1.85 A 24-246 [» ]
3A8D X-ray 1.75 A 24-246 [» ]
3AAS X-ray 1.75 A 24-246 [» ]
3AAU X-ray 1.80 A 24-246 [» ]
3AAV X-ray 1.70 A/B 24-246 [» ]
3ATI X-ray 1.71 A 24-246 [» ]
3ATK X-ray 1.74 A 24-246 [» ]
3ATL X-ray 1.74 A 24-246 [» ]
3ATM X-ray 1.72 A 24-246 [» ]
3BTD X-ray 1.90 E 24-246 [» ]
3BTE X-ray 1.85 E 24-246 [» ]
3BTF X-ray 1.80 E 24-246 [» ]
3BTG X-ray 1.90 E 24-246 [» ]
3BTH X-ray 1.75 E 24-246 [» ]
3BTK X-ray 1.85 E 24-246 [» ]
3BTM X-ray 1.80 E 24-246 [» ]
3BTQ X-ray 1.90 E 24-246 [» ]
3BTT X-ray 1.90 E 24-246 [» ]
3BTW X-ray 2.05 E 24-246 [» ]
3D65 X-ray 1.64 E 24-246 [» ]
3E8L X-ray 2.48 A/B 24-246 [» ]
3GY2 X-ray 1.57 A 24-246 [» ]
3GY3 X-ray 1.70 A 24-246 [» ]
3GY4 X-ray 1.55 A 24-246 [» ]
3GY5 X-ray 1.57 A 24-246 [» ]
3GY6 X-ray 1.70 A 24-246 [» ]
3GY7 X-ray 1.55 A 24-246 [» ]
3GY8 X-ray 1.75 A 24-246 [» ]
3I29 X-ray 2.40 A 24-246 [» ]
3ITI X-ray 1.55 A 24-246 [» ]
3LJJ X-ray 1.55 A 24-246 [» ]
3LJO X-ray 1.50 A 24-246 [» ]
3M35 X-ray 2.20 A 24-246 [» ]
3M7Q X-ray 1.70 A 24-246 [» ]
3MFJ X-ray 0.80 A 24-246 [» ]
3MI4 X-ray 0.80 A 24-246 [» ]
3NK8 X-ray 1.15 A 24-246 [» ]
3NKK X-ray 1.12 A 24-246 [» ]
3OTJ Other 2.15 E 24-246 [» ]
3PLB X-ray 1.18 A 24-246 [» ]
3PLK X-ray 1.53 A 24-246 [» ]
3PLP X-ray 1.63 A 24-246 [» ]
3PM3 X-ray 1.53 A 24-246 [» ]
3PMJ X-ray 1.45 A 24-246 [» ]
3PTB X-ray 1.70 A 24-246 [» ]
3PTN X-ray 1.70 A 24-246 [» ]
3PWB X-ray 1.63 A 24-246 [» ]
3PWC X-ray 1.60 A 24-246 [» ]
3PYH X-ray 2.00 A 24-246 [» ]
3Q00 X-ray 1.70 A 24-246 [» ]
3QK1 X-ray 2.08 A 24-246 [» ]
3RDZ X-ray 2.26 A/B 24-246 [» ]
3RU4 X-ray 1.68 T 24-246 [» ]
3RXA X-ray 1.70 A 24-246 [» ]
3RXB X-ray 1.70 A 24-246 [» ]
3RXC X-ray 1.70 A 24-246 [» ]
3RXD X-ray 1.70 A 24-246 [» ]
3RXE X-ray 1.70 A 24-246 [» ]
3RXF X-ray 1.70 A 24-246 [» ]
3RXG X-ray 1.70 A 24-246 [» ]
3RXH X-ray 1.70 A 24-246 [» ]
3RXI X-ray 1.60 A 24-246 [» ]
3RXJ X-ray 1.70 A 24-246 [» ]
3RXK X-ray 1.60 A 24-246 [» ]
3RXL X-ray 1.70 A 24-246 [» ]
3RXM X-ray 1.70 A 24-246 [» ]
3RXO X-ray 1.60 A 24-246 [» ]
3RXP X-ray 1.60 A 24-246 [» ]
3RXQ X-ray 1.68 A 24-246 [» ]
3RXR X-ray 1.72 A 24-246 [» ]
3RXS X-ray 1.74 A 24-246 [» ]
3RXT X-ray 1.70 A 24-246 [» ]
3RXU X-ray 1.68 A 24-246 [» ]
3RXV X-ray 1.70 A 24-246 [» ]
3T25 X-ray 1.70 A 24-246 [» ]
3T26 X-ray 1.70 A 24-246 [» ]
3T27 X-ray 1.95 A 24-246 [» ]
3T28 X-ray 2.80 A 24-246 [» ]
3T29 X-ray 1.75 A 24-246 [» ]
3TPI X-ray 1.90 Z 18-246 [» ]
3UNQ X-ray 1.62 A 24-246 [» ]
3UNR X-ray 1.20 A 24-246 [» ]
3UNS X-ray 1.80 A 24-246 [» ]
3UOP X-ray 1.69 A 24-246 [» ]
3UPE X-ray 1.54 A 24-246 [» ]
3UQO X-ray 1.80 A 24-246 [» ]
3UQV X-ray 2.40 A 24-246 [» ]
3UUZ X-ray 2.10 A/B 24-246 [» ]
3UWI X-ray 1.43 A 24-246 [» ]
3UY9 X-ray 3.22 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 24-246 [» ]
3V0X X-ray 1.90 A 24-246 [» ]
3V12 X-ray 1.80 A 24-246 [» ]
3V13 X-ray 1.63 A 24-246 [» ]
3VEQ X-ray 2.25 B 24-246 [» ]
3VPK X-ray 1.94 A 24-246 [» ]
4AB8 X-ray 1.60 A 24-246 [» ]
4AB9 X-ray 1.20 A 24-246 [» ]
4ABA X-ray 1.25 A 24-246 [» ]
4ABB X-ray 1.25 A 24-246 [» ]
4ABD X-ray 1.25 A 24-246 [» ]
4ABE X-ray 1.30 A 24-246 [» ]
4ABF X-ray 1.30 A 24-246 [» ]
4ABG X-ray 1.52 A 24-246 [» ]
4ABH X-ray 1.25 A 24-246 [» ]
4ABI X-ray 1.55 A 24-246 [» ]
4ABJ X-ray 1.45 A 24-246 [» ]
4AOQ X-ray 2.00 A/B/C 24-246 [» ]
4AOR X-ray 1.70 A/B/C 24-246 [» ]
4B1T X-ray 1.78 A/C 24-246 [» ]
4B2A X-ray 1.89 A/C 24-246 [» ]
4B2B X-ray 1.36 A/C 24-246 [» ]
4B2C X-ray 1.43 A/C 24-246 [» ]
4GUX X-ray 1.80 A/B/C 1-246 [» ]
4HGC X-ray 1.29 A 24-246 [» ]
4I8G X-ray 0.80 A 24-239 [» ]
4I8H X-ray 0.75 A 24-239 [» ]
4I8J X-ray 0.87 A 24-239 [» ]
4I8K X-ray 0.85 A 24-239 [» ]
4I8L X-ray 0.87 A 24-239 [» ]
4J2Y X-ray 2.00 B 24-246 [» ]
4KTS X-ray 1.30 A 24-246 [» ]
4KTU X-ray 1.35 A 24-246 [» ]
4NCY X-ray 1.42 A 24-246 [» ]
4NIV X-ray 1.00 A 24-246 [» ]
4NIW X-ray 1.31 A 24-246 [» ]
4NIX X-ray 1.30 A 24-246 [» ]
4NIY X-ray 2.84 A/B/C/D 24-246 [» ]
4TPI X-ray 2.20 Z 18-246 [» ]
5PTP X-ray 1.34 A 24-246 [» ]
DisProti DP00728.
ProteinModelPortali P00760.
SMRi P00760. Positions 22-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00760. 5 interactions.
MINTi MINT-87966.

Chemistry

BindingDBi P00760.
ChEMBLi CHEMBL3769.

Protein family/group databases

MEROPSi S01.151.

Proteomic databases

PaxDbi P00760.
PRIDEi P00760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000004737 ; ENSBTAP00000004737 ; ENSBTAG00000003633 .
ENSBTAT00000033479 ; ENSBTAP00000033392 ; ENSBTAG00000024245 .
GeneIDi 615026.
780933.
KEGGi bta:615026.
bta:780933.

Organism-specific databases

CTDi 5644.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P00760.
KOi K01312.
OMAi WIRQTIS.
OrthoDBi EOG75B84T.
TreeFami TF331065.

Miscellaneous databases

EvolutionaryTracei P00760.
NextBioi 20899409.
PMAP-CutDB P00760.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pancreas.
  2. Okajima T., Maniwa M., Nagao S., Fujikawa H., Goto S.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-246.
    Tissue: Pancreas.
  3. "Covalent structure of bovine trypsinogen. The position of the remaining amides."
    Mikes O., Holeysovsky V., Tomasek V., Sorm F.
    Biochem. Biophys. Res. Commun. 24:346-352(1966) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-246, DISULFIDE BONDS.
  4. Cited for: SEQUENCE REVISION.
  5. Cited for: SEQUENCE REVISION.
  6. "Human cationic trypsinogen is sulfated on Tyr154."
    Sahin-Toth M., Kukor Z., Nemoda Z.
    FEBS J. 273:5044-5050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF SULFATED TYROSINE.
  7. "The disulphide bridges of trypsin."
    Kauffman D.L.
    J. Mol. Biol. 12:929-932(1965) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  8. "The refined crystal structure of bovine beta-trypsin at 1.8-A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0."
    Bode W., Schwager P.
    J. Mol. Biol. 98:693-717(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF CALCIUM-BINDING SITE.
  9. "Structure of bovine trypsinogen at 1.9-A resolution."
    Kossiakoff A.A., Chambers J.L., Kay L.M., Stroud R.M.
    Biochemistry 16:654-664(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  10. "An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.)."
    Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J., Joseph-Horne T., Shewry P., Brady R.L.
    J. Biol. Chem. 282:27760-27768(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 24-246 IN COMPLEX WITH V.HEDERIFOLIA TRYPSIN INHIBITOR, DISULFIDE BONDS.
  11. "The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake."
    Millers E.K., Johnson L.A., Birrell G.W., Masci P.P., Lavin M.F., de Jersey J., Guddat L.W.
    PLoS ONE 8:E54104-E54104(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 24-246 IN COMPLEX WITH THE SNAKE VENOM PROTEASE INHIBITOR TEXTILININ-1, DISULFIDE BONDS, METAL-BINDING SITES GLU-75; ASN-77; VAL-80 AND GLU-85.

Entry informationi

Entry nameiTRY1_BOVIN
AccessioniPrimary (citable) accession number: P00760
Secondary accession number(s): A6H6Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 2, 2008
Last modified: November 26, 2014
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3