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P00755

- K1KB1_MOUSE

UniProt

P00755 - K1KB1_MOUSE

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Protein

Kallikrein 1-related peptidase b1

Gene
Klk1b1, Klk-1, Klk1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. bradykinin biosynthetic process Source: MGI
  2. cardiac muscle contraction Source: MGI
  3. left ventricular cardiac muscle tissue morphogenesis Source: MGI
  4. regulation of systemic arterial blood pressure Source: MGI
  5. tissue kallikrein-kinin cascade Source: MGI
  6. vasodilation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35. 3474.
ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiS01.164.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b1 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K1
Short name:
mGK-1
Tissue kallikrein-1
Gene namesi
Name:Klk1b1
Synonyms:Klk-1, Klk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:892019. Klk1b1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 InferredAdd
BLAST
Propeptidei19 – 246Activation peptide InferredPRO_0000027966
Chaini25 – 261237Kallikrein 1-related peptidase b1PRO_0000027967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 173 By similarity
Disulfide bondi50 ↔ 66 By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...) Inferred
Disulfide bondi152 ↔ 219 By similarity
Disulfide bondi184 ↔ 198 By similarity
Disulfide bondi209 ↔ 234 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP00755.
PaxDbiP00755.
PRIDEiP00755.

PTM databases

PhosphoSiteiP00755.

Expressioni

Gene expression databases

BgeeiP00755.
CleanExiMM_KLK1.
MM_KLK1B1.
GenevestigatoriP00755.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077879.

Structurei

3D structure databases

ProteinModelPortaliP00755.
SMRiP00755. Positions 25-261.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 258234Peptidase S1Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00750000117405.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP00755.
KOiK01325.
OrthoDBiEOG75B84T.
PhylomeDBiP00755.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00755-1 [UniParc]FASTAAdd to Basket

« Hide

MWFLILFLAL SLGGIDAAPP VQSRIVGGFK CEKNSQPWHV AVYRYKEYIC    50
GGVLLDANWV LTAAHCYYEK NNVWLGKNNL YQDEPSAQHR LVSKSFLHPC 100
YNMSLHRNRI QNPQDDYSYD LMLLRLSKPA DITDVVKPIA LPTEEPKLGS 150
TCLASGWGSI IPVKFQYAKD LQCVNLKLLP NEDCDKAYVQ KVTDVMLCAG 200
VKGGGKDTCK GDSGGPLICD GVLQGLTSWG YNPCGEPKKP GVYTKLIKFT 250
SWIKDTLAQN P 261
Length:261
Mass (Da):29,022
Last modified:July 21, 1986 - v1
Checksum:i15DC946600AF1604
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00829 Genomic DNA. Translation: CAA24213.1.
J00390 Genomic DNA. Translation: AAA39349.1.
BC026378 mRNA. Translation: AAH26378.1.
CCDSiCCDS21190.1.
PIRiA00941. KQMS1.
RefSeqiNP_034775.1. NM_010645.2.
UniGeneiMm.447819.

Genome annotation databases

EnsembliENSMUST00000078835; ENSMUSP00000077879; ENSMUSG00000063133.
GeneIDi16623.
KEGGimmu:16623.
UCSCiuc009goc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00829 Genomic DNA. Translation: CAA24213.1 .
J00390 Genomic DNA. Translation: AAA39349.1 .
BC026378 mRNA. Translation: AAH26378.1 .
CCDSi CCDS21190.1.
PIRi A00941. KQMS1.
RefSeqi NP_034775.1. NM_010645.2.
UniGenei Mm.447819.

3D structure databases

ProteinModelPortali P00755.
SMRi P00755. Positions 25-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077879.

Protein family/group databases

MEROPSi S01.164.

PTM databases

PhosphoSitei P00755.

Proteomic databases

MaxQBi P00755.
PaxDbi P00755.
PRIDEi P00755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078835 ; ENSMUSP00000077879 ; ENSMUSG00000063133 .
GeneIDi 16623.
KEGGi mmu:16623.
UCSCi uc009goc.1. mouse.

Organism-specific databases

CTDi 16623.
MGIi MGI:892019. Klk1b1.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00750000117405.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P00755.
KOi K01325.
OrthoDBi EOG75B84T.
PhylomeDBi P00755.
TreeFami TF331065.

Enzyme and pathway databases

BRENDAi 3.4.21.35. 3474.
Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

Miscellaneous databases

NextBioi 290235.
PROi P00755.
SOURCEi Search...

Gene expression databases

Bgeei P00755.
CleanExi MM_KLK1.
MM_KLK1B1.
Genevestigatori P00755.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides."
    Mason A.J., Evans B.A., Cox D.R., Shine J., Richards R.I.
    Nature 303:300-307(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Quakenbush inbred.
  2. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
    Evans B.A., Drinkwater C.C., Richards R.I.
    J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiK1KB1_MOUSE
AccessioniPrimary (citable) accession number: P00755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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