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Protein

Kallikrein 1-related peptidase b1

Gene

Klk1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

GO - Biological processi

  • bradykinin biosynthetic process Source: MGI
  • cardiac muscle contraction Source: MGI
  • left ventricular cardiac muscle tissue morphogenesis Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
  • tissue kallikrein-kinin cascade Source: MGI
  • vasodilation Source: MGI

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35 3474

Protein family/group databases

MEROPSiS01.164

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b1 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K1
Short name:
mGK-1
Tissue kallikrein-1
Gene namesi
Name:Klk1b1
Synonyms:Klk-1, Klk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:892019 Klk1b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002796619 – 24Activation peptideCurated6
ChainiPRO_000002796725 – 261Kallikrein 1-related peptidase b1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP00755
PaxDbiP00755
PRIDEiP00755

PTM databases

iPTMnetiP00755
PhosphoSitePlusiP00755

Expressioni

Gene expression databases

BgeeiENSMUSG00000063133
CleanExiMM_KLK1
MM_KLK1B1
ExpressionAtlasiP00755 baseline and differential
GenevisibleiP00755 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077879

Structurei

3D structure databases

ProteinModelPortaliP00755
SMRiP00755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00910000144067
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP00755
KOiK01325
OMAiATINEKV
OrthoDBiEOG091G0DF7
PhylomeDBiP00755
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLILFLAL SLGGIDAAPP VQSRIVGGFK CEKNSQPWHV AVYRYKEYIC
60 70 80 90 100
GGVLLDANWV LTAAHCYYEK NNVWLGKNNL YQDEPSAQHR LVSKSFLHPC
110 120 130 140 150
YNMSLHRNRI QNPQDDYSYD LMLLRLSKPA DITDVVKPIA LPTEEPKLGS
160 170 180 190 200
TCLASGWGSI IPVKFQYAKD LQCVNLKLLP NEDCDKAYVQ KVTDVMLCAG
210 220 230 240 250
VKGGGKDTCK GDSGGPLICD GVLQGLTSWG YNPCGEPKKP GVYTKLIKFT
260
SWIKDTLAQN P
Length:261
Mass (Da):29,022
Last modified:July 21, 1986 - v1
Checksum:i15DC946600AF1604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00829 Genomic DNA Translation: CAA24213.1
J00390 Genomic DNA Translation: AAA39349.1
BC026378 mRNA Translation: AAH26378.1
CCDSiCCDS21190.1
PIRiA00941 KQMS1
RefSeqiNP_034775.1, NM_010645.3
UniGeneiMm.447819

Genome annotation databases

EnsembliENSMUST00000078835; ENSMUSP00000077879; ENSMUSG00000063133
GeneIDi16623
KEGGimmu:16623
UCSCiuc009goc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1KB1_MOUSE
AccessioniPrimary (citable) accession number: P00755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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