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Protein

Kallikrein 1-related peptidase b1

Gene

Klk1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

GO - Biological processi

  • bradykinin biosynthetic process Source: MGI
  • cardiac muscle contraction Source: MGI
  • left ventricular cardiac muscle tissue morphogenesis Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
  • tissue kallikrein-kinin cascade Source: MGI
  • vasodilation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.35. 3474.
ReactomeiR-MMU-1592389. Activation of Matrix Metalloproteinases.
R-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiS01.164.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b1 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K1
Short name:
mGK-1
Tissue kallikrein-1
Gene namesi
Name:Klk1b1
Synonyms:Klk-1, Klk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:892019. Klk1b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002796619 – 24Activation peptideCurated6
ChainiPRO_000002796725 – 261Kallikrein 1-related peptidase b1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...)Curated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP00755.
PaxDbiP00755.
PRIDEiP00755.

PTM databases

iPTMnetiP00755.
PhosphoSitePlusiP00755.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063133.
CleanExiMM_KLK1.
MM_KLK1B1.
GenevisibleiP00755. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077879.

Structurei

3D structure databases

ProteinModelPortaliP00755.
SMRiP00755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP00755.
KOiK01325.
OMAiCINDHYQ.
OrthoDBiEOG091G0DF7.
PhylomeDBiP00755.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLILFLAL SLGGIDAAPP VQSRIVGGFK CEKNSQPWHV AVYRYKEYIC
60 70 80 90 100
GGVLLDANWV LTAAHCYYEK NNVWLGKNNL YQDEPSAQHR LVSKSFLHPC
110 120 130 140 150
YNMSLHRNRI QNPQDDYSYD LMLLRLSKPA DITDVVKPIA LPTEEPKLGS
160 170 180 190 200
TCLASGWGSI IPVKFQYAKD LQCVNLKLLP NEDCDKAYVQ KVTDVMLCAG
210 220 230 240 250
VKGGGKDTCK GDSGGPLICD GVLQGLTSWG YNPCGEPKKP GVYTKLIKFT
260
SWIKDTLAQN P
Length:261
Mass (Da):29,022
Last modified:July 21, 1986 - v1
Checksum:i15DC946600AF1604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00829 Genomic DNA. Translation: CAA24213.1.
J00390 Genomic DNA. Translation: AAA39349.1.
BC026378 mRNA. Translation: AAH26378.1.
CCDSiCCDS21190.1.
PIRiA00941. KQMS1.
RefSeqiNP_034775.1. NM_010645.3.
UniGeneiMm.447819.

Genome annotation databases

EnsembliENSMUST00000078835; ENSMUSP00000077879; ENSMUSG00000063133.
GeneIDi16623.
KEGGimmu:16623.
UCSCiuc009goc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00829 Genomic DNA. Translation: CAA24213.1.
J00390 Genomic DNA. Translation: AAA39349.1.
BC026378 mRNA. Translation: AAH26378.1.
CCDSiCCDS21190.1.
PIRiA00941. KQMS1.
RefSeqiNP_034775.1. NM_010645.3.
UniGeneiMm.447819.

3D structure databases

ProteinModelPortaliP00755.
SMRiP00755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077879.

Protein family/group databases

MEROPSiS01.164.

PTM databases

iPTMnetiP00755.
PhosphoSitePlusiP00755.

Proteomic databases

MaxQBiP00755.
PaxDbiP00755.
PRIDEiP00755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078835; ENSMUSP00000077879; ENSMUSG00000063133.
GeneIDi16623.
KEGGimmu:16623.
UCSCiuc009goc.1. mouse.

Organism-specific databases

CTDi16623.
MGIiMGI:892019. Klk1b1.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP00755.
KOiK01325.
OMAiCINDHYQ.
OrthoDBiEOG091G0DF7.
PhylomeDBiP00755.
TreeFamiTF331065.

Enzyme and pathway databases

BRENDAi3.4.21.35. 3474.
ReactomeiR-MMU-1592389. Activation of Matrix Metalloproteinases.
R-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

PROiP00755.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063133.
CleanExiMM_KLK1.
MM_KLK1B1.
GenevisibleiP00755. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1KB1_MOUSE
AccessioniPrimary (citable) accession number: P00755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.