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P00755

- K1KB1_MOUSE

UniProt

P00755 - K1KB1_MOUSE

Protein

Kallikrein 1-related peptidase b1

Gene

Klk1b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei213 – 2131Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. bradykinin biosynthetic process Source: MGI
    2. cardiac muscle contraction Source: MGI
    3. left ventricular cardiac muscle tissue morphogenesis Source: MGI
    4. regulation of systemic arterial blood pressure Source: MGI
    5. tissue kallikrein-kinin cascade Source: MGI
    6. vasodilation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.35. 3474.
    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein 1-related peptidase b1 (EC:3.4.21.35)
    Alternative name(s):
    Glandular kallikrein K1
    Short name:
    mGK-1
    Tissue kallikrein-1
    Gene namesi
    Name:Klk1b1
    Synonyms:Klk-1, Klk1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:892019. Klk1b1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptideCuratedPRO_0000027966
    Chaini25 – 261237Kallikrein 1-related peptidase b1PRO_0000027967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
    Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP00755.
    PaxDbiP00755.
    PRIDEiP00755.

    PTM databases

    PhosphoSiteiP00755.

    Expressioni

    Gene expression databases

    BgeeiP00755.
    CleanExiMM_KLK1.
    MM_KLK1B1.
    GenevestigatoriP00755.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000077879.

    Structurei

    3D structure databases

    ProteinModelPortaliP00755.
    SMRiP00755. Positions 25-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117405.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP00755.
    KOiK01325.
    OrthoDBiEOG75B84T.
    PhylomeDBiP00755.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00755-1 [UniParc]FASTAAdd to Basket

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    MWFLILFLAL SLGGIDAAPP VQSRIVGGFK CEKNSQPWHV AVYRYKEYIC    50
    GGVLLDANWV LTAAHCYYEK NNVWLGKNNL YQDEPSAQHR LVSKSFLHPC 100
    YNMSLHRNRI QNPQDDYSYD LMLLRLSKPA DITDVVKPIA LPTEEPKLGS 150
    TCLASGWGSI IPVKFQYAKD LQCVNLKLLP NEDCDKAYVQ KVTDVMLCAG 200
    VKGGGKDTCK GDSGGPLICD GVLQGLTSWG YNPCGEPKKP GVYTKLIKFT 250
    SWIKDTLAQN P 261
    Length:261
    Mass (Da):29,022
    Last modified:July 21, 1986 - v1
    Checksum:i15DC946600AF1604
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00829 Genomic DNA. Translation: CAA24213.1.
    J00390 Genomic DNA. Translation: AAA39349.1.
    BC026378 mRNA. Translation: AAH26378.1.
    CCDSiCCDS21190.1.
    PIRiA00941. KQMS1.
    RefSeqiNP_034775.1. NM_010645.2.
    UniGeneiMm.447819.

    Genome annotation databases

    EnsembliENSMUST00000078835; ENSMUSP00000077879; ENSMUSG00000063133.
    GeneIDi16623.
    KEGGimmu:16623.
    UCSCiuc009goc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00829 Genomic DNA. Translation: CAA24213.1 .
    J00390 Genomic DNA. Translation: AAA39349.1 .
    BC026378 mRNA. Translation: AAH26378.1 .
    CCDSi CCDS21190.1.
    PIRi A00941. KQMS1.
    RefSeqi NP_034775.1. NM_010645.2.
    UniGenei Mm.447819.

    3D structure databases

    ProteinModelPortali P00755.
    SMRi P00755. Positions 25-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000077879.

    Protein family/group databases

    MEROPSi S01.164.

    PTM databases

    PhosphoSitei P00755.

    Proteomic databases

    MaxQBi P00755.
    PaxDbi P00755.
    PRIDEi P00755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078835 ; ENSMUSP00000077879 ; ENSMUSG00000063133 .
    GeneIDi 16623.
    KEGGi mmu:16623.
    UCSCi uc009goc.1. mouse.

    Organism-specific databases

    CTDi 16623.
    MGIi MGI:892019. Klk1b1.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117405.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P00755.
    KOi K01325.
    OrthoDBi EOG75B84T.
    PhylomeDBi P00755.
    TreeFami TF331065.

    Enzyme and pathway databases

    BRENDAi 3.4.21.35. 3474.
    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 290235.
    PROi P00755.
    SOURCEi Search...

    Gene expression databases

    Bgeei P00755.
    CleanExi MM_KLK1.
    MM_KLK1B1.
    Genevestigatori P00755.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides."
      Mason A.J., Evans B.A., Cox D.R., Shine J., Richards R.I.
      Nature 303:300-307(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Quakenbush inbred.
    2. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
      Evans B.A., Drinkwater C.C., Richards R.I.
      J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiK1KB1_MOUSE
    AccessioniPrimary (citable) accession number: P00755
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3