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P00740

- FA9_HUMAN

UniProt

P00740 - FA9_HUMAN

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Protein
Coagulation factor IX
Gene
F9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ ions, phospholipids, and factor VIIIa.

Catalytic activityi

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei191 – 1922Cleavage; by factor XIa
Sitei226 – 2272Cleavage; by factor XIa
Active sitei267 – 2671Charge relay system1 Publication
Active sitei315 – 3151Charge relay system1 Publication
Active sitei411 – 4111Charge relay system1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. serine-type endopeptidase activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. blood coagulation, extrinsic pathway Source: Reactome
  3. blood coagulation, intrinsic pathway Source: Reactome
  4. cellular protein metabolic process Source: Reactome
  5. peptidyl-glutamic acid carboxylation Source: Reactome
  6. post-translational protein modification Source: Reactome
  7. proteolysis Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_1050. Gamma-carboxylation of protein precursors.
REACT_1573. Extrinsic Pathway.
REACT_1906. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
REACT_326. Intrinsic Pathway.
REACT_733. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
SABIO-RKiP00740.

Protein family/group databases

MEROPSiS01.214.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor IX (EC:3.4.21.22)
Alternative name(s):
Christmas factor
Plasma thromboplastin component
Short name:
PTC
Cleaved into the following 2 chains:
Gene namesi
Name:F9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:3551. F9.

Subcellular locationi

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular region Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hemophilia B (HEMB) [MIM:306900]: An X-linked blood coagulation disorder characterized by a permanent tendency to hemorrhage, due to factor IX deficiency. It is phenotypically similar to hemophilia A, but patients present with fewer symptoms. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma.
Note: The disease is caused by mutations affecting the gene represented in this entry.36 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171I → N in HEMB; severe; UK 22.
VAR_006521
Natural varianti28 – 281C → R in HEMB; moderate; HB130.
VAR_006522
Natural varianti28 – 281C → Y in HEMB. 1 Publication
VAR_017343
Natural varianti30 – 301V → I in HEMB.
VAR_006523
Natural varianti43 – 431R → L in HEMB; severe; Bendorf, Beuten, Gleiwitz, etc.. 1 Publication
VAR_006525
Natural varianti43 – 431R → Q in HEMB; severe; San Dimas, Oxford-3, Strasbourg-2, etc.. 5 Publications
VAR_006524
Natural varianti43 – 431R → W in HEMB; severe; Boxtel, Heiden, Lienen, etc.. 2 Publications
VAR_006526
Natural varianti45 – 451K → N in HEMB; severe; Seattle E.
VAR_006527
Natural varianti46 – 461R → S in HEMB; severe; Cambridge.
VAR_006528
Natural varianti46 – 461R → T in HEMB; severe. 1 Publication
VAR_006529
Natural varianti48 – 481N → I in HEMB; severe; Calgary-16.
VAR_006530
Natural varianti49 – 491S → P in HEMB.
VAR_006531
Natural varianti52 – 521L → S in HEMB; severe; Gla mutant. 1 Publication
VAR_017344
Natural varianti53 – 531E → A in HEMB; severe; Oxford-B2; Gla mutant.
VAR_006532
Natural varianti54 – 541E → G in HEMB; severe; HB151; Gla mutant.
VAR_006533
Natural varianti55 – 551F → C in HEMB.
VAR_006534
Natural varianti58 – 581G → A in HEMB; severe; Hong Kong-1.
VAR_006535
Natural varianti58 – 581G → R in HEMB; severe; Los Angeles-4.
VAR_006536
Natural varianti62 – 632Missing in HEMB; severe.
VAR_006537
Natural varianti66 – 661E → V in HEMB; moderate.
VAR_006538
Natural varianti67 – 671E → K in HEMB; severe; Nagoya-4; Gla mutant.
VAR_006539
Natural varianti71 – 711F → S in HEMB; severe.
VAR_006540
Natural varianti73 – 731E → K in HEMB; severe; Seattle-3; Gla mutant. 1 Publication
VAR_006541
Natural varianti73 – 731E → V in HEMB; severe; Chongqing; Gla mutant. 1 Publication
VAR_006542
Natural varianti75 – 751R → Q in HEMB; mild. 1 Publication
VAR_017308
Natural varianti79 – 791E → D in HEMB. 1 Publication
VAR_017309
Natural varianti84 – 841T → R in HEMB. 1 Publication
VAR_017345
Natural varianti91 – 911Y → C in HEMB; moderate.
VAR_006543
Natural varianti93 – 931D → G in HEMB; moderate; Alabama. 1 Publication
VAR_006544
Natural varianti96 – 961Q → P in HEMB; severe; New London.
VAR_006545
Natural varianti97 – 971C → S in HEMB.
VAR_006546
Natural varianti101 – 1011P → R in HEMB.
VAR_006547
Natural varianti102 – 1021C → R in HEMB; severe; Basel.
VAR_006548
Natural varianti106 – 1061G → D in HEMB. 1 Publication
VAR_017346
Natural varianti106 – 1061G → S in HEMB; mild; Durham. 2 Publications
VAR_006549
Natural varianti108 – 1081C → S in HEMB.
VAR_006550
Natural varianti110 – 1101D → N in HEMB; severe; Oxford-D1.
VAR_006551
Natural varianti112 – 1121I → S in HEMB.
VAR_006552
Natural varianti113 – 1131N → K in HEMB; mild. 1 Publication
VAR_006553
Natural varianti115 – 1151Y → C in HEMB; severe. 1 Publication
VAR_006554
Natural varianti119 – 1191C → F in HEMB; severe.
VAR_006555
Natural varianti119 – 1191C → R in HEMB; Iran. 1 Publication
VAR_006556
Natural varianti124 – 1241E → K in HEMB. 1 Publication
VAR_017347
Natural varianti125 – 1251G → E in HEMB.
VAR_006557
Natural varianti125 – 1251G → R in HEMB. 1 Publication
VAR_017348
Natural varianti125 – 1251G → V in HEMB. 1 Publication
VAR_006558
Natural varianti129 – 1302Missing in HEMB.
VAR_006559
Natural varianti134 – 1341C → Y in HEMB. 1 Publication
VAR_017349
Natural varianti136 – 1361I → T in HEMB; mild.
VAR_006560
Natural varianti139 – 1391G → D in HEMB; severe.
VAR_006561
Natural varianti139 – 1391G → S in HEMB.
VAR_006562
Natural varianti155 – 1551C → F in HEMB; severe. 1 Publication
VAR_006563
Natural varianti160 – 1601G → E in HEMB; mild.
VAR_006564
Natural varianti167 – 1671Q → H in HEMB; mild.
VAR_006565
Natural varianti169 – 1691S → C in HEMB. 1 Publication
VAR_017350
Natural varianti170 – 1701C → F in HEMB. 1 Publication
VAR_017351
Natural varianti178 – 1781C → R in HEMB.
VAR_006566
Natural varianti178 – 1781C → W in HEMB; severe.
VAR_006567
Natural varianti191 – 1911R → C in HEMB; moderate; Albuquerque, Cardiff-1, etc.. 1 Publication
VAR_006569
Natural varianti191 – 1911R → H in HEMB; moderate; Chapel-Hill, Chicago-2, etc.. 2 Publications
VAR_006568
Natural varianti226 – 2261R → G in HEMB; severe; Madrid. 2 Publications
VAR_006571
Natural varianti226 – 2261R → Q in HEMB; severe; Hilo and Novara. 3 Publications
VAR_006572
Natural varianti226 – 2261R → W in HEMB; severe; Nagoya-1, Dernbach, Deventer, Idaho, etc.. 3 Publications
VAR_006570
Natural varianti227 – 2271V → D in HEMB; mild.
VAR_006573
Natural varianti227 – 2271V → F in HEMB; Milano. 1 Publication
VAR_017310
Natural varianti228 – 2281V → F in HEMB; severe; Kashihara. 1 Publication
VAR_017311
Natural varianti228 – 2281V → L in HEMB; mild; Cardiff-2. 1 Publication
VAR_006574
Natural varianti241 – 2411Q → H in HEMB.
VAR_006575
Natural varianti241 – 2411Q → K in HEMB. 1 Publication
VAR_017352
Natural varianti252 – 2521C → S in HEMB; severe. 1 Publication
VAR_017312
Natural varianti252 – 2521C → Y in HEMB. 1 Publication
VAR_017353
Natural varianti253 – 2531G → E in HEMB; severe.
VAR_006576
Natural varianti253 – 2531G → R in HEMB; severe; Luanda. 1 Publication
VAR_006577
Natural varianti265 – 2651A → T in HEMB; mild.
VAR_006578
Natural varianti268 – 2681C → W in HEMB; moderate. 1 Publication
VAR_017313
Natural varianti279 – 2791A → T in HEMB; mild. 2 Publications
VAR_006579
Natural varianti283 – 2831N → D in HEMB; severe.
VAR_006580
Natural varianti286 – 2861Missing in HEMB; severe.
VAR_006581
Natural varianti291 – 2911E → V in HEMB; Monschau. 1 Publication
VAR_017314
Natural varianti294 – 2941R → G in HEMB; severe.
VAR_006582
Natural varianti294 – 2941R → Q in HEMB; mild to moderate; Dreihacken, Penafiel and Seattle-4. 5 Publications
VAR_006583
Natural varianti302 – 3021H → R in HEMB. 1 Publication
VAR_006584
Natural varianti306 – 3061N → S in HEMB; mild. 1 Publication
VAR_017315
Natural varianti316 – 3161I → F in HEMB. 1 Publication
VAR_006585
Natural varianti318 – 3181L → R in HEMB. 1 Publication
VAR_017354
Natural varianti321 – 3211L → Q in HEMB; severe.
VAR_006586
Natural varianti333 – 3331P → H in HEMB; severe.
VAR_006587
Natural varianti333 – 3331P → T in HEMB. 1 Publication
VAR_017355
Natural varianti342 – 3421T → K in HEMB; mild.
VAR_006588
Natural varianti342 – 3421T → M in HEMB; moderate. 3 Publications
VAR_006589
Natural varianti344 – 3441I → L in HEMB. 1 Publication
VAR_017356
Natural varianti351 – 3511G → D in HEMB.
VAR_006590
Natural varianti356 – 3561W → C in HEMB; severe.
VAR_006591
Natural varianti357 – 3571G → E in HEMB; severe; Amagasaki. 1 Publication
VAR_006592
Natural varianti357 – 3571G → R in HEMB. 1 Publication
VAR_017316
Natural varianti362 – 3621K → E in HEMB; moderate.
VAR_006593
Natural varianti363 – 3631G → W in HEMB.
VAR_006594
Natural varianti366 – 3661A → D in HEMB.
VAR_006595
Natural varianti379 – 3791R → G in HEMB; moderate. 1 Publication
VAR_006596
Natural varianti379 – 3791R → Q in HEMB; severe; Iceland-1, London and Sesimbra. 3 Publications
VAR_006597
Natural varianti382 – 3821C → Y in HEMB.
VAR_006598
Natural varianti383 – 3831L → F in HEMB. 1 Publication
VAR_017358
Natural varianti383 – 3831L → I in HEMB. 1 Publication
VAR_017357
Natural varianti387 – 3871K → E in HEMB; mild. 1 Publication
VAR_006599
Natural varianti390 – 3901I → F in HEMB; severe.
VAR_006600
Natural varianti394 – 3941M → K in HEMB.
VAR_006601
Natural varianti395 – 3951F → I in HEMB. 1 Publication
VAR_017359
Natural varianti395 – 3951F → L in HEMB. 1 Publication
VAR_017360
Natural varianti396 – 3961C → F in HEMB. 1 Publication
VAR_017361
Natural varianti396 – 3961C → S in HEMB; severe.
VAR_006602
Natural varianti397 – 3971A → P in HEMB; mild; Hong Kong-11. 1 Publication
VAR_017317
Natural varianti404 – 4041R → T in HEMB.
VAR_006603
Natural varianti407 – 4071C → R in HEMB. 1 Publication
VAR_017362
Natural varianti407 – 4071C → S in HEMB; severe.
VAR_006604
Natural varianti410 – 4101D → H in HEMB; Mechtal. 1 Publication
VAR_017318
Natural varianti411 – 4111S → G in HEMB; Varel. 1 Publication
VAR_017320
Natural varianti411 – 4111S → I in HEMB; Schmallenberg. 1 Publication
VAR_017319
Natural varianti412 – 4121G → E in HEMB. 1 Publication
VAR_017363
Natural varianti413 – 4131G → R in HEMB; moderate to severe. 2 Publications
VAR_006605
Natural varianti414 – 4141P → T in HEMB; Bergamo. 2 Publications
VAR_017321
Natural varianti419 – 4191V → E in HEMB; moderately severe. 2 Publications
VAR_006606
Natural varianti424 – 4241F → V in HEMB. 1 Publication
VAR_006607
Natural varianti426 – 4261T → P in HEMB; severe; Barcelos. 1 Publication
VAR_006608
Natural varianti430 – 4301S → T in HEMB.
VAR_006609
Natural varianti431 – 4311W → G in HEMB.
VAR_006610
Natural varianti431 – 4311W → R in HEMB; moderate.
VAR_006611
Natural varianti432 – 4321G → S in HEMB; severe.
VAR_006612
Natural varianti432 – 4321G → V in HEMB; severe. 1 Publication
VAR_006613
Natural varianti433 – 4331E → A in HEMB.
VAR_006614
Natural varianti433 – 4331E → K in HEMB.
VAR_006615
Natural varianti435 – 4351C → Y in HEMB. 1 Publication
VAR_017364
Natural varianti436 – 4361A → V in HEMB; moderately severe; Niigata. 1 Publication
VAR_006616
Natural varianti442 – 4421G → E in HEMB. 1 Publication
VAR_017365
Natural varianti442 – 4421G → R in HEMB; severe; Angers. 1 Publication
VAR_017322
Natural varianti443 – 4431I → T in HEMB; moderately severe; Long Beach, Los Angeles and Vancouver. 2 Publications
VAR_017323
Natural varianti445 – 4451T → TIYT in HEMB; severe; Lousada.
VAR_006617
Natural varianti449 – 4491R → Q in HEMB; mild. 1 Publication
VAR_006618
Natural varianti449 – 4491R → W in HEMB; mild. 1 Publication
VAR_006619
Natural varianti450 – 4501Y → C in HEMB; severe. 1 Publication
VAR_006620
Natural varianti453 – 4531W → R in HEMB. 1 Publication
VAR_017324
Natural varianti454 – 4541I → T in HEMB; Italy. 1 Publication
VAR_006621
Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
Thrombophilia, X-linked, due to factor IX defect (THPH8) [MIM:300807]: A hemostatic disorder characterized by a tendency to thrombosis.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti384 – 3841R → L in THPH8; factor IX Padua; higher specific activity than wild-type. 1 Publication
VAR_062999

Pharmaceutical usei

Available under the name BeneFix (Baxter and American Home Products). Used to treat hemophilia B.

Keywords - Diseasei

Disease mutation, Hemophilia, Thrombophilia

Organism-specific databases

MIMi300807. phenotype.
306900. phenotype.
Orphaneti169799. Mild hemophilia B.
169796. Moderately severe hemophilia B.
169793. Severe hemophilia B.
177929. Symptomatic form of hemophilia B in female carriers.
PharmGKBiPA27954.

Protein family/group databases

Allergomei9616. Hom s Factor IX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Propeptidei29 – 4618
PRO_0000027755Add
BLAST
Chaini47 – 461415Coagulation factor IX
PRO_0000027756Add
BLAST
Chaini47 – 191145Coagulation factor IXa light chain
PRO_0000027757Add
BLAST
Propeptidei192 – 22635Activation peptide
PRO_0000027758Add
BLAST
Chaini227 – 461235Coagulation factor IXa heavy chain
PRO_0000027759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 5314-carboxyglutamate1 Publication
Modified residuei54 – 5414-carboxyglutamate1 Publication
Modified residuei61 – 6114-carboxyglutamate1 Publication
Modified residuei63 – 6314-carboxyglutamate1 Publication
Disulfide bondi64 ↔ 69
Modified residuei66 – 6614-carboxyglutamate1 Publication
Modified residuei67 – 6714-carboxyglutamate1 Publication
Modified residuei72 – 7214-carboxyglutamate1 Publication
Modified residuei73 – 7314-carboxyglutamate1 Publication
Modified residuei76 – 7614-carboxyglutamate1 Publication
Modified residuei79 – 7914-carboxyglutamate1 Publication
Modified residuei82 – 8214-carboxyglutamate1 Publication
Modified residuei86 – 8614-carboxyglutamate1 Publication
Disulfide bondi97 ↔ 108
Glycosylationi99 – 991O-linked (Glc...); alternate1 Publication
CAR_000009
Glycosylationi99 – 991O-linked (Xyl...); alternate1 Publication
Disulfide bondi102 ↔ 117
Glycosylationi107 – 1071O-linked (Fuc...)
CAR_000010
Modified residuei110 – 1101(3R)-3-hydroxyaspartate
Modified residuei114 – 1141Phosphoserine1 Publication
Disulfide bondi119 ↔ 128
Disulfide bondi134 ↔ 145
Disulfide bondi141 ↔ 155
Disulfide bondi157 ↔ 170
Disulfide bondi178 ↔ 335
Modified residuei201 – 2011Sulfotyrosine1 Publication
Glycosylationi203 – 2031N-linked (GlcNAc...)1 Publication
Modified residuei204 – 2041Phosphoserine1 Publication
Glycosylationi205 – 2051O-linked (GalNAc...)1 Publication
Glycosylationi213 – 2131N-linked (GlcNAc...)1 Publication
Glycosylationi215 – 2151O-linked (GalNAc...)1 Publication
Disulfide bondi252 ↔ 268
Disulfide bondi382 ↔ 396
Disulfide bondi407 ↔ 435

Post-translational modificationi

Activated by factor XIa, which excises the activation peptide.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Predominantly O-glucosylated at Ser-99 by POGLUT1 in vitro. Xylosylation at this site is minor.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Phosphoprotein, Sulfation, Zymogen

Proteomic databases

PaxDbiP00740.
PeptideAtlasiP00740.
PRIDEiP00740.

PTM databases

PhosphoSiteiP00740.
UniCarbKBiP00740.

Miscellaneous databases

PMAP-CutDBiP00740.

Expressioni

Tissue specificityi

Synthesized primarily in the liver and secreted in plasma.

Gene expression databases

ArrayExpressiP00740.
BgeeiP00740.
CleanExiHS_F9.
GenevestigatoriP00740.

Interactioni

Subunit structurei

Heterodimer of a light chain and a heavy chain; disulfide-linked.

Protein-protein interaction databases

BioGridi108456. 1 interaction.
DIPiDIP-58520N.
STRINGi9606.ENSP00000218099.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi50 – 523
Helixi60 – 645
Beta strandi65 – 673
Helixi71 – 755
Beta strandi78 – 803
Helixi81 – 9010
Turni96 – 994
Beta strandi107 – 1115
Beta strandi114 – 1185
Turni125 – 1284
Turni134 – 1363
Helixi137 – 1404
Beta strandi142 – 1476
Beta strandi149 – 1513
Beta strandi153 – 1564
Beta strandi161 – 1633
Beta strandi165 – 1684
Beta strandi170 – 1767
Beta strandi187 – 1893
Beta strandi241 – 2488
Beta strandi252 – 2587
Beta strandi261 – 2644
Helixi266 – 2683
Beta strandi271 – 2733
Beta strandi276 – 2805
Beta strandi282 – 2865
Beta strandi292 – 30110
Turni303 – 3064
Beta strandi307 – 3104
Turni311 – 3144
Beta strandi317 – 3237
Helixi339 – 3479
Beta strandi350 – 36011
Beta strandi370 – 3778
Helixi379 – 3846
Beta strandi394 – 3985
Beta strandi414 – 4196
Beta strandi422 – 43110
Beta strandi433 – 4364
Beta strandi442 – 4465
Helixi447 – 4504
Helixi451 – 4577

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CFHNMR-A47-93[»]
1CFINMR-A47-93[»]
1EDMX-ray1.50B/C92-130[»]
1IXANMR-A92-130[»]
1MGXNMR-A47-93[»]
1NL0X-ray2.20G47-91[»]
1RFNX-ray2.80A227-461[»]
B133-188[»]
2WPHX-ray1.50E133-191[»]
S227-461[»]
2WPIX-ray1.99E133-191[»]
S227-461[»]
2WPJX-ray1.60E133-191[»]
S227-461[»]
2WPKX-ray2.21E133-191[»]
S227-461[»]
2WPLX-ray1.82E133-191[»]
S227-461[»]
2WPMX-ray2.00E133-191[»]
S227-461[»]
3KCGX-ray1.70H227-461[»]
L131-188[»]
3LC3X-ray1.90A/C227-461[»]
B/D133-188[»]
3LC5X-ray2.62A227-461[»]
B133-188[»]
ProteinModelPortaliP00740.
SMRiP00740. Positions 47-191, 227-461.

Miscellaneous databases

EvolutionaryTraceiP00740.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 9246Gla
Add
BLAST
Domaini93 – 12937EGF-like 1; calcium-binding Reviewed prediction
Add
BLAST
Domaini130 – 17142EGF-like 2
Add
BLAST
Domaini227 – 459233Peptidase S1
Add
BLAST

Domaini

Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.

Sequence similaritiesi

Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251821.
HOVERGENiHBG013304.
InParanoidiP00740.
KOiK01321.
OMAiSAECTVF.
OrthoDBiEOG75B84T.
PhylomeDBiP00740.
TreeFamiTF327329.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR012224. Pept_S1A_FX.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00594. Gla. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001143. Factor_X. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
PR00001. GLABLOOD.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00069. GLA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P00740-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQRVNMIMAE SPGLITICLL GYLLSAECTV FLDHENANKI LNRPKRYNSG    50
KLEEFVQGNL ERECMEEKCS FEEAREVFEN TERTTEFWKQ YVDGDQCESN 100
PCLNGGSCKD DINSYECWCP FGFEGKNCEL DVTCNIKNGR CEQFCKNSAD 150
NKVVCSCTEG YRLAENQKSC EPAVPFPCGR VSVSQTSKLT RAETVFPDVD 200
YVNSTEAETI LDNITQSTQS FNDFTRVVGG EDAKPGQFPW QVVLNGKVDA 250
FCGGSIVNEK WIVTAAHCVE TGVKITVVAG EHNIEETEHT EQKRNVIRII 300
PHHNYNAAIN KYNHDIALLE LDEPLVLNSY VTPICIADKE YTNIFLKFGS 350
GYVSGWGRVF HKGRSALVLQ YLRVPLVDRA TCLRSTKFTI YNNMFCAGFH 400
EGGRDSCQGD SGGPHVTEVE GTSFLTGIIS WGEECAMKGK YGIYTKVSRY 450
VNWIKEKTKL T 461
Length:461
Mass (Da):51,778
Last modified:June 7, 2005 - v2
Checksum:iC4720C1234477EF5
GO
Isoform 2 (identifier: P00740-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-130: Missing.

Show »
Length:423
Mass (Da):47,618
Checksum:i2556B3F27FB23A77
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71I → F.1 Publication
Corresponds to variant rs150190385 [ dbSNP | Ensembl ].
VAR_006520
Natural varianti17 – 171I → N in HEMB; severe; UK 22.
VAR_006521
Natural varianti28 – 281C → R in HEMB; moderate; HB130.
VAR_006522
Natural varianti28 – 281C → Y in HEMB. 1 Publication
VAR_017343
Natural varianti30 – 301V → I in HEMB.
VAR_006523
Natural varianti37 – 371A → T in warfarin sensitivity; reduced affinity of the glutamate carboxylase for the factor IX precursor. 1 Publication
VAR_017307
Natural varianti43 – 431R → L in HEMB; severe; Bendorf, Beuten, Gleiwitz, etc.. 1 Publication
VAR_006525
Natural varianti43 – 431R → Q in HEMB; severe; San Dimas, Oxford-3, Strasbourg-2, etc.. 5 Publications
VAR_006524
Natural varianti43 – 431R → W in HEMB; severe; Boxtel, Heiden, Lienen, etc.. 2 Publications
VAR_006526
Natural varianti45 – 451K → N in HEMB; severe; Seattle E.
VAR_006527
Natural varianti46 – 461R → S in HEMB; severe; Cambridge.
VAR_006528
Natural varianti46 – 461R → T in HEMB; severe. 1 Publication
VAR_006529
Natural varianti48 – 481N → I in HEMB; severe; Calgary-16.
VAR_006530
Natural varianti49 – 491S → P in HEMB.
VAR_006531
Natural varianti52 – 521L → S in HEMB; severe; Gla mutant. 1 Publication
VAR_017344
Natural varianti53 – 531E → A in HEMB; severe; Oxford-B2; Gla mutant.
VAR_006532
Natural varianti54 – 541E → G in HEMB; severe; HB151; Gla mutant.
VAR_006533
Natural varianti55 – 551F → C in HEMB.
VAR_006534
Natural varianti58 – 581G → A in HEMB; severe; Hong Kong-1.
VAR_006535
Natural varianti58 – 581G → R in HEMB; severe; Los Angeles-4.
VAR_006536
Natural varianti62 – 632Missing in HEMB; severe.
VAR_006537
Natural varianti66 – 661E → V in HEMB; moderate.
VAR_006538
Natural varianti67 – 671E → K in HEMB; severe; Nagoya-4; Gla mutant.
VAR_006539
Natural varianti71 – 711F → S in HEMB; severe.
VAR_006540
Natural varianti73 – 731E → K in HEMB; severe; Seattle-3; Gla mutant. 1 Publication
VAR_006541
Natural varianti73 – 731E → V in HEMB; severe; Chongqing; Gla mutant. 1 Publication
VAR_006542
Natural varianti75 – 751R → Q in HEMB; mild. 1 Publication
VAR_017308
Natural varianti79 – 791E → D in HEMB. 1 Publication
VAR_017309
Natural varianti84 – 841T → R in HEMB. 1 Publication
VAR_017345
Natural varianti91 – 911Y → C in HEMB; moderate.
VAR_006543
Natural varianti93 – 931D → G in HEMB; moderate; Alabama. 1 Publication
VAR_006544
Natural varianti96 – 961Q → P in HEMB; severe; New London.
VAR_006545
Natural varianti97 – 971C → S in HEMB.
VAR_006546
Natural varianti101 – 1011P → R in HEMB.
VAR_006547
Natural varianti102 – 1021C → R in HEMB; severe; Basel.
VAR_006548
Natural varianti106 – 1061G → D in HEMB. 1 Publication
VAR_017346
Natural varianti106 – 1061G → S in HEMB; mild; Durham. 2 Publications
VAR_006549
Natural varianti108 – 1081C → S in HEMB.
VAR_006550
Natural varianti110 – 1101D → N in HEMB; severe; Oxford-D1.
VAR_006551
Natural varianti112 – 1121I → S in HEMB.
VAR_006552
Natural varianti113 – 1131N → K in HEMB; mild. 1 Publication
VAR_006553
Natural varianti115 – 1151Y → C in HEMB; severe. 1 Publication
VAR_006554
Natural varianti119 – 1191C → F in HEMB; severe.
VAR_006555
Natural varianti119 – 1191C → R in HEMB; Iran. 1 Publication
VAR_006556
Natural varianti124 – 1241E → K in HEMB. 1 Publication
VAR_017347
Natural varianti125 – 1251G → E in HEMB.
VAR_006557
Natural varianti125 – 1251G → R in HEMB. 1 Publication
VAR_017348
Natural varianti125 – 1251G → V in HEMB. 1 Publication
VAR_006558
Natural varianti129 – 1302Missing in HEMB.
VAR_006559
Natural varianti134 – 1341C → Y in HEMB. 1 Publication
VAR_017349
Natural varianti136 – 1361I → T in HEMB; mild.
VAR_006560
Natural varianti139 – 1391G → D in HEMB; severe.
VAR_006561
Natural varianti139 – 1391G → S in HEMB.
VAR_006562
Natural varianti155 – 1551C → F in HEMB; severe. 1 Publication
VAR_006563
Natural varianti160 – 1601G → E in HEMB; mild.
VAR_006564
Natural varianti167 – 1671Q → H in HEMB; mild.
VAR_006565
Natural varianti169 – 1691S → C in HEMB. 1 Publication
VAR_017350
Natural varianti170 – 1701C → F in HEMB. 1 Publication
VAR_017351
Natural varianti178 – 1781C → R in HEMB.
VAR_006566
Natural varianti178 – 1781C → W in HEMB; severe.
VAR_006567
Natural varianti191 – 1911R → C in HEMB; moderate; Albuquerque, Cardiff-1, etc.. 1 Publication
VAR_006569
Natural varianti191 – 1911R → H in HEMB; moderate; Chapel-Hill, Chicago-2, etc.. 2 Publications
VAR_006568
Natural varianti194 – 1941T → A.4 Publications
Corresponds to variant rs6048 [ dbSNP | Ensembl ].
VAR_011773
Natural varianti226 – 2261R → G in HEMB; severe; Madrid. 2 Publications
VAR_006571
Natural varianti226 – 2261R → Q in HEMB; severe; Hilo and Novara. 3 Publications
VAR_006572
Natural varianti226 – 2261R → W in HEMB; severe; Nagoya-1, Dernbach, Deventer, Idaho, etc.. 3 Publications
VAR_006570
Natural varianti227 – 2271V → D in HEMB; mild.
VAR_006573
Natural varianti227 – 2271V → F in HEMB; Milano. 1 Publication
VAR_017310
Natural varianti228 – 2281V → F in HEMB; severe; Kashihara. 1 Publication
VAR_017311
Natural varianti228 – 2281V → L in HEMB; mild; Cardiff-2. 1 Publication
VAR_006574
Natural varianti241 – 2411Q → H in HEMB.
VAR_006575
Natural varianti241 – 2411Q → K in HEMB. 1 Publication
VAR_017352
Natural varianti252 – 2521C → S in HEMB; severe. 1 Publication
VAR_017312
Natural varianti252 – 2521C → Y in HEMB. 1 Publication
VAR_017353
Natural varianti253 – 2531G → E in HEMB; severe.
VAR_006576
Natural varianti253 – 2531G → R in HEMB; severe; Luanda. 1 Publication
VAR_006577
Natural varianti265 – 2651A → T in HEMB; mild.
VAR_006578
Natural varianti268 – 2681C → W in HEMB; moderate. 1 Publication
VAR_017313
Natural varianti279 – 2791A → T in HEMB; mild. 2 Publications
VAR_006579
Natural varianti283 – 2831N → D in HEMB; severe.
VAR_006580
Natural varianti286 – 2861Missing in HEMB; severe.
VAR_006581
Natural varianti291 – 2911E → V in HEMB; Monschau. 1 Publication
VAR_017314
Natural varianti294 – 2941R → G in HEMB; severe.
VAR_006582
Natural varianti294 – 2941R → Q in HEMB; mild to moderate; Dreihacken, Penafiel and Seattle-4. 5 Publications
VAR_006583
Natural varianti302 – 3021H → R in HEMB. 1 Publication
VAR_006584
Natural varianti306 – 3061N → S in HEMB; mild. 1 Publication
VAR_017315
Natural varianti316 – 3161I → F in HEMB. 1 Publication
VAR_006585
Natural varianti318 – 3181L → R in HEMB. 1 Publication
VAR_017354
Natural varianti321 – 3211L → Q in HEMB; severe.
VAR_006586
Natural varianti333 – 3331P → H in HEMB; severe.
VAR_006587
Natural varianti333 – 3331P → T in HEMB. 1 Publication
VAR_017355
Natural varianti342 – 3421T → K in HEMB; mild.
VAR_006588
Natural varianti342 – 3421T → M in HEMB; moderate. 3 Publications
VAR_006589
Natural varianti344 – 3441I → L in HEMB. 1 Publication
VAR_017356
Natural varianti351 – 3511G → D in HEMB.
VAR_006590
Natural varianti356 – 3561W → C in HEMB; severe.
VAR_006591
Natural varianti357 – 3571G → E in HEMB; severe; Amagasaki. 1 Publication
VAR_006592
Natural varianti357 – 3571G → R in HEMB. 1 Publication
VAR_017316
Natural varianti362 – 3621K → E in HEMB; moderate.
VAR_006593
Natural varianti363 – 3631G → W in HEMB.
VAR_006594
Natural varianti366 – 3661A → D in HEMB.
VAR_006595
Natural varianti379 – 3791R → G in HEMB; moderate. 1 Publication
VAR_006596
Natural varianti379 – 3791R → Q in HEMB; severe; Iceland-1, London and Sesimbra. 3 Publications
VAR_006597
Natural varianti382 – 3821C → Y in HEMB.
VAR_006598
Natural varianti383 – 3831L → F in HEMB. 1 Publication
VAR_017358
Natural varianti383 – 3831L → I in HEMB. 1 Publication
VAR_017357
Natural varianti384 – 3841R → L in THPH8; factor IX Padua; higher specific activity than wild-type. 1 Publication
VAR_062999
Natural varianti387 – 3871K → E in HEMB; mild. 1 Publication
VAR_006599
Natural varianti390 – 3901I → F in HEMB; severe.
VAR_006600
Natural varianti394 – 3941M → K in HEMB.
VAR_006601
Natural varianti395 – 3951F → I in HEMB. 1 Publication
VAR_017359
Natural varianti395 – 3951F → L in HEMB. 1 Publication
VAR_017360
Natural varianti396 – 3961C → F in HEMB. 1 Publication
VAR_017361
Natural varianti396 – 3961C → S in HEMB; severe.
VAR_006602
Natural varianti397 – 3971A → P in HEMB; mild; Hong Kong-11. 1 Publication
VAR_017317
Natural varianti404 – 4041R → T in HEMB.
VAR_006603
Natural varianti407 – 4071C → R in HEMB. 1 Publication
VAR_017362
Natural varianti407 – 4071C → S in HEMB; severe.
VAR_006604
Natural varianti410 – 4101D → H in HEMB; Mechtal. 1 Publication
VAR_017318
Natural varianti411 – 4111S → G in HEMB; Varel. 1 Publication
VAR_017320
Natural varianti411 – 4111S → I in HEMB; Schmallenberg. 1 Publication
VAR_017319
Natural varianti412 – 4121G → E in HEMB. 1 Publication
VAR_017363
Natural varianti413 – 4131G → R in HEMB; moderate to severe. 2 Publications
VAR_006605
Natural varianti414 – 4141P → T in HEMB; Bergamo. 2 Publications
VAR_017321
Natural varianti419 – 4191V → E in HEMB; moderately severe. 2 Publications
VAR_006606
Natural varianti424 – 4241F → V in HEMB. 1 Publication
VAR_006607
Natural varianti426 – 4261T → P in HEMB; severe; Barcelos. 1 Publication
VAR_006608
Natural varianti430 – 4301S → T in HEMB.
VAR_006609
Natural varianti431 – 4311W → G in HEMB.
VAR_006610
Natural varianti431 – 4311W → R in HEMB; moderate.
VAR_006611
Natural varianti432 – 4321G → S in HEMB; severe.
VAR_006612
Natural varianti432 – 4321G → V in HEMB; severe. 1 Publication
VAR_006613
Natural varianti433 – 4331E → A in HEMB.
VAR_006614
Natural varianti433 – 4331E → K in HEMB.
VAR_006615
Natural varianti435 – 4351C → Y in HEMB. 1 Publication
VAR_017364
Natural varianti436 – 4361A → V in HEMB; moderately severe; Niigata. 1 Publication
VAR_006616
Natural varianti442 – 4421G → E in HEMB. 1 Publication
VAR_017365
Natural varianti442 – 4421G → R in HEMB; severe; Angers. 1 Publication
VAR_017322
Natural varianti443 – 4431I → T in HEMB; moderately severe; Long Beach, Los Angeles and Vancouver. 2 Publications
VAR_017323
Natural varianti445 – 4451T → TIYT in HEMB; severe; Lousada.
VAR_006617
Natural varianti449 – 4491R → Q in HEMB; mild. 1 Publication
VAR_006618
Natural varianti449 – 4491R → W in HEMB; mild. 1 Publication
VAR_006619
Natural varianti450 – 4501Y → C in HEMB; severe. 1 Publication
VAR_006620
Natural varianti453 – 4531W → R in HEMB. 1 Publication
VAR_017324
Natural varianti454 – 4541I → T in HEMB; Italy. 1 Publication
VAR_006621
Natural varianti461 – 4611T → P.1 Publication
Corresponds to variant rs4149751 [ dbSNP | Ensembl ].
VAR_014308

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 13038Missing in isoform 2.
VSP_047689Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00136 mRNA. Translation: AAA98726.1.
J00137 mRNA. Translation: AAA52763.1.
K02053
, K02048, K02049, K02051, K02052 Genomic DNA. Translation: AAA56822.1.
K02402 Genomic DNA. Translation: AAB59620.1.
M11309 mRNA. Translation: AAA52023.1.
AL033403 Genomic DNA. Translation: CAI42103.1.
AB186358 mRNA. Translation: BAD89383.1.
AF536327 Genomic DNA. Translation: AAM96188.1.
FR846239 mRNA. Translation: CCA61111.1.
AK292749 mRNA. Translation: BAF85438.1.
CH471150 Genomic DNA. Translation: EAW88433.1.
BC109214 mRNA. Translation: AAI09215.1.
BC109215 mRNA. Translation: AAI09216.1.
S68634 Genomic DNA. Translation: AAB29758.1.
M35672 mRNA. Translation: AAA51981.1.
M19063 Genomic DNA. Translation: AAA52456.1.
S66752 Genomic DNA. Translation: AAB28588.1.
CCDSiCCDS14666.1. [P00740-1]
PIRiA00922. KFHU.
RefSeqiNP_000124.1. NM_000133.3. [P00740-1]
UniGeneiHs.522798.

Genome annotation databases

EnsembliENST00000218099; ENSP00000218099; ENSG00000101981. [P00740-1]
ENST00000394090; ENSP00000377650; ENSG00000101981. [P00740-2]
GeneIDi2158.
KEGGihsa:2158.
UCSCiuc004fas.1. human. [P00740-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Factor IX entry

Factor IX Mutation Database
SeattleSNPs
BeneFix

Clinical information on BeneFix

Protein Spotlight

The Christmas Factor - Issue 41 of December 2003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00136 mRNA. Translation: AAA98726.1 .
J00137 mRNA. Translation: AAA52763.1 .
K02053
, K02048 , K02049 , K02051 , K02052 Genomic DNA. Translation: AAA56822.1 .
K02402 Genomic DNA. Translation: AAB59620.1 .
M11309 mRNA. Translation: AAA52023.1 .
AL033403 Genomic DNA. Translation: CAI42103.1 .
AB186358 mRNA. Translation: BAD89383.1 .
AF536327 Genomic DNA. Translation: AAM96188.1 .
FR846239 mRNA. Translation: CCA61111.1 .
AK292749 mRNA. Translation: BAF85438.1 .
CH471150 Genomic DNA. Translation: EAW88433.1 .
BC109214 mRNA. Translation: AAI09215.1 .
BC109215 mRNA. Translation: AAI09216.1 .
S68634 Genomic DNA. Translation: AAB29758.1 .
M35672 mRNA. Translation: AAA51981.1 .
M19063 Genomic DNA. Translation: AAA52456.1 .
S66752 Genomic DNA. Translation: AAB28588.1 .
CCDSi CCDS14666.1. [P00740-1 ]
PIRi A00922. KFHU.
RefSeqi NP_000124.1. NM_000133.3. [P00740-1 ]
UniGenei Hs.522798.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CFH NMR - A 47-93 [» ]
1CFI NMR - A 47-93 [» ]
1EDM X-ray 1.50 B/C 92-130 [» ]
1IXA NMR - A 92-130 [» ]
1MGX NMR - A 47-93 [» ]
1NL0 X-ray 2.20 G 47-91 [» ]
1RFN X-ray 2.80 A 227-461 [» ]
B 133-188 [» ]
2WPH X-ray 1.50 E 133-191 [» ]
S 227-461 [» ]
2WPI X-ray 1.99 E 133-191 [» ]
S 227-461 [» ]
2WPJ X-ray 1.60 E 133-191 [» ]
S 227-461 [» ]
2WPK X-ray 2.21 E 133-191 [» ]
S 227-461 [» ]
2WPL X-ray 1.82 E 133-191 [» ]
S 227-461 [» ]
2WPM X-ray 2.00 E 133-191 [» ]
S 227-461 [» ]
3KCG X-ray 1.70 H 227-461 [» ]
L 131-188 [» ]
3LC3 X-ray 1.90 A/C 227-461 [» ]
B/D 133-188 [» ]
3LC5 X-ray 2.62 A 227-461 [» ]
B 133-188 [» ]
ProteinModelPortali P00740.
SMRi P00740. Positions 47-191, 227-461.
ModBasei Search...

Protein-protein interaction databases

BioGridi 108456. 1 interaction.
DIPi DIP-58520N.
STRINGi 9606.ENSP00000218099.

Chemistry

BindingDBi P00740.
ChEMBLi CHEMBL2111424.
DrugBanki DB00025. Antihemophilic Factor.
DB00100. Coagulation Factor IX.
DB01109. Heparin.
DB00170. Menadione.
GuidetoPHARMACOLOGYi 2364.

Protein family/group databases

Allergomei 9616. Hom s Factor IX.
MEROPSi S01.214.

PTM databases

PhosphoSitei P00740.
UniCarbKBi P00740.

Proteomic databases

PaxDbi P00740.
PeptideAtlasi P00740.
PRIDEi P00740.

Protocols and materials databases

DNASUi 2158.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000218099 ; ENSP00000218099 ; ENSG00000101981 . [P00740-1 ]
ENST00000394090 ; ENSP00000377650 ; ENSG00000101981 . [P00740-2 ]
GeneIDi 2158.
KEGGi hsa:2158.
UCSCi uc004fas.1. human. [P00740-1 ]

Organism-specific databases

CTDi 2158.
GeneCardsi GC0XP138612.
GeneReviewsi F9.
HGNCi HGNC:3551. F9.
MIMi 300746. gene.
300807. phenotype.
306900. phenotype.
neXtProti NX_P00740.
Orphaneti 169799. Mild hemophilia B.
169796. Moderately severe hemophilia B.
169793. Severe hemophilia B.
177929. Symptomatic form of hemophilia B in female carriers.
PharmGKBi PA27954.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251821.
HOVERGENi HBG013304.
InParanoidi P00740.
KOi K01321.
OMAi SAECTVF.
OrthoDBi EOG75B84T.
PhylomeDBi P00740.
TreeFami TF327329.

Enzyme and pathway databases

Reactomei REACT_1050. Gamma-carboxylation of protein precursors.
REACT_1573. Extrinsic Pathway.
REACT_1906. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
REACT_326. Intrinsic Pathway.
REACT_733. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
SABIO-RKi P00740.

Miscellaneous databases

EvolutionaryTracei P00740.
GeneWikii Factor_IX.
GenomeRNAii 2158.
NextBioi 8719.
PMAP-CutDBi P00740.
PROi P00740.
SOURCEi Search...

Gene expression databases

ArrayExpressi P00740.
Bgeei P00740.
CleanExi HS_F9.
Genevestigatori P00740.

Family and domain databases

Gene3Di 4.10.740.10. 1 hit.
InterProi IPR017857.