##gff-version 3 P00720 UniProtKB Chain 1 164 . . . ID=PRO_0000218107;Note=Endolysin P00720 UniProtKB Active site 11 11 . . . Note=Proton donor/acceptor;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04110,ECO:0000269|PubMed:3382407,ECO:0000269|PubMed:7831309,ECO:0000269|PubMed:8266098;Dbxref=PMID:3382407,PMID:7831309,PMID:8266098 P00720 UniProtKB Active site 20 20 . . . Note=Proton donor/acceptor;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|HAMAP-Rule:MF_04110,ECO:0000269|PubMed:1892846,ECO:0000269|PubMed:3382407,ECO:0000269|PubMed:7831309,ECO:0000269|PubMed:8266098;Dbxref=PMID:1892846,PMID:3382407,PMID:7831309,PMID:8266098 P00720 UniProtKB Binding site 32 32 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8266098;Dbxref=PMID:8266098 P00720 UniProtKB Binding site 104 104 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8266098;Dbxref=PMID:8266098 P00720 UniProtKB Binding site 117 117 . . . Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Binding site 132 132 . . . Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 11 11 . . . Note=Complete loss of enzymatic activity. E->A%2CF%2CH%2CM%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 11 11 . . . Note=Loss of 84%25 of enzymatic activity. E->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3382407;Dbxref=PMID:3382407 P00720 UniProtKB Mutagenesis 11 11 . . . Note=Complete loss of activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3382407;Dbxref=PMID:3382407 P00720 UniProtKB Mutagenesis 20 20 . . . Note=Complete loss of enzymatic activity. D->A%2CN%2CS%2CT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 20 20 . . . Note=Nearly no effet on specific enzymatic activity. D->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1892846;Dbxref=PMID:1892846 P00720 UniProtKB Mutagenesis 20 20 . . . Note=Loss of 99%25 of enzymatic activity. D->E%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3382407;Dbxref=PMID:3382407 P00720 UniProtKB Mutagenesis 26 26 . . . Note=Complete loss of activity at neutral pH%3B covalently bound substrate. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8266098;Dbxref=PMID:8266098 P00720 UniProtKB Mutagenesis 26 26 . . . Note=Facilitates transglycosylation more effectively than hydrolysis%3B covalently bound substrate. T->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28707339;Dbxref=PMID:28707339 P00720 UniProtKB Mutagenesis 30 30 . . . Note=Almost complete loss of enzymatic activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 30 30 . . . Note=Almost complete loss of enzymatic activity. The enzyme is destabilized by 1.5 kcal/mol. G->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 117 117 . . . Note=10-fold decrease in enzymatic activity. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 117 117 . . . Note=500-fold decrease in enzymatic activity. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 117 117 . . . Note=50-fold decrease in enzymatic activity. S->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 132 132 . . . Note=5-fold decrease in enzymatic activity. N->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Mutagenesis 132 132 . . . Note=2-fold decrease in enzymatic activity. N->M%2CF;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7831309;Dbxref=PMID:7831309 P00720 UniProtKB Sequence conflict 12 12 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P00720 UniProtKB Sequence conflict 137 137 . . . Note=I->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P00720 UniProtKB Helix 3 11 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5JDT P00720 UniProtKB Beta strand 14 19 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5JDT P00720 UniProtKB Beta strand 21 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5V88 P00720 UniProtKB Beta strand 25 28 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5JDT P00720 UniProtKB Beta strand 31 37 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7LOE P00720 UniProtKB Helix 39 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5JDT P00720 UniProtKB Beta strand 55 57 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3HH3 P00720 UniProtKB Helix 62 64 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Beta strand 65 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6D26 P00720 UniProtKB Helix 68 79 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Turn 82 84 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Helix 85 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Helix 93 106 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Helix 108 112 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Helix 115 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Turn 123 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:209L P00720 UniProtKB Helix 126 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Beta strand 134 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A5X P00720 UniProtKB Helix 137 141 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Helix 143 155 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Beta strand 156 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7LOE P00720 UniProtKB Turn 159 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O7A P00720 UniProtKB Helix 162 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4ARJ