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P00720 (ENLYS_BPT4) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endolysin

EC=3.2.1.17
Alternative name(s):
Lysis protein
Lysozyme
Muramidase
Gene names
Name:E
OrganismEnterobacteria phage T4 (Bacteriophage T4) [Reference proteome]
Taxonomic identifier10665 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer. Ref.5

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Host cytoplasm Potential. Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164Endolysin
PRO_0000218107

Sites

Active site111Proton donor
Active site201Nucleophile

Experimental info

Sequence conflict121R → G AA sequence Ref.1
Sequence conflict1371I → R AA sequence Ref.1

Secondary structure

...................................... 164
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00720 [UniParc].

Last modified May 14, 2014. Version 2.
Checksum: 02D568CC8FC81CF1

FASTA16418,692
        10         20         30         40         50         60 
MNIFEMLRID ERLRLKIYKD TEGYYTIGIG HLLTKSPSLN AAKSELDKAI GRNCNGVITK 

        70         80         90        100        110        120 
DEAEKLFNQD VDAAVRGILR NAKLKPVYDS LDAVRRCALI NMVFQMGETG VAGFTNSLRM 

       130        140        150        160 
LQQKRWDEAA VNLAKSIWYN QTPNRAKRVI TTFRTGTWDA YKNL 

« Hide

References

« Hide 'large scale' references
[1]"The amino acid sequence of T4 phage lysozyme. IV. Dilute acid hydrolysis and the order of tryptic peptides."
Inouye M., Imada M., Tsugita A.
J. Biol. Chem. 245:3479-3484(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Nucleotide sequence of the lysozyme gene of bacteriophage T4. Analysis of mutations involving repeated sequences."
Owen J.E., Schultz D.W., Taylor A., Smith G.R.
J. Mol. Biol. 165:229-248(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Nucleotide sequence and analysis of the 58.3 to 65.5-kb early region of bacteriophage T4."
Valerie K., Stevens J., Lynch M., Henderson E.E., de Riel J.K.
Nucleic Acids Res. 14:8637-8654(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Bacteriophage T4 genome."
Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.
Microbiol. Mol. Biol. Rev. 67:86-156(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Protein determinants of phage T4 lysis inhibition."
Moussa S.H., Kuznetsov V., Tran T.A., Sacchettini J.C., Young R.
Protein Sci. 21:571-582(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"The three dimensional structure of the lysozyme from bacteriophage T4."
Matthews B.W., Remington S.J.
Proc. Natl. Acad. Sci. U.S.A. 71:4178-4182(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
[7]"Structure of bacteriophage T4 lysozyme refined at 1.7-A resolution."
Weaver L.H., Matthews B.W.
J. Mol. Biol. 193:189-200(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
[8]"Atomic coordinates for T4 phage lysozyme."
Remington S.J., ten Eyck L.F., Matthews B.W.
Biochem. Biophys. Res. Commun. 75:265-270(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
[9]"Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3."
Matsumura M., Becktel W.J., Matthews B.W.
Nature 334:406-410(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF MUTANT ILE-3.
[10]"A mutant T4 lysozyme displays five different crystal conformations."
Faber H.R., Matthews B.W.
Nature 348:263-266(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF MUTANT.
[11]"A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene."
Eriksson A.E., Baase W.A., Wozniak J.A., Matthews B.W.
Nature 355:371-373(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF MUTANT.
[12]"Assignment of the backbone 1H and 15N NMR resonances of bacteriophage T4 lysozyme."
McIntosh L.P., Wand A.J., Lowry D.F., Redfield A.G., Dahlquist F.W.
Biochemistry 29:6341-6362(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04567 Genomic DNA. Translation: CAA28212.1.
AF158101 Genomic DNA. Translation: AAD42568.1.
PIRLZBPT4. A92896.
RefSeqNP_049736.1. NC_000866.4.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
102LX-ray1.74A1-164[»]
103LX-ray1.90A1-164[»]
104LX-ray2.80A/B1-164[»]
107LX-ray1.80A1-164[»]
108LX-ray1.80A1-164[»]
109LX-ray1.85A1-164[»]
110LX-ray1.70A1-164[»]
111LX-ray1.80A1-164[»]
112LX-ray1.80A1-164[»]
113LX-ray1.80A1-164[»]
114LX-ray1.80A1-164[»]
115LX-ray1.80A1-164[»]
118LX-ray1.80A1-164[»]
119LX-ray1.65A1-164[»]
120LX-ray1.80A1-164[»]
122LX-ray1.80A1-164[»]
123LX-ray1.80A1-164[»]
125LX-ray1.85A1-164[»]
126LX-ray1.80A1-164[»]
127LX-ray1.85A1-164[»]
128LX-ray1.70A1-164[»]
129LX-ray1.70A1-164[»]
130LX-ray1.70A1-164[»]
131LX-ray1.70A1-164[»]
137LX-ray1.85A/B1-164[»]
138LX-ray1.70A1-164[»]
139LX-ray1.70A1-164[»]
140LX-ray2.10A1-164[»]
141LX-ray2.00A1-164[»]
142LX-ray2.00A1-164[»]
143LX-ray2.00A1-164[»]
144LX-ray2.10A1-164[»]
145LX-ray2.00A1-164[»]
146LX-ray1.85A1-164[»]
147LX-ray2.00A1-164[»]
148LX-ray1.90E1-164[»]
149LX-ray2.60A1-164[»]
150LX-ray2.20A/B/C/D1-164[»]
151LX-ray2.20A1-164[»]
152LX-ray2.00A1-163[»]
155LX-ray1.85A1-164[»]
156LX-ray1.80A1-164[»]
157LX-ray1.85A1-164[»]
158LX-ray1.80A1-164[»]
159LX-ray1.80A1-164[»]
160LX-ray1.80A1-164[»]
161LX-ray1.70A1-164[»]
162LX-ray1.80A1-164[»]
163LX-ray1.80A1-164[»]
164LX-ray1.80A1-164[»]
165LX-ray1.75A1-164[»]
166LX-ray1.75A1-164[»]
167LX-ray2.20A/B1-163[»]
168LX-ray2.90A/B/C/D/E1-164[»]
169LX-ray3.00A/B/C/D/E1-164[»]
170LX-ray2.60A1-164[»]
171LX-ray2.50A1-164[»]
172LX-ray1.90A1-164[»]
173LX-ray1.70A1-164[»]
174LX-ray2.30A/B1-164[»]
175LX-ray2.10A/B1-164[»]
176LX-ray2.20A/B1-164[»]
177LX-ray2.50A1-164[»]
178LX-ray2.71A1-164[»]
180LX-ray1.75A/B1-164[»]
181LX-ray1.80A1-164[»]
182LX-ray1.80A1-164[»]
183LX-ray1.80A1-164[»]
184LX-ray1.80A1-164[»]
185LX-ray1.80A1-164[»]
186LX-ray1.80A1-164[»]
187LX-ray1.80A1-164[»]
188LX-ray1.80A1-164[»]
189LX-ray2.50A1-164[»]
190LX-ray2.00A1-164[»]
191LX-ray1.95A1-164[»]
192LX-ray1.90A1-164[»]
195LX-ray1.90A1-164[»]
196LX-ray2.30A1-164[»]
197LX-ray2.10A1-164[»]
198LX-ray2.00A1-164[»]
199LX-ray1.85A1-164[»]
1B6IX-ray1.90A1-164[»]
1C60X-ray2.00A1-164[»]
1C61X-ray2.00A1-164[»]
1C62X-ray2.30A1-164[»]
1C63X-ray2.00A1-164[»]
1C64X-ray2.00A1-164[»]
1C65X-ray2.00A1-164[»]
1C66X-ray2.10A1-164[»]
1C67X-ray2.20A1-164[»]
1C68X-ray2.50A1-164[»]
1C69X-ray1.80A1-164[»]
1C6AX-ray2.10A1-164[»]
1C6BX-ray2.20A1-164[»]
1C6CX-ray2.00A1-164[»]
1C6DX-ray2.00A1-164[»]
1C6EX-ray1.90A1-164[»]
1C6FX-ray2.00A1-164[»]
1C6GX-ray1.90A1-164[»]
1C6HX-ray1.90A1-164[»]
1C6IX-ray1.90A1-164[»]
1C6JX-ray1.90A1-164[»]
1C6KX-ray1.90A1-164[»]
1C6LX-ray1.90A1-164[»]
1C6MX-ray2.10A1-164[»]
1C6NX-ray2.20A1-164[»]
1C6PX-ray1.90A1-164[»]
1C6QX-ray1.90A1-164[»]
1C6TX-ray2.00A1-164[»]
1CTWX-ray2.10A1-164[»]
1CU0X-ray2.20A1-164[»]
1CU2X-ray1.85A1-164[»]
1CU3X-ray2.12A1-164[»]
1CU5X-ray2.05A1-164[»]
1CU6X-ray2.10A1-164[»]
1CUPX-ray1.89A1-164[»]
1CUQX-ray2.05A1-164[»]
1CV0X-ray2.12A1-164[»]
1CV1X-ray2.10A1-164[»]
1CV3X-ray1.80A1-164[»]
1CV4X-ray1.90A1-164[»]
1CV5X-ray1.87A1-164[»]
1CV6X-ray1.90A1-164[»]
1CVKX-ray1.80A1-164[»]
1CX6X-ray2.01A1-164[»]
1CX7X-ray1.94A1-164[»]
1D2WX-ray1.89A1-164[»]
1D2YX-ray2.06A1-164[»]
1D3FX-ray2.05A1-164[»]
1D3JX-ray1.97A1-164[»]
1D3MX-ray2.12A1-164[»]
1D3NX-ray2.00A1-164[»]
1D9WX-ray1.70A1-164[»]
1DYAX-ray1.90A1-164[»]
1DYBX-ray1.75A1-164[»]
1DYCX-ray2.10A1-164[»]
1DYDX-ray2.10A1-164[»]
1DYEX-ray1.80A1-164[»]
1DYFX-ray1.90A1-164[»]
1DYGX-ray2.10A1-164[»]
1EPYX-ray1.85A1-164[»]
1G06X-ray1.85A1-164[»]
1G07X-ray1.70A1-164[»]
1G0GX-ray1.90A1-164[»]
1G0JX-ray1.80A1-164[»]
1G0KX-ray1.85A1-164[»]
1G0LX-ray1.80A1-164[»]
1G0MX-ray1.70A1-164[»]
1G0PX-ray1.80A1-164[»]
1G0QX-ray1.80A1-164[»]
1G1VX-ray1.90A1-164[»]
1G1WX-ray1.80A1-164[»]
1I6SX-ray1.90A1-164[»]
1JQUX-ray2.60A/B/C/D1-164[»]
1JTMX-ray1.90A1-164[»]
1JTNX-ray2.30A/B1-164[»]
1KNIX-ray1.70A1-164[»]
1KS3X-ray2.16A1-162[»]
1KW5X-ray1.75A1-162[»]
1KW7X-ray1.89A1-162[»]
1KY0X-ray1.97A1-162[»]
1KY1X-ray2.05A1-162[»]
1L00X-ray1.90A1-164[»]
1L01X-ray1.70A1-164[»]
1L02X-ray1.70A1-164[»]
1L03X-ray1.70A1-164[»]
1L04X-ray1.70A1-164[»]
1L05X-ray1.70A1-164[»]
1L06X-ray1.70A1-164[»]
1L07X-ray1.70A1-164[»]
1L08X-ray1.70A1-164[»]
1L09X-ray1.70A1-164[»]
1L0JX-ray1.98A1-162[»]
1L0KX-ray2.02A1-162[»]
1L10X-ray1.70A1-164[»]
1L11X-ray1.70A1-164[»]
1L12X-ray1.70A1-164[»]
1L13X-ray1.70A1-164[»]
1L14X-ray1.70A1-164[»]
1L15X-ray1.70A1-164[»]
1L16X-ray1.70A1-164[»]
1L17X-ray1.70A1-164[»]
1L18X-ray1.70A1-164[»]
1L19X-ray1.70A1-164[»]
1L20X-ray1.85A1-164[»]
1L21X-ray1.85A1-164[»]
1L22X-ray1.70A1-164[»]
1L23X-ray1.70A1-164[»]
1L24X-ray1.70A1-164[»]
1L25X-ray1.80A1-164[»]
1L26X-ray1.70A1-164[»]
1L27X-ray1.80A1-164[»]
1L28X-ray1.90A1-164[»]
1L29X-ray1.70A1-164[»]
1L30X-ray1.70A1-164[»]
1L31X-ray1.80A1-164[»]
1L32X-ray1.70A1-164[»]
1L33X-ray1.70A1-164[»]
1L34X-ray1.90A1-164[»]
1L35X-ray1.80A1-163[»]
1L36X-ray1.70A1-164[»]
1L37X-ray1.85A1-164[»]
1L38X-ray1.80A1-164[»]
1L39X-ray1.85A1-164[»]
1L40X-ray1.85A1-164[»]
1L41X-ray1.75A1-164[»]
1L42X-ray1.80A1-164[»]
1L43X-ray1.80A1-164[»]
1L44X-ray1.70A1-164[»]
1L45X-ray1.70A1-164[»]
1L46X-ray1.70A1-164[»]
1L47X-ray1.70A1-164[»]
1L48X-ray1.70A1-164[»]
1L49X-ray1.80A1-164[»]
1L50X-ray1.85A1-164[»]
1L51X-ray1.90A1-164[»]
1L52X-ray1.70A1-164[»]
1L53X-ray1.85A1-164[»]
1L54X-ray1.90A1-164[»]
1L55X-ray1.90A1-164[»]
1L56X-ray1.80A1-164[»]
1L57X-ray1.90A1-164[»]
1L58X-ray1.65A1-164[»]
1L59X-ray1.75A1-164[»]
1L60X-ray1.70A1-164[»]
1L61X-ray1.80A1-164[»]
1L62X-ray1.70A1-164[»]
1L63X-ray1.75A1-164[»]
1L64X-ray1.90A1-164[»]
1L65X-ray1.70A1-164[»]
1L66X-ray1.70A1-164[»]
1L67X-ray1.90A1-164[»]
1L68X-ray1.70A1-164[»]
1L69X-ray1.90A1-164[»]
1L70X-ray1.90A1-164[»]
1L71X-ray1.85A1-164[»]
1L72X-ray1.85A1-164[»]
1L73X-ray1.85A1-164[»]
1L74X-ray1.70A1-164[»]
1L75X-ray1.90A1-164[»]
1L76X-ray1.90A1-164[»]
1L77X-ray2.05A1-164[»]
1L79X-ray1.90A1-164[»]
1L80X-ray1.80A1-164[»]
1L81X-ray2.00A1-164[»]
1L82X-ray2.10A1-164[»]
1L83X-ray1.70A1-164[»]
1L84X-ray1.90A1-164[»]
1L85X-ray2.00A1-164[»]
1L86X-ray1.80A1-164[»]
1L87X-ray1.80A1-164[»]
1L88X-ray1.85A1-164[»]
1L89X-ray1.90A1-164[»]
1L90X-ray1.75A1-164[»]
1L91X-ray1.80A1-164[»]
1L92X-ray1.70A1-164[»]
1L93X-ray1.80A1-164[»]
1L94X-ray1.80A1-164[»]
1L95X-ray2.00A1-164[»]
1L96X-ray2.00A1-164[»]
1L97X-ray2.00A/B1-164[»]
1L98X-ray1.80A1-164[»]
1L99X-ray1.95A1-164[»]
1LGUX-ray1.90A1-164[»]
1LGWX-ray1.85A1-164[»]
1LGXX-ray1.90A1-164[»]
1LI2X-ray2.00A1-164[»]
1LI3X-ray1.85A1-164[»]
1LI6X-ray2.00A1-164[»]
1LLHX-ray1.80A1-164[»]
1LPYX-ray1.65A1-164[»]
1LW9X-ray1.45A1-164[»]
1LWGX-ray1.70A1-164[»]
1LWKX-ray2.10A1-164[»]
1LYDX-ray2.00A1-164[»]
1LYEX-ray1.80A1-164[»]
1LYFX-ray1.80A1-164[»]
1LYGX-ray1.80A1-164[»]
1LYHX-ray1.70A1-164[»]
1LYIX-ray2.00A1-164[»]
1LYJX-ray1.80A1-164[»]
1NHBX-ray1.80A1-164[»]
1OV5X-ray2.10A1-164[»]
1OV7X-ray2.00A1-164[»]
1OVHX-ray1.95A1-164[»]
1OVJX-ray2.00A1-164[»]
1OVKX-ray2.10A1-164[»]
1OWYX-ray1.90A1-164[»]
1OWZX-ray1.90A1-164[»]
1OYUX-ray2.50A/B1-164[»]
1P2LX-ray1.58A1-164[»]
1P2RX-ray1.58A1-164[»]
1P36X-ray1.45A1-164[»]
1P37X-ray1.57A1-164[»]
1P3NX-ray1.55A1-164[»]
1P46X-ray1.67A1-164[»]
1P56X-ray1.80A1-162[»]
1P5CX-ray2.50A/B/C/D12-163[»]
1P64X-ray1.62A1-164[»]
1P6YX-ray1.54A1-164[»]
1P7SX-ray1.50A1-164[»]
1PQDX-ray1.65A1-164[»]
1PQIX-ray1.57A1-164[»]
1PQJX-ray1.90A1-164[»]
1PQKX-ray2.00A/B/C1-164[»]
1PQMX-ray1.52A1-164[»]
1PQOX-ray1.65A1-164[»]
1QS5X-ray2.50A1-162[»]
1QS9X-ray1.85A1-162[»]
1QSBX-ray1.80A1-162[»]
1QSQX-ray1.90A1-164[»]
1QT3X-ray1.85A1-164[»]
1QT4X-ray2.10A1-164[»]
1QT5X-ray1.80A1-164[»]
1QT6X-ray1.90A1-164[»]
1QT7X-ray1.80A1-164[»]
1QT8X-ray1.90A1-164[»]
1QTBX-ray1.90A1-162[»]
1QTCX-ray2.50A1-162[»]
1QTDX-ray2.50A1-162[»]
1QTHX-ray1.90A/B1-164[»]
1QTVX-ray2.30A1-164[»]
1QTZX-ray2.00A1-164[»]
1QUDX-ray1.75A1-162[»]
1QUGX-ray1.90A1-162[»]
1QUHX-ray1.85A1-162[»]
1QUOX-ray1.90A1-162[»]
1SSWX-ray2.13A1-164[»]
1SSYX-ray2.40A/B1-164[»]
1SWYX-ray1.06A1-164[»]
1SWZX-ray1.06A1-164[»]
1SX2X-ray1.06A1-164[»]
1SX7X-ray1.06A1-164[»]
1T6HX-ray2.01A1-164[»]
1T8AX-ray2.00A1-164[»]
1T8FX-ray2.15A1-164[»]
1T8GX-ray1.80A1-164[»]
1T97X-ray2.70A/B1-164[»]
1TLAX-ray2.00A1-164[»]
1XEPX-ray1.55A1-164[»]
1ZURX-ray1.60A1-164[»]
1ZWNX-ray1.80A1-164[»]
1ZYTX-ray1.70A1-164[»]
200LX-ray1.95A1-164[»]
201LX-ray2.00A/B1-164[»]
205LX-ray2.10A1-164[»]
206LX-ray1.75A1-164[»]
209LX-ray2.70A1-164[»]
210LX-ray1.89A1-164[»]
211LX-ray1.70A1-164[»]
212LX-ray1.76A1-164[»]
213LX-ray2.13A1-164[»]
214LX-ray1.89A1-164[»]
215LX-ray1.96A1-164[»]
216LX-ray2.10A/B1-164[»]
217LX-ray1.70A1-164[»]
218LX-ray2.05A1-164[»]
219LX-ray1.66A1-164[»]
220LX-ray1.85A1-164[»]
221LX-ray1.70A1-164[»]
222LX-ray1.90A1-164[»]
223LX-ray1.90A1-164[»]
224LX-ray1.85A1-164[»]
225LX-ray1.90A1-164[»]
226LX-ray1.80A1-164[»]
227LX-ray2.00A1-164[»]
228LX-ray1.90A1-164[»]
229LX-ray1.80A1-164[»]
230LX-ray1.90A1-164[»]
231LX-ray2.50A1-164[»]
232LX-ray1.73A1-164[»]
233LX-ray1.90A1-164[»]
234LX-ray1.90A1-164[»]
235LX-ray1.90A1-164[»]
236LX-ray1.90A1-164[»]
237LX-ray1.70A1-164[»]
238LX-ray1.80A1-164[»]
239LX-ray1.80A1-164[»]
240LX-ray1.75A1-164[»]
241LX-ray1.70A1-164[»]
242LX-ray1.80A1-164[»]
243LX-ray1.75A1-164[»]
244LX-ray1.70A1-164[»]
245LX-ray1.80A1-164[»]
246LX-ray1.80A1-164[»]
247LX-ray1.75A1-164[»]
248LX-ray1.90A1-164[»]
249LX-ray1.90A1-164[»]
250LX-ray1.80A1-164[»]
251LX-ray2.60A1-164[»]
252LX-ray2.10A1-164[»]
253LX-ray2.00A1-164[»]
254LX-ray1.90A1-164[»]
255LX-ray1.80A1-164[»]
256LX-ray1.80A1-164[»]
257LX-ray1.90A1-164[»]
258LX-ray1.80A1-164[»]
259LX-ray1.92A1-164[»]
260LX-ray1.80A1-164[»]
261LX-ray2.50A1-162[»]
262LX-ray2.50A/B1-162[»]
2A4TX-ray1.70A1-164[»]
2B6TX-ray2.10A1-162[»]
2B6WX-ray2.20A1-162[»]
2B6XX-ray2.11A1-162[»]
2B6YX-ray2.40A1-162[»]
2B6ZX-ray2.40A1-162[»]
2B70X-ray2.40A1-162[»]
2B72X-ray2.10A1-162[»]
2B73X-ray2.15A1-162[»]
2B74X-ray2.10A1-162[»]
2B75X-ray2.10A1-162[»]
2B7XX-ray3.00A/B/C/D1-164[»]
2CUUX-ray1.75A1-164[»]
2F2QX-ray1.45A1-164[»]
2F32X-ray1.80A1-164[»]
2F47X-ray1.70A1-164[»]
2HUKX-ray2.00A1-164[»]
2HULX-ray1.80A1-164[»]
2HUMX-ray2.35A/B1-164[»]
2IGCX-ray1.40A1-164[»]
2L78X-ray2.00A1-164[»]
2LC9NMR-A1-164[»]
2LCBNMR-A1-164[»]
2LZMX-ray1.70A1-164[»]
2NTGX-ray1.40A1-164[»]
2NTHX-ray1.80A1-164[»]
2O4WX-ray1.90A13-164[»]
2O79X-ray1.80A1-164[»]
2O7AX-ray0.84A60-164[»]
2OE4X-ray2.10X1-164[»]
2OE7X-ray2.10X1-164[»]
2OE9X-ray2.01X1-164[»]
2OEAX-ray2.01X1-164[»]
2OTYX-ray1.83X1-162[»]
2OTZX-ray2.07X1-162[»]
2OU0X-ray1.94X1-162[»]
2OU8X-ray1.80A1-164[»]
2OU9X-ray1.55A1-164[»]
2Q9DX-ray1.40A1-164[»]
2Q9EX-ray2.10A/B/C1-164[»]
2QARX-ray2.40C/F2-162[»]
2QB0X-ray2.56B/D2-162[»]
2RAYX-ray1.80X1-162[»]
2RAZX-ray1.64X1-162[»]
2RB0X-ray1.84X1-162[»]
2RB1X-ray1.70X1-162[»]
2RB2X-ray1.46X1-162[»]
2RBNX-ray1.29A1-162[»]
2RBOX-ray1.29A1-162[»]
2RBPX-ray1.47A1-162[»]
2RBQX-ray1.63A1-162[»]
2RBRX-ray1.43A1-162[»]
2RBSX-ray1.56A1-162[»]
2RH1X-ray2.40A2-161[»]
3C7WX-ray1.77A1-164[»]
3C7YX-ray1.95A1-164[»]
3C7ZX-ray1.67A1-164[»]
3C80X-ray1.99A1-164[»]
3C81X-ray1.85A1-164[»]
3C82X-ray1.68A1-164[»]
3C83X-ray1.84A1-164[»]
3C8QX-ray1.64A1-164[»]
3C8RX-ray1.80A1-164[»]
3C8SX-ray1.68A1-164[»]
3CDOX-ray1.87A/B/C/D1-164[»]
3CDQX-ray1.68A1-164[»]
3CDRX-ray1.70A1-164[»]
3CDTX-ray1.63A1-164[»]
3CDVX-ray1.73A1-164[»]
3D4SX-ray2.80A2-161[»]
3DKEX-ray1.25X1-164[»]
3DMVX-ray1.65A1-164[»]
3DMXX-ray1.80A1-164[»]
3DMZX-ray2.00A1-164[»]
3DN0X-ray1.80A1-164[»]
3DN1X-ray1.80A1-164[»]
3DN2X-ray1.80A1-164[»]
3DN3X-ray1.80A1-164[»]
3DN4X-ray1.80A1-164[»]
3DN6X-ray1.80A1-164[»]
3DN8X-ray1.70A1-164[»]
3DNAX-ray1.70A1-164[»]
3EMLX-ray2.60A2-161[»]
3F8VX-ray1.08A1-164[»]
3F9LX-ray1.19A1-164[»]
3FA0X-ray1.09A1-162[»]
3FADX-ray1.20A1-164[»]
3FI5X-ray1.53A/B/C/D1-164[»]
3G3VX-ray2.10A1-164[»]
3G3WX-ray2.30A1-164[»]
3G3XX-ray1.80A1-164[»]
3GUIX-ray1.45A1-164[»]
3GUJX-ray1.60A1-164[»]
3GUKX-ray1.85A/B1-164[»]
3GULX-ray2.07A/B1-164[»]
3GUMX-ray2.24A/B1-164[»]
3GUNX-ray1.50A/B1-164[»]
3GUOX-ray2.16A/B1-164[»]
3GUPX-ray1.50A/B1-164[»]
3HH3X-ray1.25A1-164[»]
3HH4X-ray1.25A1-164[»]
3HH5X-ray1.25A1-164[»]
3HH6X-ray1.25A1-164[»]
3HT6X-ray1.59A1-164[»]
3HT7X-ray1.70A1-164[»]
3HT8X-ray1.60A1-164[»]
3HT9X-ray2.02A1-164[»]
3HTBX-ray1.81A1-164[»]
3HTDX-ray1.40A1-164[»]
3HTFX-ray1.85A1-164[»]
3HTGX-ray1.26A1-164[»]
3HU8X-ray1.80A1-164[»]
3HU9X-ray1.46A1-164[»]
3HUAX-ray1.40A1-164[»]
3HUKX-ray1.29A1-164[»]
3HUQX-ray1.45A1-162[»]
3HWLX-ray1.80A1-164[»]
3JR6X-ray3.00A/B/C/D1-164[»]
3K2RX-ray1.50A1-164[»]
3L2XX-ray1.80A1-164[»]
3L64X-ray1.90A1-164[»]
3LZMX-ray1.70A1-164[»]
3NY8X-ray2.84A2-161[»]
3NY9X-ray2.84A2-161[»]
3NYAX-ray3.16A2-161[»]
3ODUX-ray2.50A/B2-161[»]
3OE0X-ray2.90A2-161[»]
3OE6X-ray3.20A2-161[»]
3OE8X-ray3.10A/B/C2-161[»]
3OE9X-ray3.10A/B2-161[»]
3P0GX-ray3.50A2-161[»]
3PBLX-ray2.89A/B2-161[»]
3PDSX-ray3.50A2-162[»]
3QAKX-ray2.71A2-161[»]
3RUNX-ray1.40A1-164[»]
3RZEX-ray3.10A2-161[»]
3SB5X-ray2.46A/B/C/D1-162[»]
3SB6X-ray2.70A/B1-162[»]
3SB7X-ray2.70A/B1-162[»]
3SB8X-ray2.65A/B/C1-162[»]
3SB9X-ray2.45A/B1-162[»]
3SBAX-ray2.75A/B/C/D/E/F1-162[»]
3SBBX-ray1.43C1-162[»]
3SN6X-ray3.20R2-161[»]
3UONX-ray3.00A2-161[»]
3V2WX-ray3.35A2-161[»]
3V2YX-ray2.80A2-161[»]
3VW7X-ray2.20A2-161[»]
4ARJX-ray2.59A/B2-164[»]
4DAJX-ray3.40A/B/C/D1-161[»]
4DJHX-ray2.90A/B2-161[»]
4DKLX-ray2.80A2-161[»]
4E97X-ray1.30A/B1-164[»]
4EJ4X-ray3.40A2-161[»]
4EKPX-ray1.64A/B1-164[»]
4EKQX-ray1.54A/B1-164[»]
4EKRX-ray1.49A/B1-164[»]
4EKSX-ray1.64A/B1-164[»]
4EPIX-ray1.74A3-164[»]
4EXMX-ray2.60A/B/C/D3-164[»]
4GBRX-ray3.99B2-161[»]
4GRVX-ray2.80A2-161[»]
4HTTX-ray6.80A/B1-164[»]
4I7JX-ray1.67A/B1-164[»]
4I7KX-ray1.72A/B1-164[»]
4I7LX-ray1.52A/B1-164[»]
4I7MX-ray1.48A/B1-164[»]
4I7NX-ray1.58A/B1-164[»]
4I7OX-ray1.73A/B1-164[»]
4I7PX-ray1.60A/B1-164[»]
4I7QX-ray1.58A/B1-164[»]
4I7RX-ray1.52A/B1-164[»]
4I7SX-ray1.69A/B1-164[»]
4I7TX-ray1.55A/B1-164[»]
4IAPX-ray2.30A/B2-161[»]
4K5YX-ray2.98A/B/C2-161[»]
4LDEX-ray2.79A2-161[»]
4LDLX-ray3.10A2-161[»]
4LDOX-ray3.20A2-161[»]
4LZMX-ray1.70A1-164[»]
5LZMX-ray1.80A1-164[»]
6LZMX-ray1.80A1-164[»]
7LZMX-ray1.80A1-164[»]
ProteinModelPortalP00720.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP00720.
ChEMBLCHEMBL5206.
DrugBankDB00536. Guanidine.

Protein family/group databases

CAZyGH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1258585.

Family and domain databases

Gene3D1.10.530.40. 1 hit.
InterProIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
IPR001165. Phage_T4_Gp5_lysozyme.
[Graphical view]
PfamPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
PRINTSPR00684. T4LYSOZYME.
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP00720.

Entry information

Entry nameENLYS_BPT4
AccessionPrimary (citable) accession number: P00720
Secondary accession number(s): Q38170, Q94N07
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 14, 2014
Last modified: July 9, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries