Reviewed, UniProtKB/Swiss-Prot P00719 (LYG_STRCA)

Names and origin

Protein names	Recommended name:     Lysozyme g     EC=3.2.1.17 Alternative name(s):     1,4-beta-N-acetylmuramidase     Goose-type lysozyme
Organism	Struthio camelus (Ostrich)
Taxonomic identifier	8801 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Palaeognathae › Struthioniformes › Struthionidae › Struthio

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted.
Miscellaneous	Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.
Sequence similarities	Belongs to the glycosyl hydrolase 23 family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Lysozyme g		PRO_0000193516
Sites
	Active site	73	1	By similarity
	Active site	86	1	By similarity
Amino acid modifications
	Disulfide bond	4 ↔ 60		By similarity
	Disulfide bond	18 ↔ 29		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00719-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 02B78AF5D526B5DC	FASTA	185	20,563
	10 20 30 40 50 60 RTGCYGDVNR VDTTGASCKS AKPEKLNYCG VAASRKIAER DLQSMDRYKA LIKKVGQKLC 70 80 90 100 110 120 VDPAVIAGII SRESHAGKAL RNGWGDNGNG FGLMQVDRRS HKPVGEWNGE RHLMQGTEIL 130 140 150 160 170 180 ISMIKAIQKK FPRWTKEQQL KGGISAYNAG PGNVRSYERM DIGTTHDDYA NDVVARAQYY KQHGY

References

[1]	"Complete amino acid sequence of ostrich (Struthio camelus) egg-white lysozyme, a goose-type lysozyme." Schoentgen F., Jolles J., Jolles P. Eur. J. Biochem. 123:489-497(1982) [PubMed: 7075596] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Egg white.
[2]	"The ostrich (Struthio camelus) egg-white lysozyme." Jolles J., Perin J.-P., Jolles P. Mol. Cell. Biochem. 17:39-44(1977) [PubMed: 904618] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-34. Tissue: Egg white.

Cross-references

Sequence databases
PIR	LZOSG. A00874.
3D structure databases
HSSP	HSSP built from PDB template 153L based on UniProtKB P00718.
SMR	P00719. Positions 1-185.
ModBase	Search...
Protein family/group databases
CAZy	GH23. Glycoside Hydrolase Family 23.
Phylogenomic databases
HOVERGEN	P00719.
Enzyme and pathway databases
BRENDA	3.2.1.17. 39275.
Family and domain databases
InterPro	IPR002152. Glyco_hydro_23. IPR008258. Lytic_TGlycosylase-like_cat. [Graphical view]
Pfam	PF01464. SLT. 1 hit. [Graphical view]
PIRSF	PIRSF001065. Lysozyme_g. 1 hit.
PRINTS	PR00749. LYSOZYMEG.
ProtoNet	Search...

Entry information

Entry name

LYG_STRCA

Accession

Primary (citable) accession number: P00719

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)