P00719 (LYG_STRCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Lysozyme g EC=3.2.1.17 Alternative name(s): 1,4-beta-N-acetylmuramidase Goose-type lysozyme
Organism	Struthio camelus (Ostrich)
Taxonomic identifier	8801 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Palaeognathae › Struthioniformes › Struthionidae › Struthio

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has bacteriolytic activity against M.luteus. Ref.1
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted.
Miscellaneous	Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.
Sequence similarities	Belongs to the glycosyl hydrolase 23 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.2 Ref.3
	Chain	20 – 204	185	Lysozyme g		PRO_0000193516
Sites
	Active site	92	1	By similarity
	Active site	105	1	By similarity
Amino acid modifications
	Disulfide bond	23 ↔ 79		By similarity
	Disulfide bond	37 ↔ 48		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00719 [UniParc]. Last modified September 5, 2012. Version 2. Checksum: DD9F02D65DA21A65	FASTA	204	22,514
	10 20 30 40 50 60 MHLMLVLLGL AALLGTSQSR TGCYGDVNRV DTTGASCKSA KPEKLNYCGV AASRKIAERD 70 80 90 100 110 120 LQSMDRYKAL IKKVGQKLCV DPAVIAGIIS RESHAGKALR NGWGDNGNGF GLMQVDRRSH 130 140 150 160 170 180 KPVGEWNGER HLMQGTEILI SMIKAIQKKF PRWTKEQQLK GGISAYNAGP GNVRSYERMD 190 200 IGTTHDDYAN DVVARAQYYK QHGY

References

[1]	"Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white." Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T. Gene 492:244-249(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Tissue: Muscle.
[2]	"Complete amino acid sequence of ostrich (Struthio camelus) egg-white lysozyme, a goose-type lysozyme." Schoentgen F., Jolles J., Jolles P. Eur. J. Biochem. 123:489-497(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-204. Tissue: Egg white.
[3]	"The ostrich (Struthio camelus) egg-white lysozyme." Jolles J., Perin J.-P., Jolles P. Mol. Cell. Biochem. 17:39-44(1977) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-53. Tissue: Egg white.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB469329 Genomic DNA. Translation: BAL03620.1.
PIR	LZOSG. A00874.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GH23. Glycoside Hydrolase Family 23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006299.
Family and domain databases
InterPro	IPR002152. Glyco_hydro_23. IPR023346. Lysozyme-like_dom. IPR008258. Lytic_TGlycosylase-like_cat. [Graphical view]
Pfam	PF01464. SLT. 1 hit. [Graphical view]
PIRSF	PIRSF001065. Lysozyme_g. 1 hit.
PRINTS	PR00749. LYSOZYMEG.
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYG_STRCA

Accession

Primary (citable) accession number: P00719
Secondary accession number(s): G3XDE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	September 5, 2012
Last modified:	April 3, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program