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P00719

- LYG_STRCA

UniProt

P00719 - LYG_STRCA

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Protein
Lysozyme g
Gene
N/A
Organism
Struthio camelus (Ostrich)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Has bacteriolytic activity against M.luteus.1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921 By similarity
Active sitei105 – 1051 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme g (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Goose-type lysozyme
OrganismiStruthio camelus (Ostrich)
Taxonomic identifieri8801 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 Publications
Add
BLAST
Chaini20 – 204185Lysozyme g
PRO_0000193516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 79 By similarity
Disulfide bondi37 ↔ 48 By similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006299.

Family and domain databases

InterProiIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
PRINTSiPR00749. LYSOZYMEG.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00719-1 [UniParc]FASTAAdd to Basket

« Hide

MHLMLVLLGL AALLGTSQSR TGCYGDVNRV DTTGASCKSA KPEKLNYCGV    50
AASRKIAERD LQSMDRYKAL IKKVGQKLCV DPAVIAGIIS RESHAGKALR 100
NGWGDNGNGF GLMQVDRRSH KPVGEWNGER HLMQGTEILI SMIKAIQKKF 150
PRWTKEQQLK GGISAYNAGP GNVRSYERMD IGTTHDDYAN DVVARAQYYK 200
QHGY 204
Length:204
Mass (Da):22,514
Last modified:September 5, 2012 - v2
Checksum:iDD9F02D65DA21A65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB469329 Genomic DNA. Translation: BAL03620.1.
PIRiA00874. LZOSG.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB469329 Genomic DNA. Translation: BAL03620.1 .
PIRi A00874. LZOSG.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH23. Glycoside Hydrolase Family 23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006299.

Family and domain databases

InterProi IPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view ]
Pfami PF01464. SLT. 1 hit.
[Graphical view ]
PIRSFi PIRSF001065. Lysozyme_g. 1 hit.
PRINTSi PR00749. LYSOZYMEG.
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white."
    Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T.
    Gene 492:244-249(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Tissue: Muscle.
  2. "Complete amino acid sequence of ostrich (Struthio camelus) egg-white lysozyme, a goose-type lysozyme."
    Schoentgen F., Jolles J., Jolles P.
    Eur. J. Biochem. 123:489-497(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-204.
    Tissue: Egg white.
  3. "The ostrich (Struthio camelus) egg-white lysozyme."
    Jolles J., Perin J.-P., Jolles P.
    Mol. Cell. Biochem. 17:39-44(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-53.
    Tissue: Egg white.

Entry informationi

Entry nameiLYG_STRCA
AccessioniPrimary (citable) accession number: P00719
Secondary accession number(s): G3XDE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 5, 2012
Last modified: October 16, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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