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P00719 (LYG_STRCA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme g

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
Goose-type lysozyme
OrganismStruthio camelus (Ostrich)
Taxonomic identifier8801 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has bacteriolytic activity against M.luteus. Ref.1

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Secreted.

Miscellaneous

Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

Sequence similarities

Belongs to the glycosyl hydrolase 23 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.2 Ref.3
Chain20 – 204185Lysozyme g
PRO_0000193516

Sites

Active site921 By similarity
Active site1051 By similarity

Amino acid modifications

Disulfide bond23 ↔ 79 By similarity
Disulfide bond37 ↔ 48 By similarity

Sequences

Sequence LengthMass (Da)Tools
P00719 [UniParc].

Last modified September 5, 2012. Version 2.
Checksum: DD9F02D65DA21A65

FASTA20422,514
        10         20         30         40         50         60 
MHLMLVLLGL AALLGTSQSR TGCYGDVNRV DTTGASCKSA KPEKLNYCGV AASRKIAERD 

        70         80         90        100        110        120 
LQSMDRYKAL IKKVGQKLCV DPAVIAGIIS RESHAGKALR NGWGDNGNGF GLMQVDRRSH 

       130        140        150        160        170        180 
KPVGEWNGER HLMQGTEILI SMIKAIQKKF PRWTKEQQLK GGISAYNAGP GNVRSYERMD 

       190        200 
IGTTHDDYAN DVVARAQYYK QHGY 

« Hide

References

[1]"Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white."
Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T.
Gene 492:244-249(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Tissue: Muscle.
[2]"Complete amino acid sequence of ostrich (Struthio camelus) egg-white lysozyme, a goose-type lysozyme."
Schoentgen F., Jolles J., Jolles P.
Eur. J. Biochem. 123:489-497(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-204.
Tissue: Egg white.
[3]"The ostrich (Struthio camelus) egg-white lysozyme."
Jolles J., Perin J.-P., Jolles P.
Mol. Cell. Biochem. 17:39-44(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-53.
Tissue: Egg white.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB469329 Genomic DNA. Translation: BAL03620.1.
PIRLZOSG. A00874.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH23. Glycoside Hydrolase Family 23.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006299.

Family and domain databases

InterProIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamPF01464. SLT. 1 hit.
[Graphical view]
PIRSFPIRSF001065. Lysozyme_g. 1 hit.
PRINTSPR00749. LYSOZYMEG.
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYG_STRCA
AccessionPrimary (citable) accession number: P00719
Secondary accession number(s): G3XDE1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 5, 2012
Last modified: October 16, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries