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P00719

- LYG_STRCA

UniProt

P00719 - LYG_STRCA

Protein

Lysozyme g

Gene
N/A
Organism
Struthio camelus (Ostrich)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Has bacteriolytic activity against M.luteus.1 Publication

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921By similarity
    Active sitei105 – 1051By similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH23. Glycoside Hydrolase Family 23.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme g (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase
    Goose-type lysozyme
    OrganismiStruthio camelus (Ostrich)
    Taxonomic identifieri8801 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeStruthioniformesStruthionidaeStruthio

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19192 PublicationsAdd
    BLAST
    Chaini20 – 204185Lysozyme gPRO_0000193516Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 79By similarity
    Disulfide bondi37 ↔ 48By similarity

    Keywords - PTMi

    Disulfide bond

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 23 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006299.

    Family and domain databases

    InterProiIPR002152. Glyco_hydro_23.
    IPR023346. Lysozyme-like_dom.
    IPR008258. TGlycosylase-like_SLT.
    [Graphical view]
    PfamiPF01464. SLT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
    PRINTSiPR00749. LYSOZYMEG.
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00719-1 [UniParc]FASTAAdd to Basket

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    MHLMLVLLGL AALLGTSQSR TGCYGDVNRV DTTGASCKSA KPEKLNYCGV    50
    AASRKIAERD LQSMDRYKAL IKKVGQKLCV DPAVIAGIIS RESHAGKALR 100
    NGWGDNGNGF GLMQVDRRSH KPVGEWNGER HLMQGTEILI SMIKAIQKKF 150
    PRWTKEQQLK GGISAYNAGP GNVRSYERMD IGTTHDDYAN DVVARAQYYK 200
    QHGY 204
    Length:204
    Mass (Da):22,514
    Last modified:September 5, 2012 - v2
    Checksum:iDD9F02D65DA21A65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB469329 Genomic DNA. Translation: BAL03620.1.
    PIRiA00874. LZOSG.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB469329 Genomic DNA. Translation: BAL03620.1 .
    PIRi A00874. LZOSG.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH23. Glycoside Hydrolase Family 23.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006299.

    Family and domain databases

    InterProi IPR002152. Glyco_hydro_23.
    IPR023346. Lysozyme-like_dom.
    IPR008258. TGlycosylase-like_SLT.
    [Graphical view ]
    Pfami PF01464. SLT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001065. Lysozyme_g. 1 hit.
    PRINTSi PR00749. LYSOZYMEG.
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white."
      Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T.
      Gene 492:244-249(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Tissue: Muscle.
    2. "Complete amino acid sequence of ostrich (Struthio camelus) egg-white lysozyme, a goose-type lysozyme."
      Schoentgen F., Jolles J., Jolles P.
      Eur. J. Biochem. 123:489-497(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-204.
      Tissue: Egg white.
    3. "The ostrich (Struthio camelus) egg-white lysozyme."
      Jolles J., Perin J.-P., Jolles P.
      Mol. Cell. Biochem. 17:39-44(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-53.
      Tissue: Egg white.

    Entry informationi

    Entry nameiLYG_STRCA
    AccessioniPrimary (citable) accession number: P00719
    Secondary accession number(s): G3XDE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3