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P00718

- LYG_ANSAN

UniProt

P00718 - LYG_ANSAN

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Protein

Lysozyme g

Gene
N/A
Organism
Anser anser anser (Western graylag goose)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731
Active sitei86 – 861

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme g (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Goose-type lysozyme
OrganismiAnser anser anser (Western graylag goose)
Taxonomic identifieri8844 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Lysozyme gPRO_0000193513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 60
Disulfide bondi18 ↔ 29

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
185
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 103
Helixi18 – 214
Helixi22 – 243
Helixi31 – 4010
Helixi42 – 465
Helixi49 – 5911
Helixi63 – 7412
Turni75 – 795
Turni92 – 954
Turni98 – 1003
Helixi110 – 13021
Helixi136 – 14914
Helixi151 – 1533
Turni158 – 1636
Helixi165 – 1673
Helixi169 – 18214

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
153LX-ray1.60A1-185[»]
154LX-ray1.60A1-185[»]
ProteinModelPortaliP00718.
SMRiP00718. Positions 1-185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00718.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 23 family.Curated

Phylogenomic databases

HOVERGENiHBG006299.

Family and domain databases

InterProiIPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
PIRSFiPIRSF001065. Lysozyme_g. 1 hit.
PRINTSiPR00749. LYSOZYMEG.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P00718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RTDCYGNVNR IDTTGASCKT AKPEGLSYCG VSASKKIAER DLQAMDRYKT
60 70 80 90 100
IIKKVGEKLC VEPAVIAGII SRESHAGKVL KNGWGDRGNG FGLMQVDKRS
110 120 130 140 150
HKPQGTWNGE VHITQGTTIL INFIKTIQKK FPSWTKDQQL KGGISAYNAG
160 170 180
AGNVRSYARM DIGTTHDDYA NDVVARAQYY KQHGY
Length:185
Mass (Da):20,373
Last modified:July 21, 1986 - v1
Checksum:i0B2F0C9B2A66C324
GO

Sequence databases

PIRiA00873. LZGSG.

Cross-referencesi

Sequence databases

PIRi A00873. LZGSG.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
153L X-ray 1.60 A 1-185 [» ]
154L X-ray 1.60 A 1-185 [» ]
ProteinModelPortali P00718.
SMRi P00718. Positions 1-185.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH23. Glycoside Hydrolase Family 23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006299.

Miscellaneous databases

EvolutionaryTracei P00718.

Family and domain databases

InterProi IPR002152. Glyco_hydro_23.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
[Graphical view ]
Pfami PF01464. SLT. 1 hit.
[Graphical view ]
PIRSFi PIRSF001065. Lysozyme_g. 1 hit.
PRINTSi PR00749. LYSOZYMEG.
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete amino acid sequence of Embden goose (Anser anser) egg-white lysozyme."
    Simpson R.J., Morgan F.J.
    Biochim. Biophys. Acta 744:349-351(1983)
    Cited for: PROTEIN SEQUENCE.
    Strain: Embden breed.
    Tissue: Egg white.
  2. "Goose lysozyme structure: an evolutionary link between hen and bacteriophage lysozymes?"
    Gruetter M.G., Weaver L.H., Matthews B.W.
    Nature 303:828-831(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  3. "The refined structures of goose lysozyme and its complex with a bound trisaccharide show that the 'goose-type' lysozymes lack a catalytic aspartate residue."
    Weaver L.H., Gruetter M.G., Matthews B.W.
    J. Mol. Biol. 245:54-68(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiLYG_ANSAN
AccessioniPrimary (citable) accession number: P00718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3