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Protein

Alpha-lactalbumin

Gene

Lalba

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi97 – 10812PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Keywords - Biological processi

Lactose biosynthesis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Gene namesi
Name:Lalba
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2987. Lalba.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 159140Alpha-lactalbumin1 PublicationPRO_0000018449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 139PROSITE-ProRule annotation
Disulfide bondi47 ↔ 130PROSITE-ProRule annotation
Glycosylationi64 – 641N-linked (GlcNAc...)1 Publication
Disulfide bondi80 ↔ 96PROSITE-ProRule annotation
Disulfide bondi92 ↔ 110PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP00714.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Subunit structurei

Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014457.

Structurei

3D structure databases

ProteinModelPortaliP00714.
SMRiP00714. Positions 20-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP00714.
KOiK00704.
PhylomeDBiP00714.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRFVPLFLA CISLPAFQAT EFTKCEVSHA IEDMDGYQGI SLLEWTCVLF
60 70 80 90 100
HTSGYDSQAI VKNNGSTEYG LFQISNRNWC KSSEFPESEN ICDISCDKFL
110 120 130 140 150
DDELADDIVC AKKIVAIKGI DYWKAHKPMC SEKLEQWRCE KPGAPALVVP

ALNSETPVP
Length:159
Mass (Da):17,850
Last modified:July 21, 1986 - v1
Checksum:iD2C097A0548E7BD3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 403QGI → EGV AA sequence (PubMed:7044414).Curated
Sequence conflicti43 – 431L → P AA sequence (PubMed:7044414).Curated
Sequence conflicti57 – 604SQAI → TEAS AA sequence (PubMed:7044414).Curated
Sequence conflicti63 – 631N → D AA sequence (PubMed:7044414).Curated
Sequence conflicti78 – 781N → D AA sequence (PubMed:7044414).Curated
Sequence conflicti82 – 865SSEFP → ENQFV AA sequence (PubMed:7044414).Curated
Sequence conflicti121 – 1211D → N AA sequence (PubMed:7044414).Curated
Sequence conflicti124 – 1241K → L AA sequence (PubMed:7044414).Curated
Sequence conflicti153 – 1542NS → DG AA sequence (PubMed:7044414).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00461 Genomic DNA. Translation: CAA25150.1.
V01251 mRNA. Translation: CAA24564.2.
PIRiA93327. LART.
RefSeqiNP_036726.1. NM_012594.1.
UniGeneiRn.10479.

Genome annotation databases

GeneIDi24528.
KEGGirno:24528.
UCSCiRGD:2987. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00461 Genomic DNA. Translation: CAA25150.1.
V01251 mRNA. Translation: CAA24564.2.
PIRiA93327. LART.
RefSeqiNP_036726.1. NM_012594.1.
UniGeneiRn.10479.

3D structure databases

ProteinModelPortaliP00714.
SMRiP00714. Positions 20-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014457.

Proteomic databases

PaxDbiP00714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24528.
KEGGirno:24528.
UCSCiRGD:2987. rat.

Organism-specific databases

CTDi3906.
RGDi2987. Lalba.

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP00714.
KOiK00704.
PhylomeDBiP00714.

Miscellaneous databases

PROiP00714.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLALBA_RAT
AccessioniPrimary (citable) accession number: P00714
Secondary accession number(s): P00715
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.