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Protein

Alpha-lactalbumin

Gene

LALBA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi97 – 108Add BLAST12

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell wall macromolecule catabolic process Source: GO_Central
  • defense response to bacterium Source: ProtInc
  • defense response to Gram-negative bacterium Source: GO_Central
  • defense response to Gram-positive bacterium Source: GO_Central
  • lactose biosynthetic process Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Keywords - Biological processi

Lactose biosynthesis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS09571-MONOMER.
ReactomeiR-HSA-5653890. Lactose synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-lactalbumin
Alternative name(s):
Lactose synthase B protein
Lysozyme-like protein 7
Gene namesi
Name:LALBA
Synonyms:LYZL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6480. LALBA.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
  • Golgi lumen Source: Reactome
  • Golgi membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3906.
OpenTargetsiENSG00000167531.
PharmGKBiPA30269.

Protein family/group databases

Allergomei1289. Hom s ALA.

Polymorphism and mutation databases

BioMutaiLALBA.
DMDMi126001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001844420 – 142Alpha-lactalbuminAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 139
Disulfide bondi47 ↔ 130
Glycosylationi64N-linked (GlcNAc...)1 Publication1
Disulfide bondi80 ↔ 96
Glycosylationi90N-linked (GlcNAc...); atypical; partial1 Publication1
Disulfide bondi92 ↔ 110

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP00709.
PeptideAtlasiP00709.
PRIDEiP00709.

PTM databases

iPTMnetiP00709.
PhosphoSitePlusiP00709.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000167531.
CleanExiHS_LALBA.
ExpressionAtlasiP00709. baseline and differential.
GenevisibleiP00709. HS.

Organism-specific databases

HPAiHPA029856.

Interactioni

Subunit structurei

Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

Protein-protein interaction databases

BioGridi110101. 5 interactors.
STRINGi9606.ENSP00000301046.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 30Combined sources7
Helixi32 – 34Combined sources3
Helixi37 – 39Combined sources3
Helixi42 – 53Combined sources12
Beta strandi60 – 62Combined sources3
Beta strandi67 – 69Combined sources3
Turni70 – 73Combined sources4
Turni76 – 78Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi83 – 85Combined sources3
Beta strandi91 – 95Combined sources5
Helixi96 – 100Combined sources5
Helixi105 – 117Combined sources13
Turni118 – 120Combined sources3
Helixi121 – 124Combined sources4
Helixi128 – 130Combined sources3
Helixi134 – 137Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4VX-ray1.80A20-142[»]
1B9OX-ray1.15A20-142[»]
1CB3NMR-A120-130[»]
1HMLX-ray1.70A1-142[»]
3B0IX-ray1.80A20-142[»]
3B0OX-ray1.61A/B21-142[»]
4L41X-ray2.70A/B19-142[»]
ProteinModelPortaliP00709.
SMRiP00709.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00709.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP00709.
KOiK00704.
OMAiLAHKPLC.
OrthoDBiEOG091G0R9V.
PhylomeDBiP00709.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFVPLFLV GILFPAILAK QFTKCELSQL LKDIDGYGGI ALPELICTMF
60 70 80 90 100
HTSGYDTQAI VENNESTEYG LFQISNKLWC KSSQVPQSRN ICDISCDKFL
110 120 130 140
DDDITDDIMC AKKILDIKGI DYWLAHKALC TEKLEQWLCE KL
Length:142
Mass (Da):16,225
Last modified:July 21, 1986 - v1
Checksum:i647F448733B06D65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99F → K AA sequence (PubMed:1401360).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02452646I → V.1 PublicationCorresponds to variant rs2232565dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00270 mRNA. Translation: AAA60345.1.
X05153 Genomic DNA. Translation: CAA28799.1.
X05153 Genomic DNA. Translation: CAA28800.1.
AB049976 Genomic DNA. Translation: BAC06860.1.
CR541987 mRNA. Translation: CAG46784.1.
CR542017 mRNA. Translation: CAG46814.1.
CH471111 Genomic DNA. Translation: EAW57990.1.
BC069103 mRNA. Translation: AAH69103.1.
BC112316 mRNA. Translation: AAI12317.1.
BC112318 mRNA. Translation: AAI12319.1.
CCDSiCCDS8765.1.
PIRiA27880. LAHU.
RefSeqiNP_002280.1. NM_002289.2.
UniGeneiHs.72938.

Genome annotation databases

EnsembliENST00000301046; ENSP00000301046; ENSG00000167531.
GeneIDi3906.
KEGGihsa:3906.
UCSCiuc001rrt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00270 mRNA. Translation: AAA60345.1.
X05153 Genomic DNA. Translation: CAA28799.1.
X05153 Genomic DNA. Translation: CAA28800.1.
AB049976 Genomic DNA. Translation: BAC06860.1.
CR541987 mRNA. Translation: CAG46784.1.
CR542017 mRNA. Translation: CAG46814.1.
CH471111 Genomic DNA. Translation: EAW57990.1.
BC069103 mRNA. Translation: AAH69103.1.
BC112316 mRNA. Translation: AAI12317.1.
BC112318 mRNA. Translation: AAI12319.1.
CCDSiCCDS8765.1.
PIRiA27880. LAHU.
RefSeqiNP_002280.1. NM_002289.2.
UniGeneiHs.72938.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4VX-ray1.80A20-142[»]
1B9OX-ray1.15A20-142[»]
1CB3NMR-A120-130[»]
1HMLX-ray1.70A1-142[»]
3B0IX-ray1.80A20-142[»]
3B0OX-ray1.61A/B21-142[»]
4L41X-ray2.70A/B19-142[»]
ProteinModelPortaliP00709.
SMRiP00709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110101. 5 interactors.
STRINGi9606.ENSP00000301046.

Protein family/group databases

Allergomei1289. Hom s ALA.

PTM databases

iPTMnetiP00709.
PhosphoSitePlusiP00709.

Polymorphism and mutation databases

BioMutaiLALBA.
DMDMi126001.

Proteomic databases

PaxDbiP00709.
PeptideAtlasiP00709.
PRIDEiP00709.

Protocols and materials databases

DNASUi3906.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301046; ENSP00000301046; ENSG00000167531.
GeneIDi3906.
KEGGihsa:3906.
UCSCiuc001rrt.3. human.

Organism-specific databases

CTDi3906.
DisGeNETi3906.
GeneCardsiLALBA.
HGNCiHGNC:6480. LALBA.
HPAiHPA029856.
MIMi149750. gene.
neXtProtiNX_P00709.
OpenTargetsiENSG00000167531.
PharmGKBiPA30269.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX41. Eukaryota.
ENOG410ZQK6. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP00709.
KOiK00704.
OMAiLAHKPLC.
OrthoDBiEOG091G0R9V.
PhylomeDBiP00709.
TreeFamiTF324882.

Enzyme and pathway databases

BioCyciZFISH:HS09571-MONOMER.
ReactomeiR-HSA-5653890. Lactose synthesis.

Miscellaneous databases

EvolutionaryTraceiP00709.
GeneWikiiAlpha-lactalbumin.
GenomeRNAii3906.
PROiP00709.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167531.
CleanExiHS_LALBA.
ExpressionAtlasiP00709. baseline and differential.
GenevisibleiP00709. HS.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000545. Lactalbumin.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00136. LACTALBUMIN.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLALBA_HUMAN
AccessioniPrimary (citable) accession number: P00709
Secondary accession number(s): Q6FGX0, Q9UDK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.