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P00706 (LYSC3_ANAPL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme C-3

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
OrganismAnas platyrhynchos (Domestic duck) (Anas boschas) [Complete proteome]
Taxonomic identifier8839 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnas

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Secreted.

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 129129Lysozyme C-3
PRO_0000208859

Sites

Active site351 By similarity
Active site521 By similarity

Amino acid modifications

Disulfide bond6 ↔ 127
Disulfide bond30 ↔ 115
Disulfide bond64 ↔ 80
Disulfide bond76 ↔ 94

Natural variations

Natural variant371S → G in 30% of the molecules.

Sequences

Sequence LengthMass (Da)Tools
P00706 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 4A859252D260FA46

FASTA12914,507
        10         20         30         40         50         60 
KVYERCELAA AMKRLGLDNY RGYSLGNWVC AANYESSFNT QATNRNTDGS TDYGILEINS 

        70         80         90        100        110        120 
RWWCDNGKTP RAKNACGIPC SVLLRSDITE AVKCAKRIVS DGDGMNAWVA WRNRCKGTDV 


SRWIRGCRL 

« Hide

References

[1]"Multiple forms of duck-egg white lysozyme. Primary structure of two duck lysozymes."
Hermann J., Jolles J., Jolles P.
Eur. J. Biochem. 24:12-17(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Strain: Kaki duck.
Tissue: Egg white.

Cross-references

Sequence databases

PIRLZDK3. A00861.

3D structure databases

ProteinModelPortalP00706.
SMRP00706. Positions 1-129.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PRIDEP00706.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG052297.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYSC3_ANAPL
AccessionPrimary (citable) accession number: P00706
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 22, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries