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P00698

- LYSC_CHICK

UniProt

P00698 - LYSC_CHICK

Protein

Lysozyme C

Gene

LYZ

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.1 PublicationPROSITE-ProRule annotation

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531
    Active sitei70 – 701
    Binding sitei119 – 1191Substrate

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. lysozyme activity Source: UniProtKB-EC
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_197049. Amyloids.
    SABIO-RKP00698.

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme C (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase C
    Allergen Gal d IV
    Allergen: Gal d 4
    Gene namesi
    Name:LYZ
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: AgBase

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3294. Gal d 4.0101.
    362. Gal d 4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 147129Lysozyme CPRO_0000018495Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 145
    Disulfide bondi48 ↔ 133
    Disulfide bondi82 ↔ 98
    Disulfide bondi94 ↔ 112

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP00698.
    PRIDEiP00698.

    Expressioni

    Tissue specificityi

    In the egg white and polymorphonuclear leukocytes.

    Interactioni

    Subunit structurei

    Monomer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself4EBI-1029543,EBI-1029543
    degPP0C0V08EBI-1029543,EBI-547165From a different organism.

    Protein-protein interaction databases

    BioGridi676478. 2 interactions.
    DIPiDIP-46258N.
    IntActiP00698. 4 interactions.

    Structurei

    Secondary structure

    1
    147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi23 – 3210
    Turni33 – 375
    Helixi38 – 403
    Helixi43 – 5412
    Beta strandi55 – 573
    Beta strandi61 – 633
    Beta strandi65 – 673
    Beta strandi69 – 713
    Turni72 – 754
    Turni78 – 814
    Beta strandi85 – 873
    Helixi98 – 1025
    Beta strandi103 – 1053
    Helixi107 – 11812
    Beta strandi119 – 1213
    Helixi123 – 1253
    Helixi127 – 1326
    Turni133 – 1353
    Helixi138 – 1414
    Turni142 – 1443

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    132LX-ray1.80A19-147[»]
    193LX-ray1.33A19-147[»]
    194LX-ray1.40A19-147[»]
    1A2YX-ray1.50C19-147[»]
    1AKIX-ray1.50A19-147[»]
    1AT5X-ray1.80A19-147[»]
    1AT6X-ray1.80A19-147[»]
    1AZFX-ray1.80A19-147[»]
    1B0DX-ray1.84A19-147[»]
    1B2KX-ray1.60A/B19-147[»]
    1BGIX-ray1.70A19-147[»]
    1BHZX-ray3.90A19-147[»]
    1BVKX-ray2.70C/F19-147[»]
    1BVXX-ray1.80A19-147[»]
    1BWHX-ray1.80A19-147[»]
    1BWIX-ray1.80A19-147[»]
    1BWJX-ray1.80A19-147[»]
    1C08X-ray2.30C19-147[»]
    1C10X-ray2.03A19-147[»]
    1DPWX-ray1.64A19-147[»]
    1DPXX-ray1.65A19-147[»]
    1DQJX-ray2.00C19-147[»]
    1E8LNMR-A19-147[»]
    1F0WX-ray1.90A19-147[»]
    1F10X-ray1.70A19-147[»]
    1F3JX-ray3.10P/Q29-42[»]
    1FDLX-ray2.50Y19-147[»]
    1FLQX-ray1.80A19-147[»]
    1FLUX-ray1.78A19-147[»]
    1FLWX-ray1.81A19-147[»]
    1FLYX-ray1.83A19-147[»]
    1FN5X-ray1.78A19-147[»]
    1G7HX-ray1.85C19-147[»]
    1G7IX-ray1.80C19-147[»]
    1G7JX-ray1.75C19-147[»]
    1G7LX-ray2.00C19-147[»]
    1G7MX-ray1.90C19-147[»]
    1GPQX-ray1.60C/D19-147[»]
    1GWDX-ray1.77A19-147[»]
    1GXVNMR-219-147[»]
    1GXXNMR-A19-147[»]
    1H6MX-ray1.64A19-147[»]
    1H87X-ray1.72A19-147[»]
    1HC0X-ray1.82A19-147[»]
    1HELX-ray1.70A19-147[»]
    1HEMX-ray1.80A19-147[»]
    1HENX-ray1.80A19-147[»]
    1HEOX-ray1.80A19-147[»]
    1HEPX-ray1.80A19-147[»]
    1HEQX-ray1.80A19-147[»]
    1HERX-ray1.80A19-147[»]
    1HEWX-ray1.75A19-147[»]
    1HF4X-ray1.45A/B19-147[»]
    1HSWX-ray2.00A19-147[»]
    1HSXX-ray1.90A19-147[»]
    1IC4X-ray2.50Y19-147[»]
    1IC5X-ray2.30Y19-147[»]
    1IC7X-ray2.10Y19-147[»]
    1IEEX-ray0.94A19-147[»]
    1IO5neutron diffraction2.00A19-147[»]
    1IOQX-ray1.79A19-147[»]
    1IORX-ray1.76A19-147[»]
    1IOSX-ray1.76A19-147[»]
    1IOTX-ray1.75A19-147[»]
    1IR7X-ray1.90A19-147[»]
    1IR8X-ray1.63A19-147[»]
    1IR9X-ray1.90A19-147[»]
    1J1OX-ray1.80Y19-147[»]
    1J1PX-ray1.80Y19-147[»]
    1J1XX-ray1.80Y19-147[»]
    1JA2X-ray2.87A19-147[»]
    1JA4X-ray2.94A19-147[»]
    1JA6X-ray2.96A19-147[»]
    1JA7X-ray2.98A19-147[»]
    1JISX-ray1.90A19-147[»]
    1JITX-ray1.90A19-147[»]
    1JIYX-ray1.90A19-147[»]
    1JJ0X-ray1.90A19-147[»]
    1JJ1X-ray1.90A19-147[»]
    1JJ3X-ray1.90A/B19-147[»]
    1JPOX-ray2.10A19-147[»]
    1JTOX-ray2.50L/M19-147[»]
    1JTTX-ray2.10L19-138[»]
    1KIPX-ray2.10C19-147[»]
    1KIQX-ray1.85C19-147[»]
    1KIRX-ray2.00C19-147[»]
    1KXWX-ray1.96A19-147[»]
    1KXXX-ray1.71A19-147[»]
    1KXYX-ray1.79A19-147[»]
    1LCNX-ray1.63A/B19-147[»]
    1LJ3X-ray2.00A/B19-147[»]
    1LJ4X-ray1.95A/B19-147[»]
    1LJEX-ray2.00A/B19-147[»]
    1LJFX-ray1.80A/B19-147[»]
    1LJGX-ray1.90A/B19-147[»]
    1LJHX-ray1.80A/B19-147[»]
    1LJIX-ray2.00A/B19-147[»]
    1LJJX-ray2.00A/B19-147[»]
    1LJKX-ray2.10A/B19-147[»]
    1LKRX-ray1.60A/B19-147[»]
    1LKSX-ray1.10A19-147[»]
    1LMAX-ray1.75A19-147[»]
    1LPIX-ray2.00A19-147[»]
    1LSAX-ray1.70A19-147[»]
    1LSBX-ray1.70A19-147[»]
    1LSCX-ray1.70A19-147[»]
    1LSDX-ray1.70A19-147[»]
    1LSEX-ray1.70A19-147[»]
    1LSFX-ray1.70A19-147[»]
    1LSGX-ray2.40A19-147[»]
    1LSMX-ray1.70A19-147[»]
    1LSNX-ray1.90A19-147[»]
    1LSYX-ray1.90A1-147[»]
    1LSZX-ray2.00A1-147[»]
    1LYOX-ray1.93A19-147[»]
    1LYSX-ray1.72A/B19-147[»]
    1LYZX-ray2.00A19-147[»]
    1LZ8X-ray1.53A19-147[»]
    1LZ9X-ray1.70A19-147[»]
    1LZAX-ray1.60A19-147[»]
    1LZBX-ray1.50A19-147[»]
    1LZCX-ray1.80A19-147[»]
    1LZDX-ray1.80A19-147[»]
    1LZEX-ray1.80A19-147[»]
    1LZGX-ray1.80A19-147[»]
    1LZHX-ray6.00A/B19-147[»]
    1LZNneutron diffraction1.70A19-147[»]
    1LZTX-ray1.97A19-147[»]
    1MELX-ray2.50L/M19-147[»]
    1MLCX-ray2.50E/F19-147[»]
    1N4FX-ray1.78A19-147[»]
    1NBYX-ray1.80C19-147[»]
    1NBZX-ray1.85C19-147[»]
    1NDGX-ray1.90C19-147[»]
    1NDMX-ray2.10C19-147[»]
    1P2CX-ray2.00C/F19-147[»]
    1PS5X-ray2.00A19-147[»]
    1QIOX-ray1.20A19-147[»]
    1QTKX-ray2.03A19-147[»]
    1RCMX-ray1.90A/B19-147[»]
    1RFPX-ray1.75A19-147[»]
    1RI8X-ray1.85B19-147[»]
    1RJCX-ray1.40B19-147[»]
    1SF4X-ray2.98A19-147[»]
    1SF6X-ray3.22A19-147[»]
    1SF7X-ray3.22A19-147[»]
    1SFBX-ray3.22A19-147[»]
    1SFGX-ray3.22A19-147[»]
    1SQ2X-ray1.45L19-147[»]
    1T3PX-ray1.60A19-147[»]
    1T6VX-ray1.70L/M19-147[»]
    1UA6X-ray1.90Y19-147[»]
    1UC0X-ray1.85A19-147[»]
    1UCOX-ray2.00A/B19-147[»]
    1UIAX-ray1.76A19-147[»]
    1UIBX-ray1.76A19-147[»]
    1UICX-ray1.95A19-147[»]
    1UIDX-ray1.95A19-147[»]
    1UIEX-ray1.95A19-147[»]
    1UIFX-ray1.85A19-147[»]
    1UIGX-ray1.95A19-147[»]
    1UIHX-ray1.75A19-147[»]
    1UUZX-ray1.80C/D19-147[»]
    1V7SX-ray1.14A19-147[»]
    1V7TX-ray1.13A/B19-147[»]
    1VATX-ray1.60A19-147[»]
    1VAUX-ray1.50A19-147[»]
    1VDPX-ray1.70A/B19-147[»]
    1VDQX-ray1.50A19-147[»]
    1VDSX-ray1.60A19-147[»]
    1VDTX-ray1.70A19-147[»]
    1VEDX-ray1.90A19-147[»]
    1VFBX-ray1.80C19-147[»]
    1W6ZX-ray1.65A19-147[»]
    1WTMX-ray1.33A19-147[»]
    1WTNX-ray1.13A19-147[»]
    1XEIX-ray2.10A19-147[»]
    1XEJX-ray2.10A19-147[»]
    1XEKX-ray2.30A19-147[»]
    1XFPX-ray1.50L19-147[»]
    1XGPX-ray2.10C19-147[»]
    1XGQX-ray2.10C19-147[»]
    1XGRX-ray2.10C19-147[»]
    1XGTX-ray2.10C19-147[»]
    1XGUX-ray2.10C19-147[»]
    1YIKX-ray1.75A19-147[»]
    1YILX-ray1.60A19-147[»]
    1YKXX-ray1.90X19-147[»]
    1YKYX-ray1.90X19-147[»]
    1YKZX-ray1.80X19-147[»]
    1YL0X-ray1.90X19-147[»]
    1YL1X-ray1.90X19-147[»]
    1YQVX-ray1.70Y19-147[»]
    1Z55X-ray1.90A19-147[»]
    1ZMYX-ray3.00L/M19-147[»]
    1ZV5X-ray2.00L19-147[»]
    1ZVHX-ray1.50L19-147[»]
    1ZVYX-ray1.63B19-147[»]
    2A6UX-ray-A19-147[»]
    2A7DX-ray1.66A19-147[»]
    2A7FX-ray1.85A19-147[»]
    2AUBX-ray1.70A19-147[»]
    2B5ZX-ray1.60A19-147[»]
    2BLXX-ray1.40A19-147[»]
    2BLYX-ray1.40A19-147[»]
    2BPUX-ray1.35A19-147[»]
    2C8OX-ray1.50A19-147[»]
    2C8PX-ray1.50A19-147[»]
    2CDSX-ray2.00A19-147[»]
    2CGIX-ray1.35A19-147[»]
    2D4IX-ray1.16A/B19-147[»]
    2D4JX-ray1.16A19-147[»]
    2D4KX-ray1.15A/N19-147[»]
    2D6BX-ray1.25A19-147[»]
    2D91X-ray2.10A19-147[»]
    2DQCX-ray1.80Y19-147[»]
    2DQDX-ray1.80Y19-147[»]
    2DQEX-ray1.90Y19-147[»]
    2DQFX-ray2.50C/F19-147[»]
    2DQGX-ray2.30Y19-147[»]
    2DQHX-ray2.30Y19-147[»]
    2DQIX-ray2.00Y19-147[»]
    2DQJX-ray1.80Y19-147[»]
    2EIZX-ray1.90C19-147[»]
    2EKSX-ray2.00C19-147[»]
    2EPEX-ray2.50A19-147[»]
    2F2NX-ray1.60A19-147[»]
    2F30X-ray1.65A19-147[»]
    2F4AX-ray1.95A19-147[»]
    2F4GX-ray1.65A19-147[»]
    2FBBX-ray1.46A19-147[»]
    2G4PX-ray1.84A19-147[»]
    2G4QX-ray1.84A19-147[»]
    2H9JX-ray1.75A19-147[»]
    2H9KX-ray1.75A19-147[»]
    2HFMmodel-Y19-147[»]
    2HS7X-ray-A19-147[»]
    2HS9X-ray-A19-147[»]
    2HSOX-ray-A19-147[»]
    2HTXX-ray1.56A19-147[»]
    2HU1X-ray1.63A19-147[»]
    2HU3X-ray1.30A19-147[»]
    2HUBX-ray1.20A19-147[»]
    2I25X-ray1.80L/M19-147[»]
    2I26X-ray2.50L/M/Q19-147[»]
    2I6ZX-ray1.90A19-147[»]
    2IFFX-ray2.65Y19-147[»]
    2LYMX-ray2.00A19-147[»]
    2LYOX-ray1.93A19-147[»]
    2LYZX-ray2.00A19-147[»]
    2LZHX-ray6.00A19-147[»]
    2LZTX-ray1.97A19-147[»]
    2PC2X-ray1.54A19-147[»]
    2Q0MX-ray1.70X19-147[»]
    2VB1X-ray0.65A19-147[»]
    2W1LX-ray1.51A19-147[»]
    2W1MX-ray1.78A19-147[»]
    2W1XX-ray1.70A19-147[»]
    2W1YX-ray1.73A19-147[»]
    2WARX-ray1.80A19-147[»]
    2X0AX-ray1.52A19-147[»]
    2XBRX-ray1.29A19-147[»]
    2XBSX-ray1.37A19-147[»]
    2XJWX-ray1.67A19-147[»]
    2XTHX-ray1.80A19-147[»]
    2YBHX-ray2.00A19-147[»]
    2YBIX-ray2.00A19-147[»]
    2YBJX-ray2.00A19-147[»]
    2YBLX-ray2.00A19-147[»]
    2YBMX-ray2.00A19-147[»]
    2YBNX-ray2.00A19-147[»]
    2YDGX-ray2.00A19-147[»]
    2YSSX-ray2.40C19-147[»]
    2YVBX-ray1.62A19-147[»]
    2Z12X-ray1.15A19-147[»]
    2Z18X-ray1.15A19-147[»]
    2Z19X-ray1.15A19-147[»]
    2ZNWX-ray2.71Y/Z19-147[»]
    2ZNXX-ray2.30Y/Z19-147[»]
    2ZQ3X-ray1.60A19-147[»]
    2ZQ4X-ray2.00A19-147[»]
    2ZYPX-ray1.18A19-147[»]
    3A34X-ray1.65A19-147[»]
    3A3QX-ray2.00A19-147[»]
    3A3RX-ray1.90X19-147[»]
    3A67X-ray1.80Y19-147[»]
    3A6BX-ray1.80Y19-147[»]
    3A6CX-ray1.80Y19-147[»]
    3A8ZX-ray1.40A19-147[»]
    3A90X-ray1.45A19-147[»]
    3A91X-ray1.55A19-147[»]
    3A92X-ray1.50A19-147[»]
    3A93X-ray1.55A19-147[»]
    3A94X-ray1.55A19-147[»]
    3A95X-ray1.50A19-147[»]
    3A96X-ray1.75A19-147[»]
    3AGGX-ray1.60G19-147[»]
    3AGHX-ray1.49A19-147[»]
    3AGIX-ray1.20A19-147[»]
    3AJNX-ray1.05A19-147[»]
    3ATNX-ray1.17A19-147[»]
    3ATOX-ray1.17A19-147[»]
    3AW6X-ray2.10A19-147[»]
    3AW7X-ray2.10A19-147[»]
    3AZ4X-ray1.62A19-147[»]
    3AZ5X-ray2.34A19-147[»]
    3AZ6X-ray1.50A19-147[»]
    3AZ7X-ray2.10A19-147[»]
    3B6LX-ray2.30A1-147[»]
    3B72X-ray1.50A1-147[»]
    3D9AX-ray1.20C19-147[»]
    3E3DX-ray1.55A19-147[»]
    3EMSX-ray1.65A19-147[»]
    3EXDX-ray1.49A19-147[»]
    3F6ZX-ray2.50A/C19-147[»]
    3G3AX-ray2.20B/D/F/H19-147[»]
    3G3BX-ray2.40B/D/F/H19-147[»]
    3HFMX-ray3.00Y19-147[»]
    3IJUX-ray1.60A19-147[»]
    3IJVX-ray1.70A19-147[»]
    3J4Gelectron microscopy2.90A19-147[»]
    3KAMX-ray1.59A19-147[»]
    3LYMX-ray2.00A19-147[»]
    3LYOX-ray1.93A19-147[»]
    3LYTX-ray1.90A/B19-147[»]
    3LYZX-ray2.00A19-147[»]
    3LZTX-ray0.93A19-147[»]
    3M18X-ray1.95B19-147[»]
    3M3UX-ray2.35A19-147[»]
    3MBEX-ray2.89P/Q29-45[»]
    3N9AX-ray1.40A19-147[»]
    3N9CX-ray1.50A19-147[»]
    3N9EX-ray1.38A19-147[»]
    3OJPX-ray1.81A19-147[»]
    3OK0X-ray1.82A19-147[»]
    3OTPX-ray3.76G/H/I/J/K/L36-76[»]
    3P4ZX-ray1.60A19-147[»]
    3P64X-ray1.30A19-147[»]
    3P65X-ray2.10A19-147[»]
    3P66X-ray1.36A19-147[»]
    3P68X-ray1.60A19-147[»]
    3QE8X-ray1.49A/B19-147[»]
    3QNGX-ray1.55A19-147[»]
    3QY4X-ray1.65A19-146[»]
    3RNXX-ray1.86A19-147[»]
    3RT5X-ray1.75X19-147[»]
    3RU5X-ray1.35A19-147[»]
    3RW8X-ray1.86A19-147[»]
    3RZ4X-ray1.80A19-147[»]
    3SP3X-ray1.80A19-147[»]
    3T6UX-ray2.21A19-147[»]
    3TMUX-ray1.90A1-147[»]
    3TMVX-ray1.90A1-147[»]
    3TMWX-ray1.90A1-147[»]
    3TMXX-ray1.90A1-147[»]
    3TXBX-ray1.59A19-147[»]
    3TXDX-ray1.53A19-147[»]
    3TXEX-ray1.70A19-147[»]
    3TXFX-ray1.69A19-147[»]
    3TXGX-ray1.70A19-147[»]
    3TXHX-ray1.69A19-147[»]
    3TXIX-ray1.60A19-147[»]
    3TXJX-ray2.48A19-147[»]
    3TXKX-ray3.00A19-147[»]
    3ULRX-ray1.65A19-147[»]
    3VFXX-ray1.95A/B19-147[»]
    3W6AX-ray1.77A19-147[»]
    3ZEKX-ray1.43A19-147[»]
    3ZVQX-ray2.00A19-88[»]
    B90-147[»]
    4A7DX-ray1.50A19-147[»]
    4A8Aelectron microscopy14.20M19-147[»]
    4A8Belectron microscopy13.00M/N/O/P/Q/R19-147[»]
    4AGAX-ray1.50A19-147[»]
    4AXTX-ray1.10A19-147[»]
    4B0DX-ray1.10A19-147[»]
    4B1AX-ray1.67A19-147[»]
    4B49X-ray1.15A19-147[»]
    4B4EX-ray1.00A19-147[»]
    4B4IX-ray1.20A19-147[»]
    4B4JX-ray1.25A19-147[»]
    4BADX-ray1.35A19-147[»]
    4BAFX-ray1.51A19-147[»]
    4BAPX-ray1.21A19-147[»]
    4BS7X-ray1.70A19-147[»]
    4CJ2X-ray1.50A/B1-147[»]
    4D9ZX-ray1.71A19-147[»]
    4DC4X-ray2.65A/B/C19-147[»]
    4DD0X-ray1.70A19-147[»]
    4DD1X-ray1.70A/B19-147[»]
    4DD2X-ray1.55A19-147[»]
    4DD3X-ray1.70A19-147[»]
    4DD4X-ray1.70A19-147[»]
    4DD6X-ray1.70A19-147[»]
    4DD7X-ray1.60A19-147[»]
    4DD9X-ray1.60A19-147[»]
    4DDAX-ray2.48A19-147[»]
    4DDBX-ray3.00A19-147[»]
    4DDCX-ray1.80A/B19-147[»]
    4DT3X-ray1.80A19-147[»]
    4E3UX-ray1.50A19-147[»]
    4EOFX-ray1.83A19-147[»]
    4ET8X-ray1.90A19-147[»]
    4ET9X-ray1.90A19-147[»]
    4ETAX-ray1.91A19-147[»]
    4ETBX-ray1.91A19-147[»]
    4ETCX-ray1.91A19-147[»]
    4ETDX-ray1.90A19-147[»]
    4ETEX-ray1.90A19-147[»]
    4FJRX-ray1.86A19-147[»]
    4G49X-ray2.40A19-147[»]
    4G4AX-ray2.40A19-147[»]
    4G4BX-ray2.10A19-147[»]
    4G4CX-ray2.00A19-147[»]
    4G4HX-ray2.00A19-147[»]
    4GCBX-ray1.80A19-147[»]
    4GCCX-ray2.00A19-147[»]
    4GCDX-ray2.80A19-147[»]
    4GCEX-ray2.90A19-147[»]
    4GCFX-ray3.50A19-147[»]
    4GLAX-ray2.75A/B19-147[»]
    4GLVX-ray2.57A/C/E/G19-147[»]
    4GN3X-ray1.95A/C/E/G/I/K/M/O/Q19-147[»]
    4GN4X-ray1.86A19-147[»]
    4GN5X-ray1.86C/D19-147[»]
    4H1PX-ray2.30A19-147[»]
    4H8XX-ray1.20A19-147[»]
    4H8YX-ray1.20A19-147[»]
    4H8ZX-ray1.20A19-147[»]
    4H90X-ray1.20A19-147[»]
    4H91X-ray1.20A19-147[»]
    4H92X-ray1.20A19-147[»]
    4H93X-ray1.20A19-147[»]
    4H94X-ray1.20A19-147[»]
    4H9AX-ray1.20A19-147[»]
    4H9BX-ray1.20A19-147[»]
    4H9CX-ray1.20A19-147[»]
    4H9EX-ray1.20A19-147[»]
    4H9FX-ray1.20A19-147[»]
    4H9HX-ray1.20A19-147[»]
    4H9IX-ray1.20A19-147[»]
    4HP0X-ray1.19A19-147[»]
    4HPIX-ray1.19A19-147[»]
    4HSFX-ray1.82A19-147[»]
    4HTKX-ray1.20A19-147[»]
    4HTNX-ray1.30A19-147[»]
    4HTQX-ray1.40A19-147[»]
    4HV1X-ray2.30A19-147[»]
    4HV2X-ray2.50A19-147[»]
    4I8SX-ray2.00A19-147[»]
    4IASX-ray2.60A19-147[»]
    4IATX-ray2.00A19-147[»]
    4II8X-ray1.88A19-147[»]
    4J1AX-ray1.79A19-147[»]
    4J1BX-ray1.66A19-147[»]
    4J7VX-ray1.54A19-147[»]
    4KXIX-ray2.00A19-147[»]
    4LFPX-ray1.72A19-147[»]
    4LFXX-ray2.10A19-147[»]
    4LGKX-ray1.96A19-147[»]
    4LYMX-ray2.10A19-147[»]
    4LYOX-ray2.05A19-147[»]
    4LYTX-ray1.90A/B19-147[»]
    4LYZX-ray2.00A19-147[»]
    4LZTX-ray0.95A19-147[»]
    4M4OX-ray2.00A19-147[»]
    4M6DX-ray2.68A/C/E/G/I/K19-147[»]
    4MR1X-ray1.99A19-147[»]
    4N5RX-ray2.10A19-147[»]
    4N8ZX-ray1.20A19-147[»]
    4NEBX-ray1.48A19-147[»]
    4NFVX-ray1.63A19-147[»]
    4NG1X-ray1.82A19-147[»]
    4NG8X-ray1.09A19-147[»]
    4NGIX-ray1.70A19-147[»]
    4NGJX-ray1.10A19-147[»]
    4NGKX-ray1.50A19-147[»]
    4NGLX-ray1.52A19-147[»]
    4NGOX-ray1.58A19-147[»]
    4NGVX-ray1.64A19-147[»]
    4NGWX-ray1.37A19-147[»]
    4NGYX-ray1.35A19-147[»]
    4NGZX-ray1.70A19-147[»]
    4NY5X-ray1.85A19-147[»]
    4O34X-ray2.09A19-147[»]
    4OOOX-ray2.15A19-147[»]
    4P2EX-ray1.60A19-147[»]
    4QEQX-ray1.38A19-147[»]
    5LYMX-ray1.80A/B19-147[»]
    5LYTX-ray1.90A19-147[»]
    5LYZX-ray2.00A19-147[»]
    6LYTX-ray1.90A19-147[»]
    6LYZX-ray2.00A19-147[»]
    7LYZX-ray2.50A19-147[»]
    8LYZX-ray2.50A19-147[»]
    9LYZX-ray2.50A19-147[»]
    ProteinModelPortaliP00698.
    SMRiP00698. Positions 19-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP00698.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG85133.
    GeneTreeiENSGT00550000074398.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiP00698.
    KOiK13915.
    OMAiGNGMNAW.
    OrthoDBiEOG7BW0M5.
    PhylomeDBiP00698.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P00698-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSLLILVLC FLPLAALGKV FGRCELAAAM KRHGLDNYRG YSLGNWVCAA    50
    KFESNFNTQA TNRNTDGSTD YGILQINSRW WCNDGRTPGS RNLCNIPCSA 100
    LLSSDITASV NCAKKIVSDG NGMNAWVAWR NRCKGTDVQA WIRGCRL 147
    Length:147
    Mass (Da):16,239
    Last modified:July 21, 1986 - v1
    Checksum:i81E85743FF579468
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491A → V in CAA23711. (PubMed:6934509)Curated
    Sequence conflicti121 – 1211N → D AA sequence (PubMed:14063294)Curated
    Sequence conflicti124 – 1241N → S in CAA23711. (PubMed:6934509)Curated
    Sequence conflicti132 – 1321R → S in AAA48944. (PubMed:383714)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00885 Genomic DNA. Translation: AAA48943.1.
    V00428 mRNA. Translation: CAA23711.1.
    AF410481 Genomic DNA. Translation: AAL69327.1.
    M10640 mRNA. Translation: AAA48944.1.
    PIRiA93859. LZCH.
    RefSeqiNP_990612.1. NM_205281.1.
    UniGeneiGga.713.

    Genome annotation databases

    EnsembliENSGALT00000016196; ENSGALP00000016177; ENSGALG00000009963.
    GeneIDi396218.
    KEGGigga:396218.

    Cross-referencesi

    Web resourcesi

    Worthington enzyme manual

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00885 Genomic DNA. Translation: AAA48943.1 .
    V00428 mRNA. Translation: CAA23711.1 .
    AF410481 Genomic DNA. Translation: AAL69327.1 .
    M10640 mRNA. Translation: AAA48944.1 .
    PIRi A93859. LZCH.
    RefSeqi NP_990612.1. NM_205281.1.
    UniGenei Gga.713.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    132L X-ray 1.80 A 19-147 [» ]
    193L X-ray 1.33 A 19-147 [» ]
    194L X-ray 1.40 A 19-147 [» ]
    1A2Y X-ray 1.50 C 19-147 [» ]
    1AKI X-ray 1.50 A 19-147 [» ]
    1AT5 X-ray 1.80 A 19-147 [» ]
    1AT6 X-ray 1.80 A 19-147 [» ]
    1AZF X-ray 1.80 A 19-147 [» ]
    1B0D X-ray 1.84 A 19-147 [» ]
    1B2K X-ray 1.60 A/B 19-147 [» ]
    1BGI X-ray 1.70 A 19-147 [» ]
    1BHZ X-ray 3.90 A 19-147 [» ]
    1BVK X-ray 2.70 C/F 19-147 [» ]
    1BVX X-ray 1.80 A 19-147 [» ]
    1BWH X-ray 1.80 A 19-147 [» ]
    1BWI X-ray 1.80 A 19-147 [» ]
    1BWJ X-ray 1.80 A 19-147 [» ]
    1C08 X-ray 2.30 C 19-147 [» ]
    1C10 X-ray 2.03 A 19-147 [» ]
    1DPW X-ray 1.64 A 19-147 [» ]
    1DPX X-ray 1.65 A 19-147 [» ]
    1DQJ X-ray 2.00 C 19-147 [» ]
    1E8L NMR - A 19-147 [» ]
    1F0W X-ray 1.90 A 19-147 [» ]
    1F10 X-ray 1.70 A 19-147 [» ]
    1F3J X-ray 3.10 P/Q 29-42 [» ]
    1FDL X-ray 2.50 Y 19-147 [» ]
    1FLQ X-ray 1.80 A 19-147 [» ]
    1FLU X-ray 1.78 A 19-147 [» ]
    1FLW X-ray 1.81 A 19-147 [» ]
    1FLY X-ray 1.83 A 19-147 [» ]
    1FN5 X-ray 1.78 A 19-147 [» ]
    1G7H X-ray 1.85 C 19-147 [» ]
    1G7I X-ray 1.80 C 19-147 [» ]
    1G7J X-ray 1.75 C 19-147 [» ]
    1G7L X-ray 2.00 C 19-147 [» ]
    1G7M X-ray 1.90 C 19-147 [» ]
    1GPQ X-ray 1.60 C/D 19-147 [» ]
    1GWD X-ray 1.77 A 19-147 [» ]
    1GXV NMR - 2 19-147 [» ]
    1GXX NMR - A 19-147 [» ]
    1H6M X-ray 1.64 A 19-147 [» ]
    1H87 X-ray 1.72 A 19-147 [» ]
    1HC0 X-ray 1.82 A 19-147 [» ]
    1HEL X-ray 1.70 A 19-147 [» ]
    1HEM X-ray 1.80 A 19-147 [» ]
    1HEN X-ray 1.80 A 19-147 [» ]
    1HEO X-ray 1.80 A 19-147 [» ]
    1HEP X-ray 1.80 A 19-147 [» ]
    1HEQ X-ray 1.80 A 19-147 [» ]
    1HER X-ray 1.80 A 19-147 [» ]
    1HEW X-ray 1.75 A 19-147 [» ]
    1HF4 X-ray 1.45 A/B 19-147 [» ]
    1HSW X-ray 2.00 A 19-147 [» ]
    1HSX X-ray 1.90 A 19-147 [» ]
    1IC4 X-ray 2.50 Y 19-147 [» ]
    1IC5 X-ray 2.30 Y 19-147 [» ]
    1IC7 X-ray 2.10 Y 19-147 [» ]
    1IEE X-ray 0.94 A 19-147 [» ]
    1IO5 neutron diffraction 2.00 A 19-147 [» ]
    1IOQ X-ray 1.79 A 19-147 [» ]
    1IOR X-ray 1.76 A 19-147 [» ]
    1IOS X-ray 1.76 A 19-147 [» ]
    1IOT X-ray 1.75 A 19-147 [» ]
    1IR7 X-ray 1.90 A 19-147 [» ]
    1IR8 X-ray 1.63 A 19-147 [» ]
    1IR9 X-ray 1.90 A 19-147 [» ]
    1J1O X-ray 1.80 Y 19-147 [» ]
    1J1P X-ray 1.80 Y 19-147 [» ]
    1J1X X-ray 1.80 Y 19-147 [» ]
    1JA2 X-ray 2.87 A 19-147 [» ]
    1JA4 X-ray 2.94 A 19-147 [» ]
    1JA6 X-ray 2.96 A 19-147 [» ]
    1JA7 X-ray 2.98 A 19-147 [» ]
    1JIS X-ray 1.90 A 19-147 [» ]
    1JIT X-ray 1.90 A 19-147 [» ]
    1JIY X-ray 1.90 A 19-147 [» ]
    1JJ0 X-ray 1.90 A 19-147 [» ]
    1JJ1 X-ray 1.90 A 19-147 [» ]
    1JJ3 X-ray 1.90 A/B 19-147 [» ]
    1JPO X-ray 2.10 A 19-147 [» ]
    1JTO X-ray 2.50 L/M 19-147 [» ]
    1JTT X-ray 2.10 L 19-138 [» ]
    1KIP X-ray 2.10 C 19-147 [» ]
    1KIQ X-ray 1.85 C 19-147 [» ]
    1KIR X-ray 2.00 C 19-147 [» ]
    1KXW X-ray 1.96 A 19-147 [» ]
    1KXX X-ray 1.71 A 19-147 [» ]
    1KXY X-ray 1.79 A 19-147 [» ]
    1LCN X-ray 1.63 A/B 19-147 [» ]
    1LJ3 X-ray 2.00 A/B 19-147 [» ]
    1LJ4 X-ray 1.95 A/B 19-147 [» ]
    1LJE X-ray 2.00 A/B 19-147 [» ]
    1LJF X-ray 1.80 A/B 19-147 [» ]
    1LJG X-ray 1.90 A/B 19-147 [» ]
    1LJH X-ray 1.80 A/B 19-147 [» ]
    1LJI X-ray 2.00 A/B 19-147 [» ]
    1LJJ X-ray 2.00 A/B 19-147 [» ]
    1LJK X-ray 2.10 A/B 19-147 [» ]
    1LKR X-ray 1.60 A/B 19-147 [» ]
    1LKS X-ray 1.10 A 19-147 [» ]
    1LMA X-ray 1.75 A 19-147 [» ]
    1LPI X-ray 2.00 A 19-147 [» ]
    1LSA X-ray 1.70 A 19-147 [» ]
    1LSB X-ray 1.70 A 19-147 [» ]
    1LSC X-ray 1.70 A 19-147 [» ]
    1LSD X-ray 1.70 A 19-147 [» ]
    1LSE X-ray 1.70 A 19-147 [» ]
    1LSF X-ray 1.70 A 19-147 [» ]
    1LSG X-ray 2.40 A 19-147 [» ]
    1LSM X-ray 1.70 A 19-147 [» ]
    1LSN X-ray 1.90 A 19-147 [» ]
    1LSY X-ray 1.90 A 1-147 [» ]
    1LSZ X-ray 2.00 A 1-147 [» ]
    1LYO X-ray 1.93 A 19-147 [» ]
    1LYS X-ray 1.72 A/B 19-147 [» ]
    1LYZ X-ray 2.00 A 19-147 [» ]
    1LZ8 X-ray 1.53 A 19-147 [» ]
    1LZ9 X-ray 1.70 A 19-147 [» ]
    1LZA X-ray 1.60 A 19-147 [» ]
    1LZB X-ray 1.50 A 19-147 [» ]
    1LZC X-ray 1.80 A 19-147 [» ]
    1LZD X-ray 1.80 A 19-147 [» ]
    1LZE X-ray 1.80 A 19-147 [» ]
    1LZG X-ray 1.80 A 19-147 [» ]
    1LZH X-ray 6.00 A/B 19-147 [» ]
    1LZN neutron diffraction 1.70 A 19-147 [» ]
    1LZT X-ray 1.97 A 19-147 [» ]
    1MEL X-ray 2.50 L/M 19-147 [» ]
    1MLC X-ray 2.50 E/F 19-147 [» ]
    1N4F X-ray 1.78 A 19-147 [» ]
    1NBY X-ray 1.80 C 19-147 [» ]
    1NBZ X-ray 1.85 C 19-147 [» ]
    1NDG X-ray 1.90 C 19-147 [» ]
    1NDM X-ray 2.10 C 19-147 [» ]
    1P2C X-ray 2.00 C/F 19-147 [» ]
    1PS5 X-ray 2.00 A 19-147 [» ]
    1QIO X-ray 1.20 A 19-147 [» ]
    1QTK X-ray 2.03 A 19-147 [» ]
    1RCM X-ray 1.90 A/B 19-147 [» ]
    1RFP X-ray 1.75 A 19-147 [» ]
    1RI8 X-ray 1.85 B 19-147 [» ]
    1RJC X-ray 1.40 B 19-147 [» ]
    1SF4 X-ray 2.98 A 19-147 [» ]
    1SF6 X-ray 3.22 A 19-147 [» ]
    1SF7 X-ray 3.22 A 19-147 [» ]
    1SFB X-ray 3.22 A 19-147 [» ]
    1SFG X-ray 3.22 A 19-147 [» ]
    1SQ2 X-ray 1.45 L 19-147 [» ]
    1T3P X-ray 1.60 A 19-147 [» ]
    1T6V X-ray 1.70 L/M 19-147 [» ]
    1UA6 X-ray 1.90 Y 19-147 [» ]
    1UC0 X-ray 1.85 A 19-147 [» ]
    1UCO X-ray 2.00 A/B 19-147 [» ]
    1UIA X-ray 1.76 A 19-147 [» ]
    1UIB X-ray 1.76 A 19-147 [» ]
    1UIC X-ray 1.95 A 19-147 [» ]
    1UID X-ray 1.95 A 19-147 [» ]
    1UIE X-ray 1.95 A 19-147 [» ]
    1UIF X-ray 1.85 A 19-147 [» ]
    1UIG X-ray 1.95 A 19-147 [» ]
    1UIH X-ray 1.75 A 19-147 [» ]
    1UUZ X-ray 1.80 C/D 19-147 [» ]
    1V7S X-ray 1.14 A 19-147 [» ]
    1V7T X-ray 1.13 A/B 19-147 [» ]
    1VAT X-ray 1.60 A 19-147 [» ]
    1VAU X-ray 1.50 A 19-147 [» ]
    1VDP X-ray 1.70 A/B 19-147 [» ]
    1VDQ X-ray 1.50 A 19-147 [» ]
    1VDS X-ray 1.60 A 19-147 [» ]
    1VDT X-ray 1.70 A 19-147 [» ]
    1VED X-ray 1.90 A 19-147 [» ]
    1VFB X-ray 1.80 C 19-147 [» ]
    1W6Z X-ray 1.65 A 19-147 [» ]
    1WTM X-ray 1.33 A 19-147 [» ]
    1WTN X-ray 1.13 A 19-147 [» ]
    1XEI X-ray 2.10 A 19-147 [» ]
    1XEJ X-ray 2.10 A 19-147 [» ]
    1XEK X-ray 2.30 A 19-147 [» ]
    1XFP X-ray 1.50 L 19-147 [» ]
    1XGP X-ray 2.10 C 19-147 [» ]
    1XGQ X-ray 2.10 C 19-147 [» ]
    1XGR X-ray 2.10 C 19-147 [» ]
    1XGT X-ray 2.10 C 19-147 [» ]
    1XGU X-ray 2.10 C 19-147 [» ]
    1YIK X-ray 1.75 A 19-147 [» ]
    1YIL X-ray 1.60 A 19-147 [» ]
    1YKX X-ray 1.90 X 19-147 [» ]
    1YKY X-ray 1.90 X 19-147 [» ]
    1YKZ X-ray 1.80 X 19-147 [» ]
    1YL0 X-ray 1.90 X 19-147 [» ]
    1YL1 X-ray 1.90 X 19-147 [» ]
    1YQV X-ray 1.70 Y 19-147 [» ]
    1Z55 X-ray 1.90 A 19-147 [» ]
    1ZMY X-ray 3.00 L/M 19-147 [» ]
    1ZV5 X-ray 2.00 L 19-147 [» ]
    1ZVH X-ray 1.50 L 19-147 [» ]
    1ZVY X-ray 1.63 B 19-147 [» ]
    2A6U X-ray - A 19-147 [» ]
    2A7D X-ray 1.66 A 19-147 [» ]
    2A7F X-ray 1.85 A 19-147 [» ]
    2AUB X-ray 1.70 A 19-147 [» ]
    2B5Z X-ray 1.60 A 19-147 [» ]
    2BLX X-ray 1.40 A 19-147 [» ]
    2BLY X-ray 1.40 A 19-147 [» ]
    2BPU X-ray 1.35 A 19-147 [» ]
    2C8O X-ray 1.50 A 19-147 [» ]
    2C8P X-ray 1.50 A 19-147 [» ]
    2CDS X-ray 2.00 A 19-147 [» ]
    2CGI X-ray 1.35 A 19-147 [» ]
    2D4I X-ray 1.16 A/B 19-147 [» ]
    2D4J X-ray 1.16 A 19-147 [» ]
    2D4K X-ray 1.15 A/N 19-147 [» ]
    2D6B X-ray 1.25 A 19-147 [» ]
    2D91 X-ray 2.10 A 19-147 [» ]
    2DQC X-ray 1.80 Y 19-147 [» ]
    2DQD X-ray 1.80 Y 19-147 [» ]
    2DQE X-ray 1.90 Y 19-147 [» ]
    2DQF X-ray 2.50 C/F 19-147 [» ]
    2DQG X-ray 2.30 Y 19-147 [» ]
    2DQH X-ray 2.30 Y 19-147 [» ]
    2DQI X-ray 2.00 Y 19-147 [» ]
    2DQJ X-ray 1.80 Y 19-147 [» ]
    2EIZ X-ray 1.90 C 19-147 [» ]
    2EKS X-ray 2.00 C 19-147 [» ]
    2EPE X-ray 2.50 A 19-147 [» ]
    2F2N X-ray 1.60 A 19-147 [» ]
    2F30 X-ray 1.65 A 19-147 [» ]
    2F4A X-ray 1.95 A 19-147 [» ]
    2F4G X-ray 1.65 A 19-147 [» ]
    2FBB X-ray 1.46 A 19-147 [» ]
    2G4P X-ray 1.84 A 19-147 [» ]
    2G4Q X-ray 1.84 A 19-147 [» ]
    2H9J X-ray 1.75 A 19-147 [» ]
    2H9K X-ray 1.75 A 19-147 [» ]
    2HFM model - Y 19-147 [» ]
    2HS7 X-ray - A 19-147 [» ]
    2HS9 X-ray - A 19-147 [» ]
    2HSO X-ray - A 19-147 [» ]
    2HTX X-ray 1.56 A 19-147 [» ]
    2HU1 X-ray 1.63 A 19-147 [» ]
    2HU3 X-ray 1.30 A 19-147 [» ]
    2HUB X-ray 1.20 A 19-147 [» ]
    2I25 X-ray 1.80 L/M 19-147 [» ]
    2I26 X-ray 2.50 L/M/Q 19-147 [» ]
    2I6Z X-ray 1.90 A 19-147 [» ]
    2IFF X-ray 2.65 Y 19-147 [» ]
    2LYM X-ray 2.00 A 19-147 [» ]
    2LYO X-ray 1.93 A 19-147 [» ]
    2LYZ X-ray 2.00 A 19-147 [» ]
    2LZH X-ray 6.00 A 19-147 [» ]
    2LZT X-ray 1.97 A 19-147 [» ]
    2PC2 X-ray 1.54 A 19-147 [» ]
    2Q0M X-ray 1.70 X 19-147 [» ]
    2VB1 X-ray 0.65 A 19-147 [» ]
    2W1L X-ray 1.51 A 19-147 [» ]
    2W1M X-ray 1.78 A 19-147 [» ]
    2W1X X-ray 1.70 A 19-147 [» ]
    2W1Y X-ray 1.73 A 19-147 [» ]
    2WAR X-ray 1.80 A 19-147 [» ]
    2X0A X-ray 1.52 A 19-147 [» ]
    2XBR X-ray 1.29 A 19-147 [» ]
    2XBS X-ray 1.37 A 19-147 [» ]
    2XJW X-ray 1.67 A 19-147 [» ]
    2XTH X-ray 1.80 A 19-147 [» ]
    2YBH X-ray 2.00 A 19-147 [» ]
    2YBI X-ray 2.00 A 19-147 [» ]
    2YBJ X-ray 2.00 A 19-147 [» ]
    2YBL X-ray 2.00 A 19-147 [» ]
    2YBM X-ray 2.00 A 19-147 [» ]
    2YBN X-ray 2.00 A 19-147 [» ]
    2YDG X-ray 2.00 A 19-147 [» ]
    2YSS X-ray 2.40 C 19-147 [» ]
    2YVB X-ray 1.62 A 19-147 [» ]
    2Z12 X-ray 1.15 A 19-147 [» ]
    2Z18 X-ray 1.15 A 19-147 [» ]
    2Z19 X-ray 1.15 A 19-147 [» ]
    2ZNW X-ray 2.71 Y/Z 19-147 [» ]
    2ZNX X-ray 2.30 Y/Z 19-147 [» ]
    2ZQ3 X-ray 1.60 A 19-147 [» ]
    2ZQ4 X-ray 2.00 A 19-147 [» ]
    2ZYP X-ray 1.18 A 19-147 [» ]
    3A34 X-ray 1.65 A 19-147 [» ]
    3A3Q X-ray 2.00 A 19-147 [» ]
    3A3R X-ray 1.90 X 19-147 [» ]
    3A67 X-ray 1.80 Y 19-147 [» ]
    3A6B X-ray 1.80 Y 19-147 [» ]
    3A6C X-ray 1.80 Y 19-147 [» ]
    3A8Z X-ray 1.40 A 19-147 [» ]
    3A90 X-ray 1.45 A 19-147 [» ]
    3A91 X-ray 1.55 A 19-147 [» ]
    3A92 X-ray 1.50 A 19-147 [» ]
    3A93 X-ray 1.55 A 19-147 [» ]
    3A94 X-ray 1.55 A 19-147 [» ]
    3A95 X-ray 1.50 A 19-147 [» ]
    3A96 X-ray 1.75 A 19-147 [» ]
    3AGG X-ray 1.60 G 19-147 [» ]
    3AGH X-ray 1.49 A 19-147 [» ]
    3AGI X-ray 1.20 A 19-147 [» ]
    3AJN X-ray 1.05 A 19-147 [» ]
    3ATN X-ray 1.17 A 19-147 [» ]
    3ATO X-ray 1.17 A 19-147 [» ]
    3AW6 X-ray 2.10 A 19-147 [» ]
    3AW7 X-ray 2.10 A 19-147 [» ]
    3AZ4 X-ray 1.62 A 19-147 [» ]
    3AZ5 X-ray 2.34 A 19-147 [» ]
    3AZ6 X-ray 1.50 A 19-147 [» ]
    3AZ7 X-ray 2.10 A 19-147 [» ]
    3B6L X-ray 2.30 A 1-147 [» ]
    3B72 X-ray 1.50 A 1-147 [» ]
    3D9A X-ray 1.20 C 19-147 [» ]
    3E3D X-ray 1.55 A 19-147 [» ]
    3EMS X-ray 1.65 A 19-147 [» ]
    3EXD X-ray 1.49 A 19-147 [» ]
    3F6Z X-ray 2.50 A/C 19-147 [» ]
    3G3A X-ray 2.20 B/D/F/H 19-147 [» ]
    3G3B X-ray 2.40 B/D/F/H 19-147 [» ]
    3HFM X-ray 3.00 Y 19-147 [» ]
    3IJU X-ray 1.60 A 19-147 [» ]
    3IJV X-ray 1.70 A 19-147 [» ]
    3J4G electron microscopy 2.90 A 19-147 [» ]
    3KAM X-ray 1.59 A 19-147 [» ]
    3LYM X-ray 2.00 A 19-147 [» ]
    3LYO X-ray 1.93 A 19-147 [» ]
    3LYT X-ray 1.90 A/B 19-147 [» ]
    3LYZ X-ray 2.00 A 19-147 [» ]
    3LZT X-ray 0.93 A 19-147 [» ]
    3M18 X-ray 1.95 B 19-147 [» ]
    3M3U X-ray 2.35 A 19-147 [» ]
    3MBE X-ray 2.89 P/Q 29-45 [» ]
    3N9A X-ray 1.40 A 19-147 [» ]
    3N9C X-ray 1.50 A 19-147 [» ]
    3N9E X-ray 1.38 A 19-147 [» ]
    3OJP X-ray 1.81 A 19-147 [» ]
    3OK0 X-ray 1.82 A 19-147 [» ]
    3OTP X-ray 3.76 G/H/I/J/K/L 36-76 [» ]
    3P4Z X-ray 1.60 A 19-147 [» ]
    3P64 X-ray 1.30 A 19-147 [» ]
    3P65 X-ray 2.10 A 19-147 [» ]
    3P66 X-ray 1.36 A 19-147 [» ]
    3P68 X-ray 1.60 A 19-147 [» ]
    3QE8 X-ray 1.49 A/B 19-147 [» ]
    3QNG X-ray 1.55 A 19-147 [» ]
    3QY4 X-ray 1.65 A 19-146 [» ]
    3RNX X-ray 1.86 A 19-147 [» ]
    3RT5 X-ray 1.75 X 19-147 [» ]
    3RU5 X-ray 1.35 A 19-147 [» ]
    3RW8 X-ray 1.86 A 19-147 [» ]
    3RZ4 X-ray 1.80 A 19-147 [» ]
    3SP3 X-ray 1.80 A 19-147 [» ]
    3T6U X-ray 2.21 A 19-147 [» ]
    3TMU X-ray 1.90 A 1-147 [» ]
    3TMV X-ray 1.90 A 1-147 [» ]
    3TMW X-ray 1.90 A 1-147 [» ]
    3TMX X-ray 1.90 A 1-147 [» ]
    3TXB X-ray 1.59 A 19-147 [» ]
    3TXD X-ray 1.53 A 19-147 [» ]
    3TXE X-ray 1.70 A 19-147 [» ]
    3TXF X-ray 1.69 A 19-147 [» ]
    3TXG X-ray 1.70 A 19-147 [» ]
    3TXH X-ray 1.69 A 19-147 [» ]
    3TXI X-ray 1.60 A 19-147 [» ]
    3TXJ X-ray 2.48 A 19-147 [» ]
    3TXK X-ray 3.00 A 19-147 [» ]
    3ULR X-ray 1.65 A 19-147 [» ]
    3VFX X-ray 1.95 A/B 19-147 [» ]
    3W6A X-ray 1.77 A 19-147 [» ]
    3ZEK X-ray 1.43 A 19-147 [» ]
    3ZVQ X-ray 2.00 A 19-88 [» ]
    B 90-147 [» ]
    4A7D X-ray 1.50 A 19-147 [» ]
    4A8A electron microscopy 14.20 M 19-147 [» ]
    4A8B electron microscopy 13.00 M/N/O/P/Q/R 19-147 [» ]
    4AGA X-ray 1.50 A 19-147 [» ]
    4AXT X-ray 1.10 A 19-147 [» ]
    4B0D X-ray 1.10 A 19-147 [» ]
    4B1A X-ray 1.67 A 19-147 [» ]
    4B49 X-ray 1.15 A 19-147 [» ]
    4B4E X-ray 1.00 A 19-147 [» ]
    4B4I X-ray 1.20 A 19-147 [» ]
    4B4J X-ray 1.25 A 19-147 [» ]
    4BAD X-ray 1.35 A 19-147 [» ]
    4BAF X-ray 1.51 A 19-147 [» ]
    4BAP X-ray 1.21 A 19-147 [» ]
    4BS7 X-ray 1.70 A 19-147 [» ]
    4CJ2 X-ray 1.50 A/B 1-147 [» ]
    4D9Z X-ray 1.71 A 19-147 [» ]
    4DC4 X-ray 2.65 A/B/C 19-147 [» ]
    4DD0 X-ray 1.70 A 19-147 [» ]
    4DD1 X-ray 1.70 A/B 19-147 [» ]
    4DD2 X-ray 1.55 A 19-147 [» ]
    4DD3 X-ray 1.70 A 19-147 [» ]
    4DD4 X-ray 1.70 A 19-147 [» ]
    4DD6 X-ray 1.70 A 19-147 [» ]
    4DD7 X-ray 1.60 A 19-147 [» ]
    4DD9 X-ray 1.60 A 19-147 [» ]
    4DDA X-ray 2.48 A 19-147 [» ]
    4DDB X-ray 3.00 A 19-147 [» ]
    4DDC X-ray 1.80 A/B 19-147 [» ]
    4DT3 X-ray 1.80 A 19-147 [» ]
    4E3U X-ray 1.50 A 19-147 [» ]
    4EOF X-ray 1.83 A 19-147 [» ]
    4ET8 X-ray 1.90 A 19-147 [» ]
    4ET9 X-ray 1.90 A 19-147 [» ]
    4ETA X-ray 1.91 A 19-147 [» ]
    4ETB X-ray 1.91 A 19-147 [» ]
    4ETC X-ray 1.91 A 19-147 [» ]
    4ETD X-ray 1.90 A 19-147 [» ]
    4ETE X-ray 1.90 A 19-147 [» ]
    4FJR X-ray 1.86 A 19-147 [» ]
    4G49 X-ray 2.40 A 19-147 [» ]
    4G4A X-ray 2.40 A 19-147 [» ]
    4G4B X-ray 2.10 A 19-147 [» ]
    4G4C X-ray 2.00 A 19-147 [» ]
    4G4H X-ray 2.00 A 19-147 [» ]
    4GCB X-ray 1.80 A 19-147 [» ]
    4GCC X-ray 2.00 A 19-147 [» ]
    4GCD X-ray 2.80 A 19-147 [» ]
    4GCE X-ray 2.90 A 19-147 [» ]
    4GCF X-ray 3.50 A 19-147 [» ]
    4GLA X-ray 2.75 A/B 19-147 [» ]
    4GLV X-ray 2.57 A/C/E/G 19-147 [» ]
    4GN3 X-ray 1.95 A/C/E/G/I/K/M/O/Q 19-147 [» ]
    4GN4 X-ray 1.86 A 19-147 [» ]
    4GN5 X-ray 1.86 C/D 19-147 [» ]
    4H1P X-ray 2.30 A 19-147 [» ]
    4H8X X-ray 1.20 A 19-147 [» ]
    4H8Y X-ray 1.20 A 19-147 [» ]
    4H8Z X-ray 1.20 A 19-147 [» ]
    4H90 X-ray 1.20 A 19-147 [» ]
    4H91 X-ray 1.20 A 19-147 [» ]
    4H92 X-ray 1.20 A 19-147 [» ]
    4H93 X-ray 1.20 A 19-147 [» ]
    4H94 X-ray 1.20 A 19-147 [» ]
    4H9A X-ray 1.20 A 19-147 [» ]
    4H9B X-ray 1.20 A 19-147 [» ]
    4H9C X-ray 1.20 A 19-147 [» ]
    4H9E X-ray 1.20 A 19-147 [» ]
    4H9F X-ray 1.20 A 19-147 [» ]
    4H9H X-ray 1.20 A 19-147 [» ]
    4H9I X-ray 1.20 A 19-147 [» ]
    4HP0 X-ray 1.19 A 19-147 [» ]
    4HPI X-ray 1.19 A 19-147 [» ]
    4HSF X-ray 1.82 A 19-147 [» ]
    4HTK X-ray 1.20 A 19-147 [» ]
    4HTN X-ray 1.30 A 19-147 [» ]
    4HTQ X-ray 1.40 A 19-147 [» ]
    4HV1 X-ray 2.30 A 19-147 [» ]
    4HV2 X-ray 2.50 A 19-147 [» ]
    4I8S X-ray 2.00 A 19-147 [» ]
    4IAS X-ray 2.60 A 19-147 [» ]
    4IAT X-ray 2.00 A 19-147 [» ]
    4II8 X-ray 1.88 A 19-147 [» ]
    4J1A X-ray 1.79 A 19-147 [» ]
    4J1B X-ray 1.66 A 19-147 [» ]
    4J7V X-ray 1.54 A 19-147 [» ]
    4KXI X-ray 2.00 A 19-147 [» ]
    4LFP X-ray 1.72 A 19-147 [» ]
    4LFX X-ray 2.10 A 19-147 [» ]
    4LGK X-ray 1.96 A 19-147 [» ]
    4LYM X-ray 2.10 A 19-147 [» ]
    4LYO X-ray 2.05 A 19-147 [» ]
    4LYT X-ray 1.90 A/B 19-147 [» ]
    4LYZ X-ray 2.00 A 19-147 [» ]
    4LZT X-ray 0.95 A 19-147 [» ]
    4M4O X-ray 2.00 A 19-147 [» ]
    4M6D X-ray 2.68 A/C/E/G/I/K 19-147 [» ]
    4MR1 X-ray 1.99 A 19-147 [» ]
    4N5R X-ray 2.10 A 19-147 [» ]
    4N8Z X-ray 1.20 A 19-147 [» ]
    4NEB X-ray 1.48 A 19-147 [» ]
    4NFV X-ray 1.63 A 19-147 [» ]
    4NG1 X-ray 1.82 A 19-147 [» ]
    4NG8 X-ray 1.09 A 19-147 [» ]
    4NGI X-ray 1.70 A 19-147 [» ]
    4NGJ X-ray 1.10 A 19-147 [» ]
    4NGK X-ray 1.50 A 19-147 [» ]
    4NGL X-ray 1.52 A 19-147 [» ]
    4NGO X-ray 1.58 A 19-147 [» ]
    4NGV X-ray 1.64 A 19-147 [» ]
    4NGW X-ray 1.37 A 19-147 [» ]
    4NGY X-ray 1.35 A 19-147 [» ]
    4NGZ X-ray 1.70 A 19-147 [» ]
    4NY5 X-ray 1.85 A 19-147 [» ]
    4O34 X-ray 2.09 A 19-147 [» ]
    4OOO X-ray 2.15 A 19-147 [» ]
    4P2E X-ray 1.60 A 19-147 [» ]
    4QEQ X-ray 1.38 A 19-147 [» ]
    5LYM X-ray 1.80 A/B 19-147 [» ]
    5LYT X-ray 1.90 A 19-147 [» ]
    5LYZ X-ray 2.00 A 19-147 [» ]
    6LYT X-ray 1.90 A 19-147 [» ]
    6LYZ X-ray 2.00 A 19-147 [» ]
    7LYZ X-ray 2.50 A 19-147 [» ]
    8LYZ X-ray 2.50 A 19-147 [» ]
    9LYZ X-ray 2.50 A 19-147 [» ]
    ProteinModelPortali P00698.
    SMRi P00698. Positions 19-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676478. 2 interactions.
    DIPi DIP-46258N.
    IntActi P00698. 4 interactions.

    Chemistry

    ChEMBLi CHEMBL1932892.
    DrugBanki DB00128. L-Aspartic Acid.

    Protein family/group databases

    Allergomei 3294. Gal d 4.0101.
    362. Gal d 4.
    CAZyi GH22. Glycoside Hydrolase Family 22.

    Proteomic databases

    PaxDbi P00698.
    PRIDEi P00698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000016196 ; ENSGALP00000016177 ; ENSGALG00000009963 .
    GeneIDi 396218.
    KEGGi gga:396218.

    Organism-specific databases

    CTDi 4069.

    Phylogenomic databases

    eggNOGi NOG85133.
    GeneTreei ENSGT00550000074398.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi P00698.
    KOi K13915.
    OMAi GNGMNAW.
    OrthoDBi EOG7BW0M5.
    PhylomeDBi P00698.
    TreeFami TF324882.

    Enzyme and pathway databases

    Reactomei REACT_197049. Amyloids.
    SABIO-RK P00698.

    Miscellaneous databases

    EvolutionaryTracei P00698.
    NextBioi 20816270.
    PROi P00698.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Exons encode functional and structural units of chicken lysozyme."
      Jung A., Sippel A.E., Grez M., Schutz G.
      Proc. Natl. Acad. Sci. U.S.A. 77:5759-5763(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 121.
    2. "The chicken lysozyme chromatin domain contains a second, widely expressed gene."
      Chong S., Riggs A.D., Bonifer C.
      Nucleic Acids Res. 30:463-467(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Precursor of egg white lysozyme. Amino acid sequence of an NH2-terminal extension."
      Palmiter R.D., Gagnon J., Ericsson L.H., Walsh K.A.
      J. Biol. Chem. 252:6386-6393(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-20.
    4. "The amino acid sequence of egg white lysozyme."
      Canfield R.E.
      J. Biol. Chem. 238:2698-2707(1963) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-147.
    5. "Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs."
      Buell G.N., Wickens M.P., Carbon J., Schimke R.T.
      J. Biol. Chem. 254:9277-9283(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-146.
    6. "The disulfide bonds of egg white lysozyme (muramidase)."
      Canfield R.E., Liu A.K.
      J. Biol. Chem. 240:1997-2002(1965) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    7. "The disulfide bridges of hen's egg-white lysozyme."
      Jauregui-Adell J., Jolles J., Jolles P.
      Biochim. Biophys. Acta 107:97-111(1965) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    8. "Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white."
      Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T.
      Gene 492:244-249(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Vertebrate lysozymes."
      Imoto T., Johnson L.N., North A.C.T., Phillips D.C., Rupley J.A.
      (In) Boyer P.D. (eds.); The enzymes (3rd ed.), pp.7:665-868, Academic Press, New York (1972)
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), REVIEW.
    10. "Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2-A resolution."
      Blake C.C.F., Koenig D.F., Mair G.A., North A.C.T., Phillips D.C., Sarma V.R.
      Nature 206:757-761(1965) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
    11. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF TRICLINIC LYSOZYME.
    12. "Structures of triclinic mono- and di-N-acetylglucosamine: lysozyme complexes -- a crystallographic study."
      Kurachi K., Sieker L.C., Jensen L.H.
      J. Mol. Biol. 101:11-24(1976) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF TRICLINIC LYSOZYME.
    13. "Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution."
      Fischmann T.O., Bentley G.A., Bhat T.N., Boulot G., Mariuzza R.A., Phillips S.E., Tello D., Poljak R.J.
      J. Biol. Chem. 266:12915-12920(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF COMPLEX WITH ANTIBODY.
    14. "Sequential 1H NMR assignments and secondary structure of hen egg white lysozyme in solution."
      Redfield C., Dobson C.M.
      Biochemistry 27:122-136(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    15. "Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea."
      Schwalbe H., Fiebig K.M., Buck M., Jones J.A., Grimshaw S.B., Spencer A., Glaser S.J., Smith L.J., Dobson C.M.
      Biochemistry 36:8977-8991(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    16. "Conversion of Trp 62 of hen egg-white lysozyme to Tyr by site-directed mutagenesis."
      Kumagai I., Kojima S., Tamaki E., Miura K.
      J. Biochem. 102:733-740(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS.

    Entry informationi

    Entry nameiLYSC_CHICK
    AccessioniPrimary (citable) accession number: P00698
    Secondary accession number(s): Q90884
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 163 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3