Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysozyme C

Gene

LYZ

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.PROSITE-ProRule annotation1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531
Active sitei70 – 701
Binding sitei119 – 1191Substrate

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
  3. retina homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.17. 1306.
ReactomeiREACT_317091. Amyloids.
SABIO-RKP00698.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Allergen Gal d IV
Allergen: Gal d 4
Gene namesi
Name:LYZ
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: AgBase
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3294. Gal d 4.0101.
362. Gal d 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 147129Lysozyme CPRO_0000018495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 145
Disulfide bondi48 ↔ 133
Disulfide bondi82 ↔ 98
Disulfide bondi94 ↔ 112

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP00698.
PRIDEiP00698.

Expressioni

Tissue specificityi

In the egg white and polymorphonuclear leukocytes.

Gene expression databases

ExpressionAtlasiP00698. baseline and differential.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-1029543,EBI-1029543
degPP0C0V08EBI-1029543,EBI-547165From a different organism.

Protein-protein interaction databases

BioGridi676478. 2 interactions.
DIPiDIP-46258N.
IntActiP00698. 4 interactions.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 3210Combined sources
Turni33 – 375Combined sources
Helixi38 – 403Combined sources
Helixi43 – 5412Combined sources
Beta strandi55 – 573Combined sources
Beta strandi61 – 633Combined sources
Beta strandi65 – 673Combined sources
Beta strandi69 – 713Combined sources
Turni72 – 754Combined sources
Turni78 – 814Combined sources
Beta strandi85 – 873Combined sources
Helixi98 – 1025Combined sources
Beta strandi103 – 1053Combined sources
Helixi107 – 11812Combined sources
Beta strandi119 – 1213Combined sources
Helixi123 – 1253Combined sources
Helixi127 – 1326Combined sources
Turni133 – 1353Combined sources
Helixi138 – 1414Combined sources
Turni142 – 1443Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
132LX-ray1.80A19-147[»]
193LX-ray1.33A19-147[»]
194LX-ray1.40A19-147[»]
1A2YX-ray1.50C19-147[»]
1AKIX-ray1.50A19-147[»]
1AT5X-ray1.80A19-147[»]
1AT6X-ray1.80A19-147[»]
1AZFX-ray1.80A19-147[»]
1B0DX-ray1.84A19-147[»]
1B2KX-ray1.60A/B19-147[»]
1BGIX-ray1.70A19-147[»]
1BHZX-ray3.90A19-147[»]
1BVKX-ray2.70C/F19-147[»]
1BVXX-ray1.80A19-147[»]
1BWHX-ray1.80A19-147[»]
1BWIX-ray1.80A19-147[»]
1BWJX-ray1.80A19-147[»]
1C08X-ray2.30C19-147[»]
1C10X-ray2.03A19-147[»]
1DPWX-ray1.64A19-147[»]
1DPXX-ray1.65A19-147[»]
1DQJX-ray2.00C19-147[»]
1E8LNMR-A19-147[»]
1F0WX-ray1.90A19-147[»]
1F10X-ray1.70A19-147[»]
1F3JX-ray3.10P/Q29-42[»]
1FDLX-ray2.50Y19-147[»]
1FLQX-ray1.80A19-147[»]
1FLUX-ray1.78A19-147[»]
1FLWX-ray1.81A19-147[»]
1FLYX-ray1.83A19-147[»]
1FN5X-ray1.78A19-147[»]
1G7HX-ray1.85C19-147[»]
1G7IX-ray1.80C19-147[»]
1G7JX-ray1.75C19-147[»]
1G7LX-ray2.00C19-147[»]
1G7MX-ray1.90C19-147[»]
1GPQX-ray1.60C/D19-147[»]
1GWDX-ray1.77A19-147[»]
1GXVNMR-219-147[»]
1GXXNMR-A19-147[»]
1H6MX-ray1.64A19-147[»]
1H87X-ray1.72A19-147[»]
1HC0X-ray1.82A19-147[»]
1HELX-ray1.70A19-147[»]
1HEMX-ray1.80A19-147[»]
1HENX-ray1.80A19-147[»]
1HEOX-ray1.80A19-147[»]
1HEPX-ray1.80A19-147[»]
1HEQX-ray1.80A19-147[»]
1HERX-ray1.80A19-147[»]
1HEWX-ray1.75A19-147[»]
1HF4X-ray1.45A/B19-147[»]
1HSWX-ray2.00A19-147[»]
1HSXX-ray1.90A19-147[»]
1IC4X-ray2.50Y19-147[»]
1IC5X-ray2.30Y19-147[»]
1IC7X-ray2.10Y19-147[»]
1IEEX-ray0.94A19-147[»]
1IO5neutron diffraction2.00A19-147[»]
1IOQX-ray1.79A19-147[»]
1IORX-ray1.76A19-147[»]
1IOSX-ray1.76A19-147[»]
1IOTX-ray1.75A19-147[»]
1IR7X-ray1.90A19-147[»]
1IR8X-ray1.63A19-147[»]
1IR9X-ray1.90A19-147[»]
1J1OX-ray1.80Y19-147[»]
1J1PX-ray1.80Y19-147[»]
1J1XX-ray1.80Y19-147[»]
1JA2X-ray2.87A19-147[»]
1JA4X-ray2.94A19-147[»]
1JA6X-ray2.96A19-147[»]
1JA7X-ray2.98A19-147[»]
1JISX-ray1.90A19-147[»]
1JITX-ray1.90A19-147[»]
1JIYX-ray1.90A19-147[»]
1JJ0X-ray1.90A19-147[»]
1JJ1X-ray1.90A19-147[»]
1JJ3X-ray1.90A/B19-147[»]
1JPOX-ray2.10A19-147[»]
1JTOX-ray2.50L/M19-147[»]
1JTTX-ray2.10L19-138[»]
1KIPX-ray2.10C19-147[»]
1KIQX-ray1.85C19-147[»]
1KIRX-ray2.00C19-147[»]
1KXWX-ray1.96A19-147[»]
1KXXX-ray1.71A19-147[»]
1KXYX-ray1.79A19-147[»]
1LCNX-ray1.63A/B19-147[»]
1LJ3X-ray2.00A/B19-147[»]
1LJ4X-ray1.95A/B19-147[»]
1LJEX-ray2.00A/B19-147[»]
1LJFX-ray1.80A/B19-147[»]
1LJGX-ray1.90A/B19-147[»]
1LJHX-ray1.80A/B19-147[»]
1LJIX-ray2.00A/B19-147[»]
1LJJX-ray2.00A/B19-147[»]
1LJKX-ray2.10A/B19-147[»]
1LKRX-ray1.60A/B19-147[»]
1LKSX-ray1.10A19-147[»]
1LMAX-ray1.75A19-147[»]
1LPIX-ray2.00A19-147[»]
1LSAX-ray1.70A19-147[»]
1LSBX-ray1.70A19-147[»]
1LSCX-ray1.70A19-147[»]
1LSDX-ray1.70A19-147[»]
1LSEX-ray1.70A19-147[»]
1LSFX-ray1.70A19-147[»]
1LSGX-ray2.40A19-147[»]
1LSMX-ray1.70A19-147[»]
1LSNX-ray1.90A19-147[»]
1LSYX-ray1.90A1-147[»]
1LSZX-ray2.00A1-147[»]
1LYOX-ray1.93A19-147[»]
1LYSX-ray1.72A/B19-147[»]
1LYZX-ray2.00A19-147[»]
1LZ8X-ray1.53A19-147[»]
1LZ9X-ray1.70A19-147[»]
1LZAX-ray1.60A19-147[»]
1LZBX-ray1.50A19-147[»]
1LZCX-ray1.80A19-147[»]
1LZDX-ray1.80A19-147[»]
1LZEX-ray1.80A19-147[»]
1LZGX-ray1.80A19-147[»]
1LZHX-ray6.00A/B19-147[»]
1LZNneutron diffraction1.70A19-147[»]
1LZTX-ray1.97A19-147[»]
1MELX-ray2.50L/M19-147[»]
1MLCX-ray2.50E/F19-147[»]
1N4FX-ray1.78A19-147[»]
1NBYX-ray1.80C19-147[»]
1NBZX-ray1.85C19-147[»]
1NDGX-ray1.90C19-147[»]
1NDMX-ray2.10C19-147[»]
1P2CX-ray2.00C/F19-147[»]
1PS5X-ray2.00A19-147[»]
1QIOX-ray1.20A19-147[»]
1QTKX-ray2.03A19-147[»]
1RCMX-ray1.90A/B19-147[»]
1RFPX-ray1.75A19-147[»]
1RI8X-ray1.85B19-147[»]
1RJCX-ray1.40B19-147[»]
1SF4X-ray2.98A19-147[»]
1SF6X-ray3.22A19-147[»]
1SF7X-ray3.22A19-147[»]
1SFBX-ray3.22A19-147[»]
1SFGX-ray3.22A19-147[»]
1SQ2X-ray1.45L19-147[»]
1T3PX-ray1.60A19-147[»]
1T6VX-ray1.70L/M19-147[»]
1UA6X-ray1.90Y19-147[»]
1UC0X-ray1.85A19-147[»]
1UCOX-ray2.00A/B19-147[»]
1UIAX-ray1.76A19-147[»]
1UIBX-ray1.76A19-147[»]
1UICX-ray1.95A19-147[»]
1UIDX-ray1.95A19-147[»]
1UIEX-ray1.95A19-147[»]
1UIFX-ray1.85A19-147[»]
1UIGX-ray1.95A19-147[»]
1UIHX-ray1.75A19-147[»]
1UUZX-ray1.80C/D19-147[»]
1V7SX-ray1.14A19-147[»]
1V7TX-ray1.13A/B19-147[»]
1VATX-ray1.60A19-147[»]
1VAUX-ray1.50A19-147[»]
1VDPX-ray1.70A/B19-147[»]
1VDQX-ray1.50A19-147[»]
1VDSX-ray1.60A19-147[»]
1VDTX-ray1.70A19-147[»]
1VEDX-ray1.90A19-147[»]
1VFBX-ray1.80C19-147[»]
1W6ZX-ray1.65A19-147[»]
1WTMX-ray1.33A19-147[»]
1WTNX-ray1.13A19-147[»]
1XEIX-ray2.10A19-147[»]
1XEJX-ray2.10A19-147[»]
1XEKX-ray2.30A19-147[»]
1XFPX-ray1.50L19-147[»]
1XGPX-ray2.10C19-147[»]
1XGQX-ray2.10C19-147[»]
1XGRX-ray2.10C19-147[»]
1XGTX-ray2.10C19-147[»]
1XGUX-ray2.10C19-147[»]
1YIKX-ray1.75A19-147[»]
1YILX-ray1.60A19-147[»]
1YKXX-ray1.90X19-147[»]
1YKYX-ray1.90X19-147[»]
1YKZX-ray1.80X19-147[»]
1YL0X-ray1.90X19-147[»]
1YL1X-ray1.90X19-147[»]
1YQVX-ray1.70Y19-147[»]
1Z55X-ray1.90A19-147[»]
1ZMYX-ray3.00L/M19-147[»]
1ZV5X-ray2.00L19-147[»]
1ZVHX-ray1.50L19-147[»]
1ZVYX-ray1.63B19-147[»]
2A6UX-ray-A19-147[»]
2A7DX-ray1.66A19-147[»]
2A7FX-ray1.85A19-147[»]
2AUBX-ray1.70A19-147[»]
2B5ZX-ray1.60A19-147[»]
2BLXX-ray1.40A19-147[»]
2BLYX-ray1.40A19-147[»]
2BPUX-ray1.35A19-147[»]
2C8OX-ray1.50A19-147[»]
2C8PX-ray1.50A19-147[»]
2CDSX-ray2.00A19-147[»]
2CGIX-ray1.35A19-147[»]
2D4IX-ray1.16A/B19-147[»]
2D4JX-ray1.16A19-147[»]
2D4KX-ray1.15A/N19-147[»]
2D6BX-ray1.25A19-147[»]
2D91X-ray2.10A19-147[»]
2DQCX-ray1.80Y19-147[»]
2DQDX-ray1.80Y19-147[»]
2DQEX-ray1.90Y19-147[»]
2DQFX-ray2.50C/F19-147[»]
2DQGX-ray2.30Y19-147[»]
2DQHX-ray2.30Y19-147[»]
2DQIX-ray2.00Y19-147[»]
2DQJX-ray1.80Y19-147[»]
2EIZX-ray1.90C19-147[»]
2EKSX-ray2.00C19-147[»]
2EPEX-ray2.50A19-147[»]
2F2NX-ray1.60A19-147[»]
2F30X-ray1.65A19-147[»]
2F4AX-ray1.95A19-147[»]
2F4GX-ray1.65A19-147[»]
2FBBX-ray1.46A19-147[»]
2G4PX-ray1.84A19-147[»]
2G4QX-ray1.84A19-147[»]
2H9JX-ray1.75A19-147[»]
2H9KX-ray1.75A19-147[»]
2HFMmodel-Y19-147[»]
2HS7X-ray-A19-147[»]
2HS9X-ray-A19-147[»]
2HSOX-ray-A19-147[»]
2HTXX-ray1.56A19-147[»]
2HU1X-ray1.63A19-147[»]
2HU3X-ray1.30A19-147[»]
2HUBX-ray1.20A19-147[»]
2I25X-ray1.80L/M19-147[»]
2I26X-ray2.50L/M/Q19-147[»]
2I6ZX-ray1.90A19-147[»]
2IFFX-ray2.65Y19-147[»]
2LYMX-ray2.00A19-147[»]
2LYOX-ray1.93A19-147[»]
2LYZX-ray2.00A19-147[»]
2LZHX-ray6.00A19-147[»]
2LZTX-ray1.97A19-147[»]
2PC2X-ray1.54A19-147[»]
2Q0MX-ray1.70X19-147[»]
2VB1X-ray0.65A19-147[»]
2W1LX-ray1.51A19-147[»]
2W1MX-ray1.78A19-147[»]
2W1XX-ray1.70A19-147[»]
2W1YX-ray1.73A19-147[»]
2WARX-ray1.80A19-147[»]
2X0AX-ray1.52A19-147[»]
2XBRX-ray1.29A19-147[»]
2XBSX-ray1.37A19-147[»]
2XJWX-ray1.67A19-147[»]
2XTHX-ray1.80A19-147[»]
2YBHX-ray2.00A19-147[»]
2YBIX-ray2.00A19-147[»]
2YBJX-ray2.00A19-147[»]
2YBLX-ray2.00A19-147[»]
2YBMX-ray2.00A19-147[»]
2YBNX-ray2.00A19-147[»]
2YDGX-ray2.00A19-147[»]
2YSSX-ray2.40C19-147[»]
2YVBX-ray1.62A19-147[»]
2Z12X-ray1.15A19-147[»]
2Z18X-ray1.15A19-147[»]
2Z19X-ray1.15A19-147[»]
2ZNWX-ray2.71Y/Z19-147[»]
2ZNXX-ray2.30Y/Z19-147[»]
2ZQ3X-ray1.60A19-147[»]
2ZQ4X-ray2.00A19-147[»]
2ZYPX-ray1.18A19-147[»]
3A34X-ray1.65A19-147[»]
3A3QX-ray2.00A19-147[»]
3A3RX-ray1.90X19-147[»]
3A67X-ray1.80Y19-147[»]
3A6BX-ray1.80Y19-147[»]
3A6CX-ray1.80Y19-147[»]
3A8ZX-ray1.40A19-147[»]
3A90X-ray1.45A19-147[»]
3A91X-ray1.55A19-147[»]
3A92X-ray1.50A19-147[»]
3A93X-ray1.55A19-147[»]
3A94X-ray1.55A19-147[»]
3A95X-ray1.50A19-147[»]
3A96X-ray1.75A19-147[»]
3AGGX-ray1.60G19-147[»]
3AGHX-ray1.49A19-147[»]
3AGIX-ray1.20A19-147[»]
3AJNX-ray1.05A19-147[»]
3ATNX-ray1.17A19-147[»]
3ATOX-ray1.17A19-147[»]
3AW6X-ray2.10A19-147[»]
3AW7X-ray2.10A19-147[»]
3AZ4X-ray1.62A19-147[»]
3AZ5X-ray2.34A19-147[»]
3AZ6X-ray1.50A19-147[»]
3AZ7X-ray2.10A19-147[»]
3B6LX-ray2.30A1-147[»]
3B72X-ray1.50A1-147[»]
3D9AX-ray1.20C19-147[»]
3E3DX-ray1.55A19-147[»]
3EMSX-ray1.65A19-147[»]
3EXDX-ray1.49A19-147[»]
3F6ZX-ray2.50A/C19-147[»]
3G3AX-ray2.20B/D/F/H19-147[»]
3G3BX-ray2.40B/D/F/H19-147[»]
3HFMX-ray3.00Y19-147[»]
3IJUX-ray1.60A19-147[»]
3IJVX-ray1.70A19-147[»]
3J4Gelectron microscopy2.90A19-147[»]
3J6Kelectron microscopy2.50A19-147[»]
3KAMX-ray1.59A19-147[»]
3LYMX-ray2.00A19-147[»]
3LYOX-ray1.93A19-147[»]
3LYTX-ray1.90A/B19-147[»]
3LYZX-ray2.00A19-147[»]
3LZTX-ray0.93A19-147[»]
3M18X-ray1.95B19-147[»]
3M3UX-ray2.35A19-147[»]
3MBEX-ray2.89P/Q29-45[»]
3N9AX-ray1.40A19-147[»]
3N9CX-ray1.50A19-147[»]
3N9EX-ray1.38A19-147[»]
3OJPX-ray1.81A19-147[»]
3OK0X-ray1.82A19-147[»]
3OTPX-ray3.76G/H/I/J/K/L36-76[»]
3P4ZX-ray1.60A19-147[»]
3P64X-ray1.30A19-147[»]
3P65X-ray2.10A19-147[»]
3P66X-ray1.36A19-147[»]
3P68X-ray1.60A19-147[»]
3QE8X-ray1.49A/B19-147[»]
3QNGX-ray1.55A19-147[»]
3QY4X-ray1.65A19-146[»]
3RNXX-ray1.86A19-147[»]
3RT5X-ray1.75X19-147[»]
3RU5X-ray1.35A19-147[»]
3RW8X-ray1.86A19-147[»]
3RZ4X-ray1.80A19-147[»]
3SP3X-ray1.80A19-147[»]
3T6UX-ray2.21A19-147[»]
3TMUX-ray1.90A1-147[»]
3TMVX-ray1.90A1-147[»]
3TMWX-ray1.90A1-147[»]
3TMXX-ray1.90A1-147[»]
3TXBX-ray1.59A19-147[»]
3TXDX-ray1.53A19-147[»]
3TXEX-ray1.70A19-147[»]
3TXFX-ray1.69A19-147[»]
3TXGX-ray1.70A19-147[»]
3TXHX-ray1.69A19-147[»]
3TXIX-ray1.60A19-147[»]
3TXJX-ray2.48A19-147[»]
3TXKX-ray3.00A19-147[»]
3ULRX-ray1.65A19-147[»]
3VFXX-ray1.95A/B19-147[»]
3W6AX-ray1.77A19-147[»]
3WL2X-ray0.96A/B19-147[»]
3WMKX-ray1.46A19-147[»]
3WPJX-ray2.00A19-147[»]
3WPKX-ray2.00A19-147[»]
3WPLX-ray2.00A19-147[»]
3WU7X-ray2.00A19-147[»]
3WU8X-ray2.00A19-147[»]
3WU9X-ray2.00A19-147[»]
3WUAX-ray2.00A19-147[»]
3WULX-ray2.00A19-147[»]
3WUMX-ray2.00A19-147[»]
3WXTX-ray2.00A19-147[»]
3WXUX-ray2.00A19-147[»]
3ZEKX-ray1.43A19-147[»]
3ZVQX-ray2.00A19-88[»]
B90-147[»]
4A7DX-ray1.50A19-147[»]
4A8Aelectron microscopy14.20M19-147[»]
4A8Belectron microscopy13.00M/N/O/P/Q/R19-147[»]
4AGAX-ray1.50A19-147[»]
4AXTX-ray1.10A19-147[»]
4B0DX-ray1.10A19-147[»]
4B1AX-ray1.67A19-147[»]
4B49X-ray1.15A19-147[»]
4B4EX-ray1.00A19-147[»]
4B4IX-ray1.20A19-147[»]
4B4JX-ray1.25A19-147[»]
4BADX-ray1.35A19-147[»]
4BAFX-ray1.51A19-147[»]
4BAPX-ray1.21A19-147[»]
4BS7X-ray1.70A19-147[»]
4C3WX-ray1.28A19-147[»]
4CJ2X-ray1.50A/B1-147[»]
4D9ZX-ray1.71A19-147[»]
4DC4X-ray2.65A/B/C19-147[»]
4DD0X-ray1.70A19-147[»]
4DD1X-ray1.70A/B19-147[»]
4DD2X-ray1.55A19-147[»]
4DD3X-ray1.70A19-147[»]
4DD4X-ray1.70A19-147[»]
4DD6X-ray1.70A19-147[»]
4DD7X-ray1.60A19-147[»]
4DD9X-ray1.60A19-147[»]
4DDAX-ray2.48A19-147[»]
4DDBX-ray3.00A19-147[»]
4DDCX-ray1.80A/B19-147[»]
4DT3X-ray1.80A19-147[»]
4E3UX-ray1.50A19-147[»]
4EOFX-ray1.83A19-147[»]
4ET8X-ray1.90A19-147[»]
4ET9X-ray1.90A19-147[»]
4ETAX-ray1.91A19-147[»]
4ETBX-ray1.91A19-147[»]
4ETCX-ray1.91A19-147[»]
4ETDX-ray1.90A19-147[»]
4ETEX-ray1.90A19-147[»]
4FJRX-ray1.86A19-147[»]
4G49X-ray2.40A19-147[»]
4G4AX-ray2.40A19-147[»]
4G4BX-ray2.10A19-147[»]
4G4CX-ray2.00A19-147[»]
4G4HX-ray2.00A19-147[»]
4GCBX-ray1.80A19-147[»]
4GCCX-ray2.00A19-147[»]
4GCDX-ray2.80A19-147[»]
4GCEX-ray2.90A19-147[»]
4GCFX-ray3.50A19-147[»]
4GLAX-ray2.75A/B19-147[»]
4GLVX-ray2.57A/C/E/G19-147[»]
4GN3X-ray1.95A/C/E/G/I/K/M/O/Q19-147[»]
4GN4X-ray1.86A19-147[»]
4GN5X-ray1.86C/D19-147[»]
4H1PX-ray2.30A19-147[»]
4H8XX-ray1.20A19-147[»]
4H8YX-ray1.20A19-147[»]
4H8ZX-ray1.20A19-147[»]
4H90X-ray1.20A19-147[»]
4H91X-ray1.20A19-147[»]
4H92X-ray1.20A19-147[»]
4H93X-ray1.20A19-147[»]
4H94X-ray1.20A19-147[»]
4H9AX-ray1.20A19-147[»]
4H9BX-ray1.20A19-147[»]
4H9CX-ray1.20A19-147[»]
4H9EX-ray1.20A19-147[»]
4H9FX-ray1.20A19-147[»]
4H9HX-ray1.20A19-147[»]
4H9IX-ray1.20A19-147[»]
4HP0X-ray1.19A19-147[»]
4HPIX-ray1.19A19-147[»]
4HSFX-ray1.82A19-147[»]
4HTKX-ray1.20A19-147[»]
4HTNX-ray1.30A19-147[»]
4HTQX-ray1.40A19-147[»]
4HV1X-ray2.30A19-147[»]
4HV2X-ray2.50A19-147[»]
4I8SX-ray2.00A19-147[»]
4IASX-ray2.60A19-147[»]
4IATX-ray2.00A19-147[»]
4II8X-ray1.88A19-147[»]
4J1AX-ray1.79A19-147[»]
4J1BX-ray1.66A19-147[»]
4J7VX-ray1.54A19-147[»]
4KXIX-ray2.00A19-147[»]
4LFPX-ray1.72A19-147[»]
4LFXX-ray2.10A19-147[»]
4LGKX-ray1.96A19-147[»]
4LT0X-ray2.10A19-147[»]
4LT1X-ray2.30A19-147[»]
4LT2X-ray2.00A19-147[»]
4LT3X-ray2.00A19-147[»]
4LYMX-ray2.10A19-147[»]
4LYOX-ray2.05A19-147[»]
4LYTX-ray1.90A/B19-147[»]
4LYZX-ray2.00A19-147[»]
4LZTX-ray0.95A19-147[»]
4M4OX-ray2.00A19-147[»]
4M6DX-ray2.68A/C/E/G/I/K19-147[»]
4MR1X-ray1.99A19-147[»]
4MWKX-ray0.98A19-147[»]
4MWMX-ray1.12A19-147[»]
4MWNX-ray1.42A19-147[»]
4N0JX-ray1.90A/B20-147[»]
4N1CX-ray1.70C19-147[»]
4N1EX-ray2.23I/J/K/L19-147[»]
4N5RX-ray2.10A19-147[»]
4N8ZX-ray1.20A19-147[»]
4NEBX-ray1.48A19-147[»]
4NFVX-ray1.63A19-147[»]
4NG1X-ray1.82A19-147[»]
4NG8X-ray1.09A19-147[»]
4NGIX-ray1.70A19-147[»]
4NGJX-ray1.10A19-147[»]
4NGKX-ray1.50A19-147[»]
4NGLX-ray1.52A19-147[»]
4NGOX-ray1.58A19-147[»]
4NGVX-ray1.64A19-147[»]
4NGWX-ray1.37A19-147[»]
4NGYX-ray1.35A19-147[»]
4NGZX-ray1.70A19-147[»]
4NHIX-ray1.34A19-147[»]
4NHPX-ray1.42A19-147[»]
4NHQX-ray1.92A19-147[»]
4NHSX-ray1.99A19-147[»]
4NHTX-ray1.65A19-147[»]
4NIJX-ray1.86A19-147[»]
4NSGX-ray2.00A19-147[»]
4NSHX-ray2.10A19-147[»]
4NSIX-ray2.30A19-147[»]
4NSJX-ray1.70A19-147[»]
4NWEX-ray1.58A19-147[»]
4NWHX-ray1.65A19-147[»]
4NY5X-ray1.85A19-147[»]
4O34X-ray2.09A19-147[»]
4OOOX-ray2.15A19-147[»]
4OOTX-ray1.80A19-147[»]
4OW9X-ray2.10A/B19-147[»]
4OWAX-ray1.80A/B19-147[»]
4OWBX-ray1.69A19-147[»]
4OWCX-ray1.62A19-147[»]
4OWEX-ray1.41A19-147[»]
4OWHX-ray1.48A19-147[»]
4OXEX-ray1.13A19-147[»]
4P2EX-ray1.60A19-147[»]
4PHIX-ray1.81A/B/C/D19-147[»]
4PPOX-ray1.73A19-147[»]
4PRQX-ray1.72A/B/C/D19-147[»]
4PRUX-ray2.20A/B19-147[»]
4QEQX-ray1.38A19-147[»]
4QGZX-ray2.51A19-147[»]
4QY9X-ray2.05A19-147[»]
4RDSX-ray1.23A19-147[»]
4TUNX-ray1.92A/B19-147[»]
4TWSX-ray1.45A19-147[»]
4UWNX-ray1.67A19-147[»]
4UWUX-ray1.78A19-147[»]
4UWVX-ray1.77A19-147[»]
4W94X-ray1.55A19-147[»]
4W96X-ray1.50A19-147[»]
4XADX-ray1.25A19-147[»]
4XANX-ray1.47A19-147[»]
5LYMX-ray1.80A/B19-147[»]
5LYTX-ray1.90A19-147[»]
5LYZX-ray2.00A19-147[»]
6LYTX-ray1.90A19-147[»]
6LYZX-ray2.00A19-147[»]
7LYZX-ray2.50A19-147[»]
8LYZX-ray2.50A19-147[»]
9LYZX-ray2.50A19-147[»]
ProteinModelPortaliP00698.
SMRiP00698. Positions 19-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00698.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85133.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP00698.
KOiK13915.
OMAiCAAKFES.
OrthoDBiEOG7BW0M5.
PhylomeDBiP00698.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030056. Lysozyme_C.
[Graphical view]
PANTHERiPTHR11407:SF22. PTHR11407:SF22. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLILVLC FLPLAALGKV FGRCELAAAM KRHGLDNYRG YSLGNWVCAA
60 70 80 90 100
KFESNFNTQA TNRNTDGSTD YGILQINSRW WCNDGRTPGS RNLCNIPCSA
110 120 130 140
LLSSDITASV NCAKKIVSDG NGMNAWVAWR NRCKGTDVQA WIRGCRL
Length:147
Mass (Da):16,239
Last modified:July 21, 1986 - v1
Checksum:i81E85743FF579468
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → V in CAA23711 (PubMed:6934509).Curated
Sequence conflicti121 – 1211N → D AA sequence (PubMed:14063294).Curated
Sequence conflicti124 – 1241N → S in CAA23711 (PubMed:6934509).Curated
Sequence conflicti132 – 1321R → S in AAA48944 (PubMed:383714).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00885 Genomic DNA. Translation: AAA48943.1.
V00428 mRNA. Translation: CAA23711.1.
AF410481 Genomic DNA. Translation: AAL69327.1.
M10640 mRNA. Translation: AAA48944.1.
PIRiA93859. LZCH.
RefSeqiNP_990612.1. NM_205281.1.
UniGeneiGga.713.

Genome annotation databases

EnsembliENSGALT00000016196; ENSGALP00000016177; ENSGALG00000009963.
GeneIDi396218.
KEGGigga:396218.

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00885 Genomic DNA. Translation: AAA48943.1.
V00428 mRNA. Translation: CAA23711.1.
AF410481 Genomic DNA. Translation: AAL69327.1.
M10640 mRNA. Translation: AAA48944.1.
PIRiA93859. LZCH.
RefSeqiNP_990612.1. NM_205281.1.
UniGeneiGga.713.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
132LX-ray1.80A19-147[»]
193LX-ray1.33A19-147[»]
194LX-ray1.40A19-147[»]
1A2YX-ray1.50C19-147[»]
1AKIX-ray1.50A19-147[»]
1AT5X-ray1.80A19-147[»]
1AT6X-ray1.80A19-147[»]
1AZFX-ray1.80A19-147[»]
1B0DX-ray1.84A19-147[»]
1B2KX-ray1.60A/B19-147[»]
1BGIX-ray1.70A19-147[»]
1BHZX-ray3.90A19-147[»]
1BVKX-ray2.70C/F19-147[»]
1BVXX-ray1.80A19-147[»]
1BWHX-ray1.80A19-147[»]
1BWIX-ray1.80A19-147[»]
1BWJX-ray1.80A19-147[»]
1C08X-ray2.30C19-147[»]
1C10X-ray2.03A19-147[»]
1DPWX-ray1.64A19-147[»]
1DPXX-ray1.65A19-147[»]
1DQJX-ray2.00C19-147[»]
1E8LNMR-A19-147[»]
1F0WX-ray1.90A19-147[»]
1F10X-ray1.70A19-147[»]
1F3JX-ray3.10P/Q29-42[»]
1FDLX-ray2.50Y19-147[»]
1FLQX-ray1.80A19-147[»]
1FLUX-ray1.78A19-147[»]
1FLWX-ray1.81A19-147[»]
1FLYX-ray1.83A19-147[»]
1FN5X-ray1.78A19-147[»]
1G7HX-ray1.85C19-147[»]
1G7IX-ray1.80C19-147[»]
1G7JX-ray1.75C19-147[»]
1G7LX-ray2.00C19-147[»]
1G7MX-ray1.90C19-147[»]
1GPQX-ray1.60C/D19-147[»]
1GWDX-ray1.77A19-147[»]
1GXVNMR-219-147[»]
1GXXNMR-A19-147[»]
1H6MX-ray1.64A19-147[»]
1H87X-ray1.72A19-147[»]
1HC0X-ray1.82A19-147[»]
1HELX-ray1.70A19-147[»]
1HEMX-ray1.80A19-147[»]
1HENX-ray1.80A19-147[»]
1HEOX-ray1.80A19-147[»]
1HEPX-ray1.80A19-147[»]
1HEQX-ray1.80A19-147[»]
1HERX-ray1.80A19-147[»]
1HEWX-ray1.75A19-147[»]
1HF4X-ray1.45A/B19-147[»]
1HSWX-ray2.00A19-147[»]
1HSXX-ray1.90A19-147[»]
1IC4X-ray2.50Y19-147[»]
1IC5X-ray2.30Y19-147[»]
1IC7X-ray2.10Y19-147[»]
1IEEX-ray0.94A19-147[»]
1IO5neutron diffraction2.00A19-147[»]
1IOQX-ray1.79A19-147[»]
1IORX-ray1.76A19-147[»]
1IOSX-ray1.76A19-147[»]
1IOTX-ray1.75A19-147[»]
1IR7X-ray1.90A19-147[»]
1IR8X-ray1.63A19-147[»]
1IR9X-ray1.90A19-147[»]
1J1OX-ray1.80Y19-147[»]
1J1PX-ray1.80Y19-147[»]
1J1XX-ray1.80Y19-147[»]
1JA2X-ray2.87A19-147[»]
1JA4X-ray2.94A19-147[»]
1JA6X-ray2.96A19-147[»]
1JA7X-ray2.98A19-147[»]
1JISX-ray1.90A19-147[»]
1JITX-ray1.90A19-147[»]
1JIYX-ray1.90A19-147[»]
1JJ0X-ray1.90A19-147[»]
1JJ1X-ray1.90A19-147[»]
1JJ3X-ray1.90A/B19-147[»]
1JPOX-ray2.10A19-147[»]
1JTOX-ray2.50L/M19-147[»]
1JTTX-ray2.10L19-138[»]
1KIPX-ray2.10C19-147[»]
1KIQX-ray1.85C19-147[»]
1KIRX-ray2.00C19-147[»]
1KXWX-ray1.96A19-147[»]
1KXXX-ray1.71A19-147[»]
1KXYX-ray1.79A19-147[»]
1LCNX-ray1.63A/B19-147[»]
1LJ3X-ray2.00A/B19-147[»]
1LJ4X-ray1.95A/B19-147[»]
1LJEX-ray2.00A/B19-147[»]
1LJFX-ray1.80A/B19-147[»]
1LJGX-ray1.90A/B19-147[»]
1LJHX-ray1.80A/B19-147[»]
1LJIX-ray2.00A/B19-147[»]
1LJJX-ray2.00A/B19-147[»]
1LJKX-ray2.10A/B19-147[»]
1LKRX-ray1.60A/B19-147[»]
1LKSX-ray1.10A19-147[»]
1LMAX-ray1.75A19-147[»]
1LPIX-ray2.00A19-147[»]
1LSAX-ray1.70A19-147[»]
1LSBX-ray1.70A19-147[»]
1LSCX-ray1.70A19-147[»]
1LSDX-ray1.70A19-147[»]
1LSEX-ray1.70A19-147[»]
1LSFX-ray1.70A19-147[»]
1LSGX-ray2.40A19-147[»]
1LSMX-ray1.70A19-147[»]
1LSNX-ray1.90A19-147[»]
1LSYX-ray1.90A1-147[»]
1LSZX-ray2.00A1-147[»]
1LYOX-ray1.93A19-147[»]
1LYSX-ray1.72A/B19-147[»]
1LYZX-ray2.00A19-147[»]
1LZ8X-ray1.53A19-147[»]
1LZ9X-ray1.70A19-147[»]
1LZAX-ray1.60A19-147[»]
1LZBX-ray1.50A19-147[»]
1LZCX-ray1.80A19-147[»]
1LZDX-ray1.80A19-147[»]
1LZEX-ray1.80A19-147[»]
1LZGX-ray1.80A19-147[»]
1LZHX-ray6.00A/B19-147[»]
1LZNneutron diffraction1.70A19-147[»]
1LZTX-ray1.97A19-147[»]
1MELX-ray2.50L/M19-147[»]
1MLCX-ray2.50E/F19-147[»]
1N4FX-ray1.78A19-147[»]
1NBYX-ray1.80C19-147[»]
1NBZX-ray1.85C19-147[»]
1NDGX-ray1.90C19-147[»]
1NDMX-ray2.10C19-147[»]
1P2CX-ray2.00C/F19-147[»]
1PS5X-ray2.00A19-147[»]
1QIOX-ray1.20A19-147[»]
1QTKX-ray2.03A19-147[»]
1RCMX-ray1.90A/B19-147[»]
1RFPX-ray1.75A19-147[»]
1RI8X-ray1.85B19-147[»]
1RJCX-ray1.40B19-147[»]
1SF4X-ray2.98A19-147[»]
1SF6X-ray3.22A19-147[»]
1SF7X-ray3.22A19-147[»]
1SFBX-ray3.22A19-147[»]
1SFGX-ray3.22A19-147[»]
1SQ2X-ray1.45L19-147[»]
1T3PX-ray1.60A19-147[»]
1T6VX-ray1.70L/M19-147[»]
1UA6X-ray1.90Y19-147[»]
1UC0X-ray1.85A19-147[»]
1UCOX-ray2.00A/B19-147[»]
1UIAX-ray1.76A19-147[»]
1UIBX-ray1.76A19-147[»]
1UICX-ray1.95A19-147[»]
1UIDX-ray1.95A19-147[»]
1UIEX-ray1.95A19-147[»]
1UIFX-ray1.85A19-147[»]
1UIGX-ray1.95A19-147[»]
1UIHX-ray1.75A19-147[»]
1UUZX-ray1.80C/D19-147[»]
1V7SX-ray1.14A19-147[»]
1V7TX-ray1.13A/B19-147[»]
1VATX-ray1.60A19-147[»]
1VAUX-ray1.50A19-147[»]
1VDPX-ray1.70A/B19-147[»]
1VDQX-ray1.50A19-147[»]
1VDSX-ray1.60A19-147[»]
1VDTX-ray1.70A19-147[»]
1VEDX-ray1.90A19-147[»]
1VFBX-ray1.80C19-147[»]
1W6ZX-ray1.65A19-147[»]
1WTMX-ray1.33A19-147[»]
1WTNX-ray1.13A19-147[»]
1XEIX-ray2.10A19-147[»]
1XEJX-ray2.10A19-147[»]
1XEKX-ray2.30A19-147[»]
1XFPX-ray1.50L19-147[»]
1XGPX-ray2.10C19-147[»]
1XGQX-ray2.10C19-147[»]
1XGRX-ray2.10C19-147[»]
1XGTX-ray2.10C19-147[»]
1XGUX-ray2.10C19-147[»]
1YIKX-ray1.75A19-147[»]
1YILX-ray1.60A19-147[»]
1YKXX-ray1.90X19-147[»]
1YKYX-ray1.90X19-147[»]
1YKZX-ray1.80X19-147[»]
1YL0X-ray1.90X19-147[»]
1YL1X-ray1.90X19-147[»]
1YQVX-ray1.70Y19-147[»]
1Z55X-ray1.90A19-147[»]
1ZMYX-ray3.00L/M19-147[»]
1ZV5X-ray2.00L19-147[»]
1ZVHX-ray1.50L19-147[»]
1ZVYX-ray1.63B19-147[»]
2A6UX-ray-A19-147[»]
2A7DX-ray1.66A19-147[»]
2A7FX-ray1.85A19-147[»]
2AUBX-ray1.70A19-147[»]
2B5ZX-ray1.60A19-147[»]
2BLXX-ray1.40A19-147[»]
2BLYX-ray1.40A19-147[»]
2BPUX-ray1.35A19-147[»]
2C8OX-ray1.50A19-147[»]
2C8PX-ray1.50A19-147[»]
2CDSX-ray2.00A19-147[»]
2CGIX-ray1.35A19-147[»]
2D4IX-ray1.16A/B19-147[»]
2D4JX-ray1.16A19-147[»]
2D4KX-ray1.15A/N19-147[»]
2D6BX-ray1.25A19-147[»]
2D91X-ray2.10A19-147[»]
2DQCX-ray1.80Y19-147[»]
2DQDX-ray1.80Y19-147[»]
2DQEX-ray1.90Y19-147[»]
2DQFX-ray2.50C/F19-147[»]
2DQGX-ray2.30Y19-147[»]
2DQHX-ray2.30Y19-147[»]
2DQIX-ray2.00Y19-147[»]
2DQJX-ray1.80Y19-147[»]
2EIZX-ray1.90C19-147[»]
2EKSX-ray2.00C19-147[»]
2EPEX-ray2.50A19-147[»]
2F2NX-ray1.60A19-147[»]
2F30X-ray1.65A19-147[»]
2F4AX-ray1.95A19-147[»]
2F4GX-ray1.65A19-147[»]
2FBBX-ray1.46A19-147[»]
2G4PX-ray1.84A19-147[»]
2G4QX-ray1.84A19-147[»]
2H9JX-ray1.75A19-147[»]
2H9KX-ray1.75A19-147[»]
2HFMmodel-Y19-147[»]
2HS7X-ray-A19-147[»]
2HS9X-ray-A19-147[»]
2HSOX-ray-A19-147[»]
2HTXX-ray1.56A19-147[»]
2HU1X-ray1.63A19-147[»]
2HU3X-ray1.30A19-147[»]
2HUBX-ray1.20A19-147[»]
2I25X-ray1.80L/M19-147[»]
2I26X-ray2.50L/M/Q19-147[»]
2I6ZX-ray1.90A19-147[»]
2IFFX-ray2.65Y19-147[»]
2LYMX-ray2.00A19-147[»]
2LYOX-ray1.93A19-147[»]
2LYZX-ray2.00A19-147[»]
2LZHX-ray6.00A19-147[»]
2LZTX-ray1.97A19-147[»]
2PC2X-ray1.54A19-147[»]
2Q0MX-ray1.70X19-147[»]
2VB1X-ray0.65A19-147[»]
2W1LX-ray1.51A19-147[»]
2W1MX-ray1.78A19-147[»]
2W1XX-ray1.70A19-147[»]
2W1YX-ray1.73A19-147[»]
2WARX-ray1.80A19-147[»]
2X0AX-ray1.52A19-147[»]
2XBRX-ray1.29A19-147[»]
2XBSX-ray1.37A19-147[»]
2XJWX-ray1.67A19-147[»]
2XTHX-ray1.80A19-147[»]
2YBHX-ray2.00A19-147[»]
2YBIX-ray2.00A19-147[»]
2YBJX-ray2.00A19-147[»]
2YBLX-ray2.00A19-147[»]
2YBMX-ray2.00A19-147[»]
2YBNX-ray2.00A19-147[»]
2YDGX-ray2.00A19-147[»]
2YSSX-ray2.40C19-147[»]
2YVBX-ray1.62A19-147[»]
2Z12X-ray1.15A19-147[»]
2Z18X-ray1.15A19-147[»]
2Z19X-ray1.15A19-147[»]
2ZNWX-ray2.71Y/Z19-147[»]
2ZNXX-ray2.30Y/Z19-147[»]
2ZQ3X-ray1.60A19-147[»]
2ZQ4X-ray2.00A19-147[»]
2ZYPX-ray1.18A19-147[»]
3A34X-ray1.65A19-147[»]
3A3QX-ray2.00A19-147[»]
3A3RX-ray1.90X19-147[»]
3A67X-ray1.80Y19-147[»]
3A6BX-ray1.80Y19-147[»]
3A6CX-ray1.80Y19-147[»]
3A8ZX-ray1.40A19-147[»]
3A90X-ray1.45A19-147[»]
3A91X-ray1.55A19-147[»]
3A92X-ray1.50A19-147[»]
3A93X-ray1.55A19-147[»]
3A94X-ray1.55A19-147[»]
3A95X-ray1.50A19-147[»]
3A96X-ray1.75A19-147[»]
3AGGX-ray1.60G19-147[»]
3AGHX-ray1.49A19-147[»]
3AGIX-ray1.20A19-147[»]
3AJNX-ray1.05A19-147[»]
3ATNX-ray1.17A19-147[»]
3ATOX-ray1.17A19-147[»]
3AW6X-ray2.10A19-147[»]
3AW7X-ray2.10A19-147[»]
3AZ4X-ray1.62A19-147[»]
3AZ5X-ray2.34A19-147[»]
3AZ6X-ray1.50A19-147[»]
3AZ7X-ray2.10A19-147[»]
3B6LX-ray2.30A1-147[»]
3B72X-ray1.50A1-147[»]
3D9AX-ray1.20C19-147[»]
3E3DX-ray1.55A19-147[»]
3EMSX-ray1.65A19-147[»]
3EXDX-ray1.49A19-147[»]
3F6ZX-ray2.50A/C19-147[»]
3G3AX-ray2.20B/D/F/H19-147[»]
3G3BX-ray2.40B/D/F/H19-147[»]
3HFMX-ray3.00Y19-147[»]
3IJUX-ray1.60A19-147[»]
3IJVX-ray1.70A19-147[»]
3J4Gelectron microscopy2.90A19-147[»]
3J6Kelectron microscopy2.50A19-147[»]
3KAMX-ray1.59A19-147[»]
3LYMX-ray2.00A19-147[»]
3LYOX-ray1.93A19-147[»]
3LYTX-ray1.90A/B19-147[»]
3LYZX-ray2.00A19-147[»]
3LZTX-ray0.93A19-147[»]
3M18X-ray1.95B19-147[»]
3M3UX-ray2.35A19-147[»]
3MBEX-ray2.89P/Q29-45[»]
3N9AX-ray1.40A19-147[»]
3N9CX-ray1.50A19-147[»]
3N9EX-ray1.38A19-147[»]
3OJPX-ray1.81A19-147[»]
3OK0X-ray1.82A19-147[»]
3OTPX-ray3.76G/H/I/J/K/L36-76[»]
3P4ZX-ray1.60A19-147[»]
3P64X-ray1.30A19-147[»]
3P65X-ray2.10A19-147[»]
3P66X-ray1.36A19-147[»]
3P68X-ray1.60A19-147[»]
3QE8X-ray1.49A/B19-147[»]
3QNGX-ray1.55A19-147[»]
3QY4X-ray1.65A19-146[»]
3RNXX-ray1.86A19-147[»]
3RT5X-ray1.75X19-147[»]
3RU5X-ray1.35A19-147[»]
3RW8X-ray1.86A19-147[»]
3RZ4X-ray1.80A19-147[»]
3SP3X-ray1.80A19-147[»]
3T6UX-ray2.21A19-147[»]
3TMUX-ray1.90A1-147[»]
3TMVX-ray1.90A1-147[»]
3TMWX-ray1.90A1-147[»]
3TMXX-ray1.90A1-147[»]
3TXBX-ray1.59A19-147[»]
3TXDX-ray1.53A19-147[»]
3TXEX-ray1.70A19-147[»]
3TXFX-ray1.69A19-147[»]
3TXGX-ray1.70A19-147[»]
3TXHX-ray1.69A19-147[»]
3TXIX-ray1.60A19-147[»]
3TXJX-ray2.48A19-147[»]
3TXKX-ray3.00A19-147[»]
3ULRX-ray1.65A19-147[»]
3VFXX-ray1.95A/B19-147[»]
3W6AX-ray1.77A19-147[»]
3WL2X-ray0.96A/B19-147[»]
3WMKX-ray1.46A19-147[»]
3WPJX-ray2.00A19-147[»]
3WPKX-ray2.00A19-147[»]
3WPLX-ray2.00A19-147[»]
3WU7X-ray2.00A19-147[»]
3WU8X-ray2.00A19-147[»]
3WU9X-ray2.00A19-147[»]
3WUAX-ray2.00A19-147[»]
3WULX-ray2.00A19-147[»]
3WUMX-ray2.00A19-147[»]
3WXTX-ray2.00A19-147[»]
3WXUX-ray2.00A19-147[»]
3ZEKX-ray1.43A19-147[»]
3ZVQX-ray2.00A19-88[»]
B90-147[»]
4A7DX-ray1.50A19-147[»]
4A8Aelectron microscopy14.20M19-147[»]
4A8Belectron microscopy13.00M/N/O/P/Q/R19-147[»]
4AGAX-ray1.50A19-147[»]
4AXTX-ray1.10A19-147[»]
4B0DX-ray1.10A19-147[»]
4B1AX-ray1.67A19-147[»]
4B49X-ray1.15A19-147[»]
4B4EX-ray1.00A19-147[»]
4B4IX-ray1.20A19-147[»]
4B4JX-ray1.25A19-147[»]
4BADX-ray1.35A19-147[»]
4BAFX-ray1.51A19-147[»]
4BAPX-ray1.21A19-147[»]
4BS7X-ray1.70A19-147[»]
4C3WX-ray1.28A19-147[»]
4CJ2X-ray1.50A/B1-147[»]
4D9ZX-ray1.71A19-147[»]
4DC4X-ray2.65A/B/C19-147[»]
4DD0X-ray1.70A19-147[»]
4DD1X-ray1.70A/B19-147[»]
4DD2X-ray1.55A19-147[»]
4DD3X-ray1.70A19-147[»]
4DD4X-ray1.70A19-147[»]
4DD6X-ray1.70A19-147[»]
4DD7X-ray1.60A19-147[»]
4DD9X-ray1.60A19-147[»]
4DDAX-ray2.48A19-147[»]
4DDBX-ray3.00A19-147[»]
4DDCX-ray1.80A/B19-147[»]
4DT3X-ray1.80A19-147[»]
4E3UX-ray1.50A19-147[»]
4EOFX-ray1.83A19-147[»]
4ET8X-ray1.90A19-147[»]
4ET9X-ray1.90A19-147[»]
4ETAX-ray1.91A19-147[»]
4ETBX-ray1.91A19-147[»]
4ETCX-ray1.91A19-147[»]
4ETDX-ray1.90A19-147[»]
4ETEX-ray1.90A19-147[»]
4FJRX-ray1.86A19-147[»]
4G49X-ray2.40A19-147[»]
4G4AX-ray2.40A19-147[»]
4G4BX-ray2.10A19-147[»]
4G4CX-ray2.00A19-147[»]
4G4HX-ray2.00A19-147[»]
4GCBX-ray1.80A19-147[»]
4GCCX-ray2.00A19-147[»]
4GCDX-ray2.80A19-147[»]
4GCEX-ray2.90A19-147[»]
4GCFX-ray3.50A19-147[»]
4GLAX-ray2.75A/B19-147[»]
4GLVX-ray2.57A/C/E/G19-147[»]
4GN3X-ray1.95A/C/E/G/I/K/M/O/Q19-147[»]
4GN4X-ray1.86A19-147[»]
4GN5X-ray1.86C/D19-147[»]
4H1PX-ray2.30A19-147[»]
4H8XX-ray1.20A19-147[»]
4H8YX-ray1.20A19-147[»]
4H8ZX-ray1.20A19-147[»]
4H90X-ray1.20A19-147[»]
4H91X-ray1.20A19-147[»]
4H92X-ray1.20A19-147[»]
4H93X-ray1.20A19-147[»]
4H94X-ray1.20A19-147[»]
4H9AX-ray1.20A19-147[»]
4H9BX-ray1.20A19-147[»]
4H9CX-ray1.20A19-147[»]
4H9EX-ray1.20A19-147[»]
4H9FX-ray1.20A19-147[»]
4H9HX-ray1.20A19-147[»]
4H9IX-ray1.20A19-147[»]
4HP0X-ray1.19A19-147[»]
4HPIX-ray1.19A19-147[»]
4HSFX-ray1.82A19-147[»]
4HTKX-ray1.20A19-147[»]
4HTNX-ray1.30A19-147[»]
4HTQX-ray1.40A19-147[»]
4HV1X-ray2.30A19-147[»]
4HV2X-ray2.50A19-147[»]
4I8SX-ray2.00A19-147[»]
4IASX-ray2.60A19-147[»]
4IATX-ray2.00A19-147[»]
4II8X-ray1.88A19-147[»]
4J1AX-ray1.79A19-147[»]
4J1BX-ray1.66A19-147[»]
4J7VX-ray1.54A19-147[»]
4KXIX-ray2.00A19-147[»]
4LFPX-ray1.72A19-147[»]
4LFXX-ray2.10A19-147[»]
4LGKX-ray1.96A19-147[»]
4LT0X-ray2.10A19-147[»]
4LT1X-ray2.30A19-147[»]
4LT2X-ray2.00A19-147[»]
4LT3X-ray2.00A19-147[»]
4LYMX-ray2.10A19-147[»]
4LYOX-ray2.05A19-147[»]
4LYTX-ray1.90A/B19-147[»]
4LYZX-ray2.00A19-147[»]
4LZTX-ray0.95A19-147[»]
4M4OX-ray2.00A19-147[»]
4M6DX-ray2.68A/C/E/G/I/K19-147[»]
4MR1X-ray1.99A19-147[»]
4MWKX-ray0.98A19-147[»]
4MWMX-ray1.12A19-147[»]
4MWNX-ray1.42A19-147[»]
4N0JX-ray1.90A/B20-147[»]
4N1CX-ray1.70C19-147[»]
4N1EX-ray2.23I/J/K/L19-147[»]
4N5RX-ray2.10A19-147[»]
4N8ZX-ray1.20A19-147[»]
4NEBX-ray1.48A19-147[»]
4NFVX-ray1.63A19-147[»]
4NG1X-ray1.82A19-147[»]
4NG8X-ray1.09A19-147[»]
4NGIX-ray1.70A19-147[»]
4NGJX-ray1.10A19-147[»]
4NGKX-ray1.50A19-147[»]
4NGLX-ray1.52A19-147[»]
4NGOX-ray1.58A19-147[»]
4NGVX-ray1.64A19-147[»]
4NGWX-ray1.37A19-147[»]
4NGYX-ray1.35A19-147[»]
4NGZX-ray1.70A19-147[»]
4NHIX-ray1.34A19-147[»]
4NHPX-ray1.42A19-147[»]
4NHQX-ray1.92A19-147[»]
4NHSX-ray1.99A19-147[»]
4NHTX-ray1.65A19-147[»]
4NIJX-ray1.86A19-147[»]
4NSGX-ray2.00A19-147[»]
4NSHX-ray2.10A19-147[»]
4NSIX-ray2.30A19-147[»]
4NSJX-ray1.70A19-147[»]
4NWEX-ray1.58A19-147[»]
4NWHX-ray1.65A19-147[»]
4NY5X-ray1.85A19-147[»]
4O34X-ray2.09A19-147[»]
4OOOX-ray2.15A19-147[»]
4OOTX-ray1.80A19-147[»]
4OW9X-ray2.10A/B19-147[»]
4OWAX-ray1.80A/B19-147[»]
4OWBX-ray1.69A19-147[»]
4OWCX-ray1.62A19-147[»]
4OWEX-ray1.41A19-147[»]
4OWHX-ray1.48A19-147[»]
4OXEX-ray1.13A19-147[»]
4P2EX-ray1.60A19-147[»]
4PHIX-ray1.81A/B/C/D19-147[»]
4PPOX-ray1.73A19-147[»]
4PRQX-ray1.72A/B/C/D19-147[»]
4PRUX-ray2.20A/B19-147[»]
4QEQX-ray1.38A19-147[»]
4QGZX-ray2.51A19-147[»]
4QY9X-ray2.05A19-147[»]
4RDSX-ray1.23A19-147[»]
4TUNX-ray1.92A/B19-147[»]
4TWSX-ray1.45A19-147[»]
4UWNX-ray1.67A19-147[»]
4UWUX-ray1.78A19-147[»]
4UWVX-ray1.77A19-147[»]
4W94X-ray1.55A19-147[»]
4W96X-ray1.50A19-147[»]
4XADX-ray1.25A19-147[»]
4XANX-ray1.47A19-147[»]
5LYMX-ray1.80A/B19-147[»]
5LYTX-ray1.90A19-147[»]
5LYZX-ray2.00A19-147[»]
6LYTX-ray1.90A19-147[»]
6LYZX-ray2.00A19-147[»]
7LYZX-ray2.50A19-147[»]
8LYZX-ray2.50A19-147[»]
9LYZX-ray2.50A19-147[»]
ProteinModelPortaliP00698.
SMRiP00698. Positions 19-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676478. 2 interactions.
DIPiDIP-46258N.
IntActiP00698. 4 interactions.

Chemistry

ChEMBLiCHEMBL1932892.

Protein family/group databases

Allergomei3294. Gal d 4.0101.
362. Gal d 4.
CAZyiGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbiP00698.
PRIDEiP00698.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016196; ENSGALP00000016177; ENSGALG00000009963.
GeneIDi396218.
KEGGigga:396218.

Organism-specific databases

CTDi4069.

Phylogenomic databases

eggNOGiNOG85133.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP00698.
KOiK13915.
OMAiCAAKFES.
OrthoDBiEOG7BW0M5.
PhylomeDBiP00698.
TreeFamiTF324882.

Enzyme and pathway databases

BRENDAi3.2.1.17. 1306.
ReactomeiREACT_317091. Amyloids.
SABIO-RKP00698.

Miscellaneous databases

EvolutionaryTraceiP00698.
NextBioi20816270.
PROiP00698.

Gene expression databases

ExpressionAtlasiP00698. baseline and differential.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030056. Lysozyme_C.
[Graphical view]
PANTHERiPTHR11407:SF22. PTHR11407:SF22. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Exons encode functional and structural units of chicken lysozyme."
    Jung A., Sippel A.E., Grez M., Schutz G.
    Proc. Natl. Acad. Sci. U.S.A. 77:5759-5763(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 121.
  2. "The chicken lysozyme chromatin domain contains a second, widely expressed gene."
    Chong S., Riggs A.D., Bonifer C.
    Nucleic Acids Res. 30:463-467(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Precursor of egg white lysozyme. Amino acid sequence of an NH2-terminal extension."
    Palmiter R.D., Gagnon J., Ericsson L.H., Walsh K.A.
    J. Biol. Chem. 252:6386-6393(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-20.
  4. "The amino acid sequence of egg white lysozyme."
    Canfield R.E.
    J. Biol. Chem. 238:2698-2707(1962) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-147.
  5. "Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs."
    Buell G.N., Wickens M.P., Carbon J., Schimke R.T.
    J. Biol. Chem. 254:9277-9283(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-146.
  6. "The disulfide bonds of egg white lysozyme (muramidase)."
    Canfield R.E., Liu A.K.
    J. Biol. Chem. 240:1997-2002(1964) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  7. "The disulfide bridges of hen's egg-white lysozyme."
    Jauregui-Adell J., Jolles J., Jolles P.
    Biochim. Biophys. Acta 107:97-111(1964) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  8. "Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white."
    Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T.
    Gene 492:244-249(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Vertebrate lysozymes."
    Imoto T., Johnson L.N., North A.C.T., Phillips D.C., Rupley J.A.
    (In) Boyer P.D. (eds.); The enzymes (3rd ed.), pp.7:665-868, Academic Press, New York (1971)
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), REVIEW.
  10. "Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2-A resolution."
    Blake C.C.F., Koenig D.F., Mair G.A., North A.C.T., Phillips D.C., Sarma V.R.
    Nature 206:757-761(1964) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF TRICLINIC LYSOZYME.
  12. "Structures of triclinic mono- and di-N-acetylglucosamine: lysozyme complexes -- a crystallographic study."
    Kurachi K., Sieker L.C., Jensen L.H.
    J. Mol. Biol. 101:11-24(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF TRICLINIC LYSOZYME.
  13. "Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution."
    Fischmann T.O., Bentley G.A., Bhat T.N., Boulot G., Mariuzza R.A., Phillips S.E., Tello D., Poljak R.J.
    J. Biol. Chem. 266:12915-12920(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF COMPLEX WITH ANTIBODY.
  14. "Sequential 1H NMR assignments and secondary structure of hen egg white lysozyme in solution."
    Redfield C., Dobson C.M.
    Biochemistry 27:122-136(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  15. "Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea."
    Schwalbe H., Fiebig K.M., Buck M., Jones J.A., Grimshaw S.B., Spencer A., Glaser S.J., Smith L.J., Dobson C.M.
    Biochemistry 36:8977-8991(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  16. "Conversion of Trp 62 of hen egg-white lysozyme to Tyr by site-directed mutagenesis."
    Kumagai I., Kojima S., Tamaki E., Miura K.
    J. Biochem. 102:733-740(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.

Entry informationi

Entry nameiLYSC_CHICK
AccessioniPrimary (citable) accession number: P00698
Secondary accession number(s): Q90884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 1, 2015
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.