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P00698 (LYSC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 161. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme C

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Allergen Gal d IV
Allergen=Gal d 4
Gene names
Name:LYZ
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. Ref.8

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subunit structure

Monomer.

Subcellular location

Secreted.

Tissue specificity

In the egg white and polymorphonuclear leukocytes.

Allergenic properties

Causes an allergic reaction in human.

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself4EBI-1029543,EBI-1029543
degPP0C0V08EBI-1029543,EBI-547165From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.4
Chain19 – 147129Lysozyme C
PRO_0000018495

Sites

Active site531
Active site701
Binding site1191Substrate

Amino acid modifications

Disulfide bond24 ↔ 145 Ref.6 Ref.7
Disulfide bond48 ↔ 133 Ref.6 Ref.7
Disulfide bond82 ↔ 98 Ref.6 Ref.7
Disulfide bond94 ↔ 112 Ref.6 Ref.7

Experimental info

Sequence conflict491A → V in CAA23711. Ref.1
Sequence conflict1211N → D AA sequence Ref.4
Sequence conflict1241N → S in CAA23711. Ref.1
Sequence conflict1321R → S in AAA48944. Ref.5

Secondary structure

................................. 147
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00698 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 81E85743FF579468

FASTA14716,239
        10         20         30         40         50         60 
MRSLLILVLC FLPLAALGKV FGRCELAAAM KRHGLDNYRG YSLGNWVCAA KFESNFNTQA 

        70         80         90        100        110        120 
TNRNTDGSTD YGILQINSRW WCNDGRTPGS RNLCNIPCSA LLSSDITASV NCAKKIVSDG 

       130        140 
NGMNAWVAWR NRCKGTDVQA WIRGCRL 

« Hide

References

[1]"Exons encode functional and structural units of chicken lysozyme."
Jung A., Sippel A.E., Grez M., Schutz G.
Proc. Natl. Acad. Sci. U.S.A. 77:5759-5763(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 121.
[2]"The chicken lysozyme chromatin domain contains a second, widely expressed gene."
Chong S., Riggs A.D., Bonifer C.
Nucleic Acids Res. 30:463-467(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Precursor of egg white lysozyme. Amino acid sequence of an NH2-terminal extension."
Palmiter R.D., Gagnon J., Ericsson L.H., Walsh K.A.
J. Biol. Chem. 252:6386-6393(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-20.
[4]"The amino acid sequence of egg white lysozyme."
Canfield R.E.
J. Biol. Chem. 238:2698-2707(1963) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-147.
[5]"Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs."
Buell G.N., Wickens M.P., Carbon J., Schimke R.T.
J. Biol. Chem. 254:9277-9283(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-146.
[6]"The disulfide bonds of egg white lysozyme (muramidase)."
Canfield R.E., Liu A.K.
J. Biol. Chem. 240:1997-2002(1965) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
[7]"The disulfide bridges of hen's egg-white lysozyme."
Jauregui-Adell J., Jolles J., Jolles P.
Biochim. Biophys. Acta 107:97-111(1965) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
[8]"Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white."
Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T.
Gene 492:244-249(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Vertebrate lysozymes."
Imoto T., Johnson L.N., North A.C.T., Phillips D.C., Rupley J.A.
(In) Boyer P.D. (eds.); The enzymes (3rd ed.), pp.7:665-868, Academic Press, New York (1972)
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), REVIEW.
[10]"Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2-A resolution."
Blake C.C.F., Koenig D.F., Mair G.A., North A.C.T., Phillips D.C., Sarma V.R.
Nature 206:757-761(1965) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[11]"The structure of triclinic lysozyme at 2.5-A resolution."
Moult J., Yonath A., Traub W., Smilansky A., Podjarny A., Rabinovich D., Saya A.
J. Mol. Biol. 100:179-195(1976) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF TRICLINIC LYSOZYME.
[12]"Structures of triclinic mono- and di-N-acetylglucosamine: lysozyme complexes -- a crystallographic study."
Kurachi K., Sieker L.C., Jensen L.H.
J. Mol. Biol. 101:11-24(1976) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF TRICLINIC LYSOZYME.
[13]"Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution."
Fischmann T.O., Bentley G.A., Bhat T.N., Boulot G., Mariuzza R.A., Phillips S.E., Tello D., Poljak R.J.
J. Biol. Chem. 266:12915-12920(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF COMPLEX WITH ANTIBODY.
[14]"Sequential 1H NMR assignments and secondary structure of hen egg white lysozyme in solution."
Redfield C., Dobson C.M.
Biochemistry 27:122-136(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[15]"Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea."
Schwalbe H., Fiebig K.M., Buck M., Jones J.A., Grimshaw S.B., Spencer A., Glaser S.J., Smith L.J., Dobson C.M.
Biochemistry 36:8977-8991(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[16]"Conversion of Trp 62 of hen egg-white lysozyme to Tyr by site-directed mutagenesis."
Kumagai I., Kojima S., Tamaki E., Miura K.
J. Biochem. 102:733-740(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00885 Genomic DNA. Translation: AAA48943.1.
V00428 mRNA. Translation: CAA23711.1.
AF410481 Genomic DNA. Translation: AAL69327.1.
M10640 mRNA. Translation: AAA48944.1.
PIRLZCH. A93859.
RefSeqNP_990612.1. NM_205281.1.
UniGeneGga.713.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
132LX-ray1.80A19-147[»]
193LX-ray1.33A19-147[»]
194LX-ray1.40A19-147[»]
1A2YX-ray1.50C19-147[»]
1AKIX-ray1.50A19-147[»]
1AT5X-ray1.80A19-147[»]
1AT6X-ray1.80A19-147[»]
1AZFX-ray1.80A19-147[»]
1B0DX-ray1.84A19-147[»]
1B2KX-ray1.60A/B19-147[»]
1BGIX-ray1.70A19-147[»]
1BHZX-ray3.90A19-147[»]
1BVKX-ray2.70C/F19-147[»]
1BVXX-ray1.80A19-147[»]
1BWHX-ray1.80A19-147[»]
1BWIX-ray1.80A19-147[»]
1BWJX-ray1.80A19-147[»]
1C08X-ray2.30C19-147[»]
1C10X-ray2.03A19-147[»]
1DPWX-ray1.64A19-147[»]
1DPXX-ray1.65A19-147[»]
1DQJX-ray2.00C19-147[»]
1E8LNMR-A19-147[»]
1F0WX-ray1.90A19-147[»]
1F10X-ray1.70A19-147[»]
1F3JX-ray3.10P/Q29-42[»]
1FDLX-ray2.50Y19-147[»]
1FLQX-ray1.80A19-147[»]
1FLUX-ray1.78A19-147[»]
1FLWX-ray1.81A19-147[»]
1FLYX-ray1.83A19-147[»]
1FN5X-ray1.78A19-147[»]
1G7HX-ray1.85C19-147[»]
1G7IX-ray1.80C19-147[»]
1G7JX-ray1.75C19-147[»]
1G7LX-ray2.00C19-147[»]
1G7MX-ray1.90C19-147[»]
1GPQX-ray1.60C/D19-147[»]
1GWDX-ray1.77A19-147[»]
1GXVNMR-219-147[»]
1GXXNMR-A19-147[»]
1H6MX-ray1.64A19-147[»]
1H87X-ray1.72A19-147[»]
1HC0X-ray1.82A19-147[»]
1HELX-ray1.70A19-147[»]
1HEMX-ray1.80A19-147[»]
1HENX-ray1.80A19-147[»]
1HEOX-ray1.80A19-147[»]
1HEPX-ray1.80A19-147[»]
1HEQX-ray1.80A19-147[»]
1HERX-ray1.80A19-147[»]
1HEWX-ray1.75A19-147[»]
1HF4X-ray1.45A/B19-147[»]
1HSWX-ray2.00A19-147[»]
1HSXX-ray1.90A19-147[»]
1IC4X-ray2.50Y19-147[»]
1IC5X-ray2.30Y19-147[»]
1IC7X-ray2.10Y19-147[»]
1IEEX-ray0.94A19-147[»]
1IO5neutron diffraction2.00A19-147[»]
1IOQX-ray1.79A19-147[»]
1IORX-ray1.76A19-147[»]
1IOSX-ray1.76A19-147[»]
1IOTX-ray1.75A19-147[»]
1IR7X-ray1.90A19-147[»]
1IR8X-ray1.63A19-147[»]
1IR9X-ray1.90A19-147[»]
1J1OX-ray1.80Y19-147[»]
1J1PX-ray1.80Y19-147[»]
1J1XX-ray1.80Y19-147[»]
1JA2X-ray2.87A19-147[»]
1JA4X-ray2.94A19-147[»]
1JA6X-ray2.96A19-147[»]
1JA7X-ray2.98A19-147[»]
1JISX-ray1.90A19-147[»]
1JITX-ray1.90A19-147[»]
1JIYX-ray1.90A19-147[»]
1JJ0X-ray1.90A19-147[»]
1JJ1X-ray1.90A19-147[»]
1JJ3X-ray1.90A/B19-147[»]
1JPOX-ray2.10A19-147[»]
1JTOX-ray2.50L/M19-147[»]
1JTTX-ray2.10L19-138[»]
1KIPX-ray2.10C19-147[»]
1KIQX-ray1.85C19-147[»]
1KIRX-ray2.00C19-147[»]
1KXWX-ray1.96A19-147[»]
1KXXX-ray1.71A19-147[»]
1KXYX-ray1.79A19-147[»]
1LCNX-ray1.63A/B19-147[»]
1LJ3X-ray2.00A/B19-147[»]
1LJ4X-ray1.95A/B19-147[»]
1LJEX-ray2.00A/B19-147[»]
1LJFX-ray1.80A/B19-147[»]
1LJGX-ray1.90A/B19-147[»]
1LJHX-ray1.80A/B19-147[»]
1LJIX-ray2.00A/B19-147[»]
1LJJX-ray2.00A/B19-147[»]
1LJKX-ray2.10A/B19-147[»]
1LKRX-ray1.60A/B19-147[»]
1LKSX-ray1.10A19-147[»]
1LMAX-ray1.75A19-147[»]
1LPIX-ray2.00A19-147[»]
1LSAX-ray1.70A19-147[»]
1LSBX-ray1.70A19-147[»]
1LSCX-ray1.70A19-147[»]
1LSDX-ray1.70A19-147[»]
1LSEX-ray1.70A19-147[»]
1LSFX-ray1.70A19-147[»]
1LSGX-ray2.40A19-147[»]
1LSMX-ray1.70A19-147[»]
1LSNX-ray1.90A19-147[»]
1LSYX-ray1.90A1-147[»]
1LSZX-ray2.00A1-147[»]
1LYOX-ray1.93A19-147[»]
1LYSX-ray1.72A/B19-147[»]
1LYZX-ray2.00A19-147[»]
1LZ8X-ray1.53A19-147[»]
1LZ9X-ray1.70A19-147[»]
1LZAX-ray1.60A19-147[»]
1LZBX-ray1.50A19-147[»]
1LZCX-ray1.80A19-147[»]
1LZDX-ray1.80A19-147[»]
1LZEX-ray1.80A19-147[»]
1LZGX-ray1.80A19-147[»]
1LZHX-ray6.00A/B19-147[»]
1LZNneutron diffraction1.70A19-147[»]
1LZTX-ray1.97A19-147[»]
1MELX-ray2.50L/M19-147[»]
1MLCX-ray2.50E/F19-147[»]
1N4FX-ray1.78A19-147[»]
1NBYX-ray1.80C19-147[»]
1NBZX-ray1.85C19-147[»]
1NDGX-ray1.90C19-147[»]
1NDMX-ray2.10C19-147[»]
1P2CX-ray2.00C/F19-147[»]
1PS5X-ray2.00A19-147[»]
1QIOX-ray1.20A19-147[»]
1QTKX-ray2.03A19-147[»]
1RCMX-ray1.90A/B19-147[»]
1RFPX-ray1.75A19-147[»]
1RI8X-ray1.85B19-147[»]
1RJCX-ray1.40B19-147[»]
1SF4X-ray2.98A19-147[»]
1SF6X-ray3.22A19-147[»]
1SF7X-ray3.22A19-147[»]
1SFBX-ray3.22A19-147[»]
1SFGX-ray3.22A19-147[»]
1SQ2X-ray1.45L19-147[»]
1T3PX-ray1.60A19-147[»]
1T6VX-ray1.70L/M19-147[»]
1UA6X-ray1.90Y19-147[»]
1UC0X-ray1.85A19-147[»]
1UCOX-ray2.00A/B19-147[»]
1UIAX-ray1.76A19-147[»]
1UIBX-ray1.76A19-147[»]
1UICX-ray1.95A19-147[»]
1UIDX-ray1.95A19-147[»]
1UIEX-ray1.95A19-147[»]
1UIFX-ray1.85A19-147[»]
1UIGX-ray1.95A19-147[»]
1UIHX-ray1.75A19-147[»]
1UUZX-ray1.80C/D19-147[»]
1V7SX-ray1.14A19-147[»]
1V7TX-ray1.13A/B19-147[»]
1VATX-ray1.60A19-147[»]
1VAUX-ray1.50A19-147[»]
1VDPX-ray1.70A/B19-147[»]
1VDQX-ray1.50A19-147[»]
1VDSX-ray1.60A19-147[»]
1VDTX-ray1.70A19-147[»]
1VEDX-ray1.90A19-147[»]
1VFBX-ray1.80C19-147[»]
1W6ZX-ray1.65A19-147[»]
1WTMX-ray1.33A19-147[»]
1WTNX-ray1.13A19-147[»]
1XEIX-ray2.10A19-147[»]
1XEJX-ray2.10A19-147[»]
1XEKX-ray2.30A19-147[»]
1XFPX-ray1.50L19-147[»]
1XGPX-ray2.10C19-147[»]
1XGQX-ray2.10C19-147[»]
1XGRX-ray2.10C19-147[»]
1XGTX-ray2.10C19-147[»]
1XGUX-ray2.10C19-147[»]
1YIKX-ray1.75A19-147[»]
1YILX-ray1.60A19-147[»]
1YKXX-ray1.90X19-147[»]
1YKYX-ray1.90X19-147[»]
1YKZX-ray1.80X19-147[»]
1YL0X-ray1.90X19-147[»]
1YL1X-ray1.90X19-147[»]
1YQVX-ray1.70Y19-147[»]
1Z55X-ray1.90A19-147[»]
1ZMYX-ray3.00L/M19-147[»]
1ZV5X-ray2.00L19-147[»]
1ZVHX-ray1.50L19-147[»]
1ZVYX-ray1.63B19-147[»]
2A6UX-ray-A19-147[»]
2A7DX-ray1.66A19-147[»]
2A7FX-ray1.85A19-147[»]
2AUBX-ray1.70A19-147[»]
2B5ZX-ray1.60A19-147[»]
2BLXX-ray1.40A19-147[»]
2BLYX-ray1.40A19-147[»]
2BPUX-ray1.35A19-147[»]
2C8OX-ray1.50A19-147[»]
2C8PX-ray1.50A19-147[»]
2CDSX-ray2.00A19-147[»]
2CGIX-ray1.35A19-147[»]
2D4IX-ray1.16A/B19-147[»]
2D4JX-ray1.16A19-147[»]
2D4KX-ray1.15A/N19-147[»]
2D6BX-ray1.25A19-147[»]
2D91X-ray2.10A19-147[»]
2DQCX-ray1.80Y19-147[»]
2DQDX-ray1.80Y19-147[»]
2DQEX-ray1.90Y19-147[»]
2DQFX-ray2.50C/F19-147[»]
2DQGX-ray2.30Y19-147[»]
2DQHX-ray2.30Y19-147[»]
2DQIX-ray2.00Y19-147[»]
2DQJX-ray1.80Y19-147[»]
2EIZX-ray1.90C19-147[»]
2EKSX-ray2.00C19-147[»]
2EPEX-ray2.50A19-147[»]
2F2NX-ray1.60A19-147[»]
2F30X-ray1.65A19-147[»]
2F4AX-ray1.95A19-147[»]
2F4GX-ray1.65A19-147[»]
2FBBX-ray1.46A19-147[»]
2G4PX-ray1.84A19-147[»]
2G4QX-ray1.84A19-147[»]
2H9JX-ray1.75A19-147[»]
2H9KX-ray1.75A19-147[»]
2HFMmodel-Y19-147[»]
2HS7X-ray-A19-147[»]
2HS9X-ray-A19-147[»]
2HSOX-ray-A19-147[»]
2HTXX-ray1.56A19-147[»]
2HU1X-ray1.63A19-147[»]
2HU3X-ray1.30A19-147[»]
2HUBX-ray1.20A19-147[»]
2I25X-ray1.80L/M19-147[»]
2I26X-ray2.50L/M/Q19-147[»]
2I6ZX-ray1.90A19-147[»]
2IFFX-ray2.65Y19-147[»]
2LYMX-ray2.00A19-147[»]
2LYOX-ray1.93A19-147[»]
2LYZX-ray2.00A19-147[»]
2LZHX-ray6.00A19-147[»]
2LZTX-ray1.97A19-147[»]
2PC2X-ray1.54A19-147[»]
2Q0MX-ray1.70X19-147[»]
2VB1X-ray0.65A19-147[»]
2W1LX-ray1.51A19-147[»]
2W1MX-ray1.78A19-147[»]
2W1XX-ray1.70A19-147[»]
2W1YX-ray1.73A19-147[»]
2WARX-ray1.80A19-147[»]
2X0AX-ray1.52A19-147[»]
2XBRX-ray1.29A19-147[»]
2XBSX-ray1.37A19-147[»]
2XJWX-ray1.67A19-147[»]
2XTHX-ray1.80A19-147[»]
2YBHX-ray2.00A19-147[»]
2YBIX-ray2.00A19-147[»]
2YBJX-ray2.00A19-147[»]
2YBLX-ray2.00A19-147[»]
2YBMX-ray2.00A19-147[»]
2YBNX-ray2.00A19-147[»]
2YDGX-ray2.00A19-147[»]
2YSSX-ray2.40C19-147[»]
2YVBX-ray1.62A19-147[»]
2Z12X-ray1.15A19-147[»]
2Z18X-ray1.15A19-147[»]
2Z19X-ray1.15A19-147[»]
2ZNWX-ray2.71Y/Z19-147[»]
2ZNXX-ray2.30Y/Z19-147[»]
2ZQ3X-ray1.60A19-147[»]
2ZQ4X-ray2.00A19-147[»]
2ZYPX-ray1.18A19-147[»]
3A34X-ray1.65A19-147[»]
3A3QX-ray2.00A19-147[»]
3A3RX-ray1.90X19-147[»]
3A67X-ray1.80Y19-147[»]
3A6BX-ray1.80Y19-147[»]
3A6CX-ray1.80Y19-147[»]
3A8ZX-ray1.40A19-147[»]
3A90X-ray1.45A19-147[»]
3A91X-ray1.55A19-147[»]
3A92X-ray1.50A19-147[»]
3A93X-ray1.55A19-147[»]
3A94X-ray1.55A19-147[»]
3A95X-ray1.50A19-147[»]
3A96X-ray1.75A19-147[»]
3AGGX-ray1.60G19-147[»]
3AGHX-ray1.49A19-147[»]
3AGIX-ray1.20A19-147[»]
3AJNX-ray1.05A19-147[»]
3ATNX-ray1.17A19-147[»]
3ATOX-ray1.17A19-147[»]
3AW6X-ray2.10A19-147[»]
3AW7X-ray2.10A19-147[»]
3AZ4X-ray1.62A19-147[»]
3AZ5X-ray2.34A19-147[»]
3AZ6X-ray1.50A19-147[»]
3AZ7X-ray2.10A19-147[»]
3B6LX-ray2.30A1-147[»]
3B72X-ray1.50A1-147[»]
3D9AX-ray1.20C19-147[»]
3E3DX-ray1.55A19-147[»]
3EMSX-ray1.65A19-147[»]
3EXDX-ray1.49A19-147[»]
3F6ZX-ray2.50A/C19-147[»]
3G3AX-ray2.20B/D/F/H19-147[»]
3G3BX-ray2.40B/D/F/H19-147[»]
3HFMX-ray3.00Y19-147[»]
3IJUX-ray1.60A19-147[»]
3IJVX-ray1.70A19-147[»]
3J4Gelectron microscopy2.90A19-147[»]
3KAMX-ray1.59A19-147[»]
3LYMX-ray2.00A19-147[»]
3LYOX-ray1.93A19-147[»]
3LYTX-ray1.90A/B19-147[»]
3LYZX-ray2.00A19-147[»]
3LZTX-ray0.93A19-147[»]
3M18X-ray1.95B19-147[»]
3M3UX-ray2.35A19-147[»]
3MBEX-ray2.89P/Q29-45[»]
3N9AX-ray1.40A19-147[»]
3N9CX-ray1.50A19-147[»]
3N9EX-ray1.38A19-147[»]
3OJPX-ray1.81A19-147[»]
3OK0X-ray1.82A19-147[»]
3OTPX-ray3.76G/H/I/J/K/L36-76[»]
3P4ZX-ray1.60A19-147[»]
3P64X-ray1.30A19-147[»]
3P65X-ray2.10A19-147[»]
3P66X-ray1.36A19-147[»]
3P68X-ray1.60A19-147[»]
3QE8X-ray1.49A/B19-147[»]
3QNGX-ray1.55A19-147[»]
3QY4X-ray1.65A19-146[»]
3RNXX-ray1.86A19-147[»]
3RT5X-ray1.75X19-147[»]
3RU5X-ray1.35A19-147[»]
3RW8X-ray1.86A19-147[»]
3RZ4X-ray1.80A19-147[»]
3SP3X-ray1.80A19-147[»]
3T6UX-ray2.21A19-147[»]
3TMUX-ray1.90A1-147[»]
3TMVX-ray1.90A1-147[»]
3TMWX-ray1.90A1-147[»]
3TMXX-ray1.90A1-147[»]
3TXBX-ray1.59A19-147[»]
3TXDX-ray1.53A19-147[»]
3TXEX-ray1.70A19-147[»]
3TXFX-ray1.69A19-147[»]
3TXGX-ray1.70A19-147[»]
3TXHX-ray1.69A19-147[»]
3TXIX-ray1.60A19-147[»]
3TXJX-ray2.48A19-147[»]
3TXKX-ray3.00A19-147[»]
3ULRX-ray1.65A19-147[»]
3VFXX-ray1.95A/B19-147[»]
3W6AX-ray1.77A19-147[»]
3ZEKX-ray1.43A19-147[»]
3ZVQX-ray2.00A19-88[»]
B90-147[»]
4A7DX-ray1.50A19-147[»]
4A8Aelectron microscopy14.20M19-147[»]
4A8Belectron microscopy13.00M/N/O/P/Q/R19-147[»]
4AGAX-ray1.50A19-147[»]
4AXTX-ray1.10A19-147[»]
4B0DX-ray1.10A19-147[»]
4B1AX-ray1.67A19-147[»]
4B49X-ray1.15A19-147[»]
4B4EX-ray1.00A19-147[»]
4B4IX-ray1.20A19-147[»]
4B4JX-ray1.25A19-147[»]
4BADX-ray1.35A19-147[»]
4BAFX-ray1.51A19-147[»]
4BAPX-ray1.21A19-147[»]
4BS7X-ray1.70A19-147[»]
4CJ2X-ray1.50A/B1-147[»]
4D9ZX-ray1.71A19-147[»]
4DC4X-ray2.65A/B/C19-147[»]
4DD0X-ray1.70A19-147[»]
4DD1X-ray1.70A/B19-147[»]
4DD2X-ray1.55A19-147[»]
4DD3X-ray1.70A19-147[»]
4DD4X-ray1.70A19-147[»]
4DD6X-ray1.70A19-147[»]
4DD7X-ray1.60A19-147[»]
4DD9X-ray1.60A19-147[»]
4DDAX-ray2.48A19-147[»]
4DDBX-ray3.00A19-147[»]
4DDCX-ray1.80A/B19-147[»]
4DT3X-ray1.80A19-147[»]
4E3UX-ray1.50A19-147[»]
4EOFX-ray1.83A19-147[»]
4ET8X-ray1.90A19-147[»]
4ET9X-ray1.90A19-147[»]
4ETAX-ray1.91A19-147[»]
4ETBX-ray1.91A19-147[»]
4ETCX-ray1.91A19-147[»]
4ETDX-ray1.90A19-147[»]
4ETEX-ray1.90A19-147[»]
4FJRX-ray1.86A19-147[»]
4G49X-ray2.40A19-147[»]
4G4AX-ray2.40A19-147[»]
4G4BX-ray2.10A19-147[»]
4G4CX-ray2.00A19-147[»]
4G4HX-ray2.00A19-147[»]
4GCBX-ray1.80A19-147[»]
4GCCX-ray2.00A19-147[»]
4GCDX-ray2.80A19-147[»]
4GCEX-ray2.90A19-147[»]
4GCFX-ray3.50A19-147[»]
4GLAX-ray2.75A/B19-147[»]
4GLVX-ray2.57A/C/E/G19-147[»]
4GN3X-ray1.95A/C/E/G/I/K/M/O/Q19-147[»]
4GN4X-ray1.86A19-147[»]
4GN5X-ray1.86C/D19-147[»]
4H1PX-ray2.30A19-147[»]
4H8XX-ray1.20A19-147[»]
4H8YX-ray1.20A19-147[»]
4H8ZX-ray1.20A19-147[»]
4H90X-ray1.20A19-147[»]
4H91X-ray1.20A19-147[»]
4H92X-ray1.20A19-147[»]
4H93X-ray1.20A19-147[»]
4H94X-ray1.20A19-147[»]
4H9AX-ray1.20A19-147[»]
4H9BX-ray1.20A19-147[»]
4H9CX-ray1.20A19-147[»]
4H9EX-ray1.20A19-147[»]
4H9FX-ray1.20A19-147[»]
4H9HX-ray1.20A19-147[»]
4H9IX-ray1.20A19-147[»]
4HP0X-ray1.19A19-147[»]
4HPIX-ray1.19A19-147[»]
4HSFX-ray1.82A19-147[»]
4HTKX-ray1.20A19-147[»]
4HTNX-ray1.30A19-147[»]
4HTQX-ray1.40A19-147[»]
4HV1X-ray2.30A19-147[»]
4HV2X-ray2.50A19-147[»]
4I8SX-ray2.00A19-147[»]
4IASX-ray2.60A19-147[»]
4IATX-ray2.00A19-147[»]
4II8X-ray1.88A19-147[»]
4J1AX-ray1.79A19-147[»]
4J1BX-ray1.66A19-147[»]
4J7VX-ray1.54A19-147[»]
4LFPX-ray1.72A19-147[»]
4LFXX-ray2.10A19-147[»]
4LGKX-ray1.96A19-147[»]
4LYMX-ray2.10A19-147[»]
4LYOX-ray2.05A19-147[»]
4LYTX-ray1.90A/B19-147[»]
4LYZX-ray2.00A19-147[»]
4LZTX-ray0.95A19-147[»]
4M4OX-ray2.00A19-147[»]
4M6DX-ray2.68A/C/E/G/I/K19-147[»]
4N5RX-ray2.10A19-147[»]
4N8ZX-ray1.20A19-147[»]
4NY5X-ray1.85A19-147[»]
4P2EX-ray1.60A19-147[»]
5LYMX-ray1.80A/B19-147[»]
5LYTX-ray1.90A19-147[»]
5LYZX-ray2.00A19-147[»]
6LYTX-ray1.90A19-147[»]
6LYZX-ray2.00A19-147[»]
7LYZX-ray2.50A19-147[»]
8LYZX-ray2.50A19-147[»]
9LYZX-ray2.50A19-147[»]
ProteinModelPortalP00698.
SMRP00698. Positions 19-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid676478. 2 interactions.
IntActP00698. 4 interactions.

Chemistry

ChEMBLCHEMBL1932892.
DrugBankDB00128. L-Aspartic Acid.

Protein family/group databases

Allergome3294. Gal d 4.0101.
362. Gal d 4.
CAZyGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbP00698.
PRIDEP00698.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000016196; ENSGALP00000016177; ENSGALG00000009963.
GeneID396218.
KEGGgga:396218.

Organism-specific databases

CTD4069.

Phylogenomic databases

eggNOGNOG85133.
GeneTreeENSGT00550000074398.
HOGENOMHOG000037357.
HOVERGENHBG052297.
InParanoidP00698.
KOK13915.
OMAGNGMNAW.
OrthoDBEOG7BW0M5.
PhylomeDBP00698.
TreeFamTF324882.

Enzyme and pathway databases

SABIO-RKP00698.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP00698.
NextBio20816270.
PROP00698.

Entry information

Entry nameLYSC_CHICK
AccessionPrimary (citable) accession number: P00698
Secondary accession number(s): Q90884
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Allergens

Nomenclature of allergens and list of entries