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P00697 (LYSC1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysozyme C-1
EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Gene names
Name:Lyz1
Synonyms:Lyz
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subunit structure

Monomer.

Subcellular location

Secreted.

Tissue specificity

Expressed in lung, small intestine and spleen.

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Rat has two lysozymes, type 1 and type 2 of which only type 1 is expressed; type 2 being probably a pseudogene.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.2
Chain19 – 148130Lysozyme C-1
PRO_0000018484

Sites

Active site531 By similarity
Active site711 By similarity

Amino acid modifications

Disulfide bond24 ↔ 146 By similarity
Disulfide bond48 ↔ 134 By similarity
Disulfide bond83 ↔ 99 By similarity
Disulfide bond95 ↔ 113 By similarity

Experimental info

Sequence conflict201I → T AA sequence Ref.2
Sequence conflict641N → D AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P00697 [UniParc].

Last modified October 1, 1994. Version 2.
Checksum: 8E6E986539BD3EEE

FASTA14816,729
        10         20         30         40         50         60 
MKALLVLGFL LLSASVQAKI YERCQFARTL KRNGMSGYYG VSLADWVCLA QHESNYNTQA 

        70         80         90        100        110        120 
RNYNPGDQST DYGIFQINSR YWCNDGKTPR AKNACGIPCS ALLQDDITQA IQCAKRVVRD 

       130        140 
PQGIRAWVAW QRHCKNRDLS GYIRNCGV

« Hide

References

[1]"Evolution of rodent lysozymes: isolation and sequence of the rat lysozyme genes."
Yeh T.C., Wilson A.C., Irwin D.M.
Mol. Phylogenet. Evol. 2:65-75(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
[2]"Primary structure of rat lysozyme."
White T.J., Mross G.A., Osserman E.F., Wilson A.C.
Biochemistry 16:1430-1436(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-148.
Strain: Wistar.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L12459 Genomic DNA. Translation: AAA41551.1.
IPIIPI00211927.
PIRLZRT. A40729.
UniGeneRn.2283.

3D structure databases

ProteinModelPortalP00697.
SMRP00697. Positions 19-148.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007747.

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

PTM databases

PhosphoSiteP00697.

Proteomic databases

PaxDbP00697.
PRIDEP00697.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3026. rat.

Organism-specific databases

RGD3026. Lyz.

Phylogenomic databases

eggNOGNOG85133.
HOGENOMHOG000037357.
HOVERGENHBG052297.
InParanoidP00697.

Gene expression databases

ArrayExpressP00697.
GenevestigatorP00697.
GermOnlineENSRNOG00000005825. Rattus norvegicus.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP00697.
ChEMBLCHEMBL2297.

Entry information

Entry nameLYSC1_RAT
AccessionPrimary (citable) accession number: P00697
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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