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Protein

Thermonuclease

Gene

nuc

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond.

Catalytic activityi

Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.PROSITE-ProRule annotation

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103Calcium1
Active sitei1171 Publication1
Metal bindingi122Calcium1
Metal bindingi123Calcium; via carbonyl oxygen1
Active sitei1251 Publication1
Active sitei1691 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.31.1. 3352.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermonuclease (EC:3.1.31.1)
Short name:
TNase
Alternative name(s):
Micrococcal nuclease
Staphylococcal nuclease
Cleaved into the following 2 chains:
Gene namesi
Name:nuc
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000004522627 – 631 PublicationAdd BLAST37
ChainiPRO_000003438964 – 231Nuclease BAdd BLAST168
PropeptideiPRO_000003439064 – 821 PublicationAdd BLAST19
ChainiPRO_000003439183 – 231Nuclease AAdd BLAST149

Keywords - PTMi

Zymogen

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL0860.

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni84 – 86Combined sources3
Beta strandi91 – 99Combined sources9
Beta strandi101 – 109Combined sources9
Beta strandi112 – 118Combined sources7
Beta strandi120 – 122Combined sources3
Beta strandi126 – 128Combined sources3
Beta strandi129 – 131Combined sources3
Beta strandi134 – 136Combined sources3
Helixi137 – 150Combined sources14
Beta strandi154 – 157Combined sources4
Beta strandi166 – 168Combined sources3
Beta strandi170 – 176Combined sources7
Beta strandi177 – 179Combined sources3
Helixi181 – 187Combined sources7
Beta strandi190 – 193Combined sources4
Beta strandi198 – 200Combined sources3
Turni201 – 203Combined sources3
Helixi204 – 216Combined sources13
Helixi220 – 222Combined sources3
Beta strandi227 – 229Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A2TX-ray1.96A83-231[»]
1A2UX-ray2.00A83-231[»]
1A3TX-ray2.10A83-231[»]
1A3UX-ray2.05A83-231[»]
1A3VX-ray2.20A83-231[»]
1AEXX-ray2.10A83-231[»]
1ENAX-ray2.15A89-223[»]
1ENCX-ray1.95A83-231[»]
1EQVX-ray1.94A88-223[»]
1EY0X-ray1.60A83-231[»]
1EY4X-ray1.60A83-231[»]
1EY5X-ray1.70A83-231[»]
1EY6X-ray1.75A83-231[»]
1EY7X-ray1.88A83-231[»]
1EY8X-ray1.75A83-231[»]
1EY9X-ray1.72A83-231[»]
1EYAX-ray2.00A83-231[»]
1EYCX-ray1.85A83-231[»]
1EYDX-ray1.70A83-231[»]
1EZ6X-ray1.90A83-231[»]
1EZ8X-ray1.85A83-231[»]
1F2MX-ray2.00A83-231[»]
1F2YX-ray2.00A83-231[»]
1F2ZX-ray1.80A83-231[»]
1IHZX-ray1.65A83-231[»]
1II3X-ray1.72A83-231[»]
1JOKNMR-A83-231[»]
1JOONMR-A83-231[»]
1JOQNMR-A83-231[»]
1JORNMR-A83-231[»]
1KAAX-ray1.90A88-223[»]
1KABX-ray1.80A88-223[»]
1KDAX-ray1.90A83-231[»]
1KDBX-ray1.90A83-231[»]
1KDCX-ray2.00A83-231[»]
1NSNX-ray2.80S83-231[»]
1NUCX-ray1.90A83-231[»]
1RKNNMR-A83-192[»]
1SNCX-ray1.65A83-231[»]
1SNDX-ray1.84A/B83-231[»]
1SNMX-ray1.74A83-231[»]
1SNOX-ray1.70A83-231[»]
1SNPX-ray1.95A83-231[»]
1SNQX-ray1.70A83-231[»]
1STAX-ray1.70A83-229[»]
1STBX-ray2.00A83-230[»]
1STGX-ray1.70A83-231[»]
1STHX-ray1.85A83-231[»]
1STNX-ray1.70A83-231[»]
1STYX-ray1.67A83-230[»]
1SYBX-ray1.80A83-231[»]
1SYCX-ray1.80A83-231[»]
1SYDX-ray1.70A83-231[»]
1SYEX-ray1.80A83-231[»]
1SYFX-ray1.80A83-231[»]
1SYGX-ray1.90A83-231[»]
1TQOX-ray2.00A83-226[»]
1TR5X-ray2.10A83-226[»]
1TT2X-ray1.85A83-226[»]
1U9RX-ray2.10A83-231[»]
2ENBX-ray2.05A89-223[»]
2EXZX-ray1.90A83-231[»]
2EY1X-ray1.85A83-231[»]
2EY2X-ray1.70A83-231[»]
2EY5X-ray2.00A83-231[»]
2EY6X-ray1.65A83-231[»]
2EYFX-ray1.80A83-231[»]
2EYHX-ray1.90A83-231[»]
2EYJX-ray1.85A83-231[»]
2EYLX-ray1.70A83-231[»]
2EYMX-ray1.80A83-231[»]
2EYOX-ray1.70A83-231[»]
2EYPX-ray1.80A83-231[»]
2F0DX-ray2.50A83-231[»]
2F0EX-ray1.95A83-231[»]
2F0FX-ray2.15A83-231[»]
2F0GX-ray1.90A83-231[»]
2F0HX-ray2.15A83-231[»]
2F0IX-ray1.80A83-231[»]
2F0JX-ray1.80A83-231[»]
2F0KX-ray1.90A83-231[»]
2F0LX-ray1.90A83-231[»]
2F0MX-ray2.00A83-231[»]
2F0NX-ray1.70A83-231[»]
2F0OX-ray1.90A83-231[»]
2F0PX-ray2.05A83-231[»]
2F0QX-ray1.95A83-231[»]
2F0SX-ray1.75A83-231[»]
2F0TX-ray1.70A83-231[»]
2F0UX-ray1.83A83-231[»]
2F0VX-ray2.00A83-231[»]
2F0WX-ray2.10A83-231[»]
2F3VNMR-A83-192[»]
2F3WNMR-A83-192[»]
2FXYNMR-A137-154[»]
2FXZNMR-A179-191[»]
2GSIX-ray2.81W/X/Y/Z126-136[»]
2KHSNMR-A83-203[»]
2NUCX-ray2.00A83-231[»]
2OEOX-ray2.00A83-226[»]
2OF1X-ray1.92A83-226[»]
2PQENMR-A83-231[»]
2QDBX-ray2.20A83-231[»]
2RBMX-ray1.90A83-231[»]
2RDFX-ray2.01A83-231[»]
2RKSX-ray2.01A83-231[»]
2SNMX-ray1.97A83-231[»]
2SNSX-ray1.50A83-231[»]
2SOBNMR-A83-185[»]
3BDCX-ray1.80A83-231[»]
3C1EX-ray1.90A83-231[»]
3C1FX-ray2.00A83-231[»]
3D4DX-ray2.10A/B83-231[»]
3D6CX-ray2.00A83-231[»]
3DHQX-ray2.15A83-231[»]
3DMUX-ray1.80A83-231[»]
3E5SX-ray2.00A/B83-231[»]
3EJIX-ray1.90A83-231[»]
3EROX-ray1.85A83-231[»]
3ERQX-ray2.10A83-231[»]
3EVQX-ray2.00A83-231[»]
3H6MX-ray1.70A83-231[»]
3HEJX-ray1.80A/B/C/D83-231[»]
3HZXX-ray2.00A83-231[»]
3ITPX-ray1.75A83-231[»]
3LX0X-ray1.50A83-231[»]
3MEHX-ray1.50A83-231[»]
3MHBX-ray1.55A83-231[»]
3MXPX-ray1.61A83-231[»]
3MZ5X-ray1.58A83-231[»]
3NHHX-ray2.00A83-231[»]
3NK9X-ray1.65A83-231[»]
3NP8X-ray1.70A83-231[»]
3NQTX-ray1.90A83-231[»]
3NUCX-ray1.90A83-231[»]
3NXWX-ray1.65A83-231[»]
3OSOX-ray1.60A83-231[»]
3OWFX-ray1.85A83-231[»]
3P1HX-ray1.79A83-231[»]
3P75X-ray1.90A89-223[»]
3PMFX-ray1.60A83-231[»]
3QB3X-ray1.63A83-231[»]
3RUZX-ray1.58A83-231[»]
3S9WX-ray1.90A83-231[»]
3SHLX-ray1.48A83-231[»]
3SK4X-ray1.85A83-231[»]
3SK5X-ray1.70A83-231[»]
3SK6X-ray1.80A83-231[»]
3SK8X-ray1.90A83-231[»]
3SR1X-ray1.45A83-231[»]
3SXHX-ray1.40A83-231[»]
3T13X-ray1.80A/B83-231[»]
3T16X-ray1.80A83-231[»]
3TMEX-ray1.40A83-231[»]
3TP5X-ray1.80A83-231[»]
3TP6X-ray1.80A83-231[»]
3TP7X-ray1.90A83-231[»]
3TP8X-ray1.60A83-231[»]
3U9OX-ray1.95A83-231[»]
3V2TX-ray1.80A83-231[»]
3VA5X-ray1.55A83-231[»]
4DF7X-ray1.50A83-231[»]
4DFAX-ray1.40A83-231[»]
4DGZX-ray1.47A83-231[»]
4DU9X-ray1.63A83-231[»]
4E6IX-ray2.00A/B83-231[»]
4EQNX-ray1.80A83-231[»]
4EQOX-ray1.70A83-231[»]
4EQPX-ray1.35A83-231[»]
4EVOX-ray1.95A83-231[»]
4F7XX-ray1.70A83-231[»]
4F8MX-ray1.60A83-231[»]
4G57X-ray1.81A89-223[»]
4H7BX-ray1.60A83-231[»]
4HMIX-ray1.75A83-231[»]
4HMJX-ray1.35A83-231[»]
4HTHX-ray1.75A83-231[»]
4I65X-ray1.61A88-223[»]
4IALX-ray1.60A83-231[»]
4ID6X-ray1.90A83-231[»]
4IUNX-ray1.60A83-231[»]
4IZ8X-ray1.70A83-231[»]
4J1MX-ray1.65A83-231[»]
4J6HX-ray1.60A83-231[»]
4K14X-ray1.60A88-223[»]
4K2KX-ray1.65A83-231[»]
4K2LX-ray1.55A83-231[»]
4K5VX-ray1.75A83-231[»]
4K5WX-ray1.65A83-231[»]
4K5XX-ray1.65A83-231[»]
4K6DX-ray1.65A83-231[»]
4K8IX-ray2.10A89-223[»]
4K8JX-ray2.00A89-223[»]
4KD3X-ray1.75A83-231[»]
4KD4X-ray1.55A83-231[»]
4KHVX-ray1.60A83-231[»]
4KJNX-ray1.55A83-231[»]
4KJOX-ray1.90A83-231[»]
4KTAX-ray1.95A83-231[»]
4KV6X-ray1.55A83-231[»]
4KY5X-ray1.40A83-231[»]
4KY6X-ray1.70A83-231[»]
4KY7X-ray1.55A83-231[»]
4LAAX-ray1.58A83-231[»]
4ME5X-ray1.80A83-231[»]
4MIUX-ray1.67A83-231[»]
4N9PX-ray1.40A83-231[»]
4N9TX-ray1.60A83-231[»]
4NDXX-ray1.50A83-231[»]
4NKLX-ray1.60A83-231[»]
4NMZX-ray1.70A83-231[»]
4NP5X-ray1.50A83-231[»]
4ODGX-ray1.73A83-231[»]
4OL7X-ray1.67A/B83-231[»]
4PMBX-ray1.80A83-231[»]
4PMCX-ray1.65A83-231[»]
4PNYX-ray1.68A83-231[»]
4QB4X-ray1.60A88-223[»]
4QF4X-ray1.80A/B83-231[»]
4R8NX-ray1.65A83-223[»]
4RKBX-ray1.88A83-231[»]
4RKLX-ray1.66A83-231[»]
4S3SX-ray1.64A83-231[»]
4TRDX-ray1.60A83-231[»]
4WORX-ray1.60A83-231[»]
4YIJX-ray1.64A/B83-231[»]
4ZQ3X-ray1.90A83-231[»]
4ZUIX-ray1.70A83-231[»]
4ZUJX-ray1.72A83-231[»]
5C3WX-ray1.72A83-231[»]
5C3XX-ray1.95A83-231[»]
5C4HX-ray1.80A83-231[»]
5C4ZX-ray1.62A83-231[»]
5C5LX-ray1.75A83-231[»]
5C5MX-ray1.70A83-231[»]
5C6AX-ray1.85A83-231[»]
5CC4X-ray1.90A83-231[»]
5CGKX-ray1.85A83-231[»]
5CR3X-ray1.80A83-231[»]
5CV4X-ray1.80A83-231[»]
5CV5X-ray1.80A/B83-231[»]
5CV6X-ray1.95A83-231[»]
5CV7X-ray1.65A83-231[»]
5CV8X-ray1.58A83-231[»]
5CV9X-ray1.62A83-231[»]
5DEHX-ray1.70A83-231[»]
5E1FX-ray1.90A83-231[»]
5E3FX-ray1.75A83-231[»]
5EGTX-ray1.85A83-231[»]
5EKKX-ray2.10A83-231[»]
5EKLX-ray2.10A83-231[»]
5F2DX-ray1.70A83-231[»]
5HGTX-ray1.75A83-231[»]
5HURX-ray1.50A83-231[»]
5I6WX-ray1.90A83-231[»]
5I6YX-ray1.90A83-231[»]
5I9OX-ray1.95A/B83-231[»]
5I9PX-ray1.85A83-231[»]
5IGBX-ray1.80A83-231[»]
5IGCX-ray1.80A83-231[»]
5IGDX-ray1.80A83-231[»]
5IGEX-ray1.80A83-231[»]
5IGFX-ray1.70A83-231[»]
5IGGX-ray1.70A83-231[»]
5IIFX-ray1.85A83-231[»]
5IOCX-ray1.90A83-231[»]
5IODX-ray1.60A83-231[»]
5ISRX-ray1.90A83-231[»]
5J1ZX-ray1.73A83-231[»]
5J22X-ray1.90A83-231[»]
5JAVX-ray1.89A83-231[»]
5JOBX-ray1.45A83-231[»]
5K5PX-ray1.83A83-231[»]
5KEEX-ray1.50A83-231[»]
5KGUX-ray1.90A83-231[»]
5KIXX-ray1.75A83-231[»]
5KRUX-ray1.60A83-231[»]
5KYIX-ray1.70A83-231[»]
5KYLX-ray1.85A83-231[»]
5NUCX-ray2.10A83-231[»]
ProteinModelPortaliP00644.
SMRiP00644.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00644.

Family & Domainsi

Sequence similaritiesi

Belongs to the thermonuclease family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107Y9E. Bacteria.
COG1525. LUCA.

Family and domain databases

Gene3Di2.40.50.90. 1 hit.
InterProiIPR016071. Staphylococal_nuclease_OB-fold.
IPR002071. Thermonucl_AS.
[Graphical view]
PfamiPF00565. SNase. 1 hit.
[Graphical view]
SMARTiSM00318. SNc. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
PROSITEiPS01123. TNASE_1. 1 hit.
PS01284. TNASE_2. 1 hit.
PS50830. TNASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMTEYLLS AGICMAIVSI LLIGMAISNV SKGQYAKRFF FFATSCLVLT
60 70 80 90 100
LVVVSSLSSS ANASQTDNGV NRSGSEDPTV YSATSTKKLH KEPATLIKAI
110 120 130 140 150
DGDTVKLMYK GQPMTFRLLL VDTPETKHPK KGVEKYGPEA SAFTKKMVEN
160 170 180 190 200
AKKIEVEFDK GQRTDKYGRG LAYIYADGKM VNEALVRQGL AKVAYVYKPN
210 220 230
NTHEQHLRKS EAQAKKEKLN IWSEDNADSG Q
Length:231
Mass (Da):25,471
Last modified:July 21, 1986 - v1
Checksum:iAD5558AA28E855D7
GO

Sequence cautioni

The sequence AAA26659 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01281 mRNA. Translation: CAA24594.1.
M17123 Genomic DNA. Translation: AAA26659.1. Different initiation.
PIRiA00790. NCSAF.

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01281 mRNA. Translation: CAA24594.1.
M17123 Genomic DNA. Translation: AAA26659.1. Different initiation.
PIRiA00790. NCSAF.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A2TX-ray1.96A83-231[»]
1A2UX-ray2.00A83-231[»]
1A3TX-ray2.10A83-231[»]
1A3UX-ray2.05A83-231[»]
1A3VX-ray2.20A83-231[»]
1AEXX-ray2.10A83-231[»]
1ENAX-ray2.15A89-223[»]
1ENCX-ray1.95A83-231[»]
1EQVX-ray1.94A88-223[»]
1EY0X-ray1.60A83-231[»]
1EY4X-ray1.60A83-231[»]
1EY5X-ray1.70A83-231[»]
1EY6X-ray1.75A83-231[»]
1EY7X-ray1.88A83-231[»]
1EY8X-ray1.75A83-231[»]
1EY9X-ray1.72A83-231[»]
1EYAX-ray2.00A83-231[»]
1EYCX-ray1.85A83-231[»]
1EYDX-ray1.70A83-231[»]
1EZ6X-ray1.90A83-231[»]
1EZ8X-ray1.85A83-231[»]
1F2MX-ray2.00A83-231[»]
1F2YX-ray2.00A83-231[»]
1F2ZX-ray1.80A83-231[»]
1IHZX-ray1.65A83-231[»]
1II3X-ray1.72A83-231[»]
1JOKNMR-A83-231[»]
1JOONMR-A83-231[»]
1JOQNMR-A83-231[»]
1JORNMR-A83-231[»]
1KAAX-ray1.90A88-223[»]
1KABX-ray1.80A88-223[»]
1KDAX-ray1.90A83-231[»]
1KDBX-ray1.90A83-231[»]
1KDCX-ray2.00A83-231[»]
1NSNX-ray2.80S83-231[»]
1NUCX-ray1.90A83-231[»]
1RKNNMR-A83-192[»]
1SNCX-ray1.65A83-231[»]
1SNDX-ray1.84A/B83-231[»]
1SNMX-ray1.74A83-231[»]
1SNOX-ray1.70A83-231[»]
1SNPX-ray1.95A83-231[»]
1SNQX-ray1.70A83-231[»]
1STAX-ray1.70A83-229[»]
1STBX-ray2.00A83-230[»]
1STGX-ray1.70A83-231[»]
1STHX-ray1.85A83-231[»]
1STNX-ray1.70A83-231[»]
1STYX-ray1.67A83-230[»]
1SYBX-ray1.80A83-231[»]
1SYCX-ray1.80A83-231[»]
1SYDX-ray1.70A83-231[»]
1SYEX-ray1.80A83-231[»]
1SYFX-ray1.80A83-231[»]
1SYGX-ray1.90A83-231[»]
1TQOX-ray2.00A83-226[»]
1TR5X-ray2.10A83-226[»]
1TT2X-ray1.85A83-226[»]
1U9RX-ray2.10A83-231[»]
2ENBX-ray2.05A89-223[»]
2EXZX-ray1.90A83-231[»]
2EY1X-ray1.85A83-231[»]
2EY2X-ray1.70A83-231[»]
2EY5X-ray2.00A83-231[»]
2EY6X-ray1.65A83-231[»]
2EYFX-ray1.80A83-231[»]
2EYHX-ray1.90A83-231[»]
2EYJX-ray1.85A83-231[»]
2EYLX-ray1.70A83-231[»]
2EYMX-ray1.80A83-231[»]
2EYOX-ray1.70A83-231[»]
2EYPX-ray1.80A83-231[»]
2F0DX-ray2.50A83-231[»]
2F0EX-ray1.95A83-231[»]
2F0FX-ray2.15A83-231[»]
2F0GX-ray1.90A83-231[»]
2F0HX-ray2.15A83-231[»]
2F0IX-ray1.80A83-231[»]
2F0JX-ray1.80A83-231[»]
2F0KX-ray1.90A83-231[»]
2F0LX-ray1.90A83-231[»]
2F0MX-ray2.00A83-231[»]
2F0NX-ray1.70A83-231[»]
2F0OX-ray1.90A83-231[»]
2F0PX-ray2.05A83-231[»]
2F0QX-ray1.95A83-231[»]
2F0SX-ray1.75A83-231[»]
2F0TX-ray1.70A83-231[»]
2F0UX-ray1.83A83-231[»]
2F0VX-ray2.00A83-231[»]
2F0WX-ray2.10A83-231[»]
2F3VNMR-A83-192[»]
2F3WNMR-A83-192[»]
2FXYNMR-A137-154[»]
2FXZNMR-A179-191[»]
2GSIX-ray2.81W/X/Y/Z126-136[»]
2KHSNMR-A83-203[»]
2NUCX-ray2.00A83-231[»]
2OEOX-ray2.00A83-226[»]
2OF1X-ray1.92A83-226[»]
2PQENMR-A83-231[»]
2QDBX-ray2.20A83-231[»]
2RBMX-ray1.90A83-231[»]
2RDFX-ray2.01A83-231[»]
2RKSX-ray2.01A83-231[»]
2SNMX-ray1.97A83-231[»]
2SNSX-ray1.50A83-231[»]
2SOBNMR-A83-185[»]
3BDCX-ray1.80A83-231[»]
3C1EX-ray1.90A83-231[»]
3C1FX-ray2.00A83-231[»]
3D4DX-ray2.10A/B83-231[»]
3D6CX-ray2.00A83-231[»]
3DHQX-ray2.15A83-231[»]
3DMUX-ray1.80A83-231[»]
3E5SX-ray2.00A/B83-231[»]
3EJIX-ray1.90A83-231[»]
3EROX-ray1.85A83-231[»]
3ERQX-ray2.10A83-231[»]
3EVQX-ray2.00A83-231[»]
3H6MX-ray1.70A83-231[»]
3HEJX-ray1.80A/B/C/D83-231[»]
3HZXX-ray2.00A83-231[»]
3ITPX-ray1.75A83-231[»]
3LX0X-ray1.50A83-231[»]
3MEHX-ray1.50A83-231[»]
3MHBX-ray1.55A83-231[»]
3MXPX-ray1.61A83-231[»]
3MZ5X-ray1.58A83-231[»]
3NHHX-ray2.00A83-231[»]
3NK9X-ray1.65A83-231[»]
3NP8X-ray1.70A83-231[»]
3NQTX-ray1.90A83-231[»]
3NUCX-ray1.90A83-231[»]
3NXWX-ray1.65A83-231[»]
3OSOX-ray1.60A83-231[»]
3OWFX-ray1.85A83-231[»]
3P1HX-ray1.79A83-231[»]
3P75X-ray1.90A89-223[»]
3PMFX-ray1.60A83-231[»]
3QB3X-ray1.63A83-231[»]
3RUZX-ray1.58A83-231[»]
3S9WX-ray1.90A83-231[»]
3SHLX-ray1.48A83-231[»]
3SK4X-ray1.85A83-231[»]
3SK5X-ray1.70A83-231[»]
3SK6X-ray1.80A83-231[»]
3SK8X-ray1.90A83-231[»]
3SR1X-ray1.45A83-231[»]
3SXHX-ray1.40A83-231[»]
3T13X-ray1.80A/B83-231[»]
3T16X-ray1.80A83-231[»]
3TMEX-ray1.40A83-231[»]
3TP5X-ray1.80A83-231[»]
3TP6X-ray1.80A83-231[»]
3TP7X-ray1.90A83-231[»]
3TP8X-ray1.60A83-231[»]
3U9OX-ray1.95A83-231[»]
3V2TX-ray1.80A83-231[»]
3VA5X-ray1.55A83-231[»]
4DF7X-ray1.50A83-231[»]
4DFAX-ray1.40A83-231[»]
4DGZX-ray1.47A83-231[»]
4DU9X-ray1.63A83-231[»]
4E6IX-ray2.00A/B83-231[»]
4EQNX-ray1.80A83-231[»]
4EQOX-ray1.70A83-231[»]
4EQPX-ray1.35A83-231[»]
4EVOX-ray1.95A83-231[»]
4F7XX-ray1.70A83-231[»]
4F8MX-ray1.60A83-231[»]
4G57X-ray1.81A89-223[»]
4H7BX-ray1.60A83-231[»]
4HMIX-ray1.75A83-231[»]
4HMJX-ray1.35A83-231[»]
4HTHX-ray1.75A83-231[»]
4I65X-ray1.61A88-223[»]
4IALX-ray1.60A83-231[»]
4ID6X-ray1.90A83-231[»]
4IUNX-ray1.60A83-231[»]
4IZ8X-ray1.70A83-231[»]
4J1MX-ray1.65A83-231[»]
4J6HX-ray1.60A83-231[»]
4K14X-ray1.60A88-223[»]
4K2KX-ray1.65A83-231[»]
4K2LX-ray1.55A83-231[»]
4K5VX-ray1.75A83-231[»]
4K5WX-ray1.65A83-231[»]
4K5XX-ray1.65A83-231[»]
4K6DX-ray1.65A83-231[»]
4K8IX-ray2.10A89-223[»]
4K8JX-ray2.00A89-223[»]
4KD3X-ray1.75A83-231[»]
4KD4X-ray1.55A83-231[»]
4KHVX-ray1.60A83-231[»]
4KJNX-ray1.55A83-231[»]
4KJOX-ray1.90A83-231[»]
4KTAX-ray1.95A83-231[»]
4KV6X-ray1.55A83-231[»]
4KY5X-ray1.40A83-231[»]
4KY6X-ray1.70A83-231[»]
4KY7X-ray1.55A83-231[»]
4LAAX-ray1.58A83-231[»]
4ME5X-ray1.80A83-231[»]
4MIUX-ray1.67A83-231[»]
4N9PX-ray1.40A83-231[»]
4N9TX-ray1.60A83-231[»]
4NDXX-ray1.50A83-231[»]
4NKLX-ray1.60A83-231[»]
4NMZX-ray1.70A83-231[»]
4NP5X-ray1.50A83-231[»]
4ODGX-ray1.73A83-231[»]
4OL7X-ray1.67A/B83-231[»]
4PMBX-ray1.80A83-231[»]
4PMCX-ray1.65A83-231[»]
4PNYX-ray1.68A83-231[»]
4QB4X-ray1.60A88-223[»]
4QF4X-ray1.80A/B83-231[»]
4R8NX-ray1.65A83-223[»]
4RKBX-ray1.88A83-231[»]
4RKLX-ray1.66A83-231[»]
4S3SX-ray1.64A83-231[»]
4TRDX-ray1.60A83-231[»]
4WORX-ray1.60A83-231[»]
4YIJX-ray1.64A/B83-231[»]
4ZQ3X-ray1.90A83-231[»]
4ZUIX-ray1.70A83-231[»]
4ZUJX-ray1.72A83-231[»]
5C3WX-ray1.72A83-231[»]
5C3XX-ray1.95A83-231[»]
5C4HX-ray1.80A83-231[»]
5C4ZX-ray1.62A83-231[»]
5C5LX-ray1.75A83-231[»]
5C5MX-ray1.70A83-231[»]
5C6AX-ray1.85A83-231[»]
5CC4X-ray1.90A83-231[»]
5CGKX-ray1.85A83-231[»]
5CR3X-ray1.80A83-231[»]
5CV4X-ray1.80A83-231[»]
5CV5X-ray1.80A/B83-231[»]
5CV6X-ray1.95A83-231[»]
5CV7X-ray1.65A83-231[»]
5CV8X-ray1.58A83-231[»]
5CV9X-ray1.62A83-231[»]
5DEHX-ray1.70A83-231[»]
5E1FX-ray1.90A83-231[»]
5E3FX-ray1.75A83-231[»]
5EGTX-ray1.85A83-231[»]
5EKKX-ray2.10A83-231[»]
5EKLX-ray2.10A83-231[»]
5F2DX-ray1.70A83-231[»]
5HGTX-ray1.75A83-231[»]
5HURX-ray1.50A83-231[»]
5I6WX-ray1.90A83-231[»]
5I6YX-ray1.90A83-231[»]
5I9OX-ray1.95A/B83-231[»]
5I9PX-ray1.85A83-231[»]
5IGBX-ray1.80A83-231[»]
5IGCX-ray1.80A83-231[»]
5IGDX-ray1.80A83-231[»]
5IGEX-ray1.80A83-231[»]
5IGFX-ray1.70A83-231[»]
5IGGX-ray1.70A83-231[»]
5IIFX-ray1.85A83-231[»]
5IOCX-ray1.90A83-231[»]
5IODX-ray1.60A83-231[»]
5ISRX-ray1.90A83-231[»]
5J1ZX-ray1.73A83-231[»]
5J22X-ray1.90A83-231[»]
5JAVX-ray1.89A83-231[»]
5JOBX-ray1.45A83-231[»]
5K5PX-ray1.83A83-231[»]
5KEEX-ray1.50A83-231[»]
5KGUX-ray1.90A83-231[»]
5KIXX-ray1.75A83-231[»]
5KRUX-ray1.60A83-231[»]
5KYIX-ray1.70A83-231[»]
5KYLX-ray1.85A83-231[»]
5NUCX-ray2.10A83-231[»]
ProteinModelPortaliP00644.
SMRiP00644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4107Y9E. Bacteria.
COG1525. LUCA.

Enzyme and pathway databases

BRENDAi3.1.31.1. 3352.

Miscellaneous databases

EvolutionaryTraceiP00644.

Family and domain databases

Gene3Di2.40.50.90. 1 hit.
InterProiIPR016071. Staphylococal_nuclease_OB-fold.
IPR002071. Thermonucl_AS.
[Graphical view]
PfamiPF00565. SNase. 1 hit.
[Graphical view]
SMARTiSM00318. SNc. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 1 hit.
PROSITEiPS01123. TNASE_1. 1 hit.
PS01284. TNASE_2. 1 hit.
PS50830. TNASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUC_STAAU
AccessioniPrimary (citable) accession number: P00644
Secondary accession number(s): P13718, Q53711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.