P00638 (EXRN_BPT7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exodeoxyribonuclease
Short name=Exonuclease
EC=3.1.11.3

Gene names

Name:

6

Organism

Enterobacteria phage T7 (Bacteriophage T7)

Taxonomic identifier

10760 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Podoviridae › Autographivirinae › T7-like viruses

Virus host

Escherichia coli [TaxID: 562]

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	This enzyme is essential for phage DNA replication; it is believed to function in the removal of DNA-linked RNA primers. It is also necessary for host DNA degradation and phage genetic recombination.
Catalytic activity	Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.

Ontologies

Keywords
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	5'-3' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Exodeoxyribonuclease		PRO_0000106505

Sequences

	Sequence		Length	Mass (Da)
	P00638 [UniParc]. Last modified February 1, 1991. Version 2. Checksum: 750BE36D527E31C4	FASTA	300	34,502
	10 20 30 40 50 60 MALLDLKQFY ELREGCDDKG ILVMDGDWLV FQAMSAAEFD ASWEEEIWHR CCDHAKARQI 70 80 90 100 110 120 LEDSIKSYET RKKAWAGAPI VLAFTDSVNW RKELVDPNYK ANRKAVKKPV GYFEFLDALF 130 140 150 160 170 180 EREEFYCIRE PMLEGDDVMG VIASNPSAFG ARKAVIISCD KDFKTIPNCD FLWCTTGNIL 190 200 210 220 230 240 TQTEESADWW HLFQTIKGDI TDGYSGIAGW GDTAEDFLNN PFITEPKTSV LKSGKNKGQE 250 260 270 280 290 300 VTKWVKRDPE PHETLWDCIK SIGAKAGMTE EDIIKQGQMA RILRFNEYNF IDKEIYLWRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of bacteriophage T7 DNA and the locations of T7 genetic elements." Dunn J.J., Studier F.W. J. Mol. Biol. 166:477-535(1983) [PubMed: 6864790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Dunn J.J. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01146 Genomic DNA. Translation: CAA24418.1.
PIR	NDBPT7. S42316.
RefSeq	NP_041988.1. NC_001604.1.
3D structure databases
ProteinModelPortal	P00638.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1261052.
Phylogenomic databases
ProtClustDB	PHA0439.
Family and domain databases
InterPro	IPR020046. 5-3_exonucl_a-hlix_arch_N. [Graphical view]
Pfam	PF02739. 5_3_exonuc_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EXRN_BPT7

Accession

Primary (citable) accession number: P00638

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	February 1, 1991
Last modified:	September 21, 2011
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program