Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exonuclease

Gene

6

Organism
Enterobacteria phage T7 (Bacteriophage T7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in phage DNA replication by participating in the removal of DNA-linked RNA primers. Participates also in T7 DNA packaging, host DNA degradation and phage genetic recombination.2 Publications

Catalytic activityi

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.

GO - Molecular functioni

  • DNA binding Source: InterPro
  • exonuclease activity Source: UniProtKB-KW
  • RNA-DNA hybrid ribonuclease activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processBacterial host gene expression shutoff by virus, Degradation of host chromosome by virus, Host gene expression shutoff by virus, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease
Alternative name(s):
Exonuclease gp6
Gene product 6 (EC:3.1.11.3)
Short name:
Gp6
Gene namesi
Ordered Locus Names:6
OrganismiEnterobacteria phage T7 (Bacteriophage T7)
Taxonomic identifieri10760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000840 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001065051 – 300ExonucleaseAdd BLAST300

Structurei

3D structure databases

ProteinModelPortaliP00638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090000HV.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiView protein in InterPro
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR029060. PIN_domain-like.
PfamiView protein in Pfam
PF02739. 5_3_exonuc_N. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequencei

Sequence statusi: Complete.

P00638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLDLKQFY ELREGCDDKG ILVMDGDWLV FQAMSAAEFD ASWEEEIWHR
60 70 80 90 100
CCDHAKARQI LEDSIKSYET RKKAWAGAPI VLAFTDSVNW RKELVDPNYK
110 120 130 140 150
ANRKAVKKPV GYFEFLDALF EREEFYCIRE PMLEGDDVMG VIASNPSAFG
160 170 180 190 200
ARKAVIISCD KDFKTIPNCD FLWCTTGNIL TQTEESADWW HLFQTIKGDI
210 220 230 240 250
TDGYSGIAGW GDTAEDFLNN PFITEPKTSV LKSGKNKGQE VTKWVKRDPE
260 270 280 290 300
PHETLWDCIK SIGAKAGMTE EDIIKQGQMA RILRFNEYNF IDKEIYLWRP
Length:300
Mass (Da):34,502
Last modified:February 1, 1991 - v2
Checksum:i750BE36D527E31C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA. Translation: CAA24418.1.
PIRiS42316. NDBPT7.
RefSeqiNP_041988.1. NC_001604.1.

Genome annotation databases

GeneIDi1261052.
KEGGivg:1261052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA. Translation: CAA24418.1.
PIRiS42316. NDBPT7.
RefSeqiNP_041988.1. NC_001604.1.

3D structure databases

ProteinModelPortaliP00638.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1261052.
KEGGivg:1261052.

Phylogenomic databases

OrthoDBiVOG090000HV.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiView protein in InterPro
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR029060. PIN_domain-like.
PfamiView protein in Pfam
PF02739. 5_3_exonuc_N. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXRN_BPT7
AccessioniPrimary (citable) accession number: P00638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: May 10, 2017
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.