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Reviewed, UniProtKB/Swiss-Prot P00609 (PA23_NOTSC)

Last modified June 16, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phospholipase A2
    EC=3.1.1.4
Alternative name(s):
    Notechis II-5
    Phosphatidylcholine 2-acylhydrolase
OrganismNotechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
Taxonomic identifier70142 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataScleroglossaSerpentesColubroideaElapidaeAcanthophiinaeNotechis

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. Acts presynaptically. Notechis II-5 is less toxic than Notexin but has a higher specific phospholipase activity.

Catalytic activity

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Cofactor

Binds 1 calcium ion per subunit.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Toxic dose

LD50 is 0.045 mg/kg by intravenous injection.

Sequence similarities

Belongs to the phospholipase A2 family. Group I subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 119119Phospholipase A2
PRO_0000161676

Sites

Active site481
Active site931
Metal binding281Calcium; via carbonyl oxygen
Metal binding301Calcium; via carbonyl oxygen
Metal binding321Calcium; via carbonyl oxygen
Metal binding491Calcium

Amino acid modifications

Disulfide bond11 ↔ 71
Disulfide bond27 ↔ 118
Disulfide bond29 ↔ 45
Disulfide bond44 ↔ 99
Disulfide bond51 ↔ 92
Disulfide bond60 ↔ 85
Disulfide bond78 ↔ 90

Secondary structure

...................... 119
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P00609-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 032C9EEBF62BEE26

FASTA11913,676
        10         20         30         40         50         60 
NLVQFSYLIQ CANHGRRPTR HYMDYGCYCG WGGSGTPVDE LDRCCKIHDD CYSDAEKKGC 

        70         80         90        100        110 
SPKMSAYDYY CGENGPYCRN IKKKCLRFVC DCDVEAAFCF AKAPYNNANW NIDTKKRCQ 

« Hide

References

[1]"Isolation and amino acid sequence of a neurotoxic phospholipase A from the venom of the Australian tiger snake Notechis scutatus scutatus."
Halpert J., Eaker D.
J. Biol. Chem. 251:7343-7347(1976) [PubMed: 1002692] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"The three-dimensional structures of two toxins from snake venom throw light on the anticoagulant and neurotoxic sites of phospholipase A2."
Carredano E., Westerlund B., Persson B., Saarinen M., Ramaswamy S., Eaker D., Eklund H.
Toxicon 36:75-92(1998) [PubMed: 9604284] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
Tissue: Venom.

Cross-references

Sequence databases

PIRPSNOA5. A00750.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2NOTX-ray3.00A/B1-119[»]
ModBaseSearch...

Phylogenomic databases

HOVERGENP00609.

Enzyme and pathway databases

BRENDA3.1.1.4. 292759.

Family and domain databases

InterProIPR016090. Phospholipase_A2.
IPR013090. Phospholipase_A2_AS.
IPR001211. Phospholipase_A2_euk.
[Graphical view]
Gene3DG3DSA:1.20.90.10. Phospholipase_A2. 1 hit.
PANTHERPTHR11716. Phospholipase_A2. 1 hit.
PfamPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSPR00389. PHPHLIPASEA2.
ProDomPD000303. PhospholipaseA2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00085. PA2c. 1 hit.
[Graphical view]
PROSITEPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePA23_NOTSC
AccessionPrimary (citable) accession number: P00609
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents