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Protein

Pancreatic triacylglycerol lipase

Gene

PNLIP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153Nucleophile1
Active sitei177Charge relay system1
Metal bindingi188Calcium; via carbonyl oxygen1
Metal bindingi191Calcium; via carbonyl oxygen1
Metal bindingi193Calcium1
Metal bindingi196Calcium1
Active sitei264Charge relay system1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.3 6170

Protein family/group databases

ESTHERisussc-1plip Pancreatic_lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
PL
Short name:
PTL
Short name:
Pancreatic lipase
Gene namesi
Name:PNLIP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei971 Sus s Lipase

Chemistry databases

ChEMBLiCHEMBL1687677

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903561 – 450Pancreatic triacylglycerol lipaseAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 10PROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 104AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 102AlternatePROSITE-ProRule annotation1 Publication
Glycosylationi167N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi238 ↔ 262PROSITE-ProRule annotation1 Publication
Disulfide bondi286 ↔ 297PROSITE-ProRule annotation1 Publication
Disulfide bondi300 ↔ 305PROSITE-ProRule annotation1 Publication
Disulfide bondi434 ↔ 450PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP00591
PRIDEiP00591

PTM databases

iPTMnetiP00591

Expressioni

Inductioni

By colipase/CLPS in the presence of bile salts.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011355

Chemistry databases

BindingDBiP00591

Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni6 – 8Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi38 – 43Combined sources6
Beta strandi46 – 53Combined sources8
Helixi57 – 61Combined sources5
Beta strandi62 – 64Combined sources3
Beta strandi71 – 75Combined sources5
Helixi85 – 97Combined sources13
Beta strandi101 – 106Combined sources6
Helixi110 – 112Combined sources3
Helixi115 – 138Combined sources24
Helixi144 – 146Combined sources3
Beta strandi147 – 152Combined sources6
Helixi154 – 165Combined sources12
Turni166 – 168Combined sources3
Beta strandi170 – 177Combined sources8
Turni181 – 183Combined sources3
Beta strandi184 – 186Combined sources3
Turni188 – 190Combined sources3
Helixi194 – 196Combined sources3
Beta strandi200 – 203Combined sources4
Helixi210 – 213Combined sources4
Beta strandi223 – 227Combined sources5
Helixi229 – 231Combined sources3
Helixi242 – 246Combined sources5
Helixi254 – 274Combined sources21
Turni278 – 281Combined sources4
Helixi290 – 293Combined sources4
Beta strandi307 – 309Combined sources3
Helixi312 – 314Combined sources3
Beta strandi316 – 322Combined sources7
Beta strandi324 – 327Combined sources4
Beta strandi332 – 334Combined sources3
Beta strandi339 – 349Combined sources11
Beta strandi352 – 364Combined sources13
Beta strandi370 – 377Combined sources8
Beta strandi382 – 391Combined sources10
Beta strandi395 – 405Combined sources11
Beta strandi416 – 425Combined sources10
Beta strandi430 – 434Combined sources5
Beta strandi445 – 448Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80A/C1-450[»]
ProteinModelPortaliP00591
SMRiP00591
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00591

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 450PLATPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiP00591

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

P00591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SEVCFPRLGC FSDDAPWAGI VQRPLKILPW SPKDVDTRFL LYTNQNQNNY
60 70 80 90 100
QELVADPSTI TNSNFRMDRK TRFIIHGFID KGEEDWLSNI CKNLFKVESV
110 120 130 140 150
NCICVDWKGG SRTGYTQASQ NIRIVGAEVA YFVEVLKSSL GYSPSNVHVI
160 170 180 190 200
GHSLGSHAAG EAGRRTNGTI ERITGLDPAE PCFQGTPELV RLDPSDAKFV
210 220 230 240 250
DVIHTDAAPI IPNLGFGMSQ TVGHLDFFPN GGKQMPGCQK NILSQIVDID
260 270 280 290 300
GIWEGTRDFV ACNHLRSYKY YADSILNPDG FAGFPCDSYN VFTANKCFPC
310 320 330 340 350
PSEGCPQMGH YADRFPGKTN GVSQVFYLNT GDASNFARWR YKVSVTLSGK
360 370 380 390 400
KVTGHILVSL FGNEGNSRQY EIYKGTLQPD NTHSDEFDSD VEVGDLQKVK
410 420 430 440 450
FIWYNNNVIN PTLPRVGASK ITVERNDGKV YDFCSQETVR EEVLLTLNPC
Length:450
Mass (Da):50,084
Last modified:May 30, 2000 - v2
Checksum:i76E13BBDB4541E0E
GO

Sequence databases

PIRiA90638 LIPG
UniGeneiSsc.61171

Similar proteinsi

Entry informationi

Entry nameiLIPP_PIG
AccessioniPrimary (citable) accession number: P00591
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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