Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pancreatic triacylglycerol lipase

Gene

PNLIP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153Nucleophile1
Active sitei177Charge relay system1
Metal bindingi188Calcium; via carbonyl oxygen1
Metal bindingi191Calcium; via carbonyl oxygen1
Metal bindingi193Calcium1
Metal bindingi196Calcium1
Active sitei264Charge relay system1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.3. 6170.

Protein family/group databases

ESTHERisussc-1plip. Pancreatic_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
PL
Short name:
PTL
Short name:
Pancreatic lipase
Gene namesi
Name:PNLIP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei971. Sus s Lipase.

Chemistry databases

ChEMBLiCHEMBL1687677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903561 – 450Pancreatic triacylglycerol lipaseAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 10PROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 104AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 102AlternatePROSITE-ProRule annotation1 Publication
Glycosylationi167N-linked (GlcNAc...)1 Publication1
Disulfide bondi238 ↔ 262PROSITE-ProRule annotation1 Publication
Disulfide bondi286 ↔ 297PROSITE-ProRule annotation1 Publication
Disulfide bondi300 ↔ 305PROSITE-ProRule annotation1 Publication
Disulfide bondi434 ↔ 450PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP00591.
PRIDEiP00591.

Expressioni

Inductioni

By colipase/CLPS in the presence of bile salts.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011355.

Chemistry databases

BindingDBiP00591.

Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni6 – 8Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi38 – 43Combined sources6
Beta strandi46 – 53Combined sources8
Helixi57 – 61Combined sources5
Beta strandi62 – 64Combined sources3
Beta strandi71 – 75Combined sources5
Helixi85 – 97Combined sources13
Beta strandi101 – 106Combined sources6
Helixi110 – 112Combined sources3
Helixi115 – 138Combined sources24
Helixi144 – 146Combined sources3
Beta strandi147 – 152Combined sources6
Helixi154 – 165Combined sources12
Turni166 – 168Combined sources3
Beta strandi170 – 177Combined sources8
Turni181 – 183Combined sources3
Beta strandi184 – 186Combined sources3
Turni188 – 190Combined sources3
Helixi194 – 196Combined sources3
Beta strandi200 – 203Combined sources4
Helixi210 – 213Combined sources4
Beta strandi223 – 227Combined sources5
Helixi229 – 231Combined sources3
Helixi242 – 246Combined sources5
Helixi254 – 274Combined sources21
Turni278 – 281Combined sources4
Helixi290 – 293Combined sources4
Beta strandi307 – 309Combined sources3
Helixi312 – 314Combined sources3
Beta strandi316 – 322Combined sources7
Beta strandi324 – 327Combined sources4
Beta strandi332 – 334Combined sources3
Beta strandi339 – 349Combined sources11
Beta strandi352 – 364Combined sources13
Beta strandi370 – 377Combined sources8
Beta strandi382 – 391Combined sources10
Beta strandi395 – 405Combined sources11
Beta strandi416 – 425Combined sources10
Beta strandi430 – 434Combined sources5
Beta strandi445 – 448Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80A/C1-450[»]
ProteinModelPortaliP00591.
SMRiP00591.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 450PLATPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP00591.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SEVCFPRLGC FSDDAPWAGI VQRPLKILPW SPKDVDTRFL LYTNQNQNNY
60 70 80 90 100
QELVADPSTI TNSNFRMDRK TRFIIHGFID KGEEDWLSNI CKNLFKVESV
110 120 130 140 150
NCICVDWKGG SRTGYTQASQ NIRIVGAEVA YFVEVLKSSL GYSPSNVHVI
160 170 180 190 200
GHSLGSHAAG EAGRRTNGTI ERITGLDPAE PCFQGTPELV RLDPSDAKFV
210 220 230 240 250
DVIHTDAAPI IPNLGFGMSQ TVGHLDFFPN GGKQMPGCQK NILSQIVDID
260 270 280 290 300
GIWEGTRDFV ACNHLRSYKY YADSILNPDG FAGFPCDSYN VFTANKCFPC
310 320 330 340 350
PSEGCPQMGH YADRFPGKTN GVSQVFYLNT GDASNFARWR YKVSVTLSGK
360 370 380 390 400
KVTGHILVSL FGNEGNSRQY EIYKGTLQPD NTHSDEFDSD VEVGDLQKVK
410 420 430 440 450
FIWYNNNVIN PTLPRVGASK ITVERNDGKV YDFCSQETVR EEVLLTLNPC
Length:450
Mass (Da):50,084
Last modified:May 30, 2000 - v2
Checksum:i76E13BBDB4541E0E
GO

Sequence databases

PIRiA90638. LIPG.
UniGeneiSsc.61171.

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

PIRiA90638. LIPG.
UniGeneiSsc.61171.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80A/C1-450[»]
ProteinModelPortaliP00591.
SMRiP00591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011355.

Chemistry databases

BindingDBiP00591.
ChEMBLiCHEMBL1687677.

Protein family/group databases

Allergomei971. Sus s Lipase.
ESTHERisussc-1plip. Pancreatic_lipase.

Proteomic databases

PaxDbiP00591.
PRIDEiP00591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP00591.

Enzyme and pathway databases

BRENDAi3.1.1.3. 6170.

Miscellaneous databases

EvolutionaryTraceiP00591.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPP_PIG
AccessioniPrimary (citable) accession number: P00591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.