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Protein

Pancreatic triacylglycerol lipase

Gene

PNLIP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531Nucleophile
Active sitei177 – 1771Charge relay system
Metal bindingi188 – 1881Calcium; via carbonyl oxygen
Metal bindingi191 – 1911Calcium; via carbonyl oxygen
Metal bindingi193 – 1931Calcium
Metal bindingi196 – 1961Calcium
Active sitei264 – 2641Charge relay system

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.3. 6170.

Protein family/group databases

ESTHERisussc-1plip. Pancreatic_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
PL
Short name:
PTL
Short name:
Pancreatic lipase
Gene namesi
Name:PNLIP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei971. Sus s Lipase.

Chemistry

ChEMBLiCHEMBL1687677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Pancreatic triacylglycerol lipasePRO_0000090356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 10PROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 104AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 102AlternatePROSITE-ProRule annotation1 Publication
Glycosylationi167 – 1671N-linked (GlcNAc...)1 Publication
Disulfide bondi238 ↔ 262PROSITE-ProRule annotation1 Publication
Disulfide bondi286 ↔ 297PROSITE-ProRule annotation1 Publication
Disulfide bondi300 ↔ 305PROSITE-ProRule annotation1 Publication
Disulfide bondi434 ↔ 450PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP00591.

Expressioni

Inductioni

By colipase/CLPS in the presence of bile salts.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011355.

Chemistry

BindingDBiP00591.

Structurei

Secondary structure

1
450
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 83Combined sources
Beta strandi17 – 204Combined sources
Beta strandi38 – 436Combined sources
Beta strandi46 – 538Combined sources
Helixi57 – 615Combined sources
Beta strandi62 – 643Combined sources
Beta strandi71 – 755Combined sources
Helixi85 – 9713Combined sources
Beta strandi101 – 1066Combined sources
Helixi110 – 1123Combined sources
Helixi115 – 13824Combined sources
Helixi144 – 1463Combined sources
Beta strandi147 – 1526Combined sources
Helixi154 – 16512Combined sources
Turni166 – 1683Combined sources
Beta strandi170 – 1778Combined sources
Turni181 – 1833Combined sources
Beta strandi184 – 1863Combined sources
Turni188 – 1903Combined sources
Helixi194 – 1963Combined sources
Beta strandi200 – 2034Combined sources
Helixi210 – 2134Combined sources
Beta strandi223 – 2275Combined sources
Helixi229 – 2313Combined sources
Helixi242 – 2465Combined sources
Helixi254 – 27421Combined sources
Turni278 – 2814Combined sources
Helixi290 – 2934Combined sources
Beta strandi307 – 3093Combined sources
Helixi312 – 3143Combined sources
Beta strandi316 – 3227Combined sources
Beta strandi324 – 3274Combined sources
Beta strandi332 – 3343Combined sources
Beta strandi339 – 34911Combined sources
Beta strandi352 – 36413Combined sources
Beta strandi370 – 3778Combined sources
Beta strandi382 – 39110Combined sources
Beta strandi395 – 40511Combined sources
Beta strandi416 – 42510Combined sources
Beta strandi430 – 4345Combined sources
Beta strandi445 – 4484Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80A/C1-450[»]
ProteinModelPortaliP00591.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini339 – 450112PLATPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP00591.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SEVCFPRLGC FSDDAPWAGI VQRPLKILPW SPKDVDTRFL LYTNQNQNNY
60 70 80 90 100
QELVADPSTI TNSNFRMDRK TRFIIHGFID KGEEDWLSNI CKNLFKVESV
110 120 130 140 150
NCICVDWKGG SRTGYTQASQ NIRIVGAEVA YFVEVLKSSL GYSPSNVHVI
160 170 180 190 200
GHSLGSHAAG EAGRRTNGTI ERITGLDPAE PCFQGTPELV RLDPSDAKFV
210 220 230 240 250
DVIHTDAAPI IPNLGFGMSQ TVGHLDFFPN GGKQMPGCQK NILSQIVDID
260 270 280 290 300
GIWEGTRDFV ACNHLRSYKY YADSILNPDG FAGFPCDSYN VFTANKCFPC
310 320 330 340 350
PSEGCPQMGH YADRFPGKTN GVSQVFYLNT GDASNFARWR YKVSVTLSGK
360 370 380 390 400
KVTGHILVSL FGNEGNSRQY EIYKGTLQPD NTHSDEFDSD VEVGDLQKVK
410 420 430 440 450
FIWYNNNVIN PTLPRVGASK ITVERNDGKV YDFCSQETVR EEVLLTLNPC
Length:450
Mass (Da):50,084
Last modified:May 30, 2000 - v2
Checksum:i76E13BBDB4541E0E
GO

Sequence databases

PIRiA90638. LIPG.
UniGeneiSsc.61171.

Cross-referencesi

Web resourcesi

Worthington enzyme manual

Sequence databases

PIRiA90638. LIPG.
UniGeneiSsc.61171.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80A/C1-450[»]
ProteinModelPortaliP00591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011355.

Chemistry

BindingDBiP00591.
ChEMBLiCHEMBL1687677.

Protein family/group databases

Allergomei971. Sus s Lipase.
ESTHERisussc-1plip. Pancreatic_lipase.

Proteomic databases

PaxDbiP00591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP00591.

Enzyme and pathway databases

BRENDAi3.1.1.3. 6170.

Miscellaneous databases

EvolutionaryTraceiP00591.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPP_PIG
AccessioniPrimary (citable) accession number: P00591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 30, 2000
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.