Reviewed, UniProtKB/Swiss-Prot P00569 (KAD1_RABIT)

Names and origin

Protein names

Recommended name:
    Adenylate kinase isoenzyme 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Myokinase

Gene names

Name:

AK1

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	ATP metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Adenylate kinase isoenzyme 1		PRO_0000158913
Regions
	Nucleotide binding	15 – 23	9	ATP
	Nucleotide binding	94 – 101	8	AMP By similarity
Sites
	Binding site	39	1	AMP By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P00569-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: B579871616963214	FASTA	194	21,638
	10 20 30 40 50 60 MEEKLKKAKI IFVVGGPGSG KGTQCEKIVH KYGYTHLSTG DLLRAEVSSG SARGKKLSEI 70 80 90 100 110 120 MEKGQLVPLE TVLDMLRDAM VAKADTSKGF LIDGYPRQVQ QGEEFERRIA QPTLLLYVDA 130 140 150 160 170 180 GPETMQKRLL KRGETSGRVD DNEETIKKRL ETYYKATEPV IAFYEKRGIV RKVNAEGSVD 190 NVFSQVCTHL DALK

References

[1]	"Studies on adenosine triphosphate transphosphorylases. Amino acid sequence of rabbit muscle ATP-AMP transphosphorylase." Kuby S.A., Palmieri R.H., Frischat A., Fischer A.H., Wu L.H., Maland L., Manship M. Biochemistry 23:2393-2399(1984) [PubMed: 6089869] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	KIRBA. A00680.
3D structure databases
HSSP	HSSP built from PDB template 3ADK based on UniProtKB P00571.
SMR	P00569. Positions 1-193.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P00569.
Enzyme and pathway databases
BRENDA	2.7.4.3. 255.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR006267. Adenylate_kin1. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01360. aden_kin_iso1. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_RABIT

Accession

Primary (citable) accession number: P00569

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)