CKB

Functionⁱ

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Catalytic activityⁱ

ATP + creatine = ADP + phosphocreatine.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	130	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	132	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	191	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	232	SubstrateBy similarity	1
Binding siteⁱ	236	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	285	SubstrateBy similarity	1
Binding siteⁱ	292	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	320	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	335	ATPPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	128 – 132	ATPPROSITE-ProRule annotation		5
Nucleotide bindingⁱ	320 – 325	ATPPROSITE-ProRule annotation		6

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
creatine kinase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

brain development Source: AgBase
cellular chloride ion homeostasis Source: AgBase

Complete GO annotation...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Creatine kinase B-type (EC:2.7.3.2) Alternative name(s): B-CK Creatine kinase B chain
Gene namesⁱ	Name:CKB
Organismⁱ	Oryctolagus cuniculus (Rabbit)
Taxonomic identifierⁱ	9986 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus
Proteomesⁱ	UP000001811 Componentⁱ: Unplaced

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

mitochondrion Source: AgBase

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000211969	2 – 381	Creatine kinase B-typeAdd BLAST		380

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	4	PhosphoserineBy similarity	1
Modified residueⁱ	35	PhosphothreonineBy similarity	1
Modified residueⁱ	125	PhosphotyrosineBy similarity	1
Modified residueⁱ	199	PhosphoserineBy similarity	1
Modified residueⁱ	269	Nitrated tyrosineBy similarity	1
Modified residueⁱ	309	PhosphoserineBy similarity	1
Modified residueⁱ	322	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Nitration, Phosphoprotein

Proteomic databases

PRIDEⁱ	P00567.

PRIDEⁱ

P00567.

Interactionⁱ

Subunit structureⁱ

Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

Protein-protein interaction databases

STRINGⁱ	9986.ENSOCUP00000007616.

STRINGⁱ

9986.ENSOCUP00000007616.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P00567.
SMRⁱ	P00567.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	11 – 98	Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST		88
Domainⁱ	125 – 367	Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST		243

Sequence similaritiesⁱ

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3581. Eukaryota. COG3869. LUCA.
HOGENOMⁱ	HOG000232165.
HOVERGENⁱ	HBG001339.
InParanoidⁱ	P00567.
KEGG Orthology (KO) More...KOⁱ	K00933.

Family and domain databases

Gene3Dⁱ	1.10.135.10. 1 hit. 3.30.590.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000749. ATP-guanido_PTrfase. IPR022415. ATP-guanido_PTrfase_AS. IPR022414. ATP-guanido_PTrfase_cat. IPR022413. ATP-guanido_PTrfase_N. IPR014746. Gln_synth/guanido_kin_cat_dom.
PANTHERⁱ	PTHR11547. PTHR11547. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00217. ATP-gua_Ptrans. 1 hit. PF02807. ATP-gua_PtransN. 1 hit.
SUPFAMⁱ	SSF48034. SSF48034. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P00567-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPFSNTHNTL KLRFPAEDEF PDLSAHNNHM AKVLTPEMDA ELRAKSTPSG 
        60         70         80         90        100
FTLDDVIQTG VDNPGHPFIM TVGCVAGDEE SYEAFKELFD PIIEDRHGGY 
       110        120        130        140        150
KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE 
       160        170        180        190        200
RRAVEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP 
       210        220        230        240        250
LLLASGMARD WPDARGIWHN DNKTFLVWIN EEDHLRVISM QKGGNMKEVF 
       260        270        280        290        300
TRFCNGLTQI ETLFKSKNYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP 
       310        320        330        340        350
HLGQHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV 
       360        370        380 
QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K

Length:381

Mass (Da):42,663

Last modified:July 21, 1986 - v1

Checksum:ⁱ0001F0FF3A1F3F40

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11306 mRNA. Translation: AAA31201.1.
PIRⁱ	A00678. KIRBCB.
NCBI Reference Sequences More...RefSeqⁱ	NP_001075730.1. NM_001082261.1.
UniGeneⁱ	Ocu.3366.

Genome annotation databases

GeneIDⁱ	100009085.
KEGGⁱ	ocu:100009085.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11306 mRNA. Translation: AAA31201.1.
PIRⁱ	A00678. KIRBCB.
NCBI Reference Sequences More...RefSeqⁱ	NP_001075730.1. NM_001082261.1.
UniGeneⁱ	Ocu.3366.

3D structure databases

ProteinModelPortalⁱ	P00567.
SMRⁱ	P00567.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9986.ENSOCUP00000007616.

STRINGⁱ

9986.ENSOCUP00000007616.

Proteomic databases

PRIDEⁱ	P00567.

PRIDEⁱ

P00567.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100009085.
KEGGⁱ	ocu:100009085.

Organism-specific databases

CTDⁱ	1152.

CTDⁱ

1152.

Phylogenomic databases

eggNOGⁱ	KOG3581. Eukaryota. COG3869. LUCA.
HOGENOMⁱ	HOG000232165.
HOVERGENⁱ	HBG001339.
InParanoidⁱ	P00567.
KEGG Orthology (KO) More...KOⁱ	K00933.

Family and domain databases

Gene3Dⁱ	1.10.135.10. 1 hit. 3.30.590.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000749. ATP-guanido_PTrfase. IPR022415. ATP-guanido_PTrfase_AS. IPR022414. ATP-guanido_PTrfase_cat. IPR022413. ATP-guanido_PTrfase_N. IPR014746. Gln_synth/guanido_kin_cat_dom.
PANTHERⁱ	PTHR11547. PTHR11547. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00217. ATP-gua_Ptrans. 1 hit. PF02807. ATP-gua_PtransN. 1 hit.
SUPFAMⁱ	SSF48034. SSF48034. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCRB_RABIT
Accessionⁱ	P00567Primary (citable) accession number: P00567
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	March 15, 2017
	This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P00567 (KCRB_RABIT)

Your basket is currently empty.

Creatine kinase B-type

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ