UniProtKB - P00567 (KCRB_RABIT)
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Protein
Creatine kinase B-type
Gene
CKB
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Catalytic activityi
ATP + creatine = ADP + phosphocreatine.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 130 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 132 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 191 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 232 | SubstrateBy similarity | 1 | |
Binding sitei | 236 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 285 | SubstrateBy similarity | 1 | |
Binding sitei | 292 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 320 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 335 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 128 – 132 | ATPPROSITE-ProRule annotation | 5 | |
Nucleotide bindingi | 320 – 325 | ATPPROSITE-ProRule annotation | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- creatine kinase activity Source: UniProtKB-EC
GO - Biological processi
- brain development Source: AgBase
- cellular chloride ion homeostasis Source: AgBase
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Creatine kinase B-type (EC:2.7.3.2)Alternative name(s): B-CK Creatine kinase B chain Creatine phosphokinase M-type Short name: CPK-B |
Gene namesi | Name:CKB |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211969 | 1 – 381 | Creatine kinase B-typeAdd BLAST | 381 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | PhosphoserineBy similarity | 1 | |
Modified residuei | 35 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 125 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineBy similarity | 1 | |
Modified residuei | 269 | Nitrated tyrosineBy similarity | 1 | |
Modified residuei | 309 | PhosphoserineBy similarity | 1 | |
Modified residuei | 322 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Nitration, PhosphoproteinProteomic databases
PRIDEi | P00567. |
Interactioni
Subunit structurei
Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.By similarity
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000007616. |
Structurei
3D structure databases
ProteinModelPortali | P00567. |
SMRi | P00567. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 98 | Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 125 – 367 | Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 243 |
Sequence similaritiesi
Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3581. Eukaryota. COG3869. LUCA. |
HOGENOMi | HOG000232165. |
HOVERGENi | HBG001339. |
InParanoidi | P00567. |
KOi | K00933. |
Family and domain databases
Gene3Di | 1.10.135.10. 1 hit. |
InterProi | View protein in InterPro IPR000749. ATP-guanido_PTrfase. IPR022415. ATP-guanido_PTrfase_AS. IPR022414. ATP-guanido_PTrfase_cat. IPR022413. ATP-guanido_PTrfase_N. IPR036802. ATP-guanido_PTrfase_N_sf. IPR014746. Gln_synth/guanido_kin_cat_dom. |
PANTHERi | PTHR11547. PTHR11547. 1 hit. |
Pfami | View protein in Pfam PF00217. ATP-gua_Ptrans. 1 hit. PF02807. ATP-gua_PtransN. 1 hit. |
SUPFAMi | SSF48034. SSF48034. 1 hit. SSF55931. SSF55931. 1 hit. |
PROSITEi | View protein in PROSITE PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit. |
i Sequence
Sequence statusi: Complete.
P00567-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPFSNTHNTL KLRFPAEDEF PDLSAHNNHM AKVLTPEMDA ELRAKSTPSG
60 70 80 90 100
FTLDDVIQTG VDNPGHPFIM TVGCVAGDEE SYEAFKELFD PIIEDRHGGY
110 120 130 140 150
KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE
160 170 180 190 200
RRAVEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP
210 220 230 240 250
LLLASGMARD WPDARGIWHN DNKTFLVWIN EEDHLRVISM QKGGNMKEVF
260 270 280 290 300
TRFCNGLTQI ETLFKSKNYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP
310 320 330 340 350
HLGQHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV
360 370 380
QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11306 mRNA. Translation: AAA31201.1. |
PIRi | A00678. KIRBCB. |
RefSeqi | NP_001075730.1. NM_001082261.1. |
UniGenei | Ocu.3366. |
Genome annotation databases
GeneIDi | 100009085. |
KEGGi | ocu:100009085. |
Similar proteinsi
Entry informationi
Entry namei | KCRB_RABIT | |
Accessioni | P00567Primary (citable) accession number: P00567 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 28, 2018 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |