CKB

Functionⁱ

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Catalytic activityⁱ

ATP + creatine = ADP + phosphocreatine.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	Length	Description
Binding siteⁱ	130 – 130	1	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843
Binding siteⁱ	132 – 132	1	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843
Binding siteⁱ	191 – 191	1	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843
Binding siteⁱ	232 – 232	1	SubstrateBy similarity
Binding siteⁱ	236 – 236	1	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843
Binding siteⁱ	285 – 285	1	SubstrateBy similarity
Binding siteⁱ	292 – 292	1	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843
Binding siteⁱ	320 – 320	1	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843
Binding siteⁱ	335 – 335	1	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843

Regions

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Nucleotide bindingⁱ	128 – 132	5	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843
Nucleotide bindingⁱ	320 – 325	6	ATPPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
creatine kinase activity Source: UniProtKB-EC

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Creatine kinase B-type (EC:2.7.3.2) Alternative name(s): B-CK Creatine kinase B chain
Gene namesⁱ	Name:CKB
Organismⁱ	Oryctolagus cuniculus (Rabbit)
Taxonomic identifierⁱ	9986 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus
Proteomesⁱ	UP000001811: Unplaced

Subcellular locationⁱ

Cytoplasm

GO - Cellular componentⁱ

mitochondrion Source: AgBase

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Initiator methionineⁱ	1 – 1	1	RemovedBy similarity
Chainⁱ	2 – 381	380	Creatine kinase B-type		PRO_0000211969	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Modified residueⁱ	4 – 4	1	PhosphoserineBy similarity
Modified residueⁱ	35 – 35	1	PhosphothreonineBy similarity
Modified residueⁱ	125 – 125	1	PhosphotyrosineBy similarity
Modified residueⁱ	199 – 199	1	PhosphoserineBy similarity
Modified residueⁱ	269 – 269	1	Nitrated tyrosineBy similarity

Keywords - PTMⁱ

Nitration, Phosphoprotein

Interactionⁱ

Subunit structureⁱ

Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

Protein-protein interaction databases

STRINGⁱ	9986.ENSOCUP00000007616.

STRINGⁱ

9986.ENSOCUP00000007616.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P00567.
SMRⁱ	P00567. Positions 2-381.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	11 – 98	88	Phosphagen kinase N-terminalPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00842			Add BLAST
Domainⁱ	125 – 367	243	Phosphagen kinase C-terminalPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00843			Add BLAST

Sequence similaritiesⁱ

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation

Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	COG3869.
HOGENOMⁱ	HOG000232165.
HOVERGENⁱ	HBG001339.
InParanoidⁱ	P00567.

Family and domain databases

Gene3Dⁱ	1.10.135.10. 1 hit. 3.30.590.10. 1 hit.
InterProⁱ	IPR000749. ATP-guanido_PTrfase. IPR022415. ATP-guanido_PTrfase_AS. IPR022414. ATP-guanido_PTrfase_cat. IPR022413. ATP-guanido_PTrfase_N. IPR014746. Gln_synth/guanido_kin_cat_dom. [Graphical view]
PANTHERⁱ	PTHR11547. PTHR11547. 1 hit.
Pfamⁱ	PF00217. ATP-gua_Ptrans. 1 hit. PF02807. ATP-gua_PtransN. 1 hit. [Graphical view]
SUPFAMⁱ	SSF48034. SSF48034. 1 hit.
PROSITEⁱ	PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P00567-1 [UniParc]FASTA Add to Basket

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        10         20         30         40         50
MPFSNTHNTL KLRFPAEDEF PDLSAHNNHM AKVLTPEMDA ELRAKSTPSG 
        60         70         80         90        100
FTLDDVIQTG VDNPGHPFIM TVGCVAGDEE SYEAFKELFD PIIEDRHGGY 
       110        120        130        140        150
KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE 
       160        170        180        190        200
RRAVEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP 
       210        220        230        240        250
LLLASGMARD WPDARGIWHN DNKTFLVWIN EEDHLRVISM QKGGNMKEVF 
       260        270        280        290        300
TRFCNGLTQI ETLFKSKNYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP 
       310        320        330        340        350
HLGQHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV 
       360        370        380 
QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K

Length:381

Mass (Da):42,663

Last modified:July 21, 1986 - v1

Checksum:ⁱ0001F0FF3A1F3F40

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11306 mRNA. Translation: AAA31201.1.
PIRⁱ	A00678. KIRBCB.
RefSeqⁱ	NP_001075730.1. NM_001082261.1.
UniGeneⁱ	Ocu.3366.

Genome annotation databases

GeneIDⁱ	100009085.

GeneIDⁱ

100009085.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11306 mRNA. Translation: AAA31201.1 .
PIRⁱ	A00678. KIRBCB.
RefSeqⁱ	NP_001075730.1. NM_001082261.1.
UniGeneⁱ	Ocu.3366.

3D structure databases

ProteinModelPortalⁱ	P00567.
SMRⁱ	P00567. Positions 2-381.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9986.ENSOCUP00000007616.

STRINGⁱ

9986.ENSOCUP00000007616.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100009085.

GeneIDⁱ

100009085.

Organism-specific databases

CTDⁱ	1152.

CTDⁱ

1152.

Phylogenomic databases

eggNOGⁱ	COG3869.
HOGENOMⁱ	HOG000232165.
HOVERGENⁱ	HBG001339.
InParanoidⁱ	P00567.

Family and domain databases

Gene3Dⁱ	1.10.135.10. 1 hit. 3.30.590.10. 1 hit.
InterProⁱ	IPR000749. ATP-guanido_PTrfase. IPR022415. ATP-guanido_PTrfase_AS. IPR022414. ATP-guanido_PTrfase_cat. IPR022413. ATP-guanido_PTrfase_N. IPR014746. Gln_synth/guanido_kin_cat_dom. [Graphical view ]
PANTHERⁱ	PTHR11547. PTHR11547. 1 hit.
Pfamⁱ	PF00217. ATP-gua_Ptrans. 1 hit. PF02807. ATP-gua_PtransN. 1 hit. [Graphical view ]
SUPFAMⁱ	SSF48034. SSF48034. 1 hit.
PROSITEⁱ	PS00112. PHOSPHAGEN_KINASE. 1 hit. PS51510. PHOSPHAGEN_KINASE_C. 1 hit. PS51509. PHOSPHAGEN_KINASE_N. 1 hit. [Graphical view ]
ProtoNetⁱ	Search...

Publicationsⁱ

"Two tissue-specific isozymes of creatine kinase have closely matched amino acid sequences."
Pickering L., Pang H., Biemann K., Munro H., Schimmel P.
Proc. Natl. Acad. Sci. U.S.A. 82:2310-2314(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationⁱ

Entry nameⁱ

KCRB_RABIT

Accessionⁱ

Primary (citable) accession number: P00567

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families

External Data

Dasty 3

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

Proteomes

UniRef

Supporting data

UniParc

Help

P00567

- KCRB_RABIT

UniProt

P00567 - KCRB_RABIT

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Creatine kinase B-type

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p> Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>Contains the literature citations that are the sources of data used to annotate the entry. Each reference is numbered and contains several subsections allowing a precise description of a given citation.</p><p><a href='../manual/publications_section' target='_top'>More...</a></p>Publicationsi

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<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Publicationsⁱ

Entry informationⁱ

Miscellaneousⁱ