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P00559

- PGK1_HORSE

UniProt

P00559 - PGK1_HORSE

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Protein

Phosphoglycerate kinase 1

Gene
PGK1, PGK
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei171 – 1711Substrate By similarity
Binding sitei220 – 2201ATP By similarity
Binding sitei313 – 3131ATP; via carbonyl oxygen By similarity
Binding sitei344 – 3441ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
  2. phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKP00559.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 1 (EC:2.7.2.3)
Gene namesi
Name:PGK1
Synonyms:PGK
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 417416Phosphoglycerate kinase 1UniRule annotationPRO_0000145829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineUniRule annotation
Modified residuei6 – 61N6-succinyllysine By similarity
Modified residuei11 – 111N6-acetyllysine By similarity
Modified residuei48 – 481N6-acetyllysine; alternate By similarity
Modified residuei48 – 481N6-succinyllysine; alternate By similarity
Modified residuei75 – 751N6-acetyllysine By similarity
Modified residuei76 – 761Phosphotyrosine By similarity
Modified residuei86 – 861N6-acetyllysine By similarity
Modified residuei91 – 911N6-acetyllysine By similarity
Modified residuei97 – 971N6-acetyllysine By similarity
Modified residuei131 – 1311N6-acetyllysine; alternate By similarity
Modified residuei131 – 1311N6-malonyllysine; alternate By similarity
Modified residuei146 – 1461N6-acetyllysine By similarity
Modified residuei191 – 1911N6-succinyllysine By similarity
Modified residuei196 – 1961Phosphotyrosine By similarity
Modified residuei199 – 1991N6-acetyllysine By similarity
Modified residuei203 – 2031Phosphoserine By similarity
Modified residuei267 – 2671N6-acetyllysine By similarity
Modified residuei291 – 2911N6-acetyllysine By similarity
Modified residuei361 – 3611N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP00559.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000012929.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PGKX-ray3.00A-[»]
ProteinModelPortaliP00559.
SMRiP00559. Positions 2-417.

Miscellaneous databases

EvolutionaryTraceiP00559.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 186185Globular domain-1UniRule annotationAdd
BLAST
Regioni24 – 263Substrate binding By similarity
Regioni63 – 664Substrate binding By similarity
Regioni187 – 1904LinkerUniRule annotation
Regioni191 – 417227Globular domain-2UniRule annotationAdd
BLAST
Regioni406 – 41712Associated with globular domain 1UniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
HOVERGENiHBG008177.
InParanoidiP00559.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00559-1 [UniParc]FASTAAdd to Basket

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MSLSNKLTLD KLNVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC    50
LDNGAKSVVL MSHLGRPDVG PMPDKYSLQP VAVELKSLLG KDVLFLKDCV 100
GPEVEKACAD PAAGSVILLE NLRFHVEEEG KGKDASGNKV KAEPAKIETF 150
RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKAGGFLM KKELNYFAKA 200
LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM AFTFLKVLNN 250
MEIGTSLFDE EGAKIVKNLM SKAEKNGVKI TLPVDFVTAD KFDENAKTGQ 300
ATVASGIPAG WMGLDCGTES SKKYAEAVAR AKQIVWNGPV GVFEWEAFAR 350
GTKALMDEVV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL 400
ELLEGKVLPG VDALSNV 417
Length:417
Mass (Da):44,603
Last modified:January 23, 2007 - v2
Checksum:i5110E246AF96931A
GO

Sequence databases

PIRiA92292. KIHOG.

Cross-referencesi

Sequence databases

PIRi A92292. KIHOG.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PGK X-ray 3.00 A - [» ]
ProteinModelPortali P00559.
SMRi P00559. Positions 2-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000012929.

Proteomic databases

PRIDEi P00559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
HOVERGENi HBG008177.
InParanoidi P00559.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
SABIO-RK P00559.

Miscellaneous databases

EvolutionaryTracei P00559.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of 3-phosphoglycerate kinase from horse muscle. II. Amino acid sequence of cyanogen bromide peptides CB1-CB4 and CB6-CB14, sequence of methionine-containing regions, and complete sequence of the enzyme."
    Merrett M.
    J. Biol. Chem. 256:10293-10305(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-417.
    Tissue: Muscle.
  2. "Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme."
    Banks R.D., Blake C.C.F., Evans P.R., Haser R., Rice D.W., Hardy G.W., Merrett M., Phillips A.W.
    Nature 279:773-777(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
    Tissue: Muscle.

Entry informationi

Entry nameiPGK1_HORSE
AccessioniPrimary (citable) accession number: P00559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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