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Protein

Phosphoglycerate kinase 1

Gene

PGK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).2 Publications

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-162eP), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-278), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS)
  2. Phosphoglycerate kinase 2 (PGK2), Phosphoglycerate kinase 1 (PGK1)
  3. no protein annotated in this organism
  4. Beta-enolase (ENO3), Alpha-enolase (ENO1), Enolase 4 (ENO4), Gamma-enolase (ENO2)
  5. Pyruvate kinase, Pyruvate kinase PKM (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase, Pyruvate kinase (PKM), Pyruvate kinase, Pyruvate kinase PKLR (PKLR), Pyruvate kinase, Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (HEL-S-30), Pyruvate kinase (PKM2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39Substrate1
Binding sitei123Substrate1
Binding sitei171Substrate1
Binding sitei220ATP1
Binding sitei313ATP; via carbonyl oxygen1
Binding sitei344ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 376ATP4

GO - Molecular functioni

GO - Biological processi

  • canonical glycolysis Source: Reactome
  • epithelial cell differentiation Source: UniProtKB
  • gluconeogenesis Source: Reactome
  • phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS02359-MONOMER.
ZFISH:HS02359-MONOMER.
ReactomeiR-HSA-70171. Glycolysis.
R-HSA-70263. Gluconeogenesis.
SABIO-RKP00558.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 1 (EC:2.7.2.3)
Alternative name(s):
Cell migration-inducing gene 10 protein
Primer recognition protein 2
Short name:
PRP 2
Gene namesi
Name:PGK1
Synonyms:PGKA
ORF Names:MIG10, OK/SW-cl.110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:8896. PGK1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Phosphoglycerate kinase 1 deficiency (PGK1D)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.
See also OMIM:300653
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00607688L → P in PGK1D; with congenital non-spherocytic anemia; variant Matsue. 1 PublicationCorresponds to variant rs137852531dbSNPEnsembl.1
Natural variantiVAR_006077158G → V in PGK1D; with chronic hemolytic anemia; variant Shizuoka. 1 PublicationCorresponds to variant rs137852532dbSNPEnsembl.1
Natural variantiVAR_006078164D → V in PGK1D; with chronic hemolytic anemia and mental retardation; variant Amiens. 1 PublicationCorresponds to variant rs137852538dbSNPEnsembl.1
Natural variantiVAR_006079191Missing in PGK1D; with chronic hemolytic anemia; variant Alabama. 1 Publication1
Natural variantiVAR_006080206R → P in PGK1D; with chronic hemolytic anemia; variant Uppsala. 1 PublicationCorresponds to variant rs137852529dbSNPEnsembl.1
Natural variantiVAR_006081252E → A in PGK1D; with chronic hemolytic anemia; variant Antwerp. 1 Publication1
Natural variantiVAR_006082266V → M in PGK1D; with chronic non-spherocytic hemolytic anemia; variant Tokyo. 1 PublicationCorresponds to variant rs431905501dbSNPEnsembl.1
Natural variantiVAR_006084285D → V in PGK1D; with chronic hemolytic anemia; variant Herlev; 50% of activity. 1 PublicationCorresponds to variant rs137852535dbSNPEnsembl.1
Natural variantiVAR_006085315D → N in PGK1D; with rhabdomyolysis; variant Creteil. 1 Publication1
Natural variantiVAR_006086316C → R in PGK1D; with chronic hemolytic anemia; variant Michigan. 1 PublicationCorresponds to variant rs137852533dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNETi5230.
MalaCardsiPGK1.
MIMi300653. phenotype.
OpenTargetsiENSG00000102144.
Orphaneti713. Glycogen storage disease due to phosphoglycerate kinase 1 deficiency.
PharmGKBiPA33234.

Chemistry databases

ChEMBLiCHEMBL2096677.
DrugBankiDB00709. Lamivudine.

Polymorphism and mutation databases

BioMutaiPGK1.
DMDMi52788229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001458312 – 417Phosphoglycerate kinase 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei6N6-succinyllysineBy similarity1
Modified residuei11N6-acetyllysineCombined sources1
Modified residuei48N6-acetyllysine; alternateCombined sources1
Modified residuei48N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysineCombined sources1
Modified residuei76PhosphotyrosineBy similarity1
Modified residuei86N6-acetyllysineCombined sources1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineCombined sources1
Modified residuei131N6-acetyllysine; alternateCombined sources1
Modified residuei131N6-malonyllysine; alternate1 Publication1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei191N6-succinyllysineBy similarity1
Modified residuei196PhosphotyrosineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei267N6-acetyllysineCombined sources1
Modified residuei291N6-acetyllysineCombined sources1
Modified residuei361N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP00558.
PaxDbiP00558.
PeptideAtlasiP00558.
PRIDEiP00558.
TopDownProteomicsiP00558-1. [P00558-1]

2D gel databases

DOSAC-COBS-2DPAGEP00558.
OGPiP00558.
REPRODUCTION-2DPAGEIPI00169383.
P00558.
UCD-2DPAGEP00558.

PTM databases

iPTMnetiP00558.
PhosphoSitePlusiP00558.
SwissPalmiP00558.

Expressioni

Tissue specificityi

Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men.1 Publication

Gene expression databases

BgeeiENSG00000102144.
CleanExiHS_PGK1.
ExpressionAtlasiP00558. baseline and differential.
GenevisibleiP00558. HS.

Organism-specific databases

HPAiCAB010065.
HPA045385.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GAPDHP044062EBI-709599,EBI-354056

Protein-protein interaction databases

BioGridi111251. 93 interactors.
DIPiDIP-33679N.
IntActiP00558. 38 interactors.
MINTiMINT-1131047.
STRINGi9606.ENSP00000362413.

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Helixi9 – 11Combined sources3
Beta strandi18 – 22Combined sources5
Beta strandi29 – 32Combined sources4
Beta strandi33 – 35Combined sources3
Helixi38 – 52Combined sources15
Beta strandi56 – 61Combined sources6
Helixi73 – 76Combined sources4
Helixi79 – 89Combined sources11
Beta strandi94 – 97Combined sources4
Beta strandi99 – 101Combined sources3
Helixi102 – 109Combined sources8
Beta strandi115 – 118Combined sources4
Helixi122 – 124Combined sources3
Turni126 – 130Combined sources5
Beta strandi131 – 133Combined sources3
Beta strandi135 – 137Combined sources3
Beta strandi139 – 141Combined sources3
Helixi144 – 156Combined sources13
Beta strandi159 – 163Combined sources5
Helixi166 – 168Combined sources3
Helixi174 – 177Combined sources4
Beta strandi184 – 186Combined sources3
Helixi188 – 202Combined sources15
Beta strandi206 – 212Combined sources7
Helixi217 – 220Combined sources4
Helixi221 – 223Combined sources3
Helixi224 – 227Combined sources4
Turni228 – 230Combined sources3
Beta strandi232 – 236Combined sources5
Helixi238 – 240Combined sources3
Helixi241 – 249Combined sources9
Helixi260 – 263Combined sources4
Helixi266 – 275Combined sources10
Beta strandi279 – 281Combined sources3
Beta strandi285 – 293Combined sources9
Beta strandi298 – 302Combined sources5
Turni303 – 305Combined sources3
Beta strandi312 – 316Combined sources5
Helixi318 – 330Combined sources13
Beta strandi332 – 338Combined sources7
Helixi346 – 348Combined sources3
Helixi350 – 364Combined sources15
Beta strandi368 – 373Combined sources6
Helixi376 – 382Combined sources7
Beta strandi388 – 394Combined sources7
Helixi397 – 404Combined sources8
Helixi409 – 412Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WZBX-ray1.47A2-417[»]
2WZCX-ray1.50A2-417[»]
2WZDX-ray1.56A1-417[»]
2X13X-ray1.74A2-417[»]
2X14X-ray1.90A2-417[»]
2X15X-ray2.10A2-417[»]
2XE6X-ray1.74A1-417[»]
2XE7X-ray2.20A1-417[»]
2XE8X-ray1.79A1-417[»]
2Y3IX-ray2.90A/D1-416[»]
2YBEX-ray2.00A1-417[»]
2ZGVX-ray2.00A1-417[»]
3C39X-ray1.85A/B1-417[»]
3C3AX-ray2.30A/B1-417[»]
3C3BX-ray1.80A/B1-417[»]
3C3CX-ray2.40A/B1-417[»]
3ZOZX-ray1.95A1-417[»]
4AXXX-ray1.74A1-417[»]
4O33X-ray2.10A1-417[»]
ProteinModelPortaliP00558.
SMRiP00558.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00558.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate binding3
Regioni63 – 66Substrate binding4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiKOG1367. Eukaryota.
COG0126. LUCA.
GeneTreeiENSGT00390000008820.
HOGENOMiHOG000227107.
HOVERGENiHBG008177.
InParanoidiP00558.
KOiK00927.
OMAiIKHCLDH.
OrthoDBiEOG091G08S6.
PhylomeDBiP00558.
TreeFamiTF300489.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P00558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC
60 70 80 90 100
LDNGAKSVVL MSHLGRPDGV PMPDKYSLEP VAVELKSLLG KDVLFLKDCV
110 120 130 140 150
GPEVEKACAN PAAGSVILLE NLRFHVEEEG KGKDASGNKV KAEPAKIEAF
160 170 180 190 200
RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKAGGFLM KKELNYFAKA
210 220 230 240 250
LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM AFTFLKVLNN
260 270 280 290 300
MEIGTSLFDE EGAKIVKDLM SKAEKNGVKI TLPVDFVTAD KFDENAKTGQ
310 320 330 340 350
ATVASGIPAG WMGLDCGPES SKKYAEAVTR AKQIVWNGPV GVFEWEAFAR
360 370 380 390 400
GTKALMDEVV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL
410
ELLEGKVLPG VDALSNI
Length:417
Mass (Da):44,615
Last modified:January 23, 2007 - v3
Checksum:iB5DFC7B5FA01767C
GO
Isoform 2 (identifier: P00558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):41,429
Checksum:i2A0D80F12CCEB825
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39Missing AA sequence (PubMed:7391027).Curated1
Sequence conflicti370I → T in CAG32997 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00607688L → P in PGK1D; with congenital non-spherocytic anemia; variant Matsue. 1 PublicationCorresponds to variant rs137852531dbSNPEnsembl.1
Natural variantiVAR_006077158G → V in PGK1D; with chronic hemolytic anemia; variant Shizuoka. 1 PublicationCorresponds to variant rs137852532dbSNPEnsembl.1
Natural variantiVAR_006078164D → V in PGK1D; with chronic hemolytic anemia and mental retardation; variant Amiens. 1 PublicationCorresponds to variant rs137852538dbSNPEnsembl.1
Natural variantiVAR_006079191Missing in PGK1D; with chronic hemolytic anemia; variant Alabama. 1 Publication1
Natural variantiVAR_006080206R → P in PGK1D; with chronic hemolytic anemia; variant Uppsala. 1 PublicationCorresponds to variant rs137852529dbSNPEnsembl.1
Natural variantiVAR_006081252E → A in PGK1D; with chronic hemolytic anemia; variant Antwerp. 1 Publication1
Natural variantiVAR_006082266V → M in PGK1D; with chronic non-spherocytic hemolytic anemia; variant Tokyo. 1 PublicationCorresponds to variant rs431905501dbSNPEnsembl.1
Natural variantiVAR_006083268D → N in Munchen; 21% of activity. 2 PublicationsCorresponds to variant rs137852528dbSNPEnsembl.1
Natural variantiVAR_006084285D → V in PGK1D; with chronic hemolytic anemia; variant Herlev; 50% of activity. 1 PublicationCorresponds to variant rs137852535dbSNPEnsembl.1
Natural variantiVAR_006085315D → N in PGK1D; with rhabdomyolysis; variant Creteil. 1 Publication1
Natural variantiVAR_006086316C → R in PGK1D; with chronic hemolytic anemia; variant Michigan. 1 PublicationCorresponds to variant rs137852533dbSNPEnsembl.1
Natural variantiVAR_006087352T → N.1 PublicationCorresponds to variant rs137852530dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561591 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00572 mRNA. Translation: CAA23835.1.
L00160 mRNA. Translation: AAA60078.1.
M11968
, M11958, M11959, M11960, M11961, M11962, M11963, M11964, M11965, M11966, M11967 Genomic DNA. Translation: AAA60079.1.
AY423725 mRNA. Translation: AAS00488.1.
AB062432 mRNA. Translation: BAB93495.1.
AK291081 mRNA. Translation: BAF83770.1.
AK301740 mRNA. Translation: BAH13545.1.
AK312280 mRNA. Translation: BAG35209.1.
CR456716 mRNA. Translation: CAG32997.1.
AL049589 Genomic DNA. Translation: CAI42951.1.
CH471104 Genomic DNA. Translation: EAW98604.1.
BC023234 mRNA. Translation: AAH23234.1.
BC103752 mRNA. Translation: AAI03753.1.
BC104837 mRNA. Translation: AAI04838.1.
BC113568 mRNA. Translation: AAI13569.1.
M34017 Genomic DNA. Translation: AAA60103.1.
CCDSiCCDS14438.1. [P00558-1]
PIRiI59050. KIHUG.
RefSeqiNP_000282.1. NM_000291.3. [P00558-1]
UniGeneiHs.78771.

Genome annotation databases

EnsembliENST00000373316; ENSP00000362413; ENSG00000102144. [P00558-1]
GeneIDi5230.
KEGGihsa:5230.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Phosphoglycerate kinase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00572 mRNA. Translation: CAA23835.1.
L00160 mRNA. Translation: AAA60078.1.
M11968
, M11958, M11959, M11960, M11961, M11962, M11963, M11964, M11965, M11966, M11967 Genomic DNA. Translation: AAA60079.1.
AY423725 mRNA. Translation: AAS00488.1.
AB062432 mRNA. Translation: BAB93495.1.
AK291081 mRNA. Translation: BAF83770.1.
AK301740 mRNA. Translation: BAH13545.1.
AK312280 mRNA. Translation: BAG35209.1.
CR456716 mRNA. Translation: CAG32997.1.
AL049589 Genomic DNA. Translation: CAI42951.1.
CH471104 Genomic DNA. Translation: EAW98604.1.
BC023234 mRNA. Translation: AAH23234.1.
BC103752 mRNA. Translation: AAI03753.1.
BC104837 mRNA. Translation: AAI04838.1.
BC113568 mRNA. Translation: AAI13569.1.
M34017 Genomic DNA. Translation: AAA60103.1.
CCDSiCCDS14438.1. [P00558-1]
PIRiI59050. KIHUG.
RefSeqiNP_000282.1. NM_000291.3. [P00558-1]
UniGeneiHs.78771.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WZBX-ray1.47A2-417[»]
2WZCX-ray1.50A2-417[»]
2WZDX-ray1.56A1-417[»]
2X13X-ray1.74A2-417[»]
2X14X-ray1.90A2-417[»]
2X15X-ray2.10A2-417[»]
2XE6X-ray1.74A1-417[»]
2XE7X-ray2.20A1-417[»]
2XE8X-ray1.79A1-417[»]
2Y3IX-ray2.90A/D1-416[»]
2YBEX-ray2.00A1-417[»]
2ZGVX-ray2.00A1-417[»]
3C39X-ray1.85A/B1-417[»]
3C3AX-ray2.30A/B1-417[»]
3C3BX-ray1.80A/B1-417[»]
3C3CX-ray2.40A/B1-417[»]
3ZOZX-ray1.95A1-417[»]
4AXXX-ray1.74A1-417[»]
4O33X-ray2.10A1-417[»]
ProteinModelPortaliP00558.
SMRiP00558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111251. 93 interactors.
DIPiDIP-33679N.
IntActiP00558. 38 interactors.
MINTiMINT-1131047.
STRINGi9606.ENSP00000362413.

Chemistry databases

ChEMBLiCHEMBL2096677.
DrugBankiDB00709. Lamivudine.

PTM databases

iPTMnetiP00558.
PhosphoSitePlusiP00558.
SwissPalmiP00558.

Polymorphism and mutation databases

BioMutaiPGK1.
DMDMi52788229.

2D gel databases

DOSAC-COBS-2DPAGEP00558.
OGPiP00558.
REPRODUCTION-2DPAGEIPI00169383.
P00558.
UCD-2DPAGEP00558.

Proteomic databases

EPDiP00558.
PaxDbiP00558.
PeptideAtlasiP00558.
PRIDEiP00558.
TopDownProteomicsiP00558-1. [P00558-1]

Protocols and materials databases

DNASUi5230.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373316; ENSP00000362413; ENSG00000102144. [P00558-1]
GeneIDi5230.
KEGGihsa:5230.

Organism-specific databases

CTDi5230.
DisGeNETi5230.
GeneCardsiPGK1.
HGNCiHGNC:8896. PGK1.
HPAiCAB010065.
HPA045385.
MalaCardsiPGK1.
MIMi300653. phenotype.
311800. gene.
neXtProtiNX_P00558.
OpenTargetsiENSG00000102144.
Orphaneti713. Glycogen storage disease due to phosphoglycerate kinase 1 deficiency.
PharmGKBiPA33234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1367. Eukaryota.
COG0126. LUCA.
GeneTreeiENSGT00390000008820.
HOGENOMiHOG000227107.
HOVERGENiHBG008177.
InParanoidiP00558.
KOiK00927.
OMAiIKHCLDH.
OrthoDBiEOG091G08S6.
PhylomeDBiP00558.
TreeFamiTF300489.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciMetaCyc:HS02359-MONOMER.
ZFISH:HS02359-MONOMER.
ReactomeiR-HSA-70171. Glycolysis.
R-HSA-70263. Gluconeogenesis.
SABIO-RKP00558.

Miscellaneous databases

ChiTaRSiPGK1. human.
EvolutionaryTraceiP00558.
GeneWikiiPGK1.
GenomeRNAii5230.
PROiP00558.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102144.
CleanExiHS_PGK1.
ExpressionAtlasiP00558. baseline and differential.
GenevisibleiP00558. HS.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK1_HUMAN
AccessioniPrimary (citable) accession number: P00558
Secondary accession number(s): A8K4W6
, B7Z7A9, Q5J7W1, Q6IBT6, Q8NI87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 193 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.