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P00545

- KFMS_FSVMD

UniProt

P00545 - KFMS_FSVMD

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Protein
Tyrosine-protein kinase transforming protein fms
Gene
V-FMS
Organism
Feline sarcoma virus (strain McDonough)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Truncated version of the receptor for colony-stimulating factor 1 (CSF-1).

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei647 – 6471ATP By similarity
Active sitei810 – 8101Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi619 – 6279ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein fms (EC:2.7.10.1)
Gene namesi
Name:V-FMS
OrganismiFeline sarcoma virus (strain McDonough)
Taxonomic identifieri11778 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 543543Extracellular Reviewed prediction
Add
BLAST
Transmembranei544 – 56825Helical; Reviewed prediction
Add
BLAST
Topological domaini569 – 978410Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 978978Tyrosine-protein kinase transforming protein fms
PRO_0000155209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 118 Reviewed prediction
Glycosylationi79 – 791N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi107 – 1071N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi128 – 1281N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi161 ↔ 211 Reviewed prediction
Glycosylationi187 – 1871N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi258 ↔ 312 Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi320 – 3201N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi336 – 3361N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi369 – 3691N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi451 ↔ 516 Reviewed prediction
Glycosylationi511 – 5111N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi524 – 5241N-linked (GlcNAc...); by host Reviewed prediction
Modified residuei841 – 8411Phosphotyrosine; by autocatalysis By similarity
Modified residuei973 – 9731Phosphothreonine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP00545.
SMRiP00545. Positions 578-951.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 13480Ig-like C2-type 1
Add
BLAST
Domaini141 – 23191Ig-like C2-type 2
Add
BLAST
Domaini236 – 33196Ig-like C2-type 3
Add
BLAST
Domaini333 – 43199Ig-like C2-type 4
Add
BLAST
Domaini434 – 533100Ig-like C2-type 5
Add
BLAST
Domaini613 – 942330Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF500947. CSF-1_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00545-1 [UniParc]FASTAAdd to Basket

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RMPSGPGHYG ASAETPGPRP PLCPASSCCL PTEAMGPRAL LVLLMATAWH    50
AQGVPVIQPS GPELVVEPGT TVTLRCVGNG SVEWDGPISP HWNLDLDPPS 100
SILTTNNATF QNTGTYHCTE PGNPRGGNAT IHLYVKDPAR PWKVLAQEVT 150
VLEGQDALLP CLLTDPALEA GVSLVRVRGR PVLRQTNYSF SPWHGFTIHK 200
AKFIENHVYQ CSARVDGRTV TSMGIWLKVQ KDISGPATLT LEPAELVRIQ 250
GEAAQIVCSA SNIDVNFDVS LRHGDTKLTI SQQSDFHDNR YQKVLTLNLD 300
HVSFQDAGNY SCTATNAWGN HSASMVFRVV ESAYSNLTSE QSLLQEVTVG 350
EKVDLQVKVE AYPGLESFNW TYLGPFSDYQ DKLDFVTIKD TYRYTSTLSL 400
PRLKRSESGR YSFLARNAGG QNALTFELTL RYPPEVRVTM TLINGSDTLL 450
CEASGYPQPS VTWVQCRSHT DRCDESAGLV LEDSHSEVLS QVPFYEVIVH 500
SLLAIGTLEH NRTYECRAFN SVGNSSQTFW PISIGAHTPL PDELLFTPVL 550
LTCMSIMALL LLLLLLLLYK YKQKPKYQVR WKIIESYEGN SYTFIDPTQL 600
PYNEKWEFPR NNLQFGKTLG TGAFGKVVEA TAFGLGKEDA VLKVAVKMLK 650
STAHADEKEA LMSELKIMSH LGQHENIVNL LGACTHGGPV LVITEYCCYG 700
DLLNFLRRQA EAMLGPSLSV GQDPEAGAGY KNIHLEKKYV RRDSGFSSQG 750
VDTYVEMRPV STSSSNDSFS EEDLGKEDGR PLELRDLLHF SSQVAQGMAF 800
LASKNCIHRD VAARNVLLTS GRVAKIGDFG LARDIMNDSN YIVKGNARLP 850
VKWMAPESIF DCVYTVQSDV WSYGILLWEI FSLGLNPYPG ILVNSKFYKL 900
VKDGYQMAQP AFAPKNIYSI MQACWALEPT RRPTFQQICS LLQKQAQEDR 950
RVPNYTNLPS SSSSRLLRPW QRTPPVAR 978
Length:978
Mass (Da):108,492
Last modified:November 1, 1991 - v2
Checksum:i4C7CAC4835185EBF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti714 – 7141L → P in AAA43045. 1 Publication
Sequence conflicti971 – 9788QRTPPVAR → RGPPL in AAA43045. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01643 Genomic RNA. Translation: AAA43045.1.
S59588 Genomic DNA. Translation: AAB20028.1.
PIRiA00654. TVMVMD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01643 Genomic RNA. Translation: AAA43045.1 .
S59588 Genomic DNA. Translation: AAB20028.1 .
PIRi A00654. TVMVMD.

3D structure databases

ProteinModelPortali P00545.
SMRi P00545. Positions 578-951.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2234.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF500947. CSF-1_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases."
    Hampe A., Gobet M., Sherr C.J., Galibert F.
    Proc. Natl. Acad. Sci. U.S.A. 81:85-89(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Reassessment of the v-fms sequence: threonine phosphorylation of the COOH-terminal domain."
    Smola U., Hennig D., Hadwiger-Fangmeier A., Schuetz B., Pfaff E., Niemann H., Tamura T.
    J. Virol. 65:6181-6187(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION, PHOSPHORYLATION AT THR-973.

Entry informationi

Entry nameiKFMS_FSVMD
AccessioniPrimary (citable) accession number: P00545
Secondary accession number(s): Q86597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: April 16, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fms polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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