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P00545

- KFMS_FSVMD

UniProt

P00545 - KFMS_FSVMD

Protein

Tyrosine-protein kinase transforming protein fms

Gene

V-FMS

Organism
Feline sarcoma virus (strain McDonough)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Truncated version of the receptor for colony-stimulating factor 1 (CSF-1).

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei647 – 6471ATPPROSITE-ProRule annotation
    Active sitei810 – 8101Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi619 – 6279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2234.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transforming protein fms (EC:2.7.10.1)
    Gene namesi
    Name:V-FMS
    OrganismiFeline sarcoma virus (strain McDonough)
    Taxonomic identifieri11778 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiFelidae (cat family) [TaxID: 9681]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 978978Tyrosine-protein kinase transforming protein fmsPRO_0000155209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi76 ↔ 118PROSITE-ProRule annotation
    Glycosylationi79 – 791N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi161 ↔ 211PROSITE-ProRule annotation
    Glycosylationi187 – 1871N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi258 ↔ 312PROSITE-ProRule annotation
    Glycosylationi309 – 3091N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi336 – 3361N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi369 – 3691N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi451 ↔ 516PROSITE-ProRule annotation
    Glycosylationi511 – 5111N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi524 – 5241N-linked (GlcNAc...); by hostSequence Analysis
    Modified residuei841 – 8411Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei973 – 9731Phosphothreonine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP00545.
    SMRiP00545. Positions 578-951.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 543543ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini569 – 978410CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei544 – 56825HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 13480Ig-like C2-type 1Add
    BLAST
    Domaini141 – 23191Ig-like C2-type 2Add
    BLAST
    Domaini236 – 33196Ig-like C2-type 3Add
    BLAST
    Domaini333 – 43199Ig-like C2-type 4Add
    BLAST
    Domaini434 – 533100Ig-like C2-type 5Add
    BLAST
    Domaini613 – 942330Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
    IPR001824. Tyr_kinase_rcpt_3_CS.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500947. CSF-1_receptor. 1 hit.
    PIRSF000615. TyrPK_CSF1-R. 1 hit.
    SMARTiSM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00545-1 [UniParc]FASTAAdd to Basket

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    RMPSGPGHYG ASAETPGPRP PLCPASSCCL PTEAMGPRAL LVLLMATAWH    50
    AQGVPVIQPS GPELVVEPGT TVTLRCVGNG SVEWDGPISP HWNLDLDPPS 100
    SILTTNNATF QNTGTYHCTE PGNPRGGNAT IHLYVKDPAR PWKVLAQEVT 150
    VLEGQDALLP CLLTDPALEA GVSLVRVRGR PVLRQTNYSF SPWHGFTIHK 200
    AKFIENHVYQ CSARVDGRTV TSMGIWLKVQ KDISGPATLT LEPAELVRIQ 250
    GEAAQIVCSA SNIDVNFDVS LRHGDTKLTI SQQSDFHDNR YQKVLTLNLD 300
    HVSFQDAGNY SCTATNAWGN HSASMVFRVV ESAYSNLTSE QSLLQEVTVG 350
    EKVDLQVKVE AYPGLESFNW TYLGPFSDYQ DKLDFVTIKD TYRYTSTLSL 400
    PRLKRSESGR YSFLARNAGG QNALTFELTL RYPPEVRVTM TLINGSDTLL 450
    CEASGYPQPS VTWVQCRSHT DRCDESAGLV LEDSHSEVLS QVPFYEVIVH 500
    SLLAIGTLEH NRTYECRAFN SVGNSSQTFW PISIGAHTPL PDELLFTPVL 550
    LTCMSIMALL LLLLLLLLYK YKQKPKYQVR WKIIESYEGN SYTFIDPTQL 600
    PYNEKWEFPR NNLQFGKTLG TGAFGKVVEA TAFGLGKEDA VLKVAVKMLK 650
    STAHADEKEA LMSELKIMSH LGQHENIVNL LGACTHGGPV LVITEYCCYG 700
    DLLNFLRRQA EAMLGPSLSV GQDPEAGAGY KNIHLEKKYV RRDSGFSSQG 750
    VDTYVEMRPV STSSSNDSFS EEDLGKEDGR PLELRDLLHF SSQVAQGMAF 800
    LASKNCIHRD VAARNVLLTS GRVAKIGDFG LARDIMNDSN YIVKGNARLP 850
    VKWMAPESIF DCVYTVQSDV WSYGILLWEI FSLGLNPYPG ILVNSKFYKL 900
    VKDGYQMAQP AFAPKNIYSI MQACWALEPT RRPTFQQICS LLQKQAQEDR 950
    RVPNYTNLPS SSSSRLLRPW QRTPPVAR 978
    Length:978
    Mass (Da):108,492
    Last modified:November 1, 1991 - v2
    Checksum:i4C7CAC4835185EBF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti714 – 7141L → P in AAA43045. (PubMed:6582485)Curated
    Sequence conflicti971 – 9788QRTPPVAR → RGPPL in AAA43045. (PubMed:6582485)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01643 Genomic RNA. Translation: AAA43045.1.
    S59588 Genomic DNA. Translation: AAB20028.1.
    PIRiA00654. TVMVMD.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01643 Genomic RNA. Translation: AAA43045.1 .
    S59588 Genomic DNA. Translation: AAB20028.1 .
    PIRi A00654. TVMVMD.

    3D structure databases

    ProteinModelPortali P00545.
    SMRi P00545. Positions 578-951.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2234.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
    IPR001824. Tyr_kinase_rcpt_3_CS.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500947. CSF-1_receptor. 1 hit.
    PIRSF000615. TyrPK_CSF1-R. 1 hit.
    SMARTi SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases."
      Hampe A., Gobet M., Sherr C.J., Galibert F.
      Proc. Natl. Acad. Sci. U.S.A. 81:85-89(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Reassessment of the v-fms sequence: threonine phosphorylation of the COOH-terminal domain."
      Smola U., Hennig D., Hadwiger-Fangmeier A., Schuetz B., Pfaff E., Niemann H., Tamura T.
      J. Virol. 65:6181-6187(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION, PHOSPHORYLATION AT THR-973.

    Entry informationi

    Entry nameiKFMS_FSVMD
    AccessioniPrimary (citable) accession number: P00545
    Secondary accession number(s): Q86597
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Fms polyprotein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3