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P00545

- KFMS_FSVMD

UniProt

P00545 - KFMS_FSVMD

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Protein

Tyrosine-protein kinase transforming protein fms

Gene

V-FMS

Organism
Feline sarcoma virus (strain McDonough)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Truncated version of the receptor for colony-stimulating factor 1 (CSF-1).

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei647 – 6471ATPPROSITE-ProRule annotation
Active sitei810 – 8101Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi619 – 6279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein fms (EC:2.7.10.1)
Gene namesi
Name:V-FMS
OrganismiFeline sarcoma virus (strain McDonough)
Taxonomic identifieri11778 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 978978Tyrosine-protein kinase transforming protein fmsPRO_0000155209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 118PROSITE-ProRule annotation
Glycosylationi79 – 791N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi161 ↔ 211PROSITE-ProRule annotation
Glycosylationi187 – 1871N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi258 ↔ 312PROSITE-ProRule annotation
Glycosylationi309 – 3091N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi336 – 3361N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi369 – 3691N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi451 ↔ 516PROSITE-ProRule annotation
Glycosylationi511 – 5111N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi524 – 5241N-linked (GlcNAc...); by hostSequence Analysis
Modified residuei841 – 8411Phosphotyrosine; by autocatalysisBy similarity
Modified residuei973 – 9731Phosphothreonine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP00545.
SMRiP00545. Positions 578-951.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 543543ExtracellularSequence AnalysisAdd
BLAST
Topological domaini569 – 978410CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei544 – 56825HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 13480Ig-like C2-type 1Add
BLAST
Domaini141 – 23191Ig-like C2-type 2Add
BLAST
Domaini236 – 33196Ig-like C2-type 3Add
BLAST
Domaini333 – 43199Ig-like C2-type 4Add
BLAST
Domaini434 – 533100Ig-like C2-type 5Add
BLAST
Domaini613 – 942330Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF500947. CSF-1_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00545-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RMPSGPGHYG ASAETPGPRP PLCPASSCCL PTEAMGPRAL LVLLMATAWH
60 70 80 90 100
AQGVPVIQPS GPELVVEPGT TVTLRCVGNG SVEWDGPISP HWNLDLDPPS
110 120 130 140 150
SILTTNNATF QNTGTYHCTE PGNPRGGNAT IHLYVKDPAR PWKVLAQEVT
160 170 180 190 200
VLEGQDALLP CLLTDPALEA GVSLVRVRGR PVLRQTNYSF SPWHGFTIHK
210 220 230 240 250
AKFIENHVYQ CSARVDGRTV TSMGIWLKVQ KDISGPATLT LEPAELVRIQ
260 270 280 290 300
GEAAQIVCSA SNIDVNFDVS LRHGDTKLTI SQQSDFHDNR YQKVLTLNLD
310 320 330 340 350
HVSFQDAGNY SCTATNAWGN HSASMVFRVV ESAYSNLTSE QSLLQEVTVG
360 370 380 390 400
EKVDLQVKVE AYPGLESFNW TYLGPFSDYQ DKLDFVTIKD TYRYTSTLSL
410 420 430 440 450
PRLKRSESGR YSFLARNAGG QNALTFELTL RYPPEVRVTM TLINGSDTLL
460 470 480 490 500
CEASGYPQPS VTWVQCRSHT DRCDESAGLV LEDSHSEVLS QVPFYEVIVH
510 520 530 540 550
SLLAIGTLEH NRTYECRAFN SVGNSSQTFW PISIGAHTPL PDELLFTPVL
560 570 580 590 600
LTCMSIMALL LLLLLLLLYK YKQKPKYQVR WKIIESYEGN SYTFIDPTQL
610 620 630 640 650
PYNEKWEFPR NNLQFGKTLG TGAFGKVVEA TAFGLGKEDA VLKVAVKMLK
660 670 680 690 700
STAHADEKEA LMSELKIMSH LGQHENIVNL LGACTHGGPV LVITEYCCYG
710 720 730 740 750
DLLNFLRRQA EAMLGPSLSV GQDPEAGAGY KNIHLEKKYV RRDSGFSSQG
760 770 780 790 800
VDTYVEMRPV STSSSNDSFS EEDLGKEDGR PLELRDLLHF SSQVAQGMAF
810 820 830 840 850
LASKNCIHRD VAARNVLLTS GRVAKIGDFG LARDIMNDSN YIVKGNARLP
860 870 880 890 900
VKWMAPESIF DCVYTVQSDV WSYGILLWEI FSLGLNPYPG ILVNSKFYKL
910 920 930 940 950
VKDGYQMAQP AFAPKNIYSI MQACWALEPT RRPTFQQICS LLQKQAQEDR
960 970
RVPNYTNLPS SSSSRLLRPW QRTPPVAR
Length:978
Mass (Da):108,492
Last modified:November 1, 1991 - v2
Checksum:i4C7CAC4835185EBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti714 – 7141L → P in AAA43045. (PubMed:6582485)Curated
Sequence conflicti971 – 9788QRTPPVAR → RGPPL in AAA43045. (PubMed:6582485)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01643 Genomic RNA. Translation: AAA43045.1.
S59588 Genomic DNA. Translation: AAB20028.1.
PIRiA00654. TVMVMD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01643 Genomic RNA. Translation: AAA43045.1 .
S59588 Genomic DNA. Translation: AAB20028.1 .
PIRi A00654. TVMVMD.

3D structure databases

ProteinModelPortali P00545.
SMRi P00545. Positions 578-951.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2234.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF500947. CSF-1_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases."
    Hampe A., Gobet M., Sherr C.J., Galibert F.
    Proc. Natl. Acad. Sci. U.S.A. 81:85-89(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Reassessment of the v-fms sequence: threonine phosphorylation of the COOH-terminal domain."
    Smola U., Hennig D., Hadwiger-Fangmeier A., Schuetz B., Pfaff E., Niemann H., Tamura T.
    J. Virol. 65:6181-6187(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION, PHOSPHORYLATION AT THR-973.

Entry informationi

Entry nameiKFMS_FSVMD
AccessioniPrimary (citable) accession number: P00545
Secondary accession number(s): Q86597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: October 1, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fms polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3