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P00544

- FGR_FSVGR

UniProt

P00544 - FGR_FSVGR

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Protein
Tyrosine-protein kinase transforming protein Fgr
Gene
V-FGR, SRC-2
Organism
Feline sarcoma virus (strain Gardner-Rasheed)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei314 – 3141ATP By similarity
Active sitei405 – 4051Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi292 – 3009ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Fgr (EC:2.7.10.2)
Gene namesi
Name:V-FGR
Synonyms:SRC-2
OrganismiFeline sarcoma virus (strain Gardner-Rasheed)
Taxonomic identifieri11775 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Tyrosine-protein kinase transforming protein Fgr
PRO_0000088090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei435 – 4351Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP00544.

Structurei

3D structure databases

ProteinModelPortaliP00544.
SMRiP00544. Positions 24-543.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 26498SH2
Add
BLAST
Domaini286 – 539254Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 157135Actin
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamiPF00022. Actin. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00268. ACTIN. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00406. ACTINS_1. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00544-1 [UniParc]FASTAAdd to Basket

« Hide

ARALCRPAVC RPRPLPPLPP TAMEEEVAAL VIDNGSGMCK AGFAGDDAPR    50
AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIVTN 100
WDDMEKIWHH TFYNELRVAP EEHPVLLTEA PLNPKANREK MTQIMFETFN 150
IPSNYVAPVD SIQAEEWYFG KIGRKDAERQ LLSPGNARGA FLVRESETTK 200
GAYSLSIRDW DEARGDHVKH YKIRKLDTGG YYITTRAQFN SVQELVQHYV 250
EVNDGLCHLL TAACTTMKPQ TMGLAKDAWE ISRSSITLQR RLGTGCFGDV 300
WLGMWNGSTK VAVKTLKPGT MSPKASLEEA QIMKLLRHDK LVQLYAVVPE 350
EPIYIVTEFM CHGSLLEFLK DQEGQDLTLP QLVDMAAQVA EGMAYMERMD 400
YIHRDLRAAN ILVGERLVCK IADFGLARLI EDNEYNPRQG AKFPIKWTAP 450
EAALFGRFTI KSDVWSFGIL LTELISKGRV PYPGMNNREV LEQVEHGYHM 500
PCPPGCPASL YEAMEQTWRL DPEERPTFEY LQSFLEDYFN GPQQN 545
Length:545
Mass (Da):61,516
Last modified:July 21, 1986 - v1
Checksum:i7F4742EB7A7C413E
GO

Sequence cautioni

The sequence CAA25063.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00255 Genomic DNA. Translation: CAA25063.1. Different initiation.
PIRiA00653. TVMVRR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00255 Genomic DNA. Translation: CAA25063.1 . Different initiation.
PIRi A00653. TVMVRR.

3D structure databases

ProteinModelPortali P00544.
SMRi P00544. Positions 24-543.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P00544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2234.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
PANTHERi PTHR24418:SF224. PTHR24418:SF224. 1 hit.
Pfami PF00022. Actin. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00268. ACTIN. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00406. ACTINS_1. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase."
    Naharro G., Robbins K.C., Reddy E.P.
    Science 223:63-66(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFGR_FSVGR
AccessioniPrimary (citable) accession number: P00544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fgr polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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