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P00544

- FGR_FSVGR

UniProt

P00544 - FGR_FSVGR

Protein

Tyrosine-protein kinase transforming protein Fgr

Gene

V-FGR

Organism
Feline sarcoma virus (strain Gardner-Rasheed)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei314 – 3141ATPPROSITE-ProRule annotation
    Active sitei405 – 4051Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi292 – 3009ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. innate immune response Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2234.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transforming protein Fgr (EC:2.7.10.2)
    Gene namesi
    Name:V-FGR
    Synonyms:SRC-2
    OrganismiFeline sarcoma virus (strain Gardner-Rasheed)
    Taxonomic identifieri11775 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiFelidae (cat family) [TaxID: 9681]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 545545Tyrosine-protein kinase transforming protein FgrPRO_0000088090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei435 – 4351Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP00544.

    Structurei

    3D structure databases

    ProteinModelPortaliP00544.
    SMRiP00544. Positions 24-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini167 – 26498SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini286 – 539254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 157135ActinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    IPR028459. FGR.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00268. ACTIN. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00406. ACTINS_1. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00544-1 [UniParc]FASTAAdd to Basket

    « Hide

    ARALCRPAVC RPRPLPPLPP TAMEEEVAAL VIDNGSGMCK AGFAGDDAPR    50
    AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIVTN 100
    WDDMEKIWHH TFYNELRVAP EEHPVLLTEA PLNPKANREK MTQIMFETFN 150
    IPSNYVAPVD SIQAEEWYFG KIGRKDAERQ LLSPGNARGA FLVRESETTK 200
    GAYSLSIRDW DEARGDHVKH YKIRKLDTGG YYITTRAQFN SVQELVQHYV 250
    EVNDGLCHLL TAACTTMKPQ TMGLAKDAWE ISRSSITLQR RLGTGCFGDV 300
    WLGMWNGSTK VAVKTLKPGT MSPKASLEEA QIMKLLRHDK LVQLYAVVPE 350
    EPIYIVTEFM CHGSLLEFLK DQEGQDLTLP QLVDMAAQVA EGMAYMERMD 400
    YIHRDLRAAN ILVGERLVCK IADFGLARLI EDNEYNPRQG AKFPIKWTAP 450
    EAALFGRFTI KSDVWSFGIL LTELISKGRV PYPGMNNREV LEQVEHGYHM 500
    PCPPGCPASL YEAMEQTWRL DPEERPTFEY LQSFLEDYFN GPQQN 545
    Length:545
    Mass (Da):61,516
    Last modified:July 21, 1986 - v1
    Checksum:i7F4742EB7A7C413E
    GO

    Sequence cautioni

    The sequence CAA25063.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00255 Genomic DNA. Translation: CAA25063.1. Different initiation.
    PIRiA00653. TVMVRR.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00255 Genomic DNA. Translation: CAA25063.1 . Different initiation.
    PIRi A00653. TVMVRR.

    3D structure databases

    ProteinModelPortali P00544.
    SMRi P00544. Positions 24-543.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P00544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2234.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    IPR028459. FGR.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24418:SF224. PTHR24418:SF224. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00268. ACTIN. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00406. ACTINS_1. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase."
      Naharro G., Robbins K.C., Reddy E.P.
      Science 223:63-66(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiFGR_FSVGR
    AccessioniPrimary (citable) accession number: P00544
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Fgr polyprotein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3