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Protein

Tyrosine-protein kinase transforming protein Fgr

Gene

V-FGR

Organism
Feline sarcoma virus (strain Gardner-Rasheed)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei314 – 3141ATPPROSITE-ProRule annotation
Active sitei405 – 4051Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi292 – 3009ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Fgr (EC:2.7.10.2)
Gene namesi
Name:V-FGR
Synonyms:SRC-2
OrganismiFeline sarcoma virus (strain Gardner-Rasheed)
Taxonomic identifieri11775 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Tyrosine-protein kinase transforming protein FgrPRO_0000088090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei435 – 4351Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP00544.

Structurei

3D structure databases

ProteinModelPortaliP00544.
SMRiP00544. Positions 24-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 26498SH2PROSITE-ProRule annotationAdd
BLAST
Domaini286 – 539254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 157135ActinAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamiPF00022. Actin. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00268. ACTIN. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00406. ACTINS_1. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ARALCRPAVC RPRPLPPLPP TAMEEEVAAL VIDNGSGMCK AGFAGDDAPR
60 70 80 90 100
AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIVTN
110 120 130 140 150
WDDMEKIWHH TFYNELRVAP EEHPVLLTEA PLNPKANREK MTQIMFETFN
160 170 180 190 200
IPSNYVAPVD SIQAEEWYFG KIGRKDAERQ LLSPGNARGA FLVRESETTK
210 220 230 240 250
GAYSLSIRDW DEARGDHVKH YKIRKLDTGG YYITTRAQFN SVQELVQHYV
260 270 280 290 300
EVNDGLCHLL TAACTTMKPQ TMGLAKDAWE ISRSSITLQR RLGTGCFGDV
310 320 330 340 350
WLGMWNGSTK VAVKTLKPGT MSPKASLEEA QIMKLLRHDK LVQLYAVVPE
360 370 380 390 400
EPIYIVTEFM CHGSLLEFLK DQEGQDLTLP QLVDMAAQVA EGMAYMERMD
410 420 430 440 450
YIHRDLRAAN ILVGERLVCK IADFGLARLI EDNEYNPRQG AKFPIKWTAP
460 470 480 490 500
EAALFGRFTI KSDVWSFGIL LTELISKGRV PYPGMNNREV LEQVEHGYHM
510 520 530 540
PCPPGCPASL YEAMEQTWRL DPEERPTFEY LQSFLEDYFN GPQQN
Length:545
Mass (Da):61,516
Last modified:July 21, 1986 - v1
Checksum:i7F4742EB7A7C413E
GO

Sequence cautioni

The sequence CAA25063.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00255 Genomic DNA. Translation: CAA25063.1. Different initiation.
PIRiA00653. TVMVRR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00255 Genomic DNA. Translation: CAA25063.1. Different initiation.
PIRiA00653. TVMVRR.

3D structure databases

ProteinModelPortaliP00544.
SMRiP00544. Positions 24-543.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP00544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamiPF00022. Actin. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00268. ACTIN. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00406. ACTINS_1. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase."
    Naharro G., Robbins K.C., Reddy E.P.
    Science 223:63-66(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFGR_FSVGR
AccessioniPrimary (citable) accession number: P00544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 7, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fgr polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.