Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00544 (FGR_FSVGR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Fgr

EC=2.7.10.2
Gene names
Name:V-FGR
Synonyms:SRC-2
OrganismFeline sarcoma virus (strain Gardner-Rasheed)
Taxonomic identifier11775 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as a Gag-Fgr polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Sequence caution

The sequence CAA25063.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 545545Tyrosine-protein kinase transforming protein Fgr
PRO_0000088090

Regions

Domain167 – 26498SH2
Domain286 – 539254Protein kinase
Nucleotide binding292 – 3009ATP By similarity
Region23 – 157135Actin

Sites

Active site4051Proton acceptor By similarity
Binding site3141ATP By similarity

Amino acid modifications

Modified residue4351Phosphotyrosine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P00544 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 7F4742EB7A7C413E

FASTA54561,516
        10         20         30         40         50         60 
ARALCRPAVC RPRPLPPLPP TAMEEEVAAL VIDNGSGMCK AGFAGDDAPR AVFPSIVGRP 

        70         80         90        100        110        120 
RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIVTN WDDMEKIWHH TFYNELRVAP 

       130        140        150        160        170        180 
EEHPVLLTEA PLNPKANREK MTQIMFETFN IPSNYVAPVD SIQAEEWYFG KIGRKDAERQ 

       190        200        210        220        230        240 
LLSPGNARGA FLVRESETTK GAYSLSIRDW DEARGDHVKH YKIRKLDTGG YYITTRAQFN 

       250        260        270        280        290        300 
SVQELVQHYV EVNDGLCHLL TAACTTMKPQ TMGLAKDAWE ISRSSITLQR RLGTGCFGDV 

       310        320        330        340        350        360 
WLGMWNGSTK VAVKTLKPGT MSPKASLEEA QIMKLLRHDK LVQLYAVVPE EPIYIVTEFM 

       370        380        390        400        410        420 
CHGSLLEFLK DQEGQDLTLP QLVDMAAQVA EGMAYMERMD YIHRDLRAAN ILVGERLVCK 

       430        440        450        460        470        480 
IADFGLARLI EDNEYNPRQG AKFPIKWTAP EAALFGRFTI KSDVWSFGIL LTELISKGRV 

       490        500        510        520        530        540 
PYPGMNNREV LEQVEHGYHM PCPPGCPASL YEAMEQTWRL DPEERPTFEY LQSFLEDYFN 


GPQQN 

« Hide

References

[1]"Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase."
Naharro G., Robbins K.C., Reddy E.P.
Science 223:63-66(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00255 Genomic DNA. Translation: CAA25063.1. Different initiation.
PIRTVMVRR. A00653.

3D structure databases

ProteinModelPortalP00544.
SMRP00544. Positions 24-543.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP00544.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 2234.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24418:SF45. PTHR24418:SF45. 1 hit.
PfamPF00022. Actin. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00190. ACTIN.
PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00268. ACTIN. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00406. ACTINS_1. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFGR_FSVGR
AccessionPrimary (citable) accession number: P00544
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families