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P00543

- FES_FSVST

UniProt

P00543 - FES_FSVST

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Protein

Tyrosine-protein kinase transforming protein Fes

Gene

V-FES

Organism
Feline sarcoma virus (strain Snyder-Theilen)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei245 – 2451ATPPROSITE-ProRule annotation
Active sitei338 – 3381Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi222 – 2309ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Fes (EC:2.7.10.2)
Gene namesi
Name:V-FES
OrganismiFeline sarcoma virus (strain Snyder-Theilen)
Taxonomic identifieri11780 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Tyrosine-protein kinase transforming protein FesPRO_0000088086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei368 – 3681Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP00543.
SMRiP00543. Positions 104-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 20490SH2PROSITE-ProRule annotationAdd
BLAST
Domaini216 – 477262Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00543-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
HPREQVQLLA KKQVLQEALQ ALQVALCSQA KLQAQRELLQ AKLEQLGPGE
60 70 80 90 100
PPPVLLLQDD RHSTSSSEQE REGGRTPTLE ILKSHISGIF RPKFSLPPPL
110 120 130 140 150
QLVPEVQKPL HEQLWYHGAL PRAEVAELLT HSGDFLVRES QGKQEYVLSV
160 170 180 190 200
LWDGQPRHFI IQSADNLYRP EGDGFASIPL LVDHLLRSQQ PLTKKSGIVL
210 220 230 240 250
NRAVPKDKWV LNHEDLVLGE QIGRGNFGEV FSGRLRADNT LVAVKSCRET
260 270 280 290 300
LPPDIKAKFL QEAKILKQYS HPNIVRLIGV CTQKQPIYIV MELVQGGDFL
310 320 330 340 350
TFLRTEGARL RMKTLLQMVG DAAAGMEYLE SKCCIHRDLA ARNCLVTEKN
360 370 380 390 400
VLKISDFGMS REEADGVYAA SGGLRLVPVK WTAPEALNYG RYSSESDVWS
410 420 430 440 450
FGILLWETFS LGASPYPNLS NQQTREFVEK GGRLPCPELC PDAVFRLMEQ
460 470
CWAYEPGQRP SFSAFYQELQ SIRKRHR
Length:477
Mass (Da):53,757
Last modified:July 21, 1986 - v1
Checksum:iBB87EDB4E7A3BEB5
GO

Sequence cautioni

The sequence AAA43046.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02088 Genomic RNA. Translation: AAA43046.2. Different initiation.
PIRiA00652. TVMVCS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02088 Genomic RNA. Translation: AAA43046.2 . Different initiation.
PIRi A00652. TVMVCS.

3D structure databases

ProteinModelPortali P00543.
SMRi P00543. Positions 104-476.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2234.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes."
    Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J.
    Cell 30:775-785(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiFES_FSVST
AccessioniPrimary (citable) accession number: P00543
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fes polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3