P00543 (FES_FSVST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transforming protein Fes
EC=2.7.10.2

Gene names

Name:

V-FES

Organism

Feline sarcoma virus (strain Snyder-Theilen)

Taxonomic identifier

11780 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication defective viruses

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Miscellaneous	This protein is synthesized as a Gag-Fes polyprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain.
Sequence caution	The sequence AAA43046.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Oncogene
Domain	SH2 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Tyrosine-protein kinase transforming protein Fes		PRO_0000088086
Regions
	Domain	115 – 204	90	SH2
	Domain	216 – 477	262	Protein kinase
	Nucleotide binding	222 – 230	9	ATP By similarity
Sites
	Active site	338	1	Proton acceptor By similarity
	Binding site	245	1	ATP By similarity
Amino acid modifications
	Modified residue	368	1	Phosphotyrosine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00543 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: BB87EDB4E7A3BEB5	FASTA	477	53,757
	10 20 30 40 50 60 HPREQVQLLA KKQVLQEALQ ALQVALCSQA KLQAQRELLQ AKLEQLGPGE PPPVLLLQDD 70 80 90 100 110 120 RHSTSSSEQE REGGRTPTLE ILKSHISGIF RPKFSLPPPL QLVPEVQKPL HEQLWYHGAL 130 140 150 160 170 180 PRAEVAELLT HSGDFLVRES QGKQEYVLSV LWDGQPRHFI IQSADNLYRP EGDGFASIPL 190 200 210 220 230 240 LVDHLLRSQQ PLTKKSGIVL NRAVPKDKWV LNHEDLVLGE QIGRGNFGEV FSGRLRADNT 250 260 270 280 290 300 LVAVKSCRET LPPDIKAKFL QEAKILKQYS HPNIVRLIGV CTQKQPIYIV MELVQGGDFL 310 320 330 340 350 360 TFLRTEGARL RMKTLLQMVG DAAAGMEYLE SKCCIHRDLA ARNCLVTEKN VLKISDFGMS 370 380 390 400 410 420 REEADGVYAA SGGLRLVPVK WTAPEALNYG RYSSESDVWS FGILLWETFS LGASPYPNLS 430 440 450 460 470 NQQTREFVEK GGRLPCPELC PDAVFRLMEQ CWAYEPGQRP SFSAFYQELQ SIRKRHR

References

[1]	"Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes." Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J. Cell 30:775-785(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02088 Genomic RNA. Translation: AAA43046.2. Different initiation.
PIR	TVMVCS. A00652.
3D structure databases
ProteinModelPortal	P00543.
SMR	P00543. Positions 104-476.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.2. 2234.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FES_FSVST

Accession

Primary (citable) accession number: P00543

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program