Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00543 (FES_FSVST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Fes

EC=2.7.10.2
Gene names
Name:V-FES
OrganismFeline sarcoma virus (strain Snyder-Theilen)
Taxonomic identifier11780 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as a Gag-Fes polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Sequence caution

The sequence AAA43046.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Tyrosine-protein kinase transforming protein Fes
PRO_0000088086

Regions

Domain115 – 20490SH2
Domain216 – 477262Protein kinase
Nucleotide binding222 – 2309ATP By similarity

Sites

Active site3381Proton acceptor By similarity
Binding site2451ATP By similarity

Amino acid modifications

Modified residue3681Phosphotyrosine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P00543 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: BB87EDB4E7A3BEB5

FASTA47753,757
        10         20         30         40         50         60 
HPREQVQLLA KKQVLQEALQ ALQVALCSQA KLQAQRELLQ AKLEQLGPGE PPPVLLLQDD 

        70         80         90        100        110        120 
RHSTSSSEQE REGGRTPTLE ILKSHISGIF RPKFSLPPPL QLVPEVQKPL HEQLWYHGAL 

       130        140        150        160        170        180 
PRAEVAELLT HSGDFLVRES QGKQEYVLSV LWDGQPRHFI IQSADNLYRP EGDGFASIPL 

       190        200        210        220        230        240 
LVDHLLRSQQ PLTKKSGIVL NRAVPKDKWV LNHEDLVLGE QIGRGNFGEV FSGRLRADNT 

       250        260        270        280        290        300 
LVAVKSCRET LPPDIKAKFL QEAKILKQYS HPNIVRLIGV CTQKQPIYIV MELVQGGDFL 

       310        320        330        340        350        360 
TFLRTEGARL RMKTLLQMVG DAAAGMEYLE SKCCIHRDLA ARNCLVTEKN VLKISDFGMS 

       370        380        390        400        410        420 
REEADGVYAA SGGLRLVPVK WTAPEALNYG RYSSESDVWS FGILLWETFS LGASPYPNLS 

       430        440        450        460        470 
NQQTREFVEK GGRLPCPELC PDAVFRLMEQ CWAYEPGQRP SFSAFYQELQ SIRKRHR 

« Hide

References

[1]"Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes."
Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J.
Cell 30:775-785(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02088 Genomic RNA. Translation: AAA43046.2. Different initiation.
PIRTVMVCS. A00652.

3D structure databases

ProteinModelPortalP00543.
SMRP00543. Positions 104-476.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 2234.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24418:SF85. PTHR24418:SF85. 1 hit.
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFES_FSVST
AccessionPrimary (citable) accession number: P00543
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families