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Protein

Tyrosine-protein kinase transforming protein Fes

Gene

V-FES

Organism
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei377ATPPROSITE-ProRule annotation1
Active sitei470Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi354 – 362ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Fes (EC:2.7.10.2)
Gene namesi
Name:V-FES
OrganismiFeline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
Taxonomic identifieri11774 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000880871 – 609Tyrosine-protein kinase transforming protein FesAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei500Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP00542.

Structurei

3D structure databases

ProteinModelPortaliP00542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 174F-BAR; degeneratePROSITE-ProRule annotationAdd BLAST167
Domaini247 – 336SH2PROSITE-ProRule annotationAdd BLAST90
Domaini348 – 609Protein kinasePROSITE-ProRule annotationAdd BLAST262

Domaini

The F-BAR domain is truncated and contains only the FCH region (the coiled-coil region is missing).Curated

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation
Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF197. PTHR24418:SF197. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AARADGTMGF SSELCSPQGH GAEQQMQEAE LRLLEGMRKW MAQRVKSDRE
60 70 80 90 100
YAGLLHHMSL QDGGGRGTGP YSPISQSWAE ITSQTEGLSR LLRQHAEDLN
110 120 130 140 150
SGPLSKLGLL IRERQQLRKT YSEQWQQLQQ ELTKTHNQDI EKLKSQYRAL
160 170 180 190 200
ARDSAQARRK YQEASKDKDR DKAKLEQLGP GEPPPVLLLQ DDRHSTSSSE
210 220 230 240 250
QEREGGRTPT LEILKSHISG IFRPKFSLPP PLQLVPEVQK PLHEQLWYHG
260 270 280 290 300
ALPRAEVAEL LTHSGDFLVR ESQGKQEYVL SVLWDGQPRH FIIQSADNLY
310 320 330 340 350
RPEGDGFASI PLLVDHLLRS QQPLTKKSGI VLNRAVPKDK WVLNHEDLVL
360 370 380 390 400
GEQIGRGNFG EVFSGRLRAD NTLVAVKSCR ETLPPDIKAK FLQEAKILKQ
410 420 430 440 450
YSHPNIVRLI GVCTQKQPIY IVMELVQGGD FLTFLRTEGA RLRMKTLLQM
460 470 480 490 500
VGDAAAGMEY LESKCCIHRD LAARNCLVTE KNVLKISDFG MSREAADGIY
510 520 530 540 550
AASGGLRQVP VKWTAPEALN YGRYSSESDV WSFGILLWET FSLGASPYPN
560 570 580 590 600
LSNQQTREFV EKGGRLPCPE LCPDAVFRLM EQCWAYEPGQ RPSFSAIYQE

LQSIRKRHR
Length:609
Mass (Da):68,769
Last modified:July 21, 1986 - v1
Checksum:i53D4919757CF73A3
GO

Sequence cautioni

The sequence AAA43041 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02087 Genomic RNA. Translation: AAA43041.1. Different initiation.
PIRiA00651. TVMVGC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02087 Genomic RNA. Translation: AAA43041.1. Different initiation.
PIRiA00651. TVMVGC.

3D structure databases

ProteinModelPortaliP00542.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP00542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF197. PTHR24418:SF197. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFES_FSVGA
AccessioniPrimary (citable) accession number: P00542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 5, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fes polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.