SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P00542

- FES_FSVGA

UniProt

P00542 - FES_FSVGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tyrosine-protein kinase transforming protein Fes
Gene
V-FES
Organism
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei377 – 3771ATP By similarity
Active sitei470 – 4701Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi354 – 3629ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2234.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transforming protein Fes (EC:2.7.10.2)
    Gene namesi
    Name:V-FES
    OrganismiFeline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
    Taxonomic identifieri11774 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiFelidae (cat family) [TaxID: 9681]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 609609Tyrosine-protein kinase transforming protein Fes
    PRO_0000088087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei500 – 5001Phosphotyrosine; by autocatalysis By similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP00542.
    SMRiP00542. Positions 236-608.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 10194FCH
    Add
    BLAST
    Domaini247 – 33690SH2
    Add
    BLAST
    Domaini348 – 609262Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 FCH domain.
    Contains 1 SH2 domain.

    Keywords - Domaini

    SH2 domain

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00542-1 [UniParc]FASTAAdd to Basket

    « Hide

    AARADGTMGF SSELCSPQGH GAEQQMQEAE LRLLEGMRKW MAQRVKSDRE    50
    YAGLLHHMSL QDGGGRGTGP YSPISQSWAE ITSQTEGLSR LLRQHAEDLN 100
    SGPLSKLGLL IRERQQLRKT YSEQWQQLQQ ELTKTHNQDI EKLKSQYRAL 150
    ARDSAQARRK YQEASKDKDR DKAKLEQLGP GEPPPVLLLQ DDRHSTSSSE 200
    QEREGGRTPT LEILKSHISG IFRPKFSLPP PLQLVPEVQK PLHEQLWYHG 250
    ALPRAEVAEL LTHSGDFLVR ESQGKQEYVL SVLWDGQPRH FIIQSADNLY 300
    RPEGDGFASI PLLVDHLLRS QQPLTKKSGI VLNRAVPKDK WVLNHEDLVL 350
    GEQIGRGNFG EVFSGRLRAD NTLVAVKSCR ETLPPDIKAK FLQEAKILKQ 400
    YSHPNIVRLI GVCTQKQPIY IVMELVQGGD FLTFLRTEGA RLRMKTLLQM 450
    VGDAAAGMEY LESKCCIHRD LAARNCLVTE KNVLKISDFG MSREAADGIY 500
    AASGGLRQVP VKWTAPEALN YGRYSSESDV WSFGILLWET FSLGASPYPN 550
    LSNQQTREFV EKGGRLPCPE LCPDAVFRLM EQCWAYEPGQ RPSFSAIYQE 600
    LQSIRKRHR 609
    Length:609
    Mass (Da):68,769
    Last modified:July 21, 1986 - v1
    Checksum:i53D4919757CF73A3
    GO

    Sequence cautioni

    The sequence AAA43041.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02087 Genomic RNA. Translation: AAA43041.1. Different initiation.
    PIRiA00651. TVMVGC.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02087 Genomic RNA. Translation: AAA43041.1 . Different initiation.
    PIRi A00651. TVMVGC.

    3D structure databases

    ProteinModelPortali P00542.
    SMRi P00542. Positions 236-608.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2234.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes."
      Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J.
      Cell 30:775-785(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiFES_FSVGA
    AccessioniPrimary (citable) accession number: P00542
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: June 11, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Fes polyprotein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi