P00542 (FES_FSVGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transforming protein Fes
EC=2.7.10.2

Gene names

Name:

V-FES

Organism

Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)

Taxonomic identifier

11774 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication defective viruses

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Miscellaneous	This protein is synthesized as a Gag-Fes polyprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Contains 1 FCH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.
Sequence caution	The sequence AAA43041.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Oncogene
Domain	SH2 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	Tyrosine-protein kinase transforming protein Fes		PRO_0000088087
Regions
	Domain	8 – 101	94	FCH
	Domain	247 – 336	90	SH2
	Domain	348 – 609	262	Protein kinase
	Nucleotide binding	354 – 362	9	ATP By similarity
Sites
	Active site	470	1	Proton acceptor By similarity
	Binding site	377	1	ATP By similarity
Amino acid modifications
	Modified residue	500	1	Phosphotyrosine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00542 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 53D4919757CF73A3	FASTA	609	68,769
	10 20 30 40 50 60 AARADGTMGF SSELCSPQGH GAEQQMQEAE LRLLEGMRKW MAQRVKSDRE YAGLLHHMSL 70 80 90 100 110 120 QDGGGRGTGP YSPISQSWAE ITSQTEGLSR LLRQHAEDLN SGPLSKLGLL IRERQQLRKT 130 140 150 160 170 180 YSEQWQQLQQ ELTKTHNQDI EKLKSQYRAL ARDSAQARRK YQEASKDKDR DKAKLEQLGP 190 200 210 220 230 240 GEPPPVLLLQ DDRHSTSSSE QEREGGRTPT LEILKSHISG IFRPKFSLPP PLQLVPEVQK 250 260 270 280 290 300 PLHEQLWYHG ALPRAEVAEL LTHSGDFLVR ESQGKQEYVL SVLWDGQPRH FIIQSADNLY 310 320 330 340 350 360 RPEGDGFASI PLLVDHLLRS QQPLTKKSGI VLNRAVPKDK WVLNHEDLVL GEQIGRGNFG 370 380 390 400 410 420 EVFSGRLRAD NTLVAVKSCR ETLPPDIKAK FLQEAKILKQ YSHPNIVRLI GVCTQKQPIY 430 440 450 460 470 480 IVMELVQGGD FLTFLRTEGA RLRMKTLLQM VGDAAAGMEY LESKCCIHRD LAARNCLVTE 490 500 510 520 530 540 KNVLKISDFG MSREAADGIY AASGGLRQVP VKWTAPEALN YGRYSSESDV WSFGILLWET 550 560 570 580 590 600 FSLGASPYPN LSNQQTREFV EKGGRLPCPE LCPDAVFRLM EQCWAYEPGQ RPSFSAIYQE LQSIRKRHR

References

[1]	"Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes." Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J. Cell 30:775-785(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02087 Genomic RNA. Translation: AAA43041.1. Different initiation.
PIR	TVMVGC. A00651.
3D structure databases
ProteinModelPortal	P00542.
SMR	P00542. Positions 236-608.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.2. 2234.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR001060. FCH_dom. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF00611. FCH. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00055. FCH. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50133. FCH. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FES_FSVGA

Accession

Primary (citable) accession number: P00542

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program