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P00542 (FES_FSVGA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Fes

EC=2.7.10.2
Gene names
Name:V-FES
OrganismFeline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
Taxonomic identifier11774 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length609 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as a Gag-Fes polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

Contains 1 FCH domain.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Sequence caution

The sequence AAA43041.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 609609Tyrosine-protein kinase transforming protein Fes
PRO_0000088087

Regions

Domain8 – 10194FCH
Domain247 – 33690SH2
Domain348 – 609262Protein kinase
Nucleotide binding354 – 3629ATP By similarity

Sites

Active site4701Proton acceptor By similarity
Binding site3771ATP By similarity

Amino acid modifications

Modified residue5001Phosphotyrosine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P00542 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 53D4919757CF73A3

FASTA60968,769
        10         20         30         40         50         60 
AARADGTMGF SSELCSPQGH GAEQQMQEAE LRLLEGMRKW MAQRVKSDRE YAGLLHHMSL 

        70         80         90        100        110        120 
QDGGGRGTGP YSPISQSWAE ITSQTEGLSR LLRQHAEDLN SGPLSKLGLL IRERQQLRKT 

       130        140        150        160        170        180 
YSEQWQQLQQ ELTKTHNQDI EKLKSQYRAL ARDSAQARRK YQEASKDKDR DKAKLEQLGP 

       190        200        210        220        230        240 
GEPPPVLLLQ DDRHSTSSSE QEREGGRTPT LEILKSHISG IFRPKFSLPP PLQLVPEVQK 

       250        260        270        280        290        300 
PLHEQLWYHG ALPRAEVAEL LTHSGDFLVR ESQGKQEYVL SVLWDGQPRH FIIQSADNLY 

       310        320        330        340        350        360 
RPEGDGFASI PLLVDHLLRS QQPLTKKSGI VLNRAVPKDK WVLNHEDLVL GEQIGRGNFG 

       370        380        390        400        410        420 
EVFSGRLRAD NTLVAVKSCR ETLPPDIKAK FLQEAKILKQ YSHPNIVRLI GVCTQKQPIY 

       430        440        450        460        470        480 
IVMELVQGGD FLTFLRTEGA RLRMKTLLQM VGDAAAGMEY LESKCCIHRD LAARNCLVTE 

       490        500        510        520        530        540 
KNVLKISDFG MSREAADGIY AASGGLRQVP VKWTAPEALN YGRYSSESDV WSFGILLWET 

       550        560        570        580        590        600 
FSLGASPYPN LSNQQTREFV EKGGRLPCPE LCPDAVFRLM EQCWAYEPGQ RPSFSAIYQE 


LQSIRKRHR 

« Hide

References

[1]"Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes."
Hampe A., Laprevotte I., Galibert F., Fedele L.A., Sherr C.J.
Cell 30:775-785(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02087 Genomic RNA. Translation: AAA43041.1. Different initiation.
PIRTVMVGC. A00651.

3D structure databases

ProteinModelPortalP00542.
SMRP00542. Positions 236-608.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 2234.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFES_FSVGA
AccessionPrimary (citable) accession number: P00542
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families