Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00541 (FPS_AVISP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Fps

EC=2.7.10.2
Gene names
Name:V-FPS
OrganismAvian sarcoma virus (strain PRCII)
Taxonomic identifier11880 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostGalliformes [TaxID: 8976]

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as a Gag-Fps polyprotein.

Present in the avian viruses PRCII and Fujinami sarcoma virus (FSV). PRCII is less oncogenic than FSV and has a slightly different v-Fps protein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

Contains 1 FCH domain.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 533533Tyrosine-protein kinase transforming protein Fps
PRO_0000088094

Regions

Domain50 – 12778FCH
Domain171 – 26090SH2
Domain272 – 525254Protein kinase
Nucleotide binding278 – 2869ATP By similarity

Sites

Active site3941Proton acceptor By similarity
Binding site3011ATP By similarity

Amino acid modifications

Modified residue4241Phosphotyrosine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P00541 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 2F765877C2522D8A

FASTA53360,506
        10         20         30         40         50         60 
ASGQLHRPQP QEHTSTSAAA GTWRHTQASE SRHRLPHCSA APSHQDHSAM GFGPELWCPK 

        70         80         90        100        110        120 
GHSELLRLQD SELRLLELMK KWMSERAKSD REYAGMLHHM FSQLGSEEPP PALPLQEDRQ 

       130        140        150        160        170        180 
SVCSTDQERS GVTALETIKN HISGIFSPRF SLPPPVPLIP EVQKPLCQQA WYHGAIPRSE 

       190        200        210        220        230        240 
VQELLKCSGD FLVRESQGKQ EYVLSVLWDG QPRHFIIQAA DNLYRLEGDG FPTIPLLIDH 

       250        260        270        280        290        300 
LLQSQQPITR KSGIVLTRAV LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV 

       310        320        330        340        350        360 
KSCRETLPPE LKAKFLQEAR ILKQYNHPNI VRLIGVCTQK QPIYIVMELV QGGDFLSFLR 

       370        380        390        400        410        420 
SKGPHLKMKE LIKMMENAAA GMEYLESKHC IHRDLAARNC LVTEKNTLKI SDFGMSRQEE 

       430        440        450        460        470        480 
DGVYASTGGM KQIPVKWTAP EALNYGRYSS ESDVWSFGIL LWEAFSLGAV PYANLSNQQT 

       490        500        510        520        530 
REAIEQGVRL EPPEQCPEDV YRLMQRCWEY DPRRRPSFGA VHQDLIAIRK RHR 

« Hide

References

[1]"Nucleotide sequence of v-fps in the PRCII strain of avian sarcoma virus."
Huang C.-C., Hammond C., Bishop J.M.
J. Virol. 50:125-131(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01690 Genomic RNA. Translation: AAA42415.1.
PIRTVFVFP. A00650.

3D structure databases

ProteinModelPortalP00541.
SMRP00541. Positions 160-532.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 600.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24418:SF85. PTHR24418:SF85. 1 hit.
PfamPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFPS_AVISP
AccessionPrimary (citable) accession number: P00541
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families