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P00541

- FPS_AVISP

UniProt

P00541 - FPS_AVISP

Protein

Tyrosine-protein kinase transforming protein Fps

Gene

V-FPS

Organism
Avian sarcoma virus (strain PRCII)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei301 – 3011ATPPROSITE-ProRule annotation
    Active sitei394 – 3941Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi278 – 2869ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 600.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transforming protein Fps (EC:2.7.10.2)
    Gene namesi
    Name:V-FPS
    OrganismiAvian sarcoma virus (strain PRCII)
    Taxonomic identifieri11880 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
    Virus hostiGalliformes [TaxID: 8976]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 533533Tyrosine-protein kinase transforming protein FpsPRO_0000088094Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei424 – 4241Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP00541.
    SMRiP00541. Positions 160-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 12778FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini171 – 26090SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini272 – 525254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation
    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00541-1 [UniParc]FASTAAdd to Basket

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    ASGQLHRPQP QEHTSTSAAA GTWRHTQASE SRHRLPHCSA APSHQDHSAM    50
    GFGPELWCPK GHSELLRLQD SELRLLELMK KWMSERAKSD REYAGMLHHM 100
    FSQLGSEEPP PALPLQEDRQ SVCSTDQERS GVTALETIKN HISGIFSPRF 150
    SLPPPVPLIP EVQKPLCQQA WYHGAIPRSE VQELLKCSGD FLVRESQGKQ 200
    EYVLSVLWDG QPRHFIIQAA DNLYRLEGDG FPTIPLLIDH LLQSQQPITR 250
    KSGIVLTRAV LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV 300
    KSCRETLPPE LKAKFLQEAR ILKQYNHPNI VRLIGVCTQK QPIYIVMELV 350
    QGGDFLSFLR SKGPHLKMKE LIKMMENAAA GMEYLESKHC IHRDLAARNC 400
    LVTEKNTLKI SDFGMSRQEE DGVYASTGGM KQIPVKWTAP EALNYGRYSS 450
    ESDVWSFGIL LWEAFSLGAV PYANLSNQQT REAIEQGVRL EPPEQCPEDV 500
    YRLMQRCWEY DPRRRPSFGA VHQDLIAIRK RHR 533
    Length:533
    Mass (Da):60,506
    Last modified:July 21, 1986 - v1
    Checksum:i2F765877C2522D8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01690 Genomic RNA. Translation: AAA42415.1.
    PIRiA00650. TVFVFP.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01690 Genomic RNA. Translation: AAA42415.1 .
    PIRi A00650. TVFVFP.

    3D structure databases

    ProteinModelPortali P00541.
    SMRi P00541. Positions 160-532.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 600.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of v-fps in the PRCII strain of avian sarcoma virus."
      Huang C.-C., Hammond C., Bishop J.M.
      J. Virol. 50:125-131(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiFPS_AVISP
    AccessioniPrimary (citable) accession number: P00541
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Fps polyprotein.
    Present in the avian viruses PRCII and Fujinami sarcoma virus (FSV). PRCII is less oncogenic than FSV and has a slightly different v-Fps protein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3