SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P00541

- FPS_AVISP

UniProt

P00541 - FPS_AVISP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tyrosine-protein kinase transforming protein Fps
Gene
V-FPS
Organism
Avian sarcoma virus (strain PRCII)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei301 – 3011ATP By similarity
Active sitei394 – 3941Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi278 – 2869ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 600.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Fps (EC:2.7.10.2)
Gene namesi
Name:V-FPS
OrganismiAvian sarcoma virus (strain PRCII)
Taxonomic identifieri11880 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostiGalliformes [TaxID: 8976]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Tyrosine-protein kinase transforming protein Fps
PRO_0000088094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei424 – 4241Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP00541.
SMRiP00541. Positions 160-532.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 12778FCH
Add
BLAST
Domaini171 – 26090SH2
Add
BLAST
Domaini272 – 525254Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 FCH domain.
Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00541-1 [UniParc]FASTAAdd to Basket

« Hide

ASGQLHRPQP QEHTSTSAAA GTWRHTQASE SRHRLPHCSA APSHQDHSAM    50
GFGPELWCPK GHSELLRLQD SELRLLELMK KWMSERAKSD REYAGMLHHM 100
FSQLGSEEPP PALPLQEDRQ SVCSTDQERS GVTALETIKN HISGIFSPRF 150
SLPPPVPLIP EVQKPLCQQA WYHGAIPRSE VQELLKCSGD FLVRESQGKQ 200
EYVLSVLWDG QPRHFIIQAA DNLYRLEGDG FPTIPLLIDH LLQSQQPITR 250
KSGIVLTRAV LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV 300
KSCRETLPPE LKAKFLQEAR ILKQYNHPNI VRLIGVCTQK QPIYIVMELV 350
QGGDFLSFLR SKGPHLKMKE LIKMMENAAA GMEYLESKHC IHRDLAARNC 400
LVTEKNTLKI SDFGMSRQEE DGVYASTGGM KQIPVKWTAP EALNYGRYSS 450
ESDVWSFGIL LWEAFSLGAV PYANLSNQQT REAIEQGVRL EPPEQCPEDV 500
YRLMQRCWEY DPRRRPSFGA VHQDLIAIRK RHR 533
Length:533
Mass (Da):60,506
Last modified:July 21, 1986 - v1
Checksum:i2F765877C2522D8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01690 Genomic RNA. Translation: AAA42415.1.
PIRiA00650. TVFVFP.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01690 Genomic RNA. Translation: AAA42415.1 .
PIRi A00650. TVFVFP.

3D structure databases

ProteinModelPortali P00541.
SMRi P00541. Positions 160-532.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 600.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of v-fps in the PRCII strain of avian sarcoma virus."
    Huang C.-C., Hammond C., Bishop J.M.
    J. Virol. 50:125-131(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiFPS_AVISP
AccessioniPrimary (citable) accession number: P00541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fps polyprotein.
Present in the avian viruses PRCII and Fujinami sarcoma virus (FSV). PRCII is less oncogenic than FSV and has a slightly different v-Fps protein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi