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P00540 (MOS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proto-oncogene serine/threonine-protein kinase mos

EC=2.7.11.1
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene names
Name:MOS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

Expressed specifically in testis during spermatogenesis.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Proto-oncogene serine/threonine-protein kinase mos
PRO_0000086344

Regions

Domain60 – 341282Protein kinase
Nucleotide binding66 – 749ATP By similarity

Sites

Active site2011Proton acceptor By similarity
Binding site871ATP By similarity

Natural variations

Natural variant961R → L. Ref.3
Corresponds to variant rs34532635 [ dbSNP | Ensembl ].
VAR_040813
Natural variant1051A → S. Ref.2 Ref.3
Corresponds to variant rs35392772 [ dbSNP | Ensembl ].
VAR_040814
Natural variant1231A → T in a lung adenocarcinoma sample; somatic mutation. Ref.3
VAR_040815
Natural variant3001S → P. Ref.3
Corresponds to variant rs56300224 [ dbSNP | Ensembl ].
VAR_040816

Sequences

Sequence LengthMass (Da)Tools
P00540 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 68B1AB906ED4B308

FASTA34637,820
        10         20         30         40         50         60 
MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL AWCSIDWEQV 

        70         80         90        100        110        120 
CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV 

       130        140        150        160        170        180 
VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK 

       190        200        210        220        230        240 
YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG 

       250        260        270        280        290        300 
GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS 

       310        320        330        340 
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG 

« Hide

References

« Hide 'large scale' references
[1]"Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus."
Watson R., Oskarsson M., Vande Woude G.F.
Proc. Natl. Acad. Sci. U.S.A. 79:4078-4082(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-105.
[3]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-105; THR-123 AND PRO-300.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00119 Genomic DNA. Translation: AAA52029.1.
BC069569 mRNA. Translation: AAH69569.1.
BC069590 mRNA. Translation: AAH69590.1.
BC106737 mRNA. Translation: AAI06738.1.
BC106738 mRNA. Translation: AAI06739.1.
CCDSCCDS6164.1.
PIRTVHUMS. A00649.
RefSeqNP_005363.1. NM_005372.1.
UniGeneHs.533432.

3D structure databases

ProteinModelPortalP00540.
SMRP00540. Positions 49-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110483. 3 interactions.
IntActP00540. 3 interactions.
MINTMINT-96687.
STRING9606.ENSP00000310722.

Chemistry

ChEMBLCHEMBL1075184.

PTM databases

PhosphoSiteP00540.

Polymorphism databases

DMDM125497.

Proteomic databases

PaxDbP00540.
PRIDEP00540.

Protocols and materials databases

DNASU4342.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311923; ENSP00000310722; ENSG00000172680.
GeneID4342.
KEGGhsa:4342.
UCSCuc011leb.2. human.

Organism-specific databases

CTD4342.
GeneCardsGC08M057025.
HGNCHGNC:7199. MOS.
HPAHPA040424.
MIM190060. gene.
neXtProtNX_P00540.
PharmGKBPA30907.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000290647.
HOVERGENHBG052499.
InParanoidP00540.
KOK04367.
OMACCWRASA.
OrthoDBEOG78M02G.
PhylomeDBP00540.
TreeFamTF331103.

Enzyme and pathway databases

BRENDA2.7.10.2. 2681.
SignaLinkP00540.

Gene expression databases

BgeeP00540.
CleanExHS_MOS.
GenevestigatorP00540.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMOS_(gene).
GenomeRNAi4342.
NextBio17094.
PROP00540.
SOURCESearch...

Entry information

Entry nameMOS_HUMAN
AccessionPrimary (citable) accession number: P00540
Secondary accession number(s): Q3KPG9, Q3KPH0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM