Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P00540

- MOS_HUMAN

UniProt

P00540 - MOS_HUMAN

Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

MOS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871ATPPROSITE-ProRule annotation
    Active sitei201 – 2011Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 749ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProt
    3. protein serine/threonine kinase activity Source: UniProt

    GO - Biological processi

    1. activation of MAPK activity Source: UniProt
    2. activation of MAPKK activity Source: UniProt
    3. chromatin organization Source: UniProt
    4. establishment of meiotic spindle orientation Source: UniProt
    5. MAPK cascade Source: GOC
    6. meiotic spindle organization Source: UniProt
    7. negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProt
    8. protein autophosphorylation Source: UniProt
    9. regulation of meiosis Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2681.
    SignaLinkiP00540.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
    Alternative name(s):
    Oocyte maturation factor mos
    Proto-oncogene c-Mos
    Gene namesi
    Name:MOS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7199. MOS.

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA30907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Proto-oncogene serine/threonine-protein kinase mosPRO_0000086344Add
    BLAST

    Proteomic databases

    PaxDbiP00540.
    PRIDEiP00540.

    PTM databases

    PhosphoSiteiP00540.

    Expressioni

    Tissue specificityi

    Expressed specifically in testis during spermatogenesis.

    Gene expression databases

    BgeeiP00540.
    CleanExiHS_MOS.
    GenevestigatoriP00540.

    Organism-specific databases

    HPAiHPA040424.

    Interactioni

    Protein-protein interaction databases

    BioGridi110483. 3 interactions.
    IntActiP00540. 27 interactions.
    MINTiMINT-96687.
    STRINGi9606.ENSP00000310722.

    Structurei

    3D structure databases

    ProteinModelPortaliP00540.
    SMRiP00540. Positions 49-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 341282Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000290647.
    HOVERGENiHBG052499.
    InParanoidiP00540.
    KOiK04367.
    OMAiCCWRASA.
    OrthoDBiEOG78M02G.
    PhylomeDBiP00540.
    TreeFamiTF331103.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00540-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL    50
    AWCSIDWEQV CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR 100
    RSFWAELNVA RLRHDNIVRV VAASTRTPAG SNSLGTIIME FGGNVTLHQV 150
    IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK YSLDVVNGLL FLHSQSIVHL 200
    DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG GTYTHRAPEL 250
    LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS 300
    AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG 346
    Length:346
    Mass (Da):37,820
    Last modified:July 21, 1986 - v1
    Checksum:i68B1AB906ED4B308
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961R → L.1 Publication
    Corresponds to variant rs34532635 [ dbSNP | Ensembl ].
    VAR_040813
    Natural varianti105 – 1051A → S.2 Publications
    Corresponds to variant rs35392772 [ dbSNP | Ensembl ].
    VAR_040814
    Natural varianti123 – 1231A → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040815
    Natural varianti300 – 3001S → P.1 Publication
    Corresponds to variant rs56300224 [ dbSNP | Ensembl ].
    VAR_040816

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00119 Genomic DNA. Translation: AAA52029.1.
    BC069569 mRNA. Translation: AAH69569.1.
    BC069590 mRNA. Translation: AAH69590.1.
    BC106737 mRNA. Translation: AAI06738.1.
    BC106738 mRNA. Translation: AAI06739.1.
    CCDSiCCDS6164.1.
    PIRiA00649. TVHUMS.
    RefSeqiNP_005363.1. NM_005372.1.
    UniGeneiHs.533432.

    Genome annotation databases

    EnsembliENST00000311923; ENSP00000310722; ENSG00000172680.
    GeneIDi4342.
    KEGGihsa:4342.
    UCSCiuc011leb.2. human.

    Polymorphism databases

    DMDMi125497.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00119 Genomic DNA. Translation: AAA52029.1 .
    BC069569 mRNA. Translation: AAH69569.1 .
    BC069590 mRNA. Translation: AAH69590.1 .
    BC106737 mRNA. Translation: AAI06738.1 .
    BC106738 mRNA. Translation: AAI06739.1 .
    CCDSi CCDS6164.1.
    PIRi A00649. TVHUMS.
    RefSeqi NP_005363.1. NM_005372.1.
    UniGenei Hs.533432.

    3D structure databases

    ProteinModelPortali P00540.
    SMRi P00540. Positions 49-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110483. 3 interactions.
    IntActi P00540. 27 interactions.
    MINTi MINT-96687.
    STRINGi 9606.ENSP00000310722.

    Chemistry

    ChEMBLi CHEMBL1075184.

    PTM databases

    PhosphoSitei P00540.

    Polymorphism databases

    DMDMi 125497.

    Proteomic databases

    PaxDbi P00540.
    PRIDEi P00540.

    Protocols and materials databases

    DNASUi 4342.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311923 ; ENSP00000310722 ; ENSG00000172680 .
    GeneIDi 4342.
    KEGGi hsa:4342.
    UCSCi uc011leb.2. human.

    Organism-specific databases

    CTDi 4342.
    GeneCardsi GC08M057025.
    HGNCi HGNC:7199. MOS.
    HPAi HPA040424.
    MIMi 190060. gene.
    neXtProti NX_P00540.
    PharmGKBi PA30907.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000290647.
    HOVERGENi HBG052499.
    InParanoidi P00540.
    KOi K04367.
    OMAi CCWRASA.
    OrthoDBi EOG78M02G.
    PhylomeDBi P00540.
    TreeFami TF331103.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2681.
    SignaLinki P00540.

    Miscellaneous databases

    GeneWikii MOS_(gene).
    GenomeRNAii 4342.
    NextBioi 17094.
    PROi P00540.
    SOURCEi Search...

    Gene expression databases

    Bgeei P00540.
    CleanExi HS_MOS.
    Genevestigatori P00540.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus."
      Watson R., Oskarsson M., Vande Woude G.F.
      Proc. Natl. Acad. Sci. U.S.A. 79:4078-4082(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-105.
    3. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-105; THR-123 AND PRO-300.

    Entry informationi

    Entry nameiMOS_HUMAN
    AccessioniPrimary (citable) accession number: P00540
    Secondary accession number(s): Q3KPG9, Q3KPH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3