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Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

MOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871ATPPROSITE-ProRule annotation
Active sitei201 – 2011Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 749ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. activation of MAPKK activity Source: UniProtKB
  3. chromatin organization Source: UniProtKB
  4. establishment of meiotic spindle orientation Source: UniProtKB
  5. MAPK cascade Source: GOC
  6. meiotic spindle organization Source: UniProtKB
  7. negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProtKB
  8. protein autophosphorylation Source: UniProtKB
  9. regulation of meiosis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2681.
SignaLinkiP00540.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene namesi
Name:MOS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7199. MOS.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA30907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Proto-oncogene serine/threonine-protein kinase mosPRO_0000086344Add
BLAST

Proteomic databases

PaxDbiP00540.
PRIDEiP00540.

PTM databases

PhosphoSiteiP00540.

Expressioni

Tissue specificityi

Expressed specifically in testis during spermatogenesis.

Gene expression databases

BgeeiP00540.
CleanExiHS_MOS.
GenevestigatoriP00540.

Organism-specific databases

HPAiHPA040424.

Interactioni

Protein-protein interaction databases

BioGridi110483. 35 interactions.
IntActiP00540. 26 interactions.
MINTiMINT-96687.
STRINGi9606.ENSP00000310722.

Structurei

3D structure databases

ProteinModelPortaliP00540.
SMRiP00540. Positions 49-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 341282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118807.
HOGENOMiHOG000290647.
HOVERGENiHBG052499.
InParanoidiP00540.
KOiK04367.
OMAiCFQTPSY.
OrthoDBiEOG78M02G.
PhylomeDBiP00540.
TreeFamiTF331103.

Family and domain databases

InterProiIPR016253. Integrin-linked_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000654. Integrin-linked_kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL
60 70 80 90 100
AWCSIDWEQV CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR
110 120 130 140 150
RSFWAELNVA RLRHDNIVRV VAASTRTPAG SNSLGTIIME FGGNVTLHQV
160 170 180 190 200
IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK YSLDVVNGLL FLHSQSIVHL
210 220 230 240 250
DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG GTYTHRAPEL
260 270 280 290 300
LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS
310 320 330 340
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG
Length:346
Mass (Da):37,820
Last modified:July 21, 1986 - v1
Checksum:i68B1AB906ED4B308
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961R → L.1 Publication
Corresponds to variant rs34532635 [ dbSNP | Ensembl ].
VAR_040813
Natural varianti105 – 1051A → S.2 Publications
Corresponds to variant rs35392772 [ dbSNP | Ensembl ].
VAR_040814
Natural varianti123 – 1231A → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040815
Natural varianti300 – 3001S → P.1 Publication
Corresponds to variant rs56300224 [ dbSNP | Ensembl ].
VAR_040816

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00119 Genomic DNA. Translation: AAA52029.1.
BC069569 mRNA. Translation: AAH69569.1.
BC069590 mRNA. Translation: AAH69590.1.
BC106737 mRNA. Translation: AAI06738.1.
BC106738 mRNA. Translation: AAI06739.1.
CCDSiCCDS6164.1.
PIRiA00649. TVHUMS.
RefSeqiNP_005363.1. NM_005372.1.
UniGeneiHs.533432.

Genome annotation databases

EnsembliENST00000311923; ENSP00000310722; ENSG00000172680.
GeneIDi4342.
KEGGihsa:4342.
UCSCiuc011leb.2. human.

Polymorphism databases

DMDMi125497.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00119 Genomic DNA. Translation: AAA52029.1.
BC069569 mRNA. Translation: AAH69569.1.
BC069590 mRNA. Translation: AAH69590.1.
BC106737 mRNA. Translation: AAI06738.1.
BC106738 mRNA. Translation: AAI06739.1.
CCDSiCCDS6164.1.
PIRiA00649. TVHUMS.
RefSeqiNP_005363.1. NM_005372.1.
UniGeneiHs.533432.

3D structure databases

ProteinModelPortaliP00540.
SMRiP00540. Positions 49-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110483. 35 interactions.
IntActiP00540. 26 interactions.
MINTiMINT-96687.
STRINGi9606.ENSP00000310722.

Chemistry

ChEMBLiCHEMBL1075184.

PTM databases

PhosphoSiteiP00540.

Polymorphism databases

DMDMi125497.

Proteomic databases

PaxDbiP00540.
PRIDEiP00540.

Protocols and materials databases

DNASUi4342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311923; ENSP00000310722; ENSG00000172680.
GeneIDi4342.
KEGGihsa:4342.
UCSCiuc011leb.2. human.

Organism-specific databases

CTDi4342.
GeneCardsiGC08M057025.
HGNCiHGNC:7199. MOS.
HPAiHPA040424.
MIMi190060. gene.
neXtProtiNX_P00540.
PharmGKBiPA30907.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118807.
HOGENOMiHOG000290647.
HOVERGENiHBG052499.
InParanoidiP00540.
KOiK04367.
OMAiCFQTPSY.
OrthoDBiEOG78M02G.
PhylomeDBiP00540.
TreeFamiTF331103.

Enzyme and pathway databases

BRENDAi2.7.10.2. 2681.
SignaLinkiP00540.

Miscellaneous databases

GeneWikiiMOS_(gene).
GenomeRNAii4342.
NextBioi17094.
PROiP00540.
SOURCEiSearch...

Gene expression databases

BgeeiP00540.
CleanExiHS_MOS.
GenevestigatoriP00540.

Family and domain databases

InterProiIPR016253. Integrin-linked_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000654. Integrin-linked_kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus."
    Watson R., Oskarsson M., Vande Woude G.F.
    Proc. Natl. Acad. Sci. U.S.A. 79:4078-4082(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-105.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-105; THR-123 AND PRO-300.

Entry informationi

Entry nameiMOS_HUMAN
AccessioniPrimary (citable) accession number: P00540
Secondary accession number(s): Q3KPG9, Q3KPH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 1, 2015
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.