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P00540

- MOS_HUMAN

UniProt

P00540 - MOS_HUMAN

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Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

MOS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871ATPPROSITE-ProRule annotation
Active sitei201 – 2011Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 749ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProt
  3. protein serine/threonine kinase activity Source: UniProt

GO - Biological processi

  1. activation of MAPK activity Source: UniProt
  2. activation of MAPKK activity Source: UniProt
  3. chromatin organization Source: UniProt
  4. establishment of meiotic spindle orientation Source: UniProt
  5. MAPK cascade Source: GOC
  6. meiotic spindle organization Source: UniProt
  7. negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProt
  8. protein autophosphorylation Source: UniProt
  9. regulation of meiosis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2681.
SignaLinkiP00540.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene namesi
Name:MOS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:7199. MOS.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA30907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Proto-oncogene serine/threonine-protein kinase mosPRO_0000086344Add
BLAST

Proteomic databases

PaxDbiP00540.
PRIDEiP00540.

PTM databases

PhosphoSiteiP00540.

Expressioni

Tissue specificityi

Expressed specifically in testis during spermatogenesis.

Gene expression databases

BgeeiP00540.
CleanExiHS_MOS.
GenevestigatoriP00540.

Organism-specific databases

HPAiHPA040424.

Interactioni

Protein-protein interaction databases

BioGridi110483. 10 interactions.
IntActiP00540. 26 interactions.
MINTiMINT-96687.
STRINGi9606.ENSP00000310722.

Structurei

3D structure databases

ProteinModelPortaliP00540.
SMRiP00540. Positions 49-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 341282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118807.
HOGENOMiHOG000290647.
HOVERGENiHBG052499.
InParanoidiP00540.
KOiK04367.
OMAiCCWRASA.
OrthoDBiEOG78M02G.
PhylomeDBiP00540.
TreeFamiTF331103.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00540-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL
60 70 80 90 100
AWCSIDWEQV CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR
110 120 130 140 150
RSFWAELNVA RLRHDNIVRV VAASTRTPAG SNSLGTIIME FGGNVTLHQV
160 170 180 190 200
IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK YSLDVVNGLL FLHSQSIVHL
210 220 230 240 250
DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG GTYTHRAPEL
260 270 280 290 300
LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS
310 320 330 340
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG
Length:346
Mass (Da):37,820
Last modified:July 21, 1986 - v1
Checksum:i68B1AB906ED4B308
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961R → L.1 Publication
Corresponds to variant rs34532635 [ dbSNP | Ensembl ].
VAR_040813
Natural varianti105 – 1051A → S.2 Publications
Corresponds to variant rs35392772 [ dbSNP | Ensembl ].
VAR_040814
Natural varianti123 – 1231A → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040815
Natural varianti300 – 3001S → P.1 Publication
Corresponds to variant rs56300224 [ dbSNP | Ensembl ].
VAR_040816

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00119 Genomic DNA. Translation: AAA52029.1.
BC069569 mRNA. Translation: AAH69569.1.
BC069590 mRNA. Translation: AAH69590.1.
BC106737 mRNA. Translation: AAI06738.1.
BC106738 mRNA. Translation: AAI06739.1.
CCDSiCCDS6164.1.
PIRiA00649. TVHUMS.
RefSeqiNP_005363.1. NM_005372.1.
UniGeneiHs.533432.

Genome annotation databases

EnsembliENST00000311923; ENSP00000310722; ENSG00000172680.
GeneIDi4342.
KEGGihsa:4342.
UCSCiuc011leb.2. human.

Polymorphism databases

DMDMi125497.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00119 Genomic DNA. Translation: AAA52029.1 .
BC069569 mRNA. Translation: AAH69569.1 .
BC069590 mRNA. Translation: AAH69590.1 .
BC106737 mRNA. Translation: AAI06738.1 .
BC106738 mRNA. Translation: AAI06739.1 .
CCDSi CCDS6164.1.
PIRi A00649. TVHUMS.
RefSeqi NP_005363.1. NM_005372.1.
UniGenei Hs.533432.

3D structure databases

ProteinModelPortali P00540.
SMRi P00540. Positions 49-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110483. 10 interactions.
IntActi P00540. 26 interactions.
MINTi MINT-96687.
STRINGi 9606.ENSP00000310722.

Chemistry

ChEMBLi CHEMBL1075184.

PTM databases

PhosphoSitei P00540.

Polymorphism databases

DMDMi 125497.

Proteomic databases

PaxDbi P00540.
PRIDEi P00540.

Protocols and materials databases

DNASUi 4342.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311923 ; ENSP00000310722 ; ENSG00000172680 .
GeneIDi 4342.
KEGGi hsa:4342.
UCSCi uc011leb.2. human.

Organism-specific databases

CTDi 4342.
GeneCardsi GC08M057025.
HGNCi HGNC:7199. MOS.
HPAi HPA040424.
MIMi 190060. gene.
neXtProti NX_P00540.
PharmGKBi PA30907.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118807.
HOGENOMi HOG000290647.
HOVERGENi HBG052499.
InParanoidi P00540.
KOi K04367.
OMAi CCWRASA.
OrthoDBi EOG78M02G.
PhylomeDBi P00540.
TreeFami TF331103.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2681.
SignaLinki P00540.

Miscellaneous databases

GeneWikii MOS_(gene).
GenomeRNAii 4342.
NextBioi 17094.
PROi P00540.
SOURCEi Search...

Gene expression databases

Bgeei P00540.
CleanExi HS_MOS.
Genevestigatori P00540.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus."
    Watson R., Oskarsson M., Vande Woude G.F.
    Proc. Natl. Acad. Sci. U.S.A. 79:4078-4082(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-105.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-105; THR-123 AND PRO-300.

Entry informationi

Entry nameiMOS_HUMAN
AccessioniPrimary (citable) accession number: P00540
Secondary accession number(s): Q3KPG9, Q3KPH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3