P00540 (MOS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proto-oncogene serine/threonine-protein kinase mos
EC=2.7.11.1

Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos

Gene names

Name:

MOS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Tissue specificity	Expressed specifically in testis during spermatogenesis.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Disease	Proto-oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of meiosis Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Proto-oncogene serine/threonine-protein kinase mos		PRO_0000086344
Regions
	Domain	60 – 341	282	Protein kinase
	Nucleotide binding	66 – 74	9	ATP By similarity
Sites
	Active site	201	1	Proton acceptor By similarity
	Binding site	87	1	ATP By similarity
Natural variations
	Natural variant	96	1	R → L. Ref.3 Corresponds to variant rs34532635 [ dbSNP | Ensembl ].		VAR_040813
	Natural variant	105	1	A → S. Ref.2 Ref.3 Corresponds to variant rs35392772 [ dbSNP | Ensembl ].		VAR_040814
	Natural variant	123	1	A → T in a lung adenocarcinoma sample; somatic mutation. Ref.3		VAR_040815
	Natural variant	300	1	S → P. Ref.3 Corresponds to variant rs56300224 [ dbSNP | Ensembl ].		VAR_040816

Sequences

	Sequence		Length	Mass (Da)
	P00540 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 68B1AB906ED4B308	FASTA	346	37,820
	10 20 30 40 50 60 MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL AWCSIDWEQV 70 80 90 100 110 120 CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV 130 140 150 160 170 180 VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK 190 200 210 220 230 240 YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG 250 260 270 280 290 300 GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS 310 320 330 340 AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus." Watson R., Oskarsson M., Vande Woude G.F. Proc. Natl. Acad. Sci. U.S.A. 79:4078-4082(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-105.
[3]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-105; THR-123 AND PRO-300.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J00119 Genomic DNA. Translation: AAA52029.1. BC069569 mRNA. Translation: AAH69569.1. BC069590 mRNA. Translation: AAH69590.1. BC106737 mRNA. Translation: AAI06738.1. BC106738 mRNA. Translation: AAI06739.1.
IPI	IPI00018290.
PIR	TVHUMS. A00649.
RefSeq	NP_005363.1. NM_005372.1.
UniGene	Hs.533432.
3D structure databases
ProteinModelPortal	P00540.
ModBase	Search...
Protein-protein interaction databases
IntAct	P00540. 2 interactions.
MINT	MINT-96687.
STRING	9606.ENSP00000310722.
PTM databases
PhosphoSite	P00540.
Polymorphism databases
DMDM	125497.
Proteomic databases
PaxDb	P00540.
PRIDE	P00540.
Protocols and materials databases
DNASU	4342.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311923; ENSP00000310722; ENSG00000172680.
GeneID	4342.
KEGG	hsa:4342.
UCSC	uc011leb.2. human.
Organism-specific databases
CTD	4342.
GeneCards	GC08M057025.
HGNC	HGNC:7199. MOS.
HPA	HPA040424.
MIM	190060. gene.
neXtProt	NX_P00540.
PharmGKB	PA30907.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000290647.
HOVERGEN	HBG052499.
InParanoid	P00540.
KO	K04367.
OMA	VDSRPCS.
OrthoDB	EOG4HQDJZ.
PhylomeDB	P00540.
Enzyme and pathway databases
BRENDA	2.7.10.2. 2681.
Gene expression databases
Bgee	P00540.
CleanEx	HS_MOS.
Genevestigator	P00540.
GermOnline	ENSG00000172680. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075184.
GenomeRNAi	4342.
NextBio	17094.
SOURCE	Search...

Entry information

Entry name

MOS_HUMAN

Accession

Primary (citable) accession number: P00540
Secondary accession number(s): Q3KPG9, Q3KPH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 128 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.