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Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

Mos

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88ATPPROSITE-ProRule annotation1
Active sitei196Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 75ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: UniProtKB
  • protein kinase activity Source: RGD
  • protein serine/threonine kinase activity Source: UniProtKB
  • signal transducer activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene namesi
Name:Mos
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3103 Mos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863471 – 339Proto-oncogene serine/threonine-protein kinase mosAdd BLAST339

Proteomic databases

PaxDbiP00539
PRIDEiP00539

PTM databases

PhosphoSitePlusiP00539

Expressioni

Tissue specificityi

Expressed mainly in gonadal tissues, and cardiac and skeletal muscles.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064243

Structurei

3D structure databases

ProteinModelPortaliP00539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 335Protein kinasePROSITE-ProRule annotationAdd BLAST275

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
HOVERGENiHBG052499
InParanoidiP00539
PhylomeDBiP00539

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P00539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLILCRY LPRELSPTVD SRSCSSPLVA SRAGKFLGAT PPRAPRLSRR
60 70 80 90 100
LAWCFIDWGQ VCLLHRLGSG GFGSVYKATY HGVPVAIKQV NKCTRTLRAS
110 120 130 140 150
QRNFWAELNI ARLHHDNIIR VVAASTRTPE GSNSLGTIIM EFGGNVTLHQ
160 170 180 190 200
VIYGATRSPE PLSCREQLSL GKCLKYSLDI VNGLLFLHSQ SILHLDLKPA
210 220 230 240 250
NILISEKDVC KISDFGCSQK LQDLRCRPSL HHIGGTYTHQ APELLKGEIA
260 270 280 290 300
TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PHWQAVFTAS
310 320 330
LTGKTLQNNV QSCWEARALQ RPGAELLQKD LKAFRGALG
Length:339
Mass (Da):37,621
Last modified:February 1, 1996 - v2
Checksum:iA074246A5E471278
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47L → V in CAA37128 (PubMed:1697408).Curated1
Sequence conflicti102R → A in CAA37128 (PubMed:1697408).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00422 Genomic DNA Translation: CAA25123.1
X52952 mRNA Translation: CAA37128.1
PIRiA00648 TVRTM
UniGeneiRn.10341

Genome annotation databases

UCSCiRGD:3103 rat

Similar proteinsi

Entry informationi

Entry nameiMOS_RAT
AccessioniPrimary (citable) accession number: P00539
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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