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P00539 (MOS_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Proto-oncogene serine/threonine-protein kinase mos
EC=2.7.11.1
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene names
Name:Mos
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

Expressed mainly in gonadal tissues, and cardiac and skeletal muscles.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Proto-oncogene serine/threonine-protein kinase mos
PRO_0000086347

Regions

Domain61 – 335275Protein kinase
Nucleotide binding67 – 759ATP By similarity

Sites

Active site1961Proton acceptor By similarity
Binding site881ATP By similarity

Experimental info

Sequence conflict471L → V in CAA37128. Ref.2
Sequence conflict1021R → A in CAA37128. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P00539 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: A074246A5E471278

FASTA33937,621
        10         20         30         40         50         60 
MPSPLILCRY LPRELSPTVD SRSCSSPLVA SRAGKFLGAT PPRAPRLSRR LAWCFIDWGQ 

        70         80         90        100        110        120 
VCLLHRLGSG GFGSVYKATY HGVPVAIKQV NKCTRTLRAS QRNFWAELNI ARLHHDNIIR 

       130        140        150        160        170        180 
VVAASTRTPE GSNSLGTIIM EFGGNVTLHQ VIYGATRSPE PLSCREQLSL GKCLKYSLDI 

       190        200        210        220        230        240 
VNGLLFLHSQ SILHLDLKPA NILISEKDVC KISDFGCSQK LQDLRCRPSL HHIGGTYTHQ 

       250        260        270        280        290        300 
APELLKGEIA TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PHWQAVFTAS 

       310        320        330 
LTGKTLQNNV QSCWEARALQ RPGAELLQKD LKAFRGALG

« Hide

References

[1]"Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins."
van der Hoorn F.A., Firzlaff J.
Nucleic Acids Res. 12:2147-2156(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Rat myogenic c-mos cDNA: cloning sequence analysis and regulation during muscle development."
Leibovitch S.A., Lenormand J.-L., Leibovitch M.-P., Guiller M., Mallard L., Harel J.
Oncogene 5:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X00422 Genomic DNA. Translation: CAA25123.1.
X52952 mRNA. Translation: CAA37128.1.
IPIIPI00327445.
PIRTVRTM. A00648.
UniGeneRn.10341.

3D structure databases

ProteinModelPortalP00539.
ModBaseSearch...

PTM databases

PhosphoSiteP00539.

Proteomic databases

PRIDEP00539.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:3103. rat.

Organism-specific databases

RGD3103. Mos.

Phylogenomic databases

HOVERGENHBG052499.
InParanoidP00539.

Enzyme and pathway databases

BRENDA2.7.10.2. 5301.

Gene expression databases

GenevestigatorP00539.
GermOnlineENSRNOG00000008567. Rattus norvegicus.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMOS_RAT
AccessionPrimary (citable) accession number: P00539
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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