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P00539

- MOS_RAT

UniProt

P00539 - MOS_RAT

Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

Mos

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881ATPPROSITE-ProRule annotation
    Active sitei196 – 1961Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 759ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProt
    3. protein kinase activity Source: RGD
    4. protein serine/threonine kinase activity Source: UniProt

    GO - Biological processi

    1. activation of MAPK activity Source: UniProt
    2. activation of MAPKK activity Source: UniProt
    3. chromatin organization Source: UniProt
    4. establishment of meiotic spindle orientation Source: UniProt
    5. intracellular signal transduction Source: RGD
    6. MAPK cascade Source: GOC
    7. meiotic spindle organization Source: UniProt
    8. negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProt
    9. protein autophosphorylation Source: UniProt
    10. protein phosphorylation Source: RGD
    11. spermatogenesis Source: RGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
    Alternative name(s):
    Oocyte maturation factor mos
    Proto-oncogene c-Mos
    Gene namesi
    Name:Mos
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3103. Mos.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Proto-oncogene serine/threonine-protein kinase mosPRO_0000086347Add
    BLAST

    Proteomic databases

    PRIDEiP00539.

    PTM databases

    PhosphoSiteiP00539.

    Expressioni

    Tissue specificityi

    Expressed mainly in gonadal tissues, and cardiac and skeletal muscles.

    Gene expression databases

    GenevestigatoriP00539.

    Structurei

    3D structure databases

    ProteinModelPortaliP00539.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 335275Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG052499.
    InParanoidiP00539.
    PhylomeDBiP00539.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00539-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSPLILCRY LPRELSPTVD SRSCSSPLVA SRAGKFLGAT PPRAPRLSRR    50
    LAWCFIDWGQ VCLLHRLGSG GFGSVYKATY HGVPVAIKQV NKCTRTLRAS 100
    QRNFWAELNI ARLHHDNIIR VVAASTRTPE GSNSLGTIIM EFGGNVTLHQ 150
    VIYGATRSPE PLSCREQLSL GKCLKYSLDI VNGLLFLHSQ SILHLDLKPA 200
    NILISEKDVC KISDFGCSQK LQDLRCRPSL HHIGGTYTHQ APELLKGEIA 250
    TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PHWQAVFTAS 300
    LTGKTLQNNV QSCWEARALQ RPGAELLQKD LKAFRGALG 339
    Length:339
    Mass (Da):37,621
    Last modified:February 1, 1996 - v2
    Checksum:iA074246A5E471278
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471L → V in CAA37128. (PubMed:1697408)Curated
    Sequence conflicti102 – 1021R → A in CAA37128. (PubMed:1697408)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00422 Genomic DNA. Translation: CAA25123.1.
    X52952 mRNA. Translation: CAA37128.1.
    PIRiA00648. TVRTM.
    UniGeneiRn.10341.

    Genome annotation databases

    UCSCiRGD:3103. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00422 Genomic DNA. Translation: CAA25123.1 .
    X52952 mRNA. Translation: CAA37128.1 .
    PIRi A00648. TVRTM.
    UniGenei Rn.10341.

    3D structure databases

    ProteinModelPortali P00539.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P00539.

    Proteomic databases

    PRIDEi P00539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:3103. rat.

    Organism-specific databases

    RGDi 3103. Mos.

    Phylogenomic databases

    HOVERGENi HBG052499.
    InParanoidi P00539.
    PhylomeDBi P00539.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5301.

    Miscellaneous databases

    PROi P00539.

    Gene expression databases

    Genevestigatori P00539.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins."
      van der Hoorn F.A., Firzlaff J.
      Nucleic Acids Res. 12:2147-2156(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Rat myogenic c-mos cDNA: cloning sequence analysis and regulation during muscle development."
      Leibovitch S.A., Lenormand J.-L., Leibovitch M.-P., Guiller M., Mallard L., Harel J.
      Oncogene 5:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiMOS_RAT
    AccessioniPrimary (citable) accession number: P00539
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3