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P00539

- MOS_RAT

UniProt

P00539 - MOS_RAT

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Protein
Proto-oncogene serine/threonine-protein kinase mos
Gene
Mos
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881ATP By similarity
Active sitei196 – 1961Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 759ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProt
  3. protein kinase activity Source: RGD
  4. protein serine/threonine kinase activity Source: UniProt

GO - Biological processi

  1. MAPK cascade Source: GOC
  2. activation of MAPK activity Source: UniProt
  3. activation of MAPKK activity Source: UniProt
  4. chromatin organization Source: UniProt
  5. establishment of meiotic spindle orientation Source: UniProt
  6. intracellular signal transduction Source: RGD
  7. meiotic spindle organization Source: UniProt
  8. negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProt
  9. protein autophosphorylation Source: UniProt
  10. protein phosphorylation Source: RGD
  11. spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene namesi
Name:Mos
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3103. Mos.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Proto-oncogene serine/threonine-protein kinase mos
PRO_0000086347Add
BLAST

Proteomic databases

PRIDEiP00539.

PTM databases

PhosphoSiteiP00539.

Expressioni

Tissue specificityi

Expressed mainly in gonadal tissues, and cardiac and skeletal muscles.

Gene expression databases

GenevestigatoriP00539.

Structurei

3D structure databases

ProteinModelPortaliP00539.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 335275Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG052499.
InParanoidiP00539.
PhylomeDBiP00539.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00539-1 [UniParc]FASTAAdd to Basket

« Hide

MPSPLILCRY LPRELSPTVD SRSCSSPLVA SRAGKFLGAT PPRAPRLSRR    50
LAWCFIDWGQ VCLLHRLGSG GFGSVYKATY HGVPVAIKQV NKCTRTLRAS 100
QRNFWAELNI ARLHHDNIIR VVAASTRTPE GSNSLGTIIM EFGGNVTLHQ 150
VIYGATRSPE PLSCREQLSL GKCLKYSLDI VNGLLFLHSQ SILHLDLKPA 200
NILISEKDVC KISDFGCSQK LQDLRCRPSL HHIGGTYTHQ APELLKGEIA 250
TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PHWQAVFTAS 300
LTGKTLQNNV QSCWEARALQ RPGAELLQKD LKAFRGALG 339
Length:339
Mass (Da):37,621
Last modified:February 1, 1996 - v2
Checksum:iA074246A5E471278
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471L → V in CAA37128. 1 Publication
Sequence conflicti102 – 1021R → A in CAA37128. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00422 Genomic DNA. Translation: CAA25123.1.
X52952 mRNA. Translation: CAA37128.1.
PIRiA00648. TVRTM.
UniGeneiRn.10341.

Genome annotation databases

UCSCiRGD:3103. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00422 Genomic DNA. Translation: CAA25123.1 .
X52952 mRNA. Translation: CAA37128.1 .
PIRi A00648. TVRTM.
UniGenei Rn.10341.

3D structure databases

ProteinModelPortali P00539.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P00539.

Proteomic databases

PRIDEi P00539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:3103. rat.

Organism-specific databases

RGDi 3103. Mos.

Phylogenomic databases

HOVERGENi HBG052499.
InParanoidi P00539.
PhylomeDBi P00539.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5301.

Miscellaneous databases

PROi P00539.

Gene expression databases

Genevestigatori P00539.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins."
    van der Hoorn F.A., Firzlaff J.
    Nucleic Acids Res. 12:2147-2156(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Rat myogenic c-mos cDNA: cloning sequence analysis and regulation during muscle development."
    Leibovitch S.A., Lenormand J.-L., Leibovitch M.-P., Guiller M., Mallard L., Harel J.
    Oncogene 5:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiMOS_RAT
AccessioniPrimary (citable) accession number: P00539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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