P00538 (MOS_MSVMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase-transforming protein mos
EC=2.7.11.1

Gene names

Name:

V-MOS

Organism

Moloney murine sarcoma virus (MoMSV)

Taxonomic identifier

11809 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication defective viruses

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence described in Ref.4 differs from that shown. Reason: Frameshift at position 358.

Ontologies

Keywords
Disease	Oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Serine/threonine-protein kinase-transforming protein mos		PRO_0000086361
Regions
	Domain	94 – 370	277	Protein kinase
	Nucleotide binding	100 – 108	9	ATP By similarity
Sites
	Active site	229	1	Proton acceptor By similarity
	Binding site	121	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00538 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 56702CF0BE08609B	FASTA	374	40,977
	10 20 30 40 50 60 MAHSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR YLPRELSPSV DSRSCSIPLV 70 80 90 100 110 120 APRKAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL GSGGFGSVYK ATYHGVPVAI 130 140 150 160 170 180 KQVNKCTEDL RASQRSFWAE LNIAGLRHDN IVRVVAASTR TPEDSNSLGT IIMEFGGNVT 190 200 210 220 230 240 LHQVIYDATR SPEPLSCRKQ LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ 250 260 270 280 290 300 DVCKISDFGC SQKLQDLRGR QASPPHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM 310 320 330 340 350 360 TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKA LQNIIQSCWE ARGLQRPSAE 370 LLQRDLKAFR GTLG

References

[1]	"Nucleotide sequence of the genome of a murine sarcoma virus." van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M. Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M. Submitted (OCT-1982) to the PIR data bank Cited for: SEQUENCE REVISION TO 256.
[3]	"Demonstration of biological activity and nucleotide sequence of an in vitro synthesized clone of the Moloney murine sarcoma virus mos gene." Donoghue D.J. J. Virol. 42:538-546(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome." Reddy E.P., Smith M.J., Aaronson S.A. Science 214:445-450(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01180 Genomic DNA. Translation: CAA24503.1.
PIR	TVMVM. A00647.
3D structure databases
ProteinModelPortal	P00538.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.2. 3394.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOS_MSVMO

Accession

Primary (citable) accession number: P00538

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program