Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00538 (MOS_MSVMO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase-transforming protein mos

EC=2.7.11.1
Gene names
Name:V-MOS
OrganismMoloney murine sarcoma virus (MoMSV)
Taxonomic identifier11809 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostMus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence described in Ref.4 differs from that shown. Reason: Frameshift at position 358.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Serine/threonine-protein kinase-transforming protein mos
PRO_0000086361

Regions

Domain94 – 370277Protein kinase
Nucleotide binding100 – 1089ATP By similarity

Sites

Active site2291Proton acceptor By similarity
Binding site1211ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P00538 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 56702CF0BE08609B

FASTA37440,977
        10         20         30         40         50         60 
MAHSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR YLPRELSPSV DSRSCSIPLV 

        70         80         90        100        110        120 
APRKAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL GSGGFGSVYK ATYHGVPVAI 

       130        140        150        160        170        180 
KQVNKCTEDL RASQRSFWAE LNIAGLRHDN IVRVVAASTR TPEDSNSLGT IIMEFGGNVT 

       190        200        210        220        230        240 
LHQVIYDATR SPEPLSCRKQ LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ 

       250        260        270        280        290        300 
DVCKISDFGC SQKLQDLRGR QASPPHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM 

       310        320        330        340        350        360 
TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKA LQNIIQSCWE ARGLQRPSAE 

       370 
LLQRDLKAFR GTLG 

« Hide

References

[1]"Nucleotide sequence of the genome of a murine sarcoma virus."
van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
Submitted (OCT-1982) to the PIR data bank
Cited for: SEQUENCE REVISION TO 256.
[3]"Demonstration of biological activity and nucleotide sequence of an in vitro synthesized clone of the Moloney murine sarcoma virus mos gene."
Donoghue D.J.
J. Virol. 42:538-546(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome."
Reddy E.P., Smith M.J., Aaronson S.A.
Science 214:445-450(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V01180 Genomic DNA. Translation: CAA24503.1.
PIRTVMVM. A00647.

3D structure databases

ProteinModelPortalP00538.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 3394.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMOS_MSVMO
AccessionPrimary (citable) accession number: P00538
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families