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P00538

- MOS_MSVMO

UniProt

P00538 - MOS_MSVMO

Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Moloney murine sarcoma virus (MoMSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei121 – 1211ATPPROSITE-ProRule annotation
    Active sitei229 – 2291Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1089ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3394.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
    Gene namesi
    Name:V-MOS
    OrganismiMoloney murine sarcoma virus (MoMSV)
    Taxonomic identifieri11809 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Serine/threonine-protein kinase-transforming protein mosPRO_0000086361Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP00538.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 370277Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00538-1 [UniParc]FASTAAdd to Basket

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    MAHSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR YLPRELSPSV    50
    DSRSCSIPLV APRKAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL 100
    GSGGFGSVYK ATYHGVPVAI KQVNKCTEDL RASQRSFWAE LNIAGLRHDN 150
    IVRVVAASTR TPEDSNSLGT IIMEFGGNVT LHQVIYDATR SPEPLSCRKQ 200
    LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ DVCKISDFGC 250
    SQKLQDLRGR QASPPHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM 300
    TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKA LQNIIQSCWE 350
    ARGLQRPSAE LLQRDLKAFR GTLG 374
    Length:374
    Mass (Da):40,977
    Last modified:July 21, 1986 - v1
    Checksum:i56702CF0BE08609B
    GO

    Sequence cautioni

    The sequence described in 1 Publication differs from that shown. Reason: Frameshift at position 358.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01180 Genomic DNA. Translation: CAA24503.1.
    PIRiA00647. TVMVM.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01180 Genomic DNA. Translation: CAA24503.1 .
    PIRi A00647. TVMVM.

    3D structure databases

    ProteinModelPortali P00538.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3394.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the genome of a murine sarcoma virus."
      van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
      Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
      Submitted (OCT-1982) to the PIR data bank
      Cited for: SEQUENCE REVISION TO 256.
    3. "Demonstration of biological activity and nucleotide sequence of an in vitro synthesized clone of the Moloney murine sarcoma virus mos gene."
      Donoghue D.J.
      J. Virol. 42:538-546(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome."
      Reddy E.P., Smith M.J., Aaronson S.A.
      Science 214:445-450(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMOS_MSVMO
    AccessioniPrimary (citable) accession number: P00538
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3