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Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Moloney murine sarcoma virus (MoMSV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211ATPPROSITE-ProRule annotation
Active sitei229 – 2291Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1089ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3394.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
Gene namesi
Name:V-MOS
OrganismiMoloney murine sarcoma virus (MoMSV)
Taxonomic identifieri11809 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Serine/threonine-protein kinase-transforming protein mosPRO_0000086361Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP00538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 370277Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR YLPRELSPSV
60 70 80 90 100
DSRSCSIPLV APRKAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL
110 120 130 140 150
GSGGFGSVYK ATYHGVPVAI KQVNKCTEDL RASQRSFWAE LNIAGLRHDN
160 170 180 190 200
IVRVVAASTR TPEDSNSLGT IIMEFGGNVT LHQVIYDATR SPEPLSCRKQ
210 220 230 240 250
LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ DVCKISDFGC
260 270 280 290 300
SQKLQDLRGR QASPPHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM
310 320 330 340 350
TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKA LQNIIQSCWE
360 370
ARGLQRPSAE LLQRDLKAFR GTLG
Length:374
Mass (Da):40,977
Last modified:July 21, 1986 - v1
Checksum:i56702CF0BE08609B
GO

Sequence cautioni

The sequence described in PubMed:6170110 differs from that shown. Reason: Frameshift at position 358. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01180 Genomic DNA. Translation: CAA24503.1.
PIRiA00647. TVMVM.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01180 Genomic DNA. Translation: CAA24503.1.
PIRiA00647. TVMVM.

3D structure databases

ProteinModelPortaliP00538.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.10.2. 3394.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the genome of a murine sarcoma virus."
    van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
    Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
    Submitted (OCT-1982) to the PIR data bank
    Cited for: SEQUENCE REVISION TO 256.
  3. "Demonstration of biological activity and nucleotide sequence of an in vitro synthesized clone of the Moloney murine sarcoma virus mos gene."
    Donoghue D.J.
    J. Virol. 42:538-546(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome."
    Reddy E.P., Smith M.J., Aaronson S.A.
    Science 214:445-450(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMOS_MSVMO
AccessioniPrimary (citable) accession number: P00538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.