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P00538

- MOS_MSVMO

UniProt

P00538 - MOS_MSVMO

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Protein
Serine/threonine-protein kinase-transforming protein mos
Gene
V-MOS
Organism
Moloney murine sarcoma virus (MoMSV)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211ATP By similarity
Active sitei229 – 2291Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1089ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3394.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
Gene namesi
Name:V-MOS
OrganismiMoloney murine sarcoma virus (MoMSV)
Taxonomic identifieri11809 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Serine/threonine-protein kinase-transforming protein mos
PRO_0000086361Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP00538.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 370277Protein kinase
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00538-1 [UniParc]FASTAAdd to Basket

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MAHSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR YLPRELSPSV    50
DSRSCSIPLV APRKAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL 100
GSGGFGSVYK ATYHGVPVAI KQVNKCTEDL RASQRSFWAE LNIAGLRHDN 150
IVRVVAASTR TPEDSNSLGT IIMEFGGNVT LHQVIYDATR SPEPLSCRKQ 200
LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ DVCKISDFGC 250
SQKLQDLRGR QASPPHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM 300
TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKA LQNIIQSCWE 350
ARGLQRPSAE LLQRDLKAFR GTLG 374
Length:374
Mass (Da):40,977
Last modified:July 21, 1986 - v1
Checksum:i56702CF0BE08609B
GO

Sequence cautioni

The sequence described in 1 Publication differs from that shown. Reason: Frameshift at position 358.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01180 Genomic DNA. Translation: CAA24503.1.
PIRiA00647. TVMVM.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01180 Genomic DNA. Translation: CAA24503.1 .
PIRi A00647. TVMVM.

3D structure databases

ProteinModelPortali P00538.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3394.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the genome of a murine sarcoma virus."
    van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
    Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
    Submitted (OCT-1982) to the PIR data bank
    Cited for: SEQUENCE REVISION TO 256.
  3. "Demonstration of biological activity and nucleotide sequence of an in vitro synthesized clone of the Moloney murine sarcoma virus mos gene."
    Donoghue D.J.
    J. Virol. 42:538-546(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome."
    Reddy E.P., Smith M.J., Aaronson S.A.
    Science 214:445-450(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMOS_MSVMO
AccessioniPrimary (citable) accession number: P00538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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