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P00537

- MOS_MSVMM

UniProt

P00537 - MOS_MSVMM

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Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Moloney murine sarcoma virus (strain m1) (MoMSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211ATPPROSITE-ProRule annotation
Active sitei229 – 2291Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1089ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3394.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
Gene namesi
Name:V-MOS
OrganismiMoloney murine sarcoma virus (strain m1) (MoMSV)
Taxonomic identifieri11811 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Serine/threonine-protein kinase-transforming protein mosPRO_0000086360Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP00537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 376283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00537-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR CLPRELSPSV
60 70 80 90 100
DSRSCSIPLV APRRAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL
110 120 130 140 150
GSGGFGSVYK ATYHGVPVAI KQVNKCTKDL RASQRSFWAE LNIARLRHDN
160 170 180 190 200
IVRVVAASTR TPEDSNSLGT IIMEFGGNVT LHQVIYGATR SPEPLSCREQ
210 220 230 240 250
LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ DVCKISDFGC
260 270 280 290 300
SQKLQDLRCR QASPHHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM
310 320 330 340 350
TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKT LQNIIQSCWE
360 370
ARALQRPGAE LLQRDLKALA DSIEPM
Length:376
Mass (Da):41,331
Last modified:July 21, 1986 - v1
Checksum:i8A1988EF20003323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02728 Genomic DNA. Translation: AAA46497.1.
PIRiA00646. TVMV1M.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02728 Genomic DNA. Translation: AAA46497.1 .
PIRi A00646. TVMV1M.

3D structure databases

ProteinModelPortali P00537.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3394.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the transforming gene of m1 murine sarcoma virus."
    Brow M.A.D., Sen A., Sutcliffe J.G.
    J. Virol. 49:579-582(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMOS_MSVMM
AccessioniPrimary (citable) accession number: P00537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3