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P00537

- MOS_MSVMM

UniProt

P00537 - MOS_MSVMM

Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Moloney murine sarcoma virus (strain m1) (MoMSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei121 – 1211ATPPROSITE-ProRule annotation
    Active sitei229 – 2291Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1089ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3394.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
    Gene namesi
    Name:V-MOS
    OrganismiMoloney murine sarcoma virus (strain m1) (MoMSV)
    Taxonomic identifieri11811 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Serine/threonine-protein kinase-transforming protein mosPRO_0000086360Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP00537.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 376283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00537-1 [UniParc]FASTAAdd to Basket

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    MARSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR CLPRELSPSV    50
    DSRSCSIPLV APRRAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL 100
    GSGGFGSVYK ATYHGVPVAI KQVNKCTKDL RASQRSFWAE LNIARLRHDN 150
    IVRVVAASTR TPEDSNSLGT IIMEFGGNVT LHQVIYGATR SPEPLSCREQ 200
    LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ DVCKISDFGC 250
    SQKLQDLRCR QASPHHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM 300
    TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKT LQNIIQSCWE 350
    ARALQRPGAE LLQRDLKALA DSIEPM 376
    Length:376
    Mass (Da):41,331
    Last modified:July 21, 1986 - v1
    Checksum:i8A1988EF20003323
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02728 Genomic DNA. Translation: AAA46497.1.
    PIRiA00646. TVMV1M.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02728 Genomic DNA. Translation: AAA46497.1 .
    PIRi A00646. TVMV1M.

    3D structure databases

    ProteinModelPortali P00537.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3394.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the transforming gene of m1 murine sarcoma virus."
      Brow M.A.D., Sen A., Sutcliffe J.G.
      J. Virol. 49:579-582(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMOS_MSVMM
    AccessioniPrimary (citable) accession number: P00537
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3