P00537 (MOS_MSVMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase-transforming protein mos
EC=2.7.11.1

Gene names

Name:

V-MOS

Organism

Moloney murine sarcoma virus (strain m1) (MoMSV)

Taxonomic identifier

11811 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication defective viruses › Moloney murine sarcoma virus

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Disease	Oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Serine/threonine-protein kinase-transforming protein mos		PRO_0000086360
Regions
	Domain	94 – 376	283	Protein kinase
	Nucleotide binding	100 – 108	9	ATP By similarity
Sites
	Active site	229	1	Proton acceptor By similarity
	Binding site	121	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00537 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 8A1988EF20003323	FASTA	376	41,331
	10 20 30 40 50 60 MARSTPCSQT SLAVPNHFSL VSHVTVPSEG VMPSPLSLCR CLPRELSPSV DSRSCSIPLV 70 80 90 100 110 120 APRRAGKLFL GTTPPRAPGL PRRLAWFSID WEQVCLMHRL GSGGFGSVYK ATYHGVPVAI 130 140 150 160 170 180 KQVNKCTKDL RASQRSFWAE LNIARLRHDN IVRVVAASTR TPEDSNSLGT IIMEFGGNVT 190 200 210 220 230 240 LHQVIYGATR SPEPLSCREQ LSLGKCLKYS LDVVNGLLFL HSQSILHLDL KPANILISEQ 250 260 270 280 290 300 DVCKISDFGC SQKLQDLRCR QASPHHIGGT YTHQAPEILK GEIATPKADI YSFGITLWQM 310 320 330 340 350 360 TTREVPYSGE PQYVQYAVVA YNLRPSLAGA VFTASLTGKT LQNIIQSCWE ARALQRPGAE 370 LLQRDLKALA DSIEPM

References

[1]	"Nucleotide sequence of the transforming gene of m1 murine sarcoma virus." Brow M.A.D., Sen A., Sutcliffe J.G. J. Virol. 49:579-582(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02728 Genomic DNA. Translation: AAA46497.1.
PIR	TVMV1M. A00646.
3D structure databases
ProteinModelPortal	P00537.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.2. 3394.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOS_MSVMM

Accession

Primary (citable) accession number: P00537

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program