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P00536 (MOS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proto-oncogene serine/threonine-protein kinase mos

EC=2.7.11.1
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene names
Name:Mos
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

Expressed specifically in testis during spermatogenesis.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Proto-oncogene serine/threonine-protein kinase mos
PRO_0000086345

Regions

Domain110 – 386277Protein kinase
Nucleotide binding116 – 1249ATP By similarity

Sites

Active site2451Proton acceptor By similarity
Binding site1371ATP By similarity

Experimental info

Sequence conflict151G → GI no nucleotide entry Ref.1
Sequence conflict151G → GI no nucleotide entry Ref.3
Sequence conflict211Missing no nucleotide entry Ref.1
Sequence conflict211Missing no nucleotide entry Ref.3
Sequence conflict2721D → V no nucleotide entry Ref.1
Sequence conflict3741G → C no nucleotide entry Ref.1

Sequences

Sequence LengthMass (Da)Tools
P00536 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 2F38ABEA747BDA38

FASTA39042,875
        10         20         30         40         50         60 
MWLVLRIKEE GKGTGEGSNL QPCSQTSLAV PTHFSLVSHV TVPSEGVMPS PLSLCRYLPR 

        70         80         90        100        110        120 
ELSPSVDSRS CSIPLVAPRK AGKLFLGTTP PRAPGLPRRL AWFSIDWEQV CLMHRLGSGG 

       130        140        150        160        170        180 
FGSVYKATYH GVPVAIKQVN KCTKDLRASQ RSFWAELNIA RLRHDNIVRV VAASTRTPED 

       190        200        210        220        230        240 
SNSLGTIIME FGGNVTLHQV IYGATRSPEP LSCREQLSLG KCLKYSLDVV NGLLFLHSQS 

       250        260        270        280        290        300 
ILHLDLKPAN ILISEQDVCK ISDFGCSQKL QDLRCRQASP HHIGGTYTHQ APEILKGEIA 

       310        320        330        340        350        360 
TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PSLAGAVFTA SLTGKTLQNI 

       370        380        390 
IQSCWEARAL QRPGAELLQR DLKAFRGALG 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the genome of a murine sarcoma virus."
van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element."
Rechavi G., Givol D., Canaani E.
Nature 300:607-611(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-97.
Strain: BALB/c.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL807387 Genomic DNA. No translation available.
PIRTVMSM. A00645.
UniGeneMm.459300.

3D structure databases

ProteinModelPortalP00536.
SMRP00536. Positions 32-385.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP00536. 1 interaction.
MINTMINT-1521104.

PTM databases

PhosphoSiteP00536.

Proteomic databases

PRIDEP00536.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc008rwo.1. mouse.

Organism-specific databases

MGIMGI:97052. Mos.

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG052499.
InParanoidP00536.

Enzyme and pathway databases

BRENDA2.7.10.2. 3474.

Gene expression databases

BgeeP00536.
CleanExMM_MOS.
GenevestigatorP00536.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP00536.
SOURCESearch...

Entry information

Entry nameMOS_MOUSE
AccessionPrimary (citable) accession number: P00536
Secondary accession number(s): E9PV67
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot