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P00536

- MOS_MOUSE

UniProt

P00536 - MOS_MOUSE

Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

Mos

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei137 – 1371ATPPROSITE-ProRule annotation
    Active sitei245 – 2451Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi116 – 1249ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProt
    3. protein serine/threonine kinase activity Source: UniProt

    GO - Biological processi

    1. activation of MAPK activity Source: UniProt
    2. activation of MAPKK activity Source: UniProt
    3. chromatin organization Source: UniProt
    4. establishment of meiotic spindle orientation Source: UniProt
    5. MAPK cascade Source: GOC
    6. meiotic spindle organization Source: UniProt
    7. negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProt
    8. protein autophosphorylation Source: UniProt

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
    Alternative name(s):
    Oocyte maturation factor mos
    Proto-oncogene c-Mos
    Gene namesi
    Name:Mos
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:97052. Mos.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProt

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Proto-oncogene serine/threonine-protein kinase mosPRO_0000086345Add
    BLAST

    Proteomic databases

    PRIDEiP00536.

    PTM databases

    PhosphoSiteiP00536.

    Expressioni

    Tissue specificityi

    Expressed specifically in testis during spermatogenesis.

    Gene expression databases

    BgeeiP00536.
    CleanExiMM_MOS.
    GenevestigatoriP00536.

    Interactioni

    Protein-protein interaction databases

    IntActiP00536. 1 interaction.
    MINTiMINT-1521104.

    Structurei

    3D structure databases

    ProteinModelPortaliP00536.
    SMRiP00536. Positions 32-385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini110 – 386277Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG052499.
    InParanoidiP00536.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00536-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLVLRIKEE GKGTGEGSNL QPCSQTSLAV PTHFSLVSHV TVPSEGVMPS    50
    PLSLCRYLPR ELSPSVDSRS CSIPLVAPRK AGKLFLGTTP PRAPGLPRRL 100
    AWFSIDWEQV CLMHRLGSGG FGSVYKATYH GVPVAIKQVN KCTKDLRASQ 150
    RSFWAELNIA RLRHDNIVRV VAASTRTPED SNSLGTIIME FGGNVTLHQV 200
    IYGATRSPEP LSCREQLSLG KCLKYSLDVV NGLLFLHSQS ILHLDLKPAN 250
    ILISEQDVCK ISDFGCSQKL QDLRCRQASP HHIGGTYTHQ APEILKGEIA 300
    TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PSLAGAVFTA 350
    SLTGKTLQNI IQSCWEARAL QRPGAELLQR DLKAFRGALG 390
    Length:390
    Mass (Da):42,875
    Last modified:July 27, 2011 - v2
    Checksum:i2F38ABEA747BDA38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151G → GI no nucleotide entry (PubMed:6173134)Curated
    Sequence conflicti15 – 151G → GI no nucleotide entry (PubMed:6292737)Curated
    Sequence conflicti21 – 211Missing no nucleotide entry (PubMed:6173134)Curated
    Sequence conflicti21 – 211Missing no nucleotide entry (PubMed:6292737)Curated
    Sequence conflicti272 – 2721D → V no nucleotide entry (PubMed:6173134)Curated
    Sequence conflicti374 – 3741G → C no nucleotide entry (PubMed:6173134)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL807387 Genomic DNA. No translation available.
    PIRiA00645. TVMSM.
    UniGeneiMm.459300.

    Genome annotation databases

    UCSCiuc008rwo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL807387 Genomic DNA. No translation available.
    PIRi A00645. TVMSM.
    UniGenei Mm.459300.

    3D structure databases

    ProteinModelPortali P00536.
    SMRi P00536. Positions 32-385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00536. 1 interaction.
    MINTi MINT-1521104.

    PTM databases

    PhosphoSitei P00536.

    Proteomic databases

    PRIDEi P00536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc008rwo.1. mouse.

    Organism-specific databases

    MGIi MGI:97052. Mos.

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG052499.
    InParanoidi P00536.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.

    Miscellaneous databases

    PROi P00536.
    SOURCEi Search...

    Gene expression databases

    Bgeei P00536.
    CleanExi MM_MOS.
    Genevestigatori P00536.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the genome of a murine sarcoma virus."
      van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
      Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element."
      Rechavi G., Givol D., Canaani E.
      Nature 300:607-611(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-97.
      Strain: BALB/c.

    Entry informationi

    Entry nameiMOS_MOUSE
    AccessioniPrimary (citable) accession number: P00536
    Secondary accession number(s): E9PV67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3