P00536 (MOS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proto-oncogene serine/threonine-protein kinase mos
EC=2.7.11.1

Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos

Gene names

Name:

Mos

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Tissue specificity	Expressed specifically in testis during spermatogenesis.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Disease	Proto-oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Proto-oncogene serine/threonine-protein kinase mos		PRO_0000086345
Regions
	Domain	110 – 386	277	Protein kinase
	Nucleotide binding	116 – 124	9	ATP By similarity
Sites
	Active site	245	1	Proton acceptor By similarity
	Binding site	137	1	ATP By similarity
Experimental info
	Sequence conflict	15	1	G → GI no nucleotide entry Ref.1
	Sequence conflict	15	1	G → GI no nucleotide entry Ref.3
	Sequence conflict	21	1	Missing no nucleotide entry Ref.1
	Sequence conflict	21	1	Missing no nucleotide entry Ref.3
	Sequence conflict	272	1	D → V no nucleotide entry Ref.1
	Sequence conflict	374	1	G → C no nucleotide entry Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P00536 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 2F38ABEA747BDA38	FASTA	390	42,875
	10 20 30 40 50 60 MWLVLRIKEE GKGTGEGSNL QPCSQTSLAV PTHFSLVSHV TVPSEGVMPS PLSLCRYLPR 70 80 90 100 110 120 ELSPSVDSRS CSIPLVAPRK AGKLFLGTTP PRAPGLPRRL AWFSIDWEQV CLMHRLGSGG 130 140 150 160 170 180 FGSVYKATYH GVPVAIKQVN KCTKDLRASQ RSFWAELNIA RLRHDNIVRV VAASTRTPED 190 200 210 220 230 240 SNSLGTIIME FGGNVTLHQV IYGATRSPEP LSCREQLSLG KCLKYSLDVV NGLLFLHSQS 250 260 270 280 290 300 ILHLDLKPAN ILISEQDVCK ISDFGCSQKL QDLRCRQASP HHIGGTYTHQ APEILKGEIA 310 320 330 340 350 360 TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PSLAGAVFTA SLTGKTLQNI 370 380 390 IQSCWEARAL QRPGAELLQR DLKAFRGALG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the genome of a murine sarcoma virus." van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M. Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element." Rechavi G., Givol D., Canaani E. Nature 300:607-611(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-97. Strain: BALB/c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL807387 Genomic DNA. No translation available.
IPI	IPI00126408.
PIR	TVMSM. A00645.
UniGene	Mm.459300.
3D structure databases
ProteinModelPortal	P00536.
SMR	P00536. Positions 32-385.
ModBase	Search...
Protein-protein interaction databases
IntAct	P00536. 1 interaction.
MINT	MINT-1521104.
PTM databases
PhosphoSite	P00536.
Proteomic databases
PRIDE	P00536.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc008rwo.1. mouse.
Organism-specific databases
MGI	MGI:97052. Mos.
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG052499.
InParanoid	P00536.
OrthoDB	EOG4HQDJZ.
Enzyme and pathway databases
BRENDA	2.7.10.2. 3474.
Gene expression databases
ArrayExpress	P00536.
Bgee	P00536.
CleanEx	MM_MOS.
Genevestigator	P00536.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

MOS_MOUSE

Accession

Primary (citable) accession number: P00536
Secondary accession number(s): E9PV67

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program