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Protein

Proto-oncogene serine/threonine-protein kinase mos

Gene

Mos

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371ATPPROSITE-ProRule annotation
Active sitei245 – 2451Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi116 – 1249ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. activation of MAPKK activity Source: UniProtKB
  3. chromatin organization Source: UniProtKB
  4. establishment of meiotic spindle orientation Source: UniProtKB
  5. MAPK cascade Source: GOC
  6. meiotic spindle organization Source: UniProtKB
  7. negative regulation of metaphase/anaphase transition of meiotic cell cycle Source: UniProtKB
  8. protein autophosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
Oocyte maturation factor mos
Proto-oncogene c-Mos
Gene namesi
Name:Mos
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:97052. Mos.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Proto-oncogene serine/threonine-protein kinase mosPRO_0000086345Add
BLAST

Proteomic databases

PRIDEiP00536.

PTM databases

PhosphoSiteiP00536.

Expressioni

Tissue specificityi

Expressed specifically in testis during spermatogenesis.

Gene expression databases

BgeeiP00536.
CleanExiMM_MOS.
ExpressionAtlasiP00536. baseline.
GenevestigatoriP00536.

Interactioni

Protein-protein interaction databases

IntActiP00536. 1 interaction.
MINTiMINT-1521104.

Structurei

3D structure databases

ProteinModelPortaliP00536.
SMRiP00536. Positions 32-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 386277Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG052499.
InParanoidiP00536.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLVLRIKEE GKGTGEGSNL QPCSQTSLAV PTHFSLVSHV TVPSEGVMPS
60 70 80 90 100
PLSLCRYLPR ELSPSVDSRS CSIPLVAPRK AGKLFLGTTP PRAPGLPRRL
110 120 130 140 150
AWFSIDWEQV CLMHRLGSGG FGSVYKATYH GVPVAIKQVN KCTKDLRASQ
160 170 180 190 200
RSFWAELNIA RLRHDNIVRV VAASTRTPED SNSLGTIIME FGGNVTLHQV
210 220 230 240 250
IYGATRSPEP LSCREQLSLG KCLKYSLDVV NGLLFLHSQS ILHLDLKPAN
260 270 280 290 300
ILISEQDVCK ISDFGCSQKL QDLRCRQASP HHIGGTYTHQ APEILKGEIA
310 320 330 340 350
TPKADIYSFG ITLWQMTTRE VPYSGEPQYV QYAVVAYNLR PSLAGAVFTA
360 370 380 390
SLTGKTLQNI IQSCWEARAL QRPGAELLQR DLKAFRGALG
Length:390
Mass (Da):42,875
Last modified:July 27, 2011 - v2
Checksum:i2F38ABEA747BDA38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151G → GI no nucleotide entry (PubMed:6173134).Curated
Sequence conflicti15 – 151G → GI no nucleotide entry (PubMed:6292737).Curated
Sequence conflicti21 – 211Missing no nucleotide entry (PubMed:6173134).Curated
Sequence conflicti21 – 211Missing no nucleotide entry (PubMed:6292737).Curated
Sequence conflicti272 – 2721D → V no nucleotide entry (PubMed:6173134).Curated
Sequence conflicti374 – 3741G → C no nucleotide entry (PubMed:6173134).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807387 Genomic DNA. No translation available.
PIRiA00645. TVMSM.
UniGeneiMm.459300.

Genome annotation databases

UCSCiuc008rwo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807387 Genomic DNA. No translation available.
PIRiA00645. TVMSM.
UniGeneiMm.459300.

3D structure databases

ProteinModelPortaliP00536.
SMRiP00536. Positions 32-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP00536. 1 interaction.
MINTiMINT-1521104.

PTM databases

PhosphoSiteiP00536.

Proteomic databases

PRIDEiP00536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008rwo.1. mouse.

Organism-specific databases

MGIiMGI:97052. Mos.

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG052499.
InParanoidiP00536.

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.

Miscellaneous databases

PROiP00536.
SOURCEiSearch...

Gene expression databases

BgeeiP00536.
CleanExiMM_MOS.
ExpressionAtlasiP00536. baseline.
GenevestigatoriP00536.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the genome of a murine sarcoma virus."
    van Beveren C., van Straaten F., Galleshaw J.A., Verma I.M.
    Cell 27:97-108(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element."
    Rechavi G., Givol D., Canaani E.
    Nature 300:607-611(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-97.
    Strain: BALB/c.

Entry informationi

Entry nameiMOS_MOUSE
AccessioniPrimary (citable) accession number: P00536
Secondary accession number(s): E9PV67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: January 7, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.