P00535 (ERBB_AVIER) Reviewed, UniProtKB/Swiss-Prot
Last modified
July 27, 2011.
Version 87.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tyrosine-protein kinase transforming protein erbB EC=2.7.10.1 | ||
| Gene names |
| ||
| Organism | Avian erythroblastosis virus (strain ES4) | ||
| Taxonomic identifier | 79685 [NCBI] | ||
| Taxonomic lineage | Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Alpharetrovirus | ||
| Virus host | Galliformes [TaxID: 8976] |
Protein attributes
| Sequence length | 604 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | The v-erbB oncogene transforms avian fibroblasts and erythroblasts in culture and induces sarcomas and erythroleukemias in chickens. It is a truncated and mutated version of the receptor for epidermal growth factor. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain. |
| Sequence caution | The sequence AAA42394.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Disease | Oncogene |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase Tyrosine-protein kinase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 604 | 604 | Tyrosine-protein kinase transforming protein erbB | PRO_0000160252 | |||||
Regions | |||||||||
| Domain | 132 – 399 | 268 | Protein kinase | ||||||
| Nucleotide binding | 138 – 146 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 257 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 165 | 1 | ATP By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 29 | 1 | R → W in AAA42394. Ref.2 | ||||||
| Sequence conflict | 140 | 1 | S → F in AAA42394. Ref.2 | ||||||
| Sequence conflict | 146 | 1 | I → V in AAA42394. Ref.2 | ||||||
Sequences
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References
| [1] | "The erbB gene of avian erythroblastosis virus is a member of the src gene family." Yamamoto T., Nishida T., Miyajima N., Kawai S., Ooi T., Toyoshima K. Cell 35:71-78(1983) [PubMed: 6313229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: H. |
| [2] | "Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene." Debuire B., Henry C., Benaissa M., Biserte G., Claverie J.-M., Saule S., Martin P., Stehelin D. Science 224:1456-1459(1984) [PubMed: 6328658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-152. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | K02006 Genomic RNA. Translation: AAA42394.1. Different initiation. K01216 Genomic RNA. Translation: AAA42400.1. |
| PIR | TVYUH. A00644. |
3D structure databases | |
| ProteinModelPortal | P00535. |
| SMR | P00535. Positions 89-423. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 589. |
Family and domain databases | |
| InterPro | IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view] |
| Pfam | PF07714. Pkinase_Tyr. 1 hit. [Graphical view] |
| PRINTS | PR00109. TYRKINASE. |
| SMART | SM00219. TyrKc. 1 hit. [Graphical view] |
| SUPFAM | SSF57184. Grow_fac_recept. 1 hit. SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ERBB_AVIER | ||||||||
| Accession | Primary (citable) accession number: P00535 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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