P00535 (ERBB_AVIER) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transforming protein erbB
EC=2.7.10.1

Gene names

Name:

V-ERBB

Organism

Avian erythroblastosis virus (strain ES4)

Taxonomic identifier

79685 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Alpharetrovirus

Virus host

Galliformes [TaxID: 8976]

Protein attributes

Sequence length	604 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The v-erbB oncogene transforms avian fibroblasts and erythroblasts in culture and induces sarcomas and erythroleukemias in chickens. It is a truncated and mutated version of the receptor for epidermal growth factor.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence AAA42394.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 604	604	Tyrosine-protein kinase transforming protein erbB		PRO_0000160252
Regions
	Domain	132 – 399	268	Protein kinase
	Nucleotide binding	138 – 146	9	ATP By similarity
Sites
	Active site	257	1	Proton acceptor By similarity
	Binding site	165	1	ATP By similarity
Experimental info
	Sequence conflict	29	1	R → W in AAA42394. Ref.2
	Sequence conflict	140	1	S → F in AAA42394. Ref.2
	Sequence conflict	146	1	I → V in AAA42394. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P00535 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 76EBCDD06745D609	FASTA	604	67,633
	10 20 30 40 50 60 MKCAHFIDGP HCVKACPAGV LGENDTLVRK YADANAVCQL CHPNCTRGCK GPGLEGCPNG 70 80 90 100 110 120 SKTPSIAAGV VGGLLCLVVV GLGIGLYLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 130 140 150 160 170 180 QAHLRILKET EFKKVKVLGS GAFGTIYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL 190 200 210 220 230 240 DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPYGCLLD YIREHKDNIG SQYLLNWCVQ 250 260 270 280 290 300 IAKGMNYLEE RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGADEKEYH AEGGKVPIKW 310 320 330 340 350 360 MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSVLEKG ERLPQPPICT 370 380 390 400 410 420 IDVYMIMVKC WMIDADSRPK FRELIAEFSK MARDPPRYLV IQGDERMHLP SPTDSKFYRT 430 440 450 460 470 480 LMEEEDMEDI VDADEYLVPH QGFFNSPSTS RTPLLSSLSA TSNNSATNCI DRNGQGHPVR 490 500 510 520 530 540 EDSFVQRYSS DPTGNFLEES IDDGFLPAPE YVNQLMPKKP STAMVQNQIY NFISLTAISK 550 560 570 580 590 600 LPMDSRYQNS HSTAVDNPEY LNTNQSPLAK TVFESSPYWI QSGNHQINLD NPDYQQDFLP TSCS

References

[1]	"The erbB gene of avian erythroblastosis virus is a member of the src gene family." Yamamoto T., Nishida T., Miyajima N., Kawai S., Ooi T., Toyoshima K. Cell 35:71-78(1983) [PubMed: 6313229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: H.
[2]	"Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene." Debuire B., Henry C., Benaissa M., Biserte G., Claverie J.-M., Saule S., Martin P., Stehelin D. Science 224:1456-1459(1984) [PubMed: 6328658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-152.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02006 Genomic RNA. Translation: AAA42394.1. Different initiation. K01216 Genomic RNA. Translation: AAA42400.1.
PIR	TVYUH. A00644.
3D structure databases
ProteinModelPortal	P00535.
SMR	P00535. Positions 89-423.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.1. 589.
Family and domain databases
InterPro	IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERBB_AVIER

Accession

Primary (citable) accession number: P00535

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	July 27, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program