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P00534

- ERBB_ALV

UniProt

P00534 - ERBB_ALV

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Protein

Tyrosine-protein kinase transforming protein erbB

Gene

V-ERBB

Organism
Avian leukosis virus (ALV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei165 – 1651ATPPROSITE-ProRule annotation
Active sitei257 – 2571Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi138 – 1469ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 590.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein erbB (EC:2.7.10.1)
Gene namesi
Name:V-ERBB
OrganismiAvian leukosis virus (ALV)
Taxonomic identifieri11864 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Tyrosine-protein kinase transforming protein erbBPRO_0000160251Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP00534.
SMRiP00534. Positions 1-58, 89-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 399268Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00534-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKCAHFIDGP HCVKACPAGV LGENDTLVWK YADANAVCQL CHPNCTRGCK
60 70 80 90 100
GPGLEGCPNG SKTPSIAAGV VGGLLCLVVV GLGIGLYLRR RHIVRKRTLR
110 120 130 140 150
RLLQERELVE PLTPSGEAPN QAHLRILKET EFKKVKVLGS GAFGTVYKGL
160 170 180 190 200
WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
210 220 230 240 250
CLTSTVQLIT QLMPYGCLLD YIREHKDNIG SQYLLNWCVQ IAKGMNYLEE
260 270 280 290 300
RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGADEKEYH AEGGKVPIKW
310 320 330 340 350
MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSVLEKG
360 370 380 390 400
ERLPQPPICT IDVYMIMVKC WMIDADSRPK FRELIAEFSK MARDPPRYLV
410 420 430 440 450
IQGDERMHLP SPTDSKFYRT LMEEEDMEDI VDADEYLVPH QGFFNSPSTS
460 470 480 490 500
RTPLLSSLSA TSNNSATNCI DRNGQGHPVR EDSFVQRYSS DPTGNFLEES
510 520 530 540 550
IDDGFLPAPE YVNQLMPKKP STAMVQNQIY NNISLTAISK LPMDSRYQNS
560 570 580 590 600
HSTAVDNPEY LNTNQSPLAK TVFESSPYWI QSGNHQINLD NPDYQQDFLP
610 620 630
NETKPNGLLK VPAAENPEYL RVAAPKSEYI EASA
Length:634
Mass (Da):70,891
Last modified:July 15, 1999 - v2
Checksum:iE705E33A0BE01FCC
GO

Sequence cautioni

The sequence AAA48763.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10066 mRNA. Translation: AAA48763.1. Different initiation.
PIRiB00643. TVFVLV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10066 mRNA. Translation: AAA48763.1 . Different initiation.
PIRi B00643. TVFVLV.

3D structure databases

ProteinModelPortali P00534.
SMRi P00534. Positions 1-58, 89-423.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.1. 590.

Family and domain databases

InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor."
    Nilsen T.W., Maroney P.A., Goodwin R.G., Rottman F.M., Crittenden L.B., Raines M.A., Kung H.-J.
    Cell 41:719-726(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiERBB_ALV
AccessioniPrimary (citable) accession number: P00534
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1999
Last modified: October 1, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by erythroleukemia cells in chickens which have been injected with the avian leukosis virus and subsequently develop leukemia. The leukemias are induced by the insertion of retroviral promoter elements in or near the c-erbB gene, which leads to c-erbB activation.
This protein is synthesized as a Gag-Env-ErbB protein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3