P00534 (ERBB_ALV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase transforming protein erbB
EC=2.7.10.1

Gene names

Name:

V-ERBB

Organism

Avian leukosis virus (ALV)

Taxonomic identifier

11864 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Alpharetrovirus

Virus host

Gallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length	634 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Miscellaneous	This protein is produced by erythroleukemia cells in chickens which have been injected with the avian leukosis virus and subsequently develop leukemia. The leukemias are induced by the insertion of retroviral promoter elements in or near the c-erbB gene, which leads to c-erbB activation. This protein is synthesized as a Gag-Env-ErbB protein.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence AAA48763.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 634	634	Tyrosine-protein kinase transforming protein erbB		PRO_0000160251
Regions
	Domain	132 – 399	268	Protein kinase
	Nucleotide binding	138 – 146	9	ATP By similarity
Sites
	Active site	257	1	Proton acceptor By similarity
	Binding site	165	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P00534 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: E705E33A0BE01FCC	FASTA	634	70,891
	10 20 30 40 50 60 MKCAHFIDGP HCVKACPAGV LGENDTLVWK YADANAVCQL CHPNCTRGCK GPGLEGCPNG 70 80 90 100 110 120 SKTPSIAAGV VGGLLCLVVV GLGIGLYLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 130 140 150 160 170 180 QAHLRILKET EFKKVKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL 190 200 210 220 230 240 DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPYGCLLD YIREHKDNIG SQYLLNWCVQ 250 260 270 280 290 300 IAKGMNYLEE RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGADEKEYH AEGGKVPIKW 310 320 330 340 350 360 MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSVLEKG ERLPQPPICT 370 380 390 400 410 420 IDVYMIMVKC WMIDADSRPK FRELIAEFSK MARDPPRYLV IQGDERMHLP SPTDSKFYRT 430 440 450 460 470 480 LMEEEDMEDI VDADEYLVPH QGFFNSPSTS RTPLLSSLSA TSNNSATNCI DRNGQGHPVR 490 500 510 520 530 540 EDSFVQRYSS DPTGNFLEES IDDGFLPAPE YVNQLMPKKP STAMVQNQIY NNISLTAISK 550 560 570 580 590 600 LPMDSRYQNS HSTAVDNPEY LNTNQSPLAK TVFESSPYWI QSGNHQINLD NPDYQQDFLP 610 620 630 NETKPNGLLK VPAAENPEYL RVAAPKSEYI EASA

References

[1]	"c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor." Nilsen T.W., Maroney P.A., Goodwin R.G., Rottman F.M., Crittenden L.B., Raines M.A., Kung H.-J. Cell 41:719-726(1985) [PubMed: 2988784] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10066 mRNA. Translation: AAA48763.1. Different initiation.
PIR	TVFVLV. B00643.
3D structure databases
ProteinModelPortal	P00534.
SMR	P00534. Positions 1-58, 89-423.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.10.1. 590.
Family and domain databases
InterPro	IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERBB_ALV

Accession

Primary (citable) accession number: P00534

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 15, 1999
Last modified:	July 27, 2011
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program