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P00534

- ERBB_ALV

UniProt

P00534 - ERBB_ALV

Protein

Tyrosine-protein kinase transforming protein erbB

Gene

V-ERBB

Organism
Avian leukosis virus (ALV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei165 – 1651ATPPROSITE-ProRule annotation
    Active sitei257 – 2571Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi138 – 1469ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 590.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transforming protein erbB (EC:2.7.10.1)
    Gene namesi
    Name:V-ERBB
    OrganismiAvian leukosis virus (ALV)
    Taxonomic identifieri11864 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 634634Tyrosine-protein kinase transforming protein erbBPRO_0000160251Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP00534.
    SMRiP00534. Positions 1-58, 89-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini132 – 399268Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00534-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKCAHFIDGP HCVKACPAGV LGENDTLVWK YADANAVCQL CHPNCTRGCK    50
    GPGLEGCPNG SKTPSIAAGV VGGLLCLVVV GLGIGLYLRR RHIVRKRTLR 100
    RLLQERELVE PLTPSGEAPN QAHLRILKET EFKKVKVLGS GAFGTVYKGL 150
    WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 200
    CLTSTVQLIT QLMPYGCLLD YIREHKDNIG SQYLLNWCVQ IAKGMNYLEE 250
    RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGADEKEYH AEGGKVPIKW 300
    MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSVLEKG 350
    ERLPQPPICT IDVYMIMVKC WMIDADSRPK FRELIAEFSK MARDPPRYLV 400
    IQGDERMHLP SPTDSKFYRT LMEEEDMEDI VDADEYLVPH QGFFNSPSTS 450
    RTPLLSSLSA TSNNSATNCI DRNGQGHPVR EDSFVQRYSS DPTGNFLEES 500
    IDDGFLPAPE YVNQLMPKKP STAMVQNQIY NNISLTAISK LPMDSRYQNS 550
    HSTAVDNPEY LNTNQSPLAK TVFESSPYWI QSGNHQINLD NPDYQQDFLP 600
    NETKPNGLLK VPAAENPEYL RVAAPKSEYI EASA 634
    Length:634
    Mass (Da):70,891
    Last modified:July 15, 1999 - v2
    Checksum:iE705E33A0BE01FCC
    GO

    Sequence cautioni

    The sequence AAA48763.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10066 mRNA. Translation: AAA48763.1. Different initiation.
    PIRiB00643. TVFVLV.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10066 mRNA. Translation: AAA48763.1 . Different initiation.
    PIRi B00643. TVFVLV.

    3D structure databases

    ProteinModelPortali P00534.
    SMRi P00534. Positions 1-58, 89-423.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 590.

    Family and domain databases

    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor."
      Nilsen T.W., Maroney P.A., Goodwin R.G., Rottman F.M., Crittenden L.B., Raines M.A., Kung H.-J.
      Cell 41:719-726(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiERBB_ALV
    AccessioniPrimary (citable) accession number: P00534
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is produced by erythroleukemia cells in chickens which have been injected with the avian leukosis virus and subsequently develop leukemia. The leukemias are induced by the insertion of retroviral promoter elements in or near the c-erbB gene, which leads to c-erbB activation.
    This protein is synthesized as a Gag-Env-ErbB protein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3