ID   EGFR$HUMAN     STANDARD;      PRT;  1210 AA.
AC   P00533;
DT   21-JUL-1986  (REL. 01, CREATED)
DT   21-JUL-1986  (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JAN-1988  (REL. 06, LAST ANNOTATION UPDATE)
DE   EPIDERMAL GROWTH FACTOR RECEPTOR (EC 2.7.1.37) (GENE NAME: C-ERBB).
OS   HUMAN (HOMO SAPIENS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1] (SEQUENCE FROM N.A.)
RA   ULLRICH A., COUSSENS L., HAYFLICK J.S., DULL T.J., GRAY A., TAM A.W.,
RA   LEE J., YARDEN Y., LIBERMANN T.A., SCHLESSINGER J., DOWNWARD J.,
RA   MAYES E.L.V., WHITTLE N., WATERFIELD M.D., SEEBURG P.H.;
RL   NATURE 309:418-425(1984).
RN   [2] (SEQUENCE OF 713-924 FROM N.A.)
RA   LIN C.R., CHEN W.S., KRUIGER W., STOLARSKY L.S., WEBER W.,
RA   EVANS R.M., VERMA I.M., GILL G.N., ROSENFELD M.G.;
RL   SCIENCE 224:843-848(1984).
RN   [3] (SEQUENCE OF 1028-1210 FROM N.A.)
RA   SIMMEN F.A., GOPE M.L., SCHULZ T.Z., WRIGHT D.A., CARPENTER G.,
RA   O'MALLEY B.W.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 124:125-132(1984).
RN   [4] (RECEPTOR ACTIVITY)
RA   MROCZKOWSKI B., MOSIG G., COHEN S.;
RL   NATURE 309:270-273(1984).
RN   [5] (REVIEW)
RA   CARPENTER G.;
RL   ANNU. REV. BIOCHEM. 56:881-914(1987).
CC   -!- THE EGF RECEPTOR MEDIATES THE BIOLOGICAL SIGNAL OF EGF AND ALSO OF
CC       TRANSFORMING GROWTH FACTOR ALPHA AND VACCINIA VIRUS GROWTH FACTOR.
CC   -!- BINDING OF EGF TO THE RECEPTOR LEADS TO INTERNALIZATION OF THE
CC       EGF-RECEPTOR COMPLEX, INDUCTION OF THE TYROSINE KINASE ACTIVITY,
CC       STIMULATION OF CELL DNA SYNTHESIS, AND CELL PROLIFERATION.
CC   -!- REF. 1 AUTHORS TRANSLATED THE CODON AAG FOR RESIDUE 540 AS ASN.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A00641; GQHUE.
DR   EMBL; X00588; HSEGFPRE.
DR   EMBL; K02047; HSEGFR.
DR   EMBL; K01885; HSEGFRCP.
KW   TRANSMEMBRANE; GLYCOPROTEIN; DUPLICATION; RECEPTOR; SIGNAL;
KW   TYROSINE-PROTEIN KINASE; PHOSPHORYLATION.
FT   SIGNAL        1     24
FT   CHAIN        25   1210       EGF RECEPTOR.
FT   DOMAIN       25    645       EXTRACELLULAR (INCLUDES EGF BINDING SITE
FT                                & 12/15 POTENTIAL CARBOHYDRATE SITES).
FT   TRANSMEM    646    668
FT   DOMAIN      669   1210       CYTOPLASMIC (TYROSINE-SPECIFIC PROTEIN
FT                                KINASE ACTIVITY).
FT   REPEAT       75    300       APPROXIMATE.
FT   REPEAT      390    600       APPROXIMATE.
FT   SIMILAR     580   1182       HIGH, WITH THE ERBB TRANSFORMING PROTEIN.
FT   ACT_SITE    745    745       ESSENTIAL FOR BINDING TO ATP.
FT   BINDING     855    857       ATP.
FT   MOD_RES     678    678       PHOSPHORYLATION (BY PROTEIN C KINASE).
FT   MOD_RES    1092   1092       PHOSPHORYLATION (AUTO).
FT   MOD_RES    1172   1172       PHOSPHORYLATION (AUTO).
FT   MOD_RES    1197   1197       PHOSPHORYLATION (AUTO, MAJOR SITE).
SQ   SEQUENCE   1210 AA;  134290 MW;  7507159 CN;
     MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV
     VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA
     VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF
     QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC
     TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
     VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK
     NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF
     ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL
     FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCK
     LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM
     GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV
     ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS
     GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
     CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA
     RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
     GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK
     FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ
     QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED
     SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN
     TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV
     APQSSEFIGA
//