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P00532

- RAF_MSV36

UniProt

P00532 - RAF_MSV36

Protein

Serine/threonine-protein kinase-transforming protein raf

Gene

V-RAF

Organism
Murine sarcoma virus 3611
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501ATPPROSITE-ProRule annotation
    Active sitei143 – 1431Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 389ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3471.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase-transforming protein raf (EC:2.7.11.1)
    Gene namesi
    Name:V-RAF
    OrganismiMurine sarcoma virus 3611
    Taxonomic identifieri11812 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Serine/threonine-protein kinase-transforming protein rafPRO_0000086601Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP00532.
    SMRiP00532. Positions 17-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 284261Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00532-1 [UniParc]FASTAAdd to Basket

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    EKNKIRPRGQ RDSSYYWKME ASEVMLSTRI GSGSFGTVYK GKWHGDVAVK    50
    ILKVVDPTPE QLQAFRNEVA VLRKTRHVNI LLFMGYMTKD NLAIVTQWCE 100
    GSSLYKHLHV QETKFQMFQL IDIARQTAQG MDYLHAKNII HRDMKSNNIF 150
    LHEGLTVKIG DFGLATVKSR WSGSQQVEQP TGSVLWMAPE VIRMQDDNPF 200
    SFQSDVYSYG IVLYELMAGE LPYAHINNRD QIIFMVGRGY ASPDLSRLYK 250
    NCPKAIKRLV ADCVKKVKEE RPLFPQILSS IELLQHSLPK INRSAPEPSL 300
    HRAAHTEDIN ACTLTTSPRL PVF 323
    Length:323
    Mass (Da):36,884
    Last modified:July 21, 1986 - v1
    Checksum:i52A5423A66E362F3
    GO

    Sequence cautioni

    The sequence AAA46579.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01691 Genomic RNA. Translation: AAA46579.1. Different initiation.
    PIRiA00638. TVMVF6.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01691 Genomic RNA. Translation: AAA46579.1 . Different initiation.
    PIRi A00638. TVMVF6.

    3D structure databases

    ProteinModelPortali P00532.
    SMRi P00532. Positions 17-290.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3471.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A common onc gene sequence transduced by avian carcinoma virus MH2 and by murine sarcoma virus 3611."
      Kan N.C., Flordellis C.S., Mark G.E., Duesberg P.H., Papas T.S.
      Science 223:813-816(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Primary structure of v-raf: relatedness to the src family of oncogenes."
      Mark G.E., Rapp U.R.
      Science 224:285-289(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRAF_MSV36
    AccessioniPrimary (citable) accession number: P00532
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Raf polyprotein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3