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Protein

Tyrosine-protein kinase transforming protein Fps

Gene

V-FPS

Organism
Fujinami sarcoma virus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPPROSITE-ProRule annotation1
Active sitei734Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi618 – 626ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2335.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Fps (EC:2.7.10.2)
Gene namesi
Name:V-FPS
OrganismiFujinami sarcoma virus
Taxonomic identifieri11885 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Chemistry databases

ChEMBLiCHEMBL5708.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000880961 – 873Tyrosine-protein kinase transforming protein FpsAdd BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei764Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Chemistry databases

BindingDBiP00530.

Structurei

3D structure databases

ProteinModelPortaliP00530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 313F-BARPROSITE-ProRule annotationAdd BLAST264
Domaini511 – 600SH2PROSITE-ProRule annotationAdd BLAST90
Domaini612 – 865Protein kinasePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation
Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF197. PTHR24418:SF197. 1 hit.
PfamiPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000632. TyrPK_fps. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASGQLHRPQP QEHTSTSAAA GTWRLTQASE SRHRLPHCSA APSHQDHSAM
60 70 80 90 100
GFGPELWCPK GHTELLRLQD SELRLLELMK KWMSQRAKSD REYAGMLHHM
110 120 130 140 150
FSQLEKQEGL GHLRATDHSS QIGESWWVLA SQTETLSQTL RRHAEELAAG
160 170 180 190 200
PLAKLSILIR DKQQLRKVFS EQWQQLSQEY AWTTQQEVEK LKAQYRSLVR
210 220 230 240 250
DSTQAKRKYQ EASKDKEREK AKEKYVRSLS KLYALHNQYV LAVQAAALHH
260 270 280 290 300
HHHYQRALPT LHESLYSLQQ EMVLVLKEIL GEYCSITSLV QEDVLAIHQK
310 320 330 340 350
VAHAVEMIDP ATEYSSFVQC HRYDSEVPPA VTFDESLLEE AENLEPGELQ
360 370 380 390 400
LNELTIESVQ HSLTSIEEEL LASRKAVSSK EQRVWELQVE LRGEELALSP
410 420 430 440 450
GERVHLLGKR QGLREAQQQL QGLVCAQAKL QAQRDMLANK LAELGSEEPP
460 470 480 490 500
PALPLQEDRQ SARSTDQERS GVTALKTIKN HISGIFSPRF SLPPPVPLIP
510 520 530 540 550
EVQKPLCQQA WYHGAIPRSE VQELLKYSGD FLVRESQGKQ EYVLSVLWDG
560 570 580 590 600
QPRHFIIQAA DNLYRLEDDG LPTIPLLIDH LLQSQRPITR KSGIVLTRAV
610 620 630 640 650
LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV KSCRETLPPE
660 670 680 690 700
LKAKFLQEAR ILKQCNHPNI VRLIGVCTQK QPIYIVMELV QGGDFLSFLR
710 720 730 740 750
SKGPRLKMKK LIKMMENAAA GMEYLESKHC IHRDLAARNC LVTEKNTLKI
760 770 780 790 800
SDFGMSRQEE DGVYASTGGM KQIPVKWTAP EALNYGWYSS ESDVWSFGIL
810 820 830 840 850
LWEAFSLGAV PYANLSNQQT REAIEQGVRL EPPEQCPEDV YRLMQRCWEY
860 870
DPHRRPSFGA VHQDLIAIRK RHR
Length:873
Mass (Da):99,536
Last modified:July 21, 1986 - v1
Checksum:i1D774D48B18466B6
GO

Sequence cautioni

The sequence AAA42402 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti63T → S in clone TS. 1
Natural varianti251H → R in clone TS. 1
Natural varianti300K → E in clone TS. 1
Natural varianti343N → S in clone TS. 1
Natural varianti438A → T in clone TS. 1
Natural varianti447E → D in clone TS. 1
Natural varianti463R → C in clone TS. 1
Natural varianti716E → D in clone TS. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02194 Genomic RNA. Translation: AAA42402.1. Different initiation.
M14930 Genomic RNA. Translation: AAA42403.1.
PIRiA00636. TVFVF.
A26898. TVFVFS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02194 Genomic RNA. Translation: AAA42402.1. Different initiation.
M14930 Genomic RNA. Translation: AAA42403.1.
PIRiA00636. TVFVF.
A26898. TVFVFS.

3D structure databases

ProteinModelPortaliP00530.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP00530.
ChEMBLiCHEMBL5708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.10.2. 2335.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF197. PTHR24418:SF197. 1 hit.
PfamiPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000632. TyrPK_fps. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPS_FUJSV
AccessioniPrimary (citable) accession number: P00530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 5, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fps polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.