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P00530 (FPS_FUJSV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Fps

EC=2.7.10.2
Gene names
Name:V-FPS
OrganismFujinami sarcoma virus
Taxonomic identifier11885 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length873 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as a Gag-Fps polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

Contains 1 FCH domain.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Sequence caution

The sequence AAA42402.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 873873Tyrosine-protein kinase transforming protein Fps
PRO_0000088096

Regions

Domain50 – 12273FCH
Domain511 – 60090SH2
Domain612 – 865254Protein kinase
Nucleotide binding618 – 6269ATP By similarity

Sites

Active site7341Proton acceptor By similarity
Binding site6411ATP By similarity

Amino acid modifications

Modified residue7641Phosphotyrosine; by autocatalysis By similarity

Natural variations

Natural variant631T → S in clone TS.
Natural variant2511H → R in clone TS.
Natural variant3001K → E in clone TS.
Natural variant3431N → S in clone TS.
Natural variant4381A → T in clone TS.
Natural variant4471E → D in clone TS.
Natural variant4631R → C in clone TS.
Natural variant7161E → D in clone TS.

Sequences

Sequence LengthMass (Da)Tools
P00530 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 1D774D48B18466B6

FASTA87399,536
        10         20         30         40         50         60 
ASGQLHRPQP QEHTSTSAAA GTWRLTQASE SRHRLPHCSA APSHQDHSAM GFGPELWCPK 

        70         80         90        100        110        120 
GHTELLRLQD SELRLLELMK KWMSQRAKSD REYAGMLHHM FSQLEKQEGL GHLRATDHSS 

       130        140        150        160        170        180 
QIGESWWVLA SQTETLSQTL RRHAEELAAG PLAKLSILIR DKQQLRKVFS EQWQQLSQEY 

       190        200        210        220        230        240 
AWTTQQEVEK LKAQYRSLVR DSTQAKRKYQ EASKDKEREK AKEKYVRSLS KLYALHNQYV 

       250        260        270        280        290        300 
LAVQAAALHH HHHYQRALPT LHESLYSLQQ EMVLVLKEIL GEYCSITSLV QEDVLAIHQK 

       310        320        330        340        350        360 
VAHAVEMIDP ATEYSSFVQC HRYDSEVPPA VTFDESLLEE AENLEPGELQ LNELTIESVQ 

       370        380        390        400        410        420 
HSLTSIEEEL LASRKAVSSK EQRVWELQVE LRGEELALSP GERVHLLGKR QGLREAQQQL 

       430        440        450        460        470        480 
QGLVCAQAKL QAQRDMLANK LAELGSEEPP PALPLQEDRQ SARSTDQERS GVTALKTIKN 

       490        500        510        520        530        540 
HISGIFSPRF SLPPPVPLIP EVQKPLCQQA WYHGAIPRSE VQELLKYSGD FLVRESQGKQ 

       550        560        570        580        590        600 
EYVLSVLWDG QPRHFIIQAA DNLYRLEDDG LPTIPLLIDH LLQSQRPITR KSGIVLTRAV 

       610        620        630        640        650        660 
LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV KSCRETLPPE LKAKFLQEAR 

       670        680        690        700        710        720 
ILKQCNHPNI VRLIGVCTQK QPIYIVMELV QGGDFLSFLR SKGPRLKMKK LIKMMENAAA 

       730        740        750        760        770        780 
GMEYLESKHC IHRDLAARNC LVTEKNTLKI SDFGMSRQEE DGVYASTGGM KQIPVKWTAP 

       790        800        810        820        830        840 
EALNYGWYSS ESDVWSFGIL LWEAFSLGAV PYANLSNQQT REAIEQGVRL EPPEQCPEDV 

       850        860        870 
YRLMQRCWEY DPHRRPSFGA VHQDLIAIRK RHR 

« Hide

References

[1]"Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses."
Shibuya M., Hanafusa H.
Cell 30:787-795(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Single amino acid substitution, from Glu1025 to Asp, of the fps oncogenic protein causes temperature sensitivity in transformation and kinase activity."
Chen L.H., Hatada E., Wheatley W., Lee W.H.
Virology 155:106-119(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] (CLONE TS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02194 Genomic RNA. Translation: AAA42402.1. Different initiation.
M14930 Genomic RNA. Translation: AAA42403.1.
PIRTVFVF. A00636.
TVFVFS. A26898.

3D structure databases

ProteinModelPortalP00530.
SMRP00530. Positions 500-872.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP00530.
ChEMBLCHEMBL5708.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 2335.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24418:SF85. PTHR24418:SF85. 1 hit.
PfamPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFPIRSF000632. TyrPK_fps. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFPS_FUJSV
AccessionPrimary (citable) accession number: P00530
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families