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P00530

- FPS_FUJSV

UniProt

P00530 - FPS_FUJSV

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Protein

Tyrosine-protein kinase transforming protein Fps

Gene

V-FPS

Organism
Fujinami sarcoma virus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPPROSITE-ProRule annotation
Active sitei734 – 7341Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi618 – 6269ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2335.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Fps (EC:2.7.10.2)
Gene namesi
Name:V-FPS
OrganismiFujinami sarcoma virus
Taxonomic identifieri11885 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Tyrosine-protein kinase transforming protein FpsPRO_0000088096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei764 – 7641Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP00530.
SMRiP00530. Positions 500-872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 12273FCHPROSITE-ProRule annotationAdd
BLAST
Domaini511 – 60090SH2PROSITE-ProRule annotationAdd
BLAST
Domaini612 – 865254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation
Contains 1 FCH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000632. TyrPK_fps. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00530-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ASGQLHRPQP QEHTSTSAAA GTWRLTQASE SRHRLPHCSA APSHQDHSAM
60 70 80 90 100
GFGPELWCPK GHTELLRLQD SELRLLELMK KWMSQRAKSD REYAGMLHHM
110 120 130 140 150
FSQLEKQEGL GHLRATDHSS QIGESWWVLA SQTETLSQTL RRHAEELAAG
160 170 180 190 200
PLAKLSILIR DKQQLRKVFS EQWQQLSQEY AWTTQQEVEK LKAQYRSLVR
210 220 230 240 250
DSTQAKRKYQ EASKDKEREK AKEKYVRSLS KLYALHNQYV LAVQAAALHH
260 270 280 290 300
HHHYQRALPT LHESLYSLQQ EMVLVLKEIL GEYCSITSLV QEDVLAIHQK
310 320 330 340 350
VAHAVEMIDP ATEYSSFVQC HRYDSEVPPA VTFDESLLEE AENLEPGELQ
360 370 380 390 400
LNELTIESVQ HSLTSIEEEL LASRKAVSSK EQRVWELQVE LRGEELALSP
410 420 430 440 450
GERVHLLGKR QGLREAQQQL QGLVCAQAKL QAQRDMLANK LAELGSEEPP
460 470 480 490 500
PALPLQEDRQ SARSTDQERS GVTALKTIKN HISGIFSPRF SLPPPVPLIP
510 520 530 540 550
EVQKPLCQQA WYHGAIPRSE VQELLKYSGD FLVRESQGKQ EYVLSVLWDG
560 570 580 590 600
QPRHFIIQAA DNLYRLEDDG LPTIPLLIDH LLQSQRPITR KSGIVLTRAV
610 620 630 640 650
LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV KSCRETLPPE
660 670 680 690 700
LKAKFLQEAR ILKQCNHPNI VRLIGVCTQK QPIYIVMELV QGGDFLSFLR
710 720 730 740 750
SKGPRLKMKK LIKMMENAAA GMEYLESKHC IHRDLAARNC LVTEKNTLKI
760 770 780 790 800
SDFGMSRQEE DGVYASTGGM KQIPVKWTAP EALNYGWYSS ESDVWSFGIL
810 820 830 840 850
LWEAFSLGAV PYANLSNQQT REAIEQGVRL EPPEQCPEDV YRLMQRCWEY
860 870
DPHRRPSFGA VHQDLIAIRK RHR
Length:873
Mass (Da):99,536
Last modified:July 21, 1986 - v1
Checksum:i1D774D48B18466B6
GO

Sequence cautioni

The sequence AAA42402.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631T → S in clone TS.
Natural varianti251 – 2511H → R in clone TS.
Natural varianti300 – 3001K → E in clone TS.
Natural varianti343 – 3431N → S in clone TS.
Natural varianti438 – 4381A → T in clone TS.
Natural varianti447 – 4471E → D in clone TS.
Natural varianti463 – 4631R → C in clone TS.
Natural varianti716 – 7161E → D in clone TS.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02194 Genomic RNA. Translation: AAA42402.1. Different initiation.
M14930 Genomic RNA. Translation: AAA42403.1.
PIRiA00636. TVFVF.
A26898. TVFVFS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02194 Genomic RNA. Translation: AAA42402.1 . Different initiation.
M14930 Genomic RNA. Translation: AAA42403.1 .
PIRi A00636. TVFVF.
A26898. TVFVFS.

3D structure databases

ProteinModelPortali P00530.
SMRi P00530. Positions 500-872.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P00530.
ChEMBLi CHEMBL5708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2335.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000632. TyrPK_fps. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses."
    Shibuya M., Hanafusa H.
    Cell 30:787-795(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Single amino acid substitution, from Glu1025 to Asp, of the fps oncogenic protein causes temperature sensitivity in transformation and kinase activity."
    Chen L.H., Hatada E., Wheatley W., Lee W.H.
    Virology 155:106-119(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] (CLONE TS).

Entry informationi

Entry nameiFPS_FUJSV
AccessioniPrimary (citable) accession number: P00530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fps polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3