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P00530

- FPS_FUJSV

UniProt

P00530 - FPS_FUJSV

Protein

Tyrosine-protein kinase transforming protein Fps

Gene

V-FPS

Organism
Fujinami sarcoma virus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPPROSITE-ProRule annotation
    Active sitei734 – 7341Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi618 – 6269ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2335.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transforming protein Fps (EC:2.7.10.2)
    Gene namesi
    Name:V-FPS
    OrganismiFujinami sarcoma virus
    Taxonomic identifieri11885 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Tyrosine-protein kinase transforming protein FpsPRO_0000088096Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei764 – 7641Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP00530.
    SMRiP00530. Positions 500-872.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 12273FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini511 – 60090SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini612 – 865254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.PROSITE-ProRule annotation
    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR016250. Tyr-prot_kinase_Fes/Fps.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000632. TyrPK_fps. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00530-1 [UniParc]FASTAAdd to Basket

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    ASGQLHRPQP QEHTSTSAAA GTWRLTQASE SRHRLPHCSA APSHQDHSAM    50
    GFGPELWCPK GHTELLRLQD SELRLLELMK KWMSQRAKSD REYAGMLHHM 100
    FSQLEKQEGL GHLRATDHSS QIGESWWVLA SQTETLSQTL RRHAEELAAG 150
    PLAKLSILIR DKQQLRKVFS EQWQQLSQEY AWTTQQEVEK LKAQYRSLVR 200
    DSTQAKRKYQ EASKDKEREK AKEKYVRSLS KLYALHNQYV LAVQAAALHH 250
    HHHYQRALPT LHESLYSLQQ EMVLVLKEIL GEYCSITSLV QEDVLAIHQK 300
    VAHAVEMIDP ATEYSSFVQC HRYDSEVPPA VTFDESLLEE AENLEPGELQ 350
    LNELTIESVQ HSLTSIEEEL LASRKAVSSK EQRVWELQVE LRGEELALSP 400
    GERVHLLGKR QGLREAQQQL QGLVCAQAKL QAQRDMLANK LAELGSEEPP 450
    PALPLQEDRQ SARSTDQERS GVTALKTIKN HISGIFSPRF SLPPPVPLIP 500
    EVQKPLCQQA WYHGAIPRSE VQELLKYSGD FLVRESQGKQ EYVLSVLWDG 550
    QPRHFIIQAA DNLYRLEDDG LPTIPLLIDH LLQSQRPITR KSGIVLTRAV 600
    LKDKWVLNHE DVLLGERIGR GNFGEVFSGR LRADNTPVAV KSCRETLPPE 650
    LKAKFLQEAR ILKQCNHPNI VRLIGVCTQK QPIYIVMELV QGGDFLSFLR 700
    SKGPRLKMKK LIKMMENAAA GMEYLESKHC IHRDLAARNC LVTEKNTLKI 750
    SDFGMSRQEE DGVYASTGGM KQIPVKWTAP EALNYGWYSS ESDVWSFGIL 800
    LWEAFSLGAV PYANLSNQQT REAIEQGVRL EPPEQCPEDV YRLMQRCWEY 850
    DPHRRPSFGA VHQDLIAIRK RHR 873
    Length:873
    Mass (Da):99,536
    Last modified:July 21, 1986 - v1
    Checksum:i1D774D48B18466B6
    GO

    Sequence cautioni

    The sequence AAA42402.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631T → S in clone TS.
    Natural varianti251 – 2511H → R in clone TS.
    Natural varianti300 – 3001K → E in clone TS.
    Natural varianti343 – 3431N → S in clone TS.
    Natural varianti438 – 4381A → T in clone TS.
    Natural varianti447 – 4471E → D in clone TS.
    Natural varianti463 – 4631R → C in clone TS.
    Natural varianti716 – 7161E → D in clone TS.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02194 Genomic RNA. Translation: AAA42402.1. Different initiation.
    M14930 Genomic RNA. Translation: AAA42403.1.
    PIRiA00636. TVFVF.
    A26898. TVFVFS.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02194 Genomic RNA. Translation: AAA42402.1 . Different initiation.
    M14930 Genomic RNA. Translation: AAA42403.1 .
    PIRi A00636. TVFVF.
    A26898. TVFVFS.

    3D structure databases

    ProteinModelPortali P00530.
    SMRi P00530. Positions 500-872.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P00530.
    ChEMBLi CHEMBL5708.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2335.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR001060. FCH_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR016250. Tyr-prot_kinase_Fes/Fps.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000632. TyrPK_fps. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00055. FCH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses."
      Shibuya M., Hanafusa H.
      Cell 30:787-795(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Single amino acid substitution, from Glu1025 to Asp, of the fps oncogenic protein causes temperature sensitivity in transformation and kinase activity."
      Chen L.H., Hatada E., Wheatley W., Lee W.H.
      Virology 155:106-119(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] (CLONE TS).

    Entry informationi

    Entry nameiFPS_FUJSV
    AccessioniPrimary (citable) accession number: P00530
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Fps polyprotein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3