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P00527

- YES_AVISY

UniProt

P00527 - YES_AVISY

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Protein

Tyrosine-protein kinase transforming protein Yes

Gene
V-YES
Organism
Avian sarcoma virus (strain Y73)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei295 – 2951ATP By similarity
Active sitei386 – 3861Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi273 – 2819ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 600.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Yes (EC:2.7.10.2)
Gene namesi
Name:V-YES
OrganismiAvian sarcoma virus (strain Y73)
Taxonomic identifieri11884 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostiGalliformes [TaxID: 8976]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 528›528Tyrosine-protein kinase transforming protein YesPRO_0000088179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei416 – 4161Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP00527.

Structurei

3D structure databases

ProteinModelPortaliP00527.
SMRiP00527. Positions 84-525.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 14262SH3Add
BLAST
Domaini148 – 24598SH2Add
BLAST
Domaini267 – 520254Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P00527-1 [UniParc]FASTAAdd to Basket

« Hide

DKGPAMKYRT DNTPEPISSH VSHYGSDSSQ ATQSPAIKGS AVNFNSHSMT    50
PFGGPSGMTP FGGASSSFSA VPSPYPSTLT GGGTVFVALY DYEARTTDDL 100
SFKGGERFQI INNTEGDWWE ARSIATGKTG YIPSNYVAPA DSIEAEEWYF 150
GKMGRKDAER LLLNPGNQRG IFLVRESETT KGAYSLSIRD WDEVRGDNVK 200
HYKIRKLDNG GYYITTRAQF ESLQKLVKHS REHADGLCHK LTTVCPTVKP 250
QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT KVAIKTLKLG 300
TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MTKGSLLDFL 350
KEGEGKFLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGDNLVC 400
KIADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI 450
LLTELVTKGR VPYPGMVNRE VLEQVERGYR MPCPQGCPES LHELMKLCWK 500
KDPDERPTFE YIQSFLEDYF TAAEPSGY 528
Length:528
Mass (Da):59,104
Last modified:February 1, 1996 - v2
Checksum:i98F748C8879D7709
GO

Sequence cautioni

The sequence CAA24496.1 differs from that shown. Reason: Erroneous initiation.

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01170 Unassigned RNA. Translation: CAA24496.1. Different initiation.
PIRiA00633. TVFVG9.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01170 Unassigned RNA. Translation: CAA24496.1 . Different initiation.
PIRi A00633. TVFVG9.

3D structure databases

ProteinModelPortali P00527.
SMRi P00527. Positions 84-525.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P00527.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 600.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus."
    Kitamura N., Kitamura A., Toyoshima K., Hirayama Y., Yoshida M.
    Nature 297:205-208(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiYES_AVISY
AccessioniPrimary (citable) accession number: P00527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Yes polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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