Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P00527 (YES_AVISY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Yes

EC=2.7.10.2
Gene names
Name:V-YES
OrganismAvian sarcoma virus (strain Y73)
Taxonomic identifier11884 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostGalliformes [TaxID: 8976]

Protein attributes

Sequence length528 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as a Gag-Yes polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence caution

The sequence CAA24496.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 528›528Tyrosine-protein kinase transforming protein Yes
PRO_0000088179

Regions

Domain81 – 14262SH3
Domain148 – 24598SH2
Domain267 – 520254Protein kinase
Nucleotide binding273 – 2819ATP By similarity

Sites

Active site3861Proton acceptor By similarity
Binding site2951ATP By similarity

Amino acid modifications

Modified residue4161Phosphotyrosine; by autocatalysis By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P00527 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 98F748C8879D7709

FASTA52859,104
        10         20         30         40         50         60 
DKGPAMKYRT DNTPEPISSH VSHYGSDSSQ ATQSPAIKGS AVNFNSHSMT PFGGPSGMTP 

        70         80         90        100        110        120 
FGGASSSFSA VPSPYPSTLT GGGTVFVALY DYEARTTDDL SFKGGERFQI INNTEGDWWE 

       130        140        150        160        170        180 
ARSIATGKTG YIPSNYVAPA DSIEAEEWYF GKMGRKDAER LLLNPGNQRG IFLVRESETT 

       190        200        210        220        230        240 
KGAYSLSIRD WDEVRGDNVK HYKIRKLDNG GYYITTRAQF ESLQKLVKHS REHADGLCHK 

       250        260        270        280        290        300 
LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT KVAIKTLKLG 

       310        320        330        340        350        360 
TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MTKGSLLDFL KEGEGKFLKL 

       370        380        390        400        410        420 
PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGDNLVC KIADFGLARL IEDNEYTARQ 

       430        440        450        460        470        480 
GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LLTELVTKGR VPYPGMVNRE VLEQVERGYR 

       490        500        510        520 
MPCPQGCPES LHELMKLCWK KDPDERPTFE YIQSFLEDYF TAAEPSGY 

« Hide

References

[1]"Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus."
Kitamura N., Kitamura A., Toyoshima K., Hirayama Y., Yoshida M.
Nature 297:205-208(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V01170 Unassigned RNA. Translation: CAA24496.1. Different initiation.
PIRTVFVG9. A00633.

3D structure databases

ProteinModelPortalP00527.
SMRP00527. Positions 84-525.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP00527.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 600.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYES_AVISY
AccessionPrimary (citable) accession number: P00527
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families