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P00521

- ABL_MLVAB

UniProt

P00521 - ABL_MLVAB

Protein

Tyrosine-protein kinase transforming protein Abl

Gene

ABL

Organism
Abelson murine leukemia virus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei157 – 1571ATPPROSITE-ProRule annotation
    Active sitei249 – 2491Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi134 – 1429ATPPROSITE-ProRule annotation
    Nucleotide bindingi202 – 2087ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1.
    SABIO-RKP00521.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase transforming protein Abl (EC:2.7.10.2)
    Alternative name(s):
    V-abl
    Gene namesi
    Name:ABL
    OrganismiAbelson murine leukemia virus
    Taxonomic identifieri11788 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 746746Tyrosine-protein kinase transforming protein AblPRO_0000088057Add
    BLAST

    Proteomic databases

    PRIDEiP00521.

    Interactioni

    Protein-protein interaction databases

    IntActiP00521. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP00521.
    SMRiP00521. Positions 1-398, 640-746.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 10391SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini128 – 379252Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi267 – 29125Kinase activation loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR015015. F-actin_binding.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF08919. F_actin_bind. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00808. FABD. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P00521-1 [UniParc]FASTAAdd to Basket

    « Hide

    YITPVNSLEK HSWYHGPVSR NAAEYLLSSG INGSFLVRES ESSPGQRSIS    50
    LRYEGRVYHY RINTASDGKL YVSSESRFNT LAELVHHHST VADGLITTLH 100
    YPAPKRNKPT IYGVSPNYDK WEMERTDITM KHKLGGGQYG EVYEGVWKKY 150
    SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTREPPFYII 200
    TEFMTYGNLL DYLRECNRQE VSAVVLLYMA TQISSAMEYL EKKNFIHRDL 250
    AARNCLVGEN HLVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN 300
    KFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYELLEK DYRMERPEGC 350
    PEKVYELMRA CWQWNPSDRP SFAEIHQAFE TMFQESSISD EVEKELGKRG 400
    TRGGAGSMLQ APELPTKTRT CRRAAEQKAS PPSLTPKLLR RQVTASPSSG 450
    LSHKKEATKG SASGMGTPAT AEPAPPSNKV GLSKASSEEM RVRRHKHSSE 500
    SPGRDKGRLA KLKPAPPPPP ACTGKAGKPA QSPSQEAGEA GGPTKTKCTS 550
    LAMDAVNTDP TKAGPPGEGL RKPVPPSVPK PQSTAKPPGT PTSPVSTPST 600
    APAPSPLAGD QQPSSAAFIP LISTRVSLRK TRQPPERIAS GTITKGVVLD 650
    STEALCLAIS RNSEQMASHS AVLEAGKNLY TFCVSYVDSI QQMRNKFAFR 700
    EAINKLESNL RELQICPATA SSGPAATQDF SKLLSSVKEI SDIVRR 746
    Length:746
    Mass (Da):81,872
    Last modified:July 21, 1986 - v1
    Checksum:iB9072FFF55FE9257
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01541 Genomic DNA. No translation available.
    K00010 Genomic RNA. Translation: AAA46470.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01541 Genomic DNA. No translation available.
    K00010 Genomic RNA. Translation: AAA46470.1 .

    3D structure databases

    ProteinModelPortali P00521.
    SMRi P00521. Positions 1-398, 640-746.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P00521. 1 interaction.

    Chemistry

    BindingDBi P00521.
    ChEMBLi CHEMBL5166.

    Proteomic databases

    PRIDEi P00521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1.
    SABIO-RK P00521.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR015015. F-actin_binding.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF08919. F_actin_bind. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00808. FABD. 1 hit.
    SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity."
      Reddy E.P., Smith M.J., Srinivasan A.
      Proc. Natl. Acad. Sci. U.S.A. 80:3623-3627(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Erratum
      Reddy E.P., Smith M.J., Srinivasan A.
      Proc. Natl. Acad. Sci. U.S.A. 80:7372-7372(1983)
      Cited for: SEQUENCE REVISION TO 588-746.
    3. "Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products."
      Groffen J., Heisterkamp N., Reynolds F.H. Jr., Stephenson J.R.
      Nature 304:167-169(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 233-327.

    Entry informationi

    Entry nameiABL_MLVAB
    AccessioniPrimary (citable) accession number: P00521
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Abl polyprotein.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3