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P00521

- ABL_MLVAB

UniProt

P00521 - ABL_MLVAB

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Protein

Tyrosine-protein kinase transforming protein Abl

Gene

ABL

Organism
Abelson murine leukemia virus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571ATPPROSITE-ProRule annotation
Active sitei249 – 2491Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi134 – 1429ATPPROSITE-ProRule annotation
Nucleotide bindingi202 – 2087ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1.
SABIO-RKP00521.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Abl (EC:2.7.10.2)
Alternative name(s):
V-abl
Gene namesi
Name:ABL
OrganismiAbelson murine leukemia virus
Taxonomic identifieri11788 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Tyrosine-protein kinase transforming protein AblPRO_0000088057Add
BLAST

Proteomic databases

PRIDEiP00521.

Interactioni

Protein-protein interaction databases

IntActiP00521. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP00521.
SMRiP00521. Positions 1-398, 640-746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10391SH2PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 379252Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi267 – 29125Kinase activation loopBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00521-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
YITPVNSLEK HSWYHGPVSR NAAEYLLSSG INGSFLVRES ESSPGQRSIS
60 70 80 90 100
LRYEGRVYHY RINTASDGKL YVSSESRFNT LAELVHHHST VADGLITTLH
110 120 130 140 150
YPAPKRNKPT IYGVSPNYDK WEMERTDITM KHKLGGGQYG EVYEGVWKKY
160 170 180 190 200
SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTREPPFYII
210 220 230 240 250
TEFMTYGNLL DYLRECNRQE VSAVVLLYMA TQISSAMEYL EKKNFIHRDL
260 270 280 290 300
AARNCLVGEN HLVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN
310 320 330 340 350
KFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYELLEK DYRMERPEGC
360 370 380 390 400
PEKVYELMRA CWQWNPSDRP SFAEIHQAFE TMFQESSISD EVEKELGKRG
410 420 430 440 450
TRGGAGSMLQ APELPTKTRT CRRAAEQKAS PPSLTPKLLR RQVTASPSSG
460 470 480 490 500
LSHKKEATKG SASGMGTPAT AEPAPPSNKV GLSKASSEEM RVRRHKHSSE
510 520 530 540 550
SPGRDKGRLA KLKPAPPPPP ACTGKAGKPA QSPSQEAGEA GGPTKTKCTS
560 570 580 590 600
LAMDAVNTDP TKAGPPGEGL RKPVPPSVPK PQSTAKPPGT PTSPVSTPST
610 620 630 640 650
APAPSPLAGD QQPSSAAFIP LISTRVSLRK TRQPPERIAS GTITKGVVLD
660 670 680 690 700
STEALCLAIS RNSEQMASHS AVLEAGKNLY TFCVSYVDSI QQMRNKFAFR
710 720 730 740
EAINKLESNL RELQICPATA SSGPAATQDF SKLLSSVKEI SDIVRR
Length:746
Mass (Da):81,872
Last modified:July 21, 1986 - v1
Checksum:iB9072FFF55FE9257
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01541 Genomic DNA. No translation available.
K00010 Genomic RNA. Translation: AAA46470.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01541 Genomic DNA. No translation available.
K00010 Genomic RNA. Translation: AAA46470.1 .

3D structure databases

ProteinModelPortali P00521.
SMRi P00521. Positions 1-398, 640-746.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00521. 1 interaction.

Chemistry

BindingDBi P00521.
ChEMBLi CHEMBL5166.

Proteomic databases

PRIDEi P00521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1.
SABIO-RK P00521.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity."
    Reddy E.P., Smith M.J., Srinivasan A.
    Proc. Natl. Acad. Sci. U.S.A. 80:3623-3627(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Erratum
    Reddy E.P., Smith M.J., Srinivasan A.
    Proc. Natl. Acad. Sci. U.S.A. 80:7372-7372(1983)
    Cited for: SEQUENCE REVISION TO 588-746.
  3. "Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products."
    Groffen J., Heisterkamp N., Reynolds F.H. Jr., Stephenson J.R.
    Nature 304:167-169(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 233-327.

Entry informationi

Entry nameiABL_MLVAB
AccessioniPrimary (citable) accession number: P00521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Abl polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3