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P00521

- ABL_MLVAB

UniProt

P00521 - ABL_MLVAB

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Protein

Tyrosine-protein kinase transforming protein Abl

Gene
ABL
Organism
Abelson murine leukemia virus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571ATP By similarity
Active sitei249 – 2491Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi134 – 1429ATP By similarity
Nucleotide bindingi202 – 2087ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1.
SABIO-RKP00521.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Abl (EC:2.7.10.2)
Alternative name(s):
V-abl
Gene namesi
Name:ABL
OrganismiAbelson murine leukemia virus
Taxonomic identifieri11788 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Tyrosine-protein kinase transforming protein AblPRO_0000088057Add
BLAST

Proteomic databases

PRIDEiP00521.

Interactioni

Protein-protein interaction databases

IntActiP00521. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP00521.
SMRiP00521. Positions 1-398, 640-746.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10391SH2Add
BLAST
Domaini128 – 379252Protein kinaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi267 – 29125Kinase activation loop By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P00521-1 [UniParc]FASTAAdd to Basket

« Hide

YITPVNSLEK HSWYHGPVSR NAAEYLLSSG INGSFLVRES ESSPGQRSIS    50
LRYEGRVYHY RINTASDGKL YVSSESRFNT LAELVHHHST VADGLITTLH 100
YPAPKRNKPT IYGVSPNYDK WEMERTDITM KHKLGGGQYG EVYEGVWKKY 150
SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTREPPFYII 200
TEFMTYGNLL DYLRECNRQE VSAVVLLYMA TQISSAMEYL EKKNFIHRDL 250
AARNCLVGEN HLVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN 300
KFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYELLEK DYRMERPEGC 350
PEKVYELMRA CWQWNPSDRP SFAEIHQAFE TMFQESSISD EVEKELGKRG 400
TRGGAGSMLQ APELPTKTRT CRRAAEQKAS PPSLTPKLLR RQVTASPSSG 450
LSHKKEATKG SASGMGTPAT AEPAPPSNKV GLSKASSEEM RVRRHKHSSE 500
SPGRDKGRLA KLKPAPPPPP ACTGKAGKPA QSPSQEAGEA GGPTKTKCTS 550
LAMDAVNTDP TKAGPPGEGL RKPVPPSVPK PQSTAKPPGT PTSPVSTPST 600
APAPSPLAGD QQPSSAAFIP LISTRVSLRK TRQPPERIAS GTITKGVVLD 650
STEALCLAIS RNSEQMASHS AVLEAGKNLY TFCVSYVDSI QQMRNKFAFR 700
EAINKLESNL RELQICPATA SSGPAATQDF SKLLSSVKEI SDIVRR 746
Length:746
Mass (Da):81,872
Last modified:July 21, 1986 - v1
Checksum:iB9072FFF55FE9257
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01541 Genomic DNA. No translation available.
K00010 Genomic RNA. Translation: AAA46470.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01541 Genomic DNA. No translation available.
K00010 Genomic RNA. Translation: AAA46470.1 .

3D structure databases

ProteinModelPortali P00521.
SMRi P00521. Positions 1-398, 640-746.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P00521. 1 interaction.

Chemistry

BindingDBi P00521.
ChEMBLi CHEMBL5166.

Proteomic databases

PRIDEi P00521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1.
SABIO-RK P00521.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity."
    Reddy E.P., Smith M.J., Srinivasan A.
    Proc. Natl. Acad. Sci. U.S.A. 80:3623-3627(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Erratum
    Reddy E.P., Smith M.J., Srinivasan A.
    Proc. Natl. Acad. Sci. U.S.A. 80:7372-7372(1983)
    Cited for: SEQUENCE REVISION TO 588-746.
  3. "Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products."
    Groffen J., Heisterkamp N., Reynolds F.H. Jr., Stephenson J.R.
    Nature 304:167-169(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 233-327.

Entry informationi

Entry nameiABL_MLVAB
AccessioniPrimary (citable) accession number: P00521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Abl polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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