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Protein

ATP phosphoribosyltransferase

Gene

HIS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).By similarity

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (HIS1)
  2. Histidine biosynthesis trifunctional protein (HIS4)
  3. Histidine biosynthesis trifunctional protein (HIS4)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (HIS6)
  5. Imidazole glycerol phosphate synthase hisHF (HIS7)
  6. Imidazoleglycerol-phosphate dehydratase (HIS3)
  7. Histidinol-phosphate aminotransferase (HIS5)
  8. Histidinol-phosphatase (HIS2)
  9. Histidine biosynthesis trifunctional protein (HIS4)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP phosphoribosyltransferase activity Source: SGD
  • magnesium ion binding Source: InterPro

GO - Biological processi

  • histidine biosynthetic process Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YER055C-MONOMER
UniPathwayiUPA00031; UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:HIS1
Ordered Locus Names:YER055C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER055C
SGDiS000000857 HIS1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519581 – 297ATP phosphoribosyltransferaseAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP00498
PaxDbiP00498
PRIDEiP00498

PTM databases

iPTMnetiP00498

Interactioni

Protein-protein interaction databases

BioGridi36795, 16 interactors
IntActiP00498, 5 interactors
MINTiP00498
STRINGi4932.YER055C

Structurei

3D structure databases

ProteinModelPortaliP00498
SMRiP00498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223250
InParanoidiP00498
KOiK00765
OMAiIFNLDNC
OrthoDBiEOG092C3OBM

Family and domain databases

Gene3Di3.30.70.120, 1 hit
HAMAPiMF_00079 HisG_Long, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR020621 ATP_PRibTrfase_HisG_long
IPR013115 HisG_C
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
PF08029 HisG_C, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
TIGR03455 HisG_C-term, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit

Sequencei

Sequence statusi: Complete.

P00498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVNHLTDR LLFAIPKKGR LYSKSVSILN GADITFHRSQ RLDIALSTSL
60 70 80 90 100
PVALVFLPAA DIPTFVGEGK CDLGITGVDQ VRESNVDVDL AIDLQFGNCK
110 120 130 140 150
LQVQVPVNGE YKKPEQLIGK TIVTSFVKLA EKYFADLEGT TVEKMTTRIK
160 170 180 190 200
FVSGSVEASC ALGIGDAIVD LVESGETMRA AGLVDIATVL STSAYLIESK
210 220 230 240 250
NPKSDKSLIA TIKSRIEGVM TAQRFVSCIY NAPEDKLPEL LKVTPGRRAP
260 270 280 290
TISKIDDEGW VAVSSMIERK TKGVVLDELK RLGASDIMVF EISNCRV
Length:297
Mass (Da):32,266
Last modified:July 21, 1986 - v1
Checksum:i9251252C0EFF8A80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01306 Genomic DNA Translation: CAA24613.1
U18813 Genomic DNA Translation: AAB64591.1
BK006939 Genomic DNA Translation: DAA07712.1
PIRiA00583 XRBY
RefSeqiNP_010975.3, NM_001178946.3

Genome annotation databases

EnsemblFungiiYER055C; YER055C; YER055C
GeneIDi856782
KEGGisce:YER055C

Similar proteinsi

Entry informationi

Entry nameiHIS1_YEAST
AccessioniPrimary (citable) accession number: P00498
Secondary accession number(s): D3DLV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health