P00498 (HIS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP phosphoribosyltransferase
Short name=ATP-PRT
Short name=ATP-PRTase
EC=2.4.2.17

Gene names

Name:	HIS1
Ordered Locus Names:	YER055C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity By similarity.
Catalytic activity	1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ATP phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from mutant phenotype. Source: SGD
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP phosphoribosyltransferase activity Inferred from mutant phenotype. Source: SGD magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	ATP phosphoribosyltransferase		PRO_0000151958

Sequences

	Sequence		Length	Mass (Da)
	P00498 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 9251252C0EFF8A80	FASTA	297	32,266
	10 20 30 40 50 60 MDLVNHLTDR LLFAIPKKGR LYSKSVSILN GADITFHRSQ RLDIALSTSL PVALVFLPAA 70 80 90 100 110 120 DIPTFVGEGK CDLGITGVDQ VRESNVDVDL AIDLQFGNCK LQVQVPVNGE YKKPEQLIGK 130 140 150 160 170 180 TIVTSFVKLA EKYFADLEGT TVEKMTTRIK FVSGSVEASC ALGIGDAIVD LVESGETMRA 190 200 210 220 230 240 AGLVDIATVL STSAYLIESK NPKSDKSLIA TIKSRIEGVM TAQRFVSCIY NAPEDKLPEL 250 260 270 280 290 LKVTPGRRAP TISKIDDEGW VAVSSMIERK TKGVVLDELK RLGASDIMVF EISNCRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae." Hinnebusch A.G., Fink G.R. J. Biol. Chem. 258:5238-5247(1983) [PubMed: 6300123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01306 Genomic DNA. Translation: CAA24613.1. U18813 Genomic DNA. Translation: AAB64591.1. BK006939 Genomic DNA. Translation: DAA07712.1.
PIR	XRBY. A00583.
RefSeq	NP_010975.1. NM_001178946.1.
3D structure databases
ProteinModelPortal	P00498.
SMR	P00498. Positions 10-297.
ModBase	Search...
Protein-protein interaction databases
IntAct	P00498. 5 interactions.
STRING	P00498.
Proteomic databases
PeptideAtlas	P00498.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER055C; YER055C; YER055C.
GeneID	856782.
KEGG	sce:YER055C.
NMPDR	fig|4932.3.peg.2039.
Organism-specific databases
CYGD	YER055c.
SGD	S000000857. HIS1.
Phylogenomic databases
eggNOG	fuNOG05224.
GeneTree	EFGT00050000003035.
HOGENOM	HBG391868.
OMA	WVALEVI.
OrthoDB	EOG4K9FN2.
Gene expression databases
ArrayExpress	P00498.
Genevestigator	P00498.
GermOnline	YER055C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013820. ATP_PRibTrfase_cat. IPR018198. ATP_PRibTrfase_CS. IPR001348. ATP_PRibTrfase_HisG. IPR020621. ATP_PRibTrfase_HisG_long. IPR013115. HisG_C. IPR011322. N-reg_PII-like_a/b. IPR015867. N-reg_PII/ATP_PRibTrfase_C. [Graphical view]
Gene3D	G3DSA:3.30.70.120. PII_glnB. 1 hit.
KO	K00765.
PANTHER	PTHR21403. ATP_phspho_trans. 1 hit.
Pfam	PF01634. HisG. 1 hit. PF08029. HisG_C. 1 hit. [Graphical view]
SUPFAM	SSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMs	TIGR00070. HisG. 1 hit. TIGR03455. HisG_C-term. 1 hit.
PROSITE	PS01316. ATP_P_PHORIBOSYLTR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982994.

Entry information

Entry name

HIS1_YEAST

Accession

Primary (citable) accession number: P00498
Secondary accession number(s): D3DLV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	December 14, 2011
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program