##gff-version 3 P00492 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7107641;Dbxref=PMID:7107641 P00492 UniProtKB Chain 2 218 . . . ID=PRO_0000139585;Note=Hypoxanthine-guanine phosphoribosyltransferase P00492 UniProtKB Active site 138 138 . . . Note=Proton acceptor;Ontology_term=ECO:0000305;evidence=ECO:0000305 P00492 UniProtKB Binding site 69 69 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8044844;Dbxref=PMID:8044844 P00492 UniProtKB Binding site 134 142 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8044844;Dbxref=PMID:8044844 P00492 UniProtKB Binding site 166 166 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8044844;Dbxref=PMID:8044844 P00492 UniProtKB Binding site 186 188 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8044844;Dbxref=PMID:8044844 P00492 UniProtKB Binding site 194 194 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8044844;Dbxref=PMID:8044844 P00492 UniProtKB Binding site 194 194 . . . . P00492 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7107641;Dbxref=PMID:7107641 P00492 UniProtKB Modified residue 103 103 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00493 P00492 UniProtKB Modified residue 142 142 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27605 P00492 UniProtKB Cross-link 115 115 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 P00492 UniProtKB Cross-link 115 115 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P00492 UniProtKB Natural variant 7 7 . . . ID=VAR_006750;Note=In HRH%3B Gravesend. G->D P00492 UniProtKB Natural variant 8 8 . . . ID=VAR_006751;Note=In LNS%3B HB. V->G P00492 UniProtKB Natural variant 8 8 . . . ID=VAR_071609;Note=In LNS%3B Asia. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17027311;Dbxref=PMID:17027311 P00492 UniProtKB Natural variant 16 16 . . . ID=VAR_006752;Note=In LNS%3B FG. G->D P00492 UniProtKB Natural variant 16 16 . . . ID=VAR_006753;Note=In HRH%3B Urangan. G->S;Dbxref=dbSNP:rs137852499 P00492 UniProtKB Natural variant 20 20 . . . ID=VAR_006754;Note=In HRH%3B Mashad%3B strongly reduces enzymatic activity. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24940672;Dbxref=PMID:24940672 P00492 UniProtKB Natural variant 23 23 . . . ID=VAR_071610;Note=In HRH%3B Reduces enzymatic activity. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24940672;Dbxref=PMID:24940672 P00492 UniProtKB Natural variant 23 23 . . . ID=VAR_006755;Note=In HRH%3B JS. C->W P00492 UniProtKB Natural variant 28 28 . . . ID=VAR_012312;Note=In LNS%3B Asia. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17027311,ECO:0000269|PubMed:2071157;Dbxref=PMID:17027311,PMID:2071157 P00492 UniProtKB Natural variant 41 41 . . . ID=VAR_006756;Note=In LNS%3B Detroit. L->P;Dbxref=dbSNP:rs137852480 P00492 UniProtKB Natural variant 42 42 . . . ID=VAR_006757;Note=In LNS%3B Isar. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7627191;Dbxref=PMID:7627191 P00492 UniProtKB Natural variant 42 42 . . . ID=VAR_006758;Note=In LNS%3B Heapey. I->T P00492 UniProtKB Natural variant 43 44 . . . ID=VAR_006759;Note=In LNS%3B Salamanca. MD->RN P00492 UniProtKB Natural variant 44 44 . . . ID=VAR_071611;Note=In LNS%3B Japan. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20544509;Dbxref=PMID:20544509 P00492 UniProtKB Natural variant 45 45 . . . ID=VAR_006760;Note=In LNS%3B RJK 2163. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=dbSNP:rs137852491,PMID:2347587 P00492 UniProtKB Natural variant 48 48 . . . ID=VAR_006761;Note=In HRH%3B AD and DD. R->H;Dbxref=dbSNP:rs387906725 P00492 UniProtKB Natural variant 50 50 . . . ID=VAR_006763;Note=In LNS%3B LW. A->P;Dbxref=dbSNP:rs1556026984 P00492 UniProtKB Natural variant 50 50 . . . ID=VAR_006762;Note=In LNS%3B 1265. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2071157;Dbxref=PMID:2071157 P00492 UniProtKB Natural variant 51 51 . . . ID=VAR_006764;Note=In HRH%3B Toronto. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6853490;Dbxref=dbSNP:rs137852494,PMID:6853490 P00492 UniProtKB Natural variant 51 51 . . . ID=VAR_006765;Note=In LNS%3B Banbury. R->P P00492 UniProtKB Natural variant 52 52 . . . ID=VAR_006766;Note=In Edinburgh. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1551676;Dbxref=dbSNP:rs137852502,PMID:1551676 P00492 UniProtKB Natural variant 53 53 . . . ID=VAR_006767;Note=In HRH%3B MG. V->A P00492 UniProtKB Natural variant 53 53 . . . ID=VAR_006768;Note=In HRH%3B TE. V->M P00492 UniProtKB Natural variant 54 54 . . . ID=VAR_006769;Note=In LNS%3B Japan-1. M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2572141;Dbxref=PMID:2572141 P00492 UniProtKB Natural variant 57 57 . . . ID=VAR_006770;Note=In LNS%3B Montreal. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2358296;Dbxref=dbSNP:rs137852495,PMID:2358296 P00492 UniProtKB Natural variant 58 58 . . . ID=VAR_006771;Note=In HRH%3B Toowong. G->R;Dbxref=dbSNP:rs137852500 P00492 UniProtKB Natural variant 60 60 . . . ID=VAR_071612;Note=In HRH%3B Reduces enzymatic activity. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24940672;Dbxref=dbSNP:rs1228634091,PMID:24940672 P00492 UniProtKB Natural variant 61 61 . . . ID=VAR_006772;Note=Enzyme activity 37%25 of normal%3B asymptomatic. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9003484;Dbxref=PMID:9003484 P00492 UniProtKB Natural variant 64 64 . . . ID=VAR_071613;Note=In LNS%3B Asia. A->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 65 65 . . . ID=VAR_071614;Note=In LNS%3B Asia. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 70 70 . . . ID=VAR_006773;Note=In LNS%3B New Haven/1510%2C Asia. G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311,ECO:0000269|PubMed:2071157;Dbxref=dbSNP:rs137852487,PMID:15571223,PMID:17027311,PMID:2071157 P00492 UniProtKB Natural variant 71 71 . . . ID=VAR_006774;Note=In LNS%3B Yale. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2910902;Dbxref=dbSNP:rs137852488,PMID:2910902 P00492 UniProtKB Natural variant 72 72 . . . ID=VAR_071615;Note=In LNS%3B Asia. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 74 74 . . . ID=VAR_006775;Note=In LNS%3B Flint/RJK 892/DW/Perth/1522%2C Japan. F->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20544509,ECO:0000269|PubMed:2071157,ECO:0000269|PubMed:2347587,ECO:0000269|PubMed:3384338;Dbxref=dbSNP:rs137852481,PMID:20544509,PMID:2071157,PMID:2347587,PMID:3384338 P00492 UniProtKB Natural variant 78 78 . . . ID=VAR_071616;Note=In LNS%3B Asia. L->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 78 78 . . . ID=VAR_006776;Note=In HRH%3B Swan. L->V;Dbxref=dbSNP:rs137852501 P00492 UniProtKB Natural variant 80 80 . . . ID=VAR_006777;Note=In HRH%3B Arlington. D->V;Dbxref=dbSNP:rs137852478 P00492 UniProtKB Natural variant 104 104 . . . ID=VAR_006778;Note=In HRH%3B Munich. S->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:3358423,ECO:0000269|PubMed:6706936;Dbxref=dbSNP:rs137852485,PMID:3358423,PMID:6706936 P00492 UniProtKB Natural variant 107 110 . . . ID=VAR_071617;Note=In LNS%3B Asia. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15571223;Dbxref=PMID:15571223 P00492 UniProtKB Natural variant 110 110 . . . ID=VAR_006779;Note=In HRH%3B London. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:3198771,ECO:0000269|PubMed:6572373;Dbxref=dbSNP:rs137852482,PMID:3198771,PMID:6572373 P00492 UniProtKB Natural variant 124 124 . . . ID=VAR_071618;Note=In HRH%3B Asia. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17027311;Dbxref=PMID:17027311 P00492 UniProtKB Natural variant 130 130 . . . ID=VAR_006780;Note=In LNS%3B Midland/RJK 896. V->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2347587,ECO:0000269|PubMed:3265398;Dbxref=dbSNP:rs137852483,PMID:2347587,PMID:3265398 P00492 UniProtKB Natural variant 131 131 . . . ID=VAR_006781;Note=In LNS%3B RJK 1784. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=PMID:2347587 P00492 UniProtKB Natural variant 132 132 . . . ID=VAR_006782;Note=In HRH%3B Ann-Arbor. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2896620;Dbxref=dbSNP:rs137852477,PMID:2896620 P00492 UniProtKB Natural variant 132 132 . . . ID=VAR_006783;Note=In LNS%3B Runcorn. I->T P00492 UniProtKB Natural variant 135 135 . . . ID=VAR_006784;Note=In HRH%3B Yeronga. D->G P00492 UniProtKB Natural variant 143 143 . . . ID=VAR_006785;Note=In LNS%3B RJK 1210. M->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=dbSNP:rs137852496,PMID:2347587 P00492 UniProtKB Natural variant 143 143 . . . ID=VAR_006786;Note=In LNS%3B RW. M->MA P00492 UniProtKB Natural variant 147 147 . . . ID=VAR_071619;Note=In LNS%3B Asia. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 159 159 . . . ID=VAR_071620;Note=In LNS%3B Asia. K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 159 159 . . . ID=VAR_071621;Note=In LNS%3B Asia. K->KV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17027311;Dbxref=PMID:17027311 P00492 UniProtKB Natural variant 161 161 . . . ID=VAR_006787;Note=In HRH%3B Milwaukee/RJK 949. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=dbSNP:rs137852484,PMID:2347587 P00492 UniProtKB Natural variant 162 162 . . . ID=VAR_006788;Note=In LNS%3B Farnham. S->R P00492 UniProtKB Natural variant 168 168 . . . ID=VAR_006789;Note=In HRH%3B Brisbane. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2246854;Dbxref=dbSNP:rs137852498,PMID:2246854 P00492 UniProtKB Natural variant 176 176 . . . ID=VAR_006790;Note=In LNS%3B Marlow. P->L;Dbxref=dbSNP:rs137852493 P00492 UniProtKB Natural variant 177 177 . . . ID=VAR_006791;Note=In LNS%3B Roanne. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9452051;Dbxref=PMID:9452051 P00492 UniProtKB Natural variant 177 177 . . . ID=VAR_006792;Note=In LNS%3B RJK 2185. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=dbSNP:rs137852492,PMID:2347587 P00492 UniProtKB Natural variant 179 180 . . . ID=VAR_006794;Note=In HRH%3B Japan-2. VG->GR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2572141;Dbxref=PMID:2572141 P00492 UniProtKB Natural variant 179 179 . . . ID=VAR_006793;Note=In LNS%3B Michigan. Missing P00492 UniProtKB Natural variant 183 183 . . . ID=VAR_006796;Note=In HRH%3B JF. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2071157;Dbxref=PMID:2071157 P00492 UniProtKB Natural variant 185 185 . . . ID=VAR_071622;Note=In HRH%3B Asia. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17027311;Dbxref=PMID:17027311 P00492 UniProtKB Natural variant 188 188 . . . ID=VAR_006795;Note=In HRH and LNS%3B Asia. V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311,ECO:0000269|PubMed:1840476;Dbxref=PMID:15571223,PMID:17027311,PMID:1840476 P00492 UniProtKB Natural variant 192 192 . . . ID=VAR_071623;Note=In HRH%3B Asia. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 194 194 . . . ID=VAR_006797;Note=In HRH%3B Moose-Jaw%3B results in cooperativity and decreased substrate affinities. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7987318;Dbxref=dbSNP:rs137852504,PMID:7987318 P00492 UniProtKB Natural variant 194 194 . . . ID=VAR_006798;Note=In LNS%3B Kinston/RJK 2188. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2347587,ECO:0000269|PubMed:6853716;Dbxref=dbSNP:rs267606863,PMID:2347587,PMID:6853716 P00492 UniProtKB Natural variant 195 195 . . . ID=VAR_006799;Note=In HRH%3B Dirranbandi%2C Asia. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15571223,ECO:0000269|PubMed:17027311;Dbxref=PMID:15571223,PMID:17027311 P00492 UniProtKB Natural variant 199 199 . . . ID=VAR_006800;Note=In LNS%3B New Briton/RJK 950. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=dbSNP:rs137852486,PMID:2347587 P00492 UniProtKB Natural variant 201 201 . . . ID=VAR_006801;Note=In HRH%3B Ashville. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2909537;Dbxref=dbSNP:rs137852479,PMID:2909537 P00492 UniProtKB Natural variant 201 201 . . . ID=VAR_006802;Note=In HRH%3B RB. D->N P00492 UniProtKB Natural variant 201 201 . . . ID=VAR_006803;Note=In LNS%3B GM. D->Y P00492 UniProtKB Natural variant 204 204 . . . ID=VAR_006804;Note=In LNS%3B RJK 1874. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=dbSNP:rs137852490,PMID:2347587 P00492 UniProtKB Natural variant 204 204 . . . ID=VAR_006805;Note=In LNS%3B 779. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2071157;Dbxref=PMID:2071157 P00492 UniProtKB Natural variant 206 206 . . . ID=VAR_006806;Note=In LNS%3B Reading/RJK 1727. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2347587;Dbxref=PMID:2347587 P00492 UniProtKB Mutagenesis 69 69 . . . Note=Reduced affinity for hypoxanthine%2C phosphoribosylpyrophosphate and IMP. Reduced catalytic activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10338013;Dbxref=PMID:10338013 P00492 UniProtKB Beta strand 7 9 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1HMP P00492 UniProtKB Beta strand 12 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SAN P00492 UniProtKB Helix 19 21 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Helix 26 28 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Turn 29 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 32 37 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Helix 39 57 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 62 68 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Turn 69 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Helix 72 87 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 88 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 95 101 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 107 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1D6N P00492 UniProtKB Beta strand 115 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6BNJ P00492 UniProtKB Helix 119 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RAC P00492 UniProtKB Helix 123 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 128 140 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Helix 141 150 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Helix 151 153 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 156 166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 169 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1Z7G P00492 UniProtKB Beta strand 177 183 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 188 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Beta strand 195 197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5BSK P00492 UniProtKB Beta strand 198 201 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1BZY P00492 UniProtKB Beta strand 203 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA P00492 UniProtKB Helix 210 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5HIA