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Protein

Coagulation factor XIII A chain

Gene

F13A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3151 Publication1
Active sitei3741 Publication1
Active sitei3971 Publication1
Metal bindingi437Calcium1 Publication1
Metal bindingi439Calcium1 Publication1
Metal bindingi486Calcium1 Publication1
Metal bindingi491Calcium1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124491-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-140875. Common Pathway of Fibrin Clot Formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13A1
Synonyms:F13A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:3531. F13A1.

Subcellular locationi

  • Cytoplasm
  • Secreted 1 Publication

  • Note: Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular region Source: Reactome
  • platelet alpha granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Involvement in diseasei

Factor XIII subunit A deficiency (FA13AD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
See also OMIM:613225
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074280167P → L in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074281172R → Q in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074282274G → V in FA13AD. 1 Publication1
Natural variantiVAR_074283343H → Y in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074284347A → D in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074285376W → R in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074286414S → L in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074287416Q → R in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074288530L → P in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074289602Q → K in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_007474682R → H in FA13AD. 1 Publication1
Natural variantiVAR_074290704R → Q in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074291716R → G in FA13AD; mild; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi2162.
MalaCardsiF13A1.
MIMi134570. gene+phenotype.
613225. phenotype.
Orphaneti331. Congenital factor XIII deficiency.
PharmGKBiPA162.

Chemistry databases

ChEMBLiCHEMBL4530.
DrugBankiDB00130. L-Glutamine.

Polymorphism and mutation databases

BioMutaiF13A1.
DMDMi119720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
PropeptideiPRO_00000336462 – 38Activation peptideAdd BLAST37
ChainiPRO_000003364739 – 732Coagulation factor XIII A chainAdd BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Glycosylationi614N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

The activation peptide is released by thrombin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38 – 39Cleavage; by thrombin; to produce active factor XIII-A2

Keywords - PTMi

Acetylation, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP00488.
PaxDbiP00488.
PeptideAtlasiP00488.
PRIDEiP00488.
TopDownProteomicsiP00488.

2D gel databases

OGPiP00488.

PTM databases

iPTMnetiP00488.
PhosphoSitePlusiP00488.

Miscellaneous databases

PMAP-CutDBP00488.

Expressioni

Gene expression databases

BgeeiENSG00000124491.
CleanExiHS_F13A1.
ExpressionAtlasiP00488. baseline and differential.
GenevisibleiP00488. HS.

Organism-specific databases

HPAiCAB002155.
HPA001804.
HPA047903.

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.2 Publications

Protein-protein interaction databases

BioGridi108460. 11 interactors.
DIPiDIP-377N.
IntActiP00488. 9 interactors.
MINTiMINT-7966415.
STRINGi9606.ENSP00000264870.

Chemistry databases

BindingDBiP00488.

Structurei

Secondary structure

1732
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 32Combined sources4
Helixi42 – 44Combined sources3
Beta strandi48 – 52Combined sources5
Helixi60 – 64Combined sources5
Beta strandi68 – 71Combined sources4
Beta strandi74 – 78Combined sources5
Beta strandi81 – 91Combined sources11
Turni95 – 97Combined sources3
Beta strandi100 – 105Combined sources6
Beta strandi107 – 109Combined sources3
Helixi112 – 114Combined sources3
Beta strandi116 – 125Combined sources10
Beta strandi132 – 139Combined sources8
Beta strandi142 – 148Combined sources7
Beta strandi156 – 166Combined sources11
Beta strandi169 – 172Combined sources4
Helixi177 – 179Combined sources3
Beta strandi181 – 184Combined sources4
Helixi199 – 205Combined sources7
Beta strandi210 – 217Combined sources8
Beta strandi220 – 227Combined sources8
Helixi235 – 245Combined sources11
Helixi250 – 252Combined sources3
Helixi256 – 266Combined sources11
Turni270 – 272Combined sources3
Beta strandi275 – 278Combined sources4
Helixi290 – 292Combined sources3
Helixi297 – 306Combined sources10
Beta strandi310 – 313Combined sources4
Helixi315 – 329Combined sources15
Beta strandi333 – 343Combined sources11
Beta strandi345 – 355Combined sources11
Beta strandi359 – 361Combined sources3
Turni363 – 365Combined sources3
Beta strandi369 – 381Combined sources13
Beta strandi384 – 386Combined sources3
Beta strandi392 – 396Combined sources5
Beta strandi402 – 404Combined sources3
Beta strandi406 – 414Combined sources9
Helixi415 – 419Combined sources5
Beta strandi425 – 428Combined sources4
Helixi429 – 437Combined sources9
Beta strandi439 – 445Combined sources7
Turni447 – 449Combined sources3
Beta strandi451 – 461Combined sources11
Beta strandi464 – 468Combined sources5
Beta strandi470 – 473Combined sources4
Beta strandi475 – 477Combined sources3
Helixi479 – 482Combined sources4
Helixi489 – 501Combined sources13
Beta strandi519 – 527Combined sources9
Beta strandi534 – 542Combined sources9
Beta strandi544 – 546Combined sources3
Beta strandi548 – 559Combined sources12
Beta strandi565 – 578Combined sources14
Beta strandi580 – 590Combined sources11
Helixi592 – 595Combined sources4
Helixi596 – 598Combined sources3
Beta strandi604 – 613Combined sources10
Turni614 – 617Combined sources4
Beta strandi618 – 626Combined sources9
Beta strandi633 – 639Combined sources7
Beta strandi647 – 654Combined sources8
Beta strandi657 – 659Combined sources3
Beta strandi661 – 670Combined sources10
Turni671 – 673Combined sources3
Beta strandi674 – 684Combined sources11
Beta strandi689 – 696Combined sources8
Beta strandi702 – 711Combined sources10
Beta strandi713 – 727Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EVUX-ray2.01A/B2-732[»]
1EX0X-ray2.00A/B2-732[»]
1F13X-ray2.10A/B2-732[»]
1FIEX-ray2.50A/B2-732[»]
1GGTX-ray2.65A/B2-732[»]
1GGUX-ray2.10A/B2-732[»]
1GGYX-ray2.50A/B2-732[»]
1QRKX-ray2.50A/B2-732[»]
4KTYX-ray1.98A/B2-732[»]
ProteinModelPortaliP00488.
SMRiP00488.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00488.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP00488.
KOiK03917.
OrthoDBiEOG091G030K.
PhylomeDBiP00488.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETSRTAFG GRRAVPPNNS NAAEDDLPTV ELQGVVPRGV NLQEFLNVTS
60 70 80 90 100
VHLFKERWDT NKVDHHTDKY ENNKLIVRRG QSFYVQIDFS RPYDPRRDLF
110 120 130 140 150
RVEYVIGRYP QENKGTYIPV PIVSELQSGK WGAKIVMRED RSVRLSIQSS
160 170 180 190 200
PKCIVGKFRM YVAVWTPYGV LRTSRNPETD TYILFNPWCE DDAVYLDNEK
210 220 230 240 250
EREEYVLNDI GVIFYGEVND IKTRSWSYGQ FEDGILDTCL YVMDRAQMDL
260 270 280 290 300
SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNIYAYGVPP SAWTGSVDIL
310 320 330 340 350
LEYRSSENPV RYGQCWVFAG VFNTFLRCLG IPARIVTNYF SAHDNDANLQ
360 370 380 390 400
MDIFLEEDGN VNSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP
410 420 430 440 450
QENSDGMYRC GPASVQAIKH GHVCFQFDAP FVFAEVNSDL IYITAKKDGT
460 470 480 490 500
HVVENVDATH IGKLIVTKQI GGDGMMDITD TYKFQEGQEE ERLALETALM
510 520 530 540 550
YGAKKPLNTE GVMKSRSNVD MDFEVENAVL GKDFKLSITF RNNSHNRYTI
560 570 580 590 600
TAYLSANITF YTGVPKAEFK KETFDVTLEP LSFKKEAVLI QAGEYMGQLL
610 620 630 640 650
EQASLHFFVT ARINETRDVL AKQKSTVLTI PEIIIKVRGT QVVGSDMTVT
660 670 680 690 700
VQFTNPLKET LRNVWVHLDG PGVTRPMKKM FREIRPNSTV QWEEVCRPWV
710 720 730
SGHRKLIASM SSDSLRHVYG ELDVQIQRRP SM
Length:732
Mass (Da):83,267
Last modified:January 23, 2007 - v4
Checksum:i51A83A9B8B1370D4
GO

Sequence cautioni

The sequence AAA52489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92089 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36Missing AA sequence (PubMed:4811064).Curated1
Sequence conflicti89F → L in AAA52488 (PubMed:3026437).Curated1

Polymorphismi

There are four main allelic forms of this protein; F13A*1A, F13A*1B, F13A*2A and F13A*2B. In addition two other intermediate forms (F13A*2A and F13A*2B) seem to exist. The sequence shown is that of F13A*2B.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01392735V → L Higher specific activity. 3 PublicationsCorresponds to variant rs5985dbSNPEnsembl.1
Natural variantiVAR_02091040V → I.1 Publication1
Natural variantiVAR_074280167P → L in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074281172R → Q in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_020911205Y → F.1 PublicationCorresponds to variant rs3024477dbSNPEnsembl.1
Natural variantiVAR_074282274G → V in FA13AD. 1 Publication1
Natural variantiVAR_074283343H → Y in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074284347A → D in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_057350351M → K.Corresponds to variant rs2230848dbSNPEnsembl.1
Natural variantiVAR_074285376W → R in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074286414S → L in FA13AD; unknown pathological significance. 1 Publication1
Natural variantiVAR_074287416Q → R in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074288530L → P in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_013928551T → I.1 PublicationCorresponds to variant rs5984dbSNPEnsembl.1
Natural variantiVAR_007471565P → L in allele F13A*1A, allele F13A*2A and allele F13*(2)A. 3 PublicationsCorresponds to variant rs5982dbSNPEnsembl.1
Natural variantiVAR_013929589L → Q.1 PublicationCorresponds to variant rs5983dbSNPEnsembl.1
Natural variantiVAR_074289602Q → K in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_060545650T → I.1 PublicationCorresponds to variant rs17852475dbSNPEnsembl.1
Natural variantiVAR_007472651V → I in allele F13A*2A and allele F13A*2B. 3 PublicationsCorresponds to variant rs5987dbSNPEnsembl.1
Natural variantiVAR_007473652Q → E in allele F13A*1A and allele F13A*1B. 5 PublicationsCorresponds to variant rs5988dbSNPEnsembl.1
Natural variantiVAR_007474682R → H in FA13AD. 1 Publication1
Natural variantiVAR_074290704R → Q in FA13AD; mild; unknown pathological significance. 1 Publication1
Natural variantiVAR_074291716R → G in FA13AD; mild; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14539 mRNA. Translation: AAA52489.1. Different initiation.
M14354 mRNA. Translation: AAA52488.1.
M22001
, M21987, M21988, M21989, M21990, M21991, M21992, M21993, M21995, M21996, M21997, M21998, M21999, M22000 Genomic DNA. Translation: AAA52415.1.
AB208852 mRNA. Translation: BAD92089.1. Different initiation.
AF418272 Genomic DNA. Translation: AAL12161.1.
AL157775, AL133326, AL391420 Genomic DNA. Translation: CAC36886.3.
AL391420, AL133326, AL157775 Genomic DNA. Translation: CAI39797.2.
AL133326, AL157775, AL391420 Genomic DNA. Translation: CAO03607.1.
BC027963 mRNA. Translation: AAH27963.1.
CCDSiCCDS4496.1.
PIRiA35583. EKHUX.
RefSeqiNP_000120.2. NM_000129.3.
UniGeneiHs.335513.

Genome annotation databases

EnsembliENST00000264870; ENSP00000264870; ENSG00000124491.
GeneIDi2162.
KEGGihsa:2162.
UCSCiuc003mwv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14539 mRNA. Translation: AAA52489.1. Different initiation.
M14354 mRNA. Translation: AAA52488.1.
M22001
, M21987, M21988, M21989, M21990, M21991, M21992, M21993, M21995, M21996, M21997, M21998, M21999, M22000 Genomic DNA. Translation: AAA52415.1.
AB208852 mRNA. Translation: BAD92089.1. Different initiation.
AF418272 Genomic DNA. Translation: AAL12161.1.
AL157775, AL133326, AL391420 Genomic DNA. Translation: CAC36886.3.
AL391420, AL133326, AL157775 Genomic DNA. Translation: CAI39797.2.
AL133326, AL157775, AL391420 Genomic DNA. Translation: CAO03607.1.
BC027963 mRNA. Translation: AAH27963.1.
CCDSiCCDS4496.1.
PIRiA35583. EKHUX.
RefSeqiNP_000120.2. NM_000129.3.
UniGeneiHs.335513.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EVUX-ray2.01A/B2-732[»]
1EX0X-ray2.00A/B2-732[»]
1F13X-ray2.10A/B2-732[»]
1FIEX-ray2.50A/B2-732[»]
1GGTX-ray2.65A/B2-732[»]
1GGUX-ray2.10A/B2-732[»]
1GGYX-ray2.50A/B2-732[»]
1QRKX-ray2.50A/B2-732[»]
4KTYX-ray1.98A/B2-732[»]
ProteinModelPortaliP00488.
SMRiP00488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108460. 11 interactors.
DIPiDIP-377N.
IntActiP00488. 9 interactors.
MINTiMINT-7966415.
STRINGi9606.ENSP00000264870.

Chemistry databases

BindingDBiP00488.
ChEMBLiCHEMBL4530.
DrugBankiDB00130. L-Glutamine.

PTM databases

iPTMnetiP00488.
PhosphoSitePlusiP00488.

Polymorphism and mutation databases

BioMutaiF13A1.
DMDMi119720.

2D gel databases

OGPiP00488.

Proteomic databases

MaxQBiP00488.
PaxDbiP00488.
PeptideAtlasiP00488.
PRIDEiP00488.
TopDownProteomicsiP00488.

Protocols and materials databases

DNASUi2162.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264870; ENSP00000264870; ENSG00000124491.
GeneIDi2162.
KEGGihsa:2162.
UCSCiuc003mwv.4. human.

Organism-specific databases

CTDi2162.
DisGeNETi2162.
GeneCardsiF13A1.
HGNCiHGNC:3531. F13A1.
HPAiCAB002155.
HPA001804.
HPA047903.
MalaCardsiF13A1.
MIMi134570. gene+phenotype.
613225. phenotype.
neXtProtiNX_P00488.
Orphaneti331. Congenital factor XIII deficiency.
PharmGKBiPA162.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP00488.
KOiK03917.
OrthoDBiEOG091G030K.
PhylomeDBiP00488.
TreeFamiTF324278.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124491-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-140875. Common Pathway of Fibrin Clot Formation.

Miscellaneous databases

ChiTaRSiF13A1. human.
EvolutionaryTraceiP00488.
GeneWikiiCoagulation_factor_XIII,_A1_polypeptide.
GenomeRNAii2162.
PMAP-CutDBP00488.
PROiP00488.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124491.
CleanExiHS_F13A1.
ExpressionAtlasiP00488. baseline and differential.
GenevisibleiP00488. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF13A_HUMAN
AccessioniPrimary (citable) accession number: P00488
Secondary accession number(s): Q59HA7
, Q8N6X2, Q96P24, Q9BX29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 206 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.