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Protein

Chloramphenicol acetyltransferase 3

Gene

cat3

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme is an effector of chloramphenicol resistance in bacteria.

Catalytic activityi

Acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei189Proton acceptor1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Chloramphenicol acetyltransferase 3 (EC:2.3.1.28)
Alternative name(s):
Chloramphenicol acetyltransferase III
Short name:
CAT-III
Gene namesi
Name:cat3
Encoded oniPlasmid IncK R3870 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Pathology & Biotechi

Chemistry databases

DrugBankiDB00446 Chloramphenicol
DB02703 Fusidic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001658771 – 213Chloramphenicol acetyltransferase 3Add BLAST213

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi8 – 10Combined sources3
Helixi14 – 22Combined sources9
Beta strandi27 – 35Combined sources9
Helixi37 – 44Combined sources8
Helixi50 – 62Combined sources13
Helixi66 – 68Combined sources3
Beta strandi69 – 73Combined sources5
Beta strandi76 – 81Combined sources6
Beta strandi84 – 91Combined sources8
Turni92 – 95Combined sources4
Beta strandi96 – 101Combined sources6
Helixi108 – 122Combined sources15
Beta strandi127 – 129Combined sources3
Beta strandi136 – 144Combined sources9
Beta strandi166 – 170Combined sources5
Beta strandi173 – 175Combined sources3
Beta strandi178 – 188Combined sources11
Turni189 – 191Combined sources3
Helixi194 – 208Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CIAX-ray2.50A1-213[»]
1CLAX-ray2.34A1-213[»]
1QCAX-ray2.20A1-213[»]
2CLAX-ray2.35A1-213[»]
3CLAX-ray1.75A1-213[»]
4CLAX-ray2.00A1-213[»]
ProteinModelPortaliP00484
SMRiP00484
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00484

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK19271

Family and domain databases

Gene3Di3.30.559.10, 1 hit
InterProiView protein in InterPro
IPR023213 CAT-like_dom_sf
IPR018372 Chloramphenicol_AcTrfase_AS
IPR001707 Cmp_AcTrfase
PANTHERiPTHR38474 PTHR38474, 1 hit
PfamiView protein in Pfam
PF00302 CAT, 1 hit
PIRSFiPIRSF000440 CAT, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002660 Cmp_AcTrfase, 1 hit
SMARTiView protein in SMART
SM01059 CAT, 1 hit
PROSITEiView protein in PROSITE
PS00100 CAT, 1 hit

Sequencei

Sequence statusi: Complete.

P00484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTKFDVKN WVRREHFEFY RHRLPCGFSL TSKIDITTLK KSLDDSAYKF
60 70 80 90 100
YPVMIYLIAQ AVNQFDELRM AIKDDELIVW DSVDPQFTVF HQETETFSAL
110 120 130 140 150
SCPYSSDIDQ FMVNYLSVME RYKSDTKLFP QGVTPENHLN ISALPWVNFD
160 170 180 190 200
SFNLNVANFT DYFAPIITMA KYQQEGDRLL LPLSVQVHHA VCDGFHVARF
210
INRLQELCNS KLK
Length:213
Mass (Da):24,994
Last modified:August 1, 1988 - v1
Checksum:i4A96839AB590CB1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07848 Genomic DNA Translation: CAA30695.1
PIRiA00567 XXECC3

Genome annotation databases

KEGGiag:CAA30695

Entry informationi

Entry nameiCAT3_ECOLX
AccessioniPrimary (citable) accession number: P00484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

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